- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06207422
The Effects of a Moderate Intensity Training Program Versus a High Intensity Training Program on Central Pain Processing (ChronicPA-PAIN)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Objectives:
Since research on the effects of chronic exercise interventions on pain modulation is scarce and since there is no optimal exercise prescription to reduce pain sensitivity, the effects of a moderate intensity training (MIT) program versus a high intensity training (HIT) program on central pain processing will be examined in healthy sedentary individuals.
Study population:
Thirty healthy sedentary adults between 18 and 55 years of age and with a body mass index (BMI) between 20 and 25 kg/cm² will be recruited. Sedentary is defined as "having a sedentary job and performing less than three hours of moderate physical activity per week". Moderate physical activity is defined as "an activity that requires at least three times the amount of passively expended energy". The sample size was calculated based on a similar previously conducted study.
Study Protocol:
The participants will be invited for a first contact moment (T0) at Ghent University Hospital or at the participant's homes. During T0, participants will be asked to sign an informed consent form. Furthermore, the procedure of the intervention will be explained and a general questionnaire on sociodemographic and health-related characteristics will be administered. Participants will then receive an ActiGraph accelerometer to take home and wear for seven consecutive days to monitor physical activity (i.e., number of steps, moderate and vigorous physical activity, and sedentary behavior).
After wearing the Actigraph accelerometer for seven consecutive days, participants will be invited for a first test moment (T1) at Ghent University Hospital. During T1, three questionnaires will be administered, namely a day survey (intake of medication, caffeine, alcohol and nicotine in the past 24 hours and performance of extreme physical exertion in the past 48 hours), the International Physical Activity Questionnaire (IPAQ) and the Hospital Anxiety and Depression Scale (HADS). Before the start of the experimental pain measurements, blood pressure will be measured with a blood pressure monitor and resting heart rate will be measured using a heart rate belt around the chest.
Next, central pain processing will be assessed:
- to evaluate pain sensitivity, pressure algometry will be performed using a digital algometer to determine the pressure pain threshold (PPT) bilaterally on the muscle belly of the extensor carpi radialis and the rectus femoris.
- to evaluate pain inhibition, a conditioned pain modulation (CPM) paradigm will be performed in which the measurement of the PPT (= test stimulus (TS)) will be repeated on the dominant body side during (at minute two) and two minutes after immersion of the non-dominant hand in a warm water bath (= conditioning stimulus (CS)) of 45.5°C for six minutes.
- to evaluate exercise-induced hypoalgesia (EIH), the PPT measurements will be repeated before (bilaterally) and after (on the dominant body side) a submaximal exercise test (Aerobic Power Index test) performed on an electrically braked bicycle ergometer. Cycling will start at a load of 25 W. Then the load will be increased by 25 W every minute until the submaximal level, defined as 75% of the predicted maximum heart rate (= 220 - age), is reached. Heart rate will be measured before, during, and after the test with a heart rate belt around the chest.
- to evaluate spinal nociception, transcutaneous electrical neurostimulation (TENS) of the n. suralis of the dominant leg will be performed using a bar electrode. The nociceptive flexion reflex (NFR) threshold will be determined, as well as the pain intensity during repetitive stimulation at the intensity of the NFR threshold to evaluate temporal summation of the NFR. The elicitation of the NFR will be evaluated by measuring the involuntary contraction of the ipsilateral biceps femoris, which will be recorded using electromyography (EMG).
After the experimental pain measurements, the test subjects will receive a Fitbit smartwatch to measure weekly step count during the 10-week exercise program.
After T1, the participants will be randomly assigned to one of two 10-week intervention programs, namely a MIT or a HIT program based on a 1:1 ratio.
Upon completion of the intervention, participants' physical activity will be monitored again for 7 consecutive days using an Actigraph accelerometer. After these 7 days, participants will be invited again for a second test moment (T2) at Ghent University Hospital. During T2, the day survey and the IPAQ will be administered again, blood pressure will be measured and the pain measurements will be repeated.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Jessica Van Oosterwijck, Professor
- Phone Number: +32 9 332 69 19
- Email: jessica.vanoosterwijck@ugent.be
Study Contact Backup
- Name: Amber Billens, MSc
- Phone Number: +32 9 332 04 53
- Email: amber.billens@ugent.be
Study Locations
-
-
-
Ghent, Belgium, 9000
- Recruiting
- Ghent University
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- age between 18 and 55 years
- BMI between 20 and 25 kg/m²
- Dutch-speaking
- sedentary job and performing less than 3 hours of moderate physical activity per week
Exclusion Criteria:
- current pain complaints or other (medical and/or psychological) health problems
- history of serious pain complaints or (medical and/or psychological) health problems
- history of serious conditions (e.g. cancer, cardiovascular disease, epilepsy, diabetes, depression, etc.)
- being pregnant
- pregnant in the past 12 months
- currently breastfeeding
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Moderate intensity training program
|
A 10-week intervention program performed at 60-70% of the heart rate reserve.
Heart rate reserve will be calculated using the Karvonen formula (target heart rate = [(predicted maximum heart rate (= 220 - age) - resting heart rate) x %intensity] + resting heart rate).
The intervention program will consist of three exercise sessions per week, of which one guided group session at Ghent University Hospital and two sessions to be carried out at home.
|
Experimental: High intensity training program
|
A 10-week intervention program performed at ≥80% of the predicted maximum heart rate (target heart rate = predicted maximum heart rate (= 220 - age) x %intensity).
The intervention program will consist of three exercise sessions per week, of which one guided group session at Ghent University Hospital and two sessions to be carried out at home.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pressure pain threshold
Time Frame: Change from baseline (T1) at 1 week after intervention (T2)
|
Pressure algometry will be performed using a digital algometer to determine the pressure pain threshold bilaterally on the muscle belly of the extensor carpi radialis and the rectus femoris.
|
Change from baseline (T1) at 1 week after intervention (T2)
|
Conditioned pain modulation
Time Frame: Change from baseline (T1) at 1 week after intervention (T2)
|
A conditioned pain modulation paradigm will be performed in which the measurement of the pressure pain threshold (= test stimulus) will be repeated on the dominant body side during (at minute two) and two minutes after immersion of the non-dominant hand in a warm water bath (= conditioning stimulus) of 45.5°C for six minutes.
|
Change from baseline (T1) at 1 week after intervention (T2)
|
Exercise-induced hypoalgesia
Time Frame: Change from baseline (T1) at 1 week after intervention (T2)
|
To evaluate exercise-induced hypoalgesia, the pressure pain threshold measurements will be repeated before (bilaterally) and after (on the dominant body side) a submaximal exercise test (Aerobic Power Index test) performed on an electrically braked bicycle ergometer.
|
Change from baseline (T1) at 1 week after intervention (T2)
|
Nociceptive flexion reflex - threshold
Time Frame: Change from baseline (T1) at 1 week after intervention (T2)
|
The nociceptive flexion reflex will be elicited by performing transcutaneous electrical nerve stimulation of the sural nerve of the dominant leg in its retromalleolar path using a bar electrode.
The elicitation of the NFR will be evaluated by measuring the involuntary contraction of the ipsilateral biceps femoris, which will be recorded using electromyography.
|
Change from baseline (T1) at 1 week after intervention (T2)
|
Nociceptive flexion reflex - temporal summation
Time Frame: Change from baseline (T1) at 1 week after intervention (T2)
|
Five 1ms rectangular wave pulse train will be administered 3 times at a frequency of 2 Hz at a constant stimulation intensity.
This procedure will be repeated 5 times.
|
Change from baseline (T1) at 1 week after intervention (T2)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Hospital anxiety and depression scale
Time Frame: Baseline (T1)
|
Self-report measure assessing anxiety and depression
|
Baseline (T1)
|
International physical activity questionnaire
Time Frame: Change from baseline (T1) at 1 week after intervention (T2)
|
Self-report measure assessing physical activity during the previous 7 days
|
Change from baseline (T1) at 1 week after intervention (T2)
|
Moderate physical activity
Time Frame: Change from baseline (T1) at 1 week after intervention (T2)
|
Moderate physical activity will be measured with an ActiGraph accelerometer during 7 consecutive days.
|
Change from baseline (T1) at 1 week after intervention (T2)
|
Vigorous physical activity
Time Frame: Change from baseline (T1) at 1 week after intervention (T2)
|
Vigorous physical activity will be measured with an ActiGraph accelerometer during 7 consecutive days.
|
Change from baseline (T1) at 1 week after intervention (T2)
|
Sedentary behavior
Time Frame: Change from baseline (T1) at 1 week after intervention (T2)
|
Sedentary behavior will be measured with an ActiGraph accelerometer during 7 consecutive days.
|
Change from baseline (T1) at 1 week after intervention (T2)
|
Step count
Time Frame: Change from baseline (T1) at 1 week after intervention (T2)
|
Step count will be measured with an ActiGraph accelerometer during 7 consecutive days.
|
Change from baseline (T1) at 1 week after intervention (T2)
|
Step count
Time Frame: During 10-week intervention program
|
Step count will be measured with a FitBit charge 4 during the 10-week intervention program
|
During 10-week intervention program
|
Resting heart rate
Time Frame: Baseline (T1)
|
Resting heart rate will be measured for 10 minutes using a heart rate belt around the chest.
|
Baseline (T1)
|
Blood pressure
Time Frame: Baseline (T1)
|
Systolic and diastolic blood pressure will be measured with a blood pressure monitor.
|
Baseline (T1)
|
Blood pressure
Time Frame: 1 week after intervention
|
Systolic and diastolic blood pressure will be measured with a blood pressure monitor.
|
1 week after intervention
|
Sociodemographic and health-related characteristics
Time Frame: Baseline (T0)
|
A general questionnaire assessing sociodemographic and health-related characteristics
|
Baseline (T0)
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Jessica Van Oosterwijck, Department of Rehabilitation Sciences, Faculty of Health Sciences, Ghent University, Belgium
Publications and helpful links
General Publications
- Belavy DL, Van Oosterwijck J, Clarkson M, Dhondt E, Mundell NL, Miller CT, Owen PJ. Pain sensitivity is reduced by exercise training: Evidence from a systematic review and meta-analysis. Neurosci Biobehav Rev. 2021 Jan;120:100-108. doi: 10.1016/j.neubiorev.2020.11.012. Epub 2020 Nov 27.
- Bernstein MS, Morabia A, Sloutskis D. Definition and prevalence of sedentarism in an urban population. Am J Public Health. 1999 Jun;89(6):862-7. doi: 10.2105/ajph.89.6.862.
- Dhondt E, Danneels L, Van Oosterwijck S, Palmans T, Rijckaert J, Van Oosterwijck J. The influence of physical activity on the nociceptive flexion reflex in healthy people. Eur J Pain. 2021 Apr;25(4):774-789. doi: 10.1002/ejp.1708. Epub 2020 Dec 27.
- Hakansson S, Jones MD, Ristov M, Marcos L, Clark T, Ram A, Morey R, Franklin A, McCarthy C, Carli LD, Ward R, Keech A. Intensity-dependent effects of aerobic training on pressure pain threshold in overweight men: A randomized trial. Eur J Pain. 2018 Nov;22(10):1813-1823. doi: 10.1002/ejp.1277. Epub 2018 Jul 11.
- Hermans L, Van Oosterwijck J, Goubert D, Goudman L, Crombez G, Calders P, Meeus M. Inventory of Personal Factors Influencing Conditioned Pain Modulation in Healthy People: A Systematic Literature Review. Pain Pract. 2016 Jul;16(6):758-69. doi: 10.1111/papr.12305. Epub 2015 May 26.
- Van Oosterwijck S, Meeus, M., van Der Wekken, Dhondt E, Billens A, & Van Oosterwijck J. Physical activity is predictive of conditioned pain modulation in healthy individuals: a cross-sectional study. [Journal of Pain - Submitted]
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- ONZ-2023-0425
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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