Search clinical trials for: moderate to severe, chronic pain

Total 475006 results

University of Ioannina

Recruiting

Opioid-free Anaesthesia in Breast Cancer Surgery

Pain, Postoperative | Breast Cancer | Anesthesia | Pain, Chronic | Cancer Recurrence | Opioid Free Anaesthesia

Greece
Mesoblast, Ltd.

Not yet recruiting

Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain (HyaluronicAcid)

Degenerative Disc Disease
University Ghent

Recruiting

The Effects of a Moderate Intensity Training Program Versus a High Intensity Training Program on Central Pain Processing (ChronicPA-PAIN)

Healthy

Belgium
Merz Therapeutics GmbH

Recruiting

A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participants Aged 18 Years and Older With Chronic Nerve Pain After Shingles or Nerve Injury (PaiNT)

Moderate to Severe Chronic Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN) or Peripheral Nerve Injury

Bulgaria, Germany, Poland, France, Hungary, Spain
Cara Therapeutics, Inc.

Recruiting

Study to Evaluate the Efficacy and Safety of Oral Difelikefalin for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica

Pruritus | Notalgia Paresthetica

United States, Poland, Spain, Canada, Germany
Stanford University

Not yet recruiting

Biometrics and Self-reported Health Changes in Adults Receiving Behavioral Treatments for Chronic Pain

Chronic Pain | Sedentary Time

United States
Stephen Robert Marder

Not yet recruiting

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

Post Traumatic Stress Disorder

United States
Taipei Medical University Hospital

Recruiting

Effects of Multiple Mega-dose of Vitamin D3 Supplementation on Ameliorating Moderate to Severe Chronic Pain in Hemodialysis Patients

Hyperparathyroidism | Chronic Pain | Hemodialysis

Taiwan
Hasselt University
KU Leuven; Maastricht University

Recruiting

High Intensity Training to Improve Diaphragm Functioning in Persons With Chronic Nonspecific Low Back Pain

Low Back Pain | Chronic Pain | Chronic Low-back Pain

Belgium
University Hospital, Grenoble

Not yet recruiting

Medical Benefit Evaluation of Ambulatory Activity Combining Rehabilitation and Therapeutic Education, Using an Intelligent Electric Bike for the Health, for the Effort Rehabilitation and the Quality of Life Improvement for Patients Suffering of Moderate Fibromyalgia (FIBROVELIS) (Fibrovelis)

Chronic Pain | Fibromyalgia | Adapted Physical Activity | Therapeutic Education | Electric Bike
Zimmer Biomet

Completed

ROSA Robot Used in Total Knee Replacement Post Market Study

Rheumatoid Arthritis | Knee Pain | Chronic Osteoarthritis | Avascular Necrosis of the Femoral Condyle | Moderate Varus, Valgus or Flexion Deformities

United States
Zimmer Biomet

Active, not recruiting

ROSA Total Knee Post Market Study EMEA

Rheumatoid Arthritis | Knee Pain | Chronic Osteoarthritis | Avascular Necrosis of the Femoral Condyle | Moderate Varus, Valgus or Flexion Deformities

Belgium, Switzerland, Germany, Israel, Italy
AstraZeneca

Active, not recruiting

Real-world, 52-week Prospective Study to Capture the Reasons for Switch to Triple Combination Therapy, Assess the Clinical and Patient Reported Outcomes in Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) Treated With Trixeo Aerosphere™ in Routine Care Settings in Greece (TRIAENA)

Pulmonary Disease, Chronic Obstructive (COPD)

Greece
Bayer

Completed

Study on the Safety of BAY1817080 How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given to Participants With Moderate Renal Impairment and End Stage Renal Disease Requiring Dialysis Compared With Matched Participants With Normal Renal Function

Overactive Bladder | Diabetic Neuropathic Pain | Endometriosis Related Pain | Refractory or Unexplained Chronic Cough

United States
Zimmer Biomet

Active, not recruiting

Persona Total Knee Arthroplasty Outcomes Study

Osteoarthritis | Rheumatoid Arthritis | Traumatic Arthritis | Knee Pain Chronic | Polyarthritis | Avascular Necrosis of the Femoral Condyle | Moderate Varus, Valgus or Flexion Deformities

United States
Cara Therapeutics, Inc.

Completed

Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica (KOMFORT)

Pruritus | Notalgia Paresthetica

United States, Canada
Hasselt University
Jessa Hospital

Completed

Acute Effects of High Intensity Training on Pain Processing and Inflammation in Chronic Low Back Pain.

Inflammation | Low Back Pain

Belgium
Craig Hospital
Mayo Clinic; University of Alabama at Birmingham; Wayne State University; NYU Langone... and other collaborators

Completed

Characterization & Treatment of Chronic Pain After Moderate to Severe TBI

Pain | Traumatic Brain Injury

United States
Sorrento Therapeutics, Inc.

Active, not recruiting

Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis

Knee Osteoarthritis | Osteoarthritis, Knee | Knee Pain Chronic

United States
Zimmer Biomet

Terminated

ROSA Total Knee Investigational Testing Authorization Study

Rheumatoid Arthritis | Knee Pain | Chronic Osteoarthritis | Moderate Varus, Valgus or Flexion Deformities | Avascular Necrosis of Femoral Condyle

Canada
University Health Network, Toronto
Unity Health Toronto; Women's College Hospital; MOUNT SINAI HOSPITAL

Completed

Sleep Health Program for Patients With Chronic Pain

Chronic Pain | Sleep | Sleep Disordered Breathing

Canada
Sathbhavana Brain Clinic

Completed

Excessive Crying in Children With Cerebral Palsy and Communication Deficits (ECCCPCD)

Pain | Cerebral Palsy | Excessive Crying
Johnson & Johnson Pharmaceutical Research & Development...

Terminated

A Study to Evaluate the Pain Relieving Effects, Safety, and Tolerability of JNJ-42160443 for the Relief of Bladder Pain

Urologic Diseases | Urinary Bladder Diseases | Cystitis | Cystitis, Interstitial

United States, Canada
Braeburn Pharmaceuticals
Medpace, Inc.; Camurus AB

Completed

Buprenorphine (CAM2038) in Subjects With a Recent History of Moderate to Severe Chronic Low Back Pain (CAM2038)

Chronic Pain | Chronic Lower Back Pain

United States
Novartis Pharmaceuticals

Completed

Efficacy and Safety of 2 Secukinumab Regimens in 90kg or More Weight Group With Moderate/Severe Chronic Plaque Psoriasis

Moderate to Severe Chronic Plaque-type Psoriasis

United States, Hungary, Italy, Russian Federation, Germany, Czechia, Canada
VA Office of Research and Development

Active, not recruiting

Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD (EXCPPTSD)

Chronic Musculoskeletal Pain | Posttraumatic Stress Disorder (PTSD) | Mild or Moderate Traumatic Brain Injury

United States
Tris Pharma, Inc.
Forest Laboratories

Completed

Safety and Efficacy Study of GRT6005 in Patients With Osteoarthritis (OA) Knee Pain

Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee

United States
Tris Pharma, Inc.

Terminated

CORAL - Cebranopadol Versus Morphine Prolonged-release in Patients With Chronic Moderate to Severe Pain Related to Cancer (CORAL)

Neoplasms | Pain | Chronic Pain

Croatia, Austria, Belgium, Bulgaria, Denmark, Germany, Hungary, Poland, Romania, Serbia, Slovakia, Chile, Spain, United Kingdom
Nektar Therapeutics

Terminated

A Study Using fMRI Imaging to Evaluate the Effect of NKTR-181 on Brain Activity in Healthy, Non-physically Dependent Recreational Opioid Users.

Moderate to Severe Chronic Pain

United States
Regeneron Pharmaceuticals
Teva Pharmaceutical Industries, Ltd.

Terminated

Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee (FACT CLBP 1)

Osteoarthritis | Chronic Low Back Pain

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Terminated

A Study To Evaluate Pregabalin In The Treatment Of Moderate To Severe Chronic Bone Pain Related To Metastatic Cancer (COPE)

Cancer | Bone Neoplasms | Pain, Intractable

Italy, Spain, United States, Canada, France, Hungary, Poland, Sweden, Taiwan, Korea, Republic of, Philippines, Peru, Venezuela, Finland, Czechia, Egypt, Mexico, Russian Federation, Thailand
Federal University of Paraíba

Completed

Influence of Genetic and Physiological in Weight Loss

Chronic Disease | Overweight and Obesity
Cerini Tamara
Schulthess Klinik

Completed

High Intensity Interval Training VS Moderate Intensity Continuous Training in Chronic Low Back Pain Subjects

Low Back Pain

Switzerland
Johnson & Johnson Pharmaceutical Research & Development...

Terminated

A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis

Pain | Osteoarthritis | Joint Pain | Arthralgia | Osteoarthritis, Knee

United States, Canada
Johnson & Johnson Pharmaceutical Research & Development...

Terminated

A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain

Pain | Osteoarthritis | Joint Pain | Arthralgia | Osteoarthritis, Knee | Osteoarthritis, Hip

United States, Poland, Canada, Korea, Republic of
Purdue Pharma LP

Completed

Long-term Safety of Once-daily Hydrocodone Bitartrate (HYD) Tablets For Moderate to Severe Chronic Nonmalignant and Nonneuropathic Pain. Includes a 24-week Extension Period.

Chronic Nonmalignant and Nonneuropathic Pain

United States
Purdue Pharma LP

Completed

Efficacy and Safety of Hydrocodone Bitartrate (HYD) in Subjects With Moderate to Severe Chronic Low Back Pain

Chronic Low Back Pain

United States
Leiden University Medical Center
KU Leuven; Maastricht University; Universiteit Leiden

Completed

Pain-related Fear as a Facilitator of Nocebo Hyperalgesia (LFS)

Hyperalgesia | Chronic Pain Syndrome | Fear of Pain | Chronic Pain, Psychogenic

Netherlands
Grünenthal GmbH
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Completed

A Study to Evaluate the Efficacy and Safety of CG5503 Prolonged Release (PR) in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee

Pain | Knee Osteoarthritis

Austria, Croatia, Germany, Hungary, Italy, Latvia, Netherlands, Poland, Portugal, Romania, Slovakia, Spain, United Kingdom
Eli Lilly and Company

Completed

A Study Comparing Dulaglutide With Insulin Glargine on Glycemic Control in Participants With Type 2 Diabetes (T2D) and Moderate or Severe Chronic Kidney Disease (CKD) (AWARD-7)

Type 2 Diabetes | Chronic Kidney Disease

Mexico, United States, Hungary, Ukraine, Brazil, Spain, Romania, South Africa, Poland
Glenmark Specialty S.A.

Completed

Pharmacodynamic and Pharmacokinetic Dose Ranging Study of Tiotropium Bromide Administered Via Inhalation Solution in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)

United States
Mundipharma (China) Pharmaceutical Co. Ltd

Completed

OXN PR Tablet 5/2.5 mg and20/10 mg PK Study in Chinese Moderate to Severe Chronic Non-malignant Patients

Chronic Pain

China
Mundipharma (China) Pharmaceutical Co. Ltd

Unknown

A Study to Evaluate Buprenorphine Transdermal Patch in Chinese Subjects With Moderate to Severe Chronic Cancer Pain

Cancer Pain

China
University Hospital, Basel, Switzerland
University Hospital, Zürich; Neonatology and Obstetrics, University Hospital...

Completed

Is Paracetamol an Effective Treatment for Chronic Moderate Pain in the Newborn After Operative Vaginal Delivery?

Pain

Switzerland
Mundipharma Research GmbH & Co KG

Completed

Oxycodone-naloxone Prolonged Release Tablets in Relieving Opioid-related Constipation

Pain
Mundipharma Research GmbH & Co KG

Completed

A Randomised, Double Blind, Placebo and Active Controlled, Double Dummy,Parallel Group Study to Determine the Safety and Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Subjects With Moderate to Severe, Chronic Nonmalignant Pain

Subjects With Moderate to Severe, Chronic Nonmalignant Pain
Mundipharma Research GmbH & Co KG

Completed

Oxycodone-naloxone in Relieving Opioid-related Constipation

Pain
Mundipharma Research GmbH & Co KG

Completed

A Study Comparing Oxycodone to Oxycodone/Naloxone in Moderate to Severe, Chronic Cancer Pain

Pain | Cancer | Constipation

United Kingdom
Mundipharma Research GmbH & Co KG

Completed

OXN PR Compared to OxyPR to Demonstrate Non-inferiority in Pain & Locomotor Function & Improvement in Symptoms of Constipation in OA Subjects

Chronic Osteoarthritis

Spain, Belgium, Finland, Czechia, Germany, Hungary
Egalet Ltd

Completed

Safety and Tolerability of Egalet-002 in Patients With Moderate-to-Severe Chronic Noncancer Pain

Moderate-to-severe Chronic Noncancer Pain

United States

Search clinical trials for: moderate to severe, chronic pain

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