Search clinical trials for: or trifunctional protein (MTP).

Total 214091 results

Prisma Health-Midlands
Medical University of South Carolina

Enrolling by invitation

Temporal Profile of Serum Vitamin D Levels in Foot and Ankle Fusion Surgery

Ankle Arthrodesis | MTP Arthrodesis

United States
Stealth BioTherapeutics Inc.
ICON Clinical Research

Completed

Evaluation of Myocardial Effects of MTP-131 for Reducing Reperfusion Injury in Patients With Acute Coronary Events (EMBRACE)

Reperfusion Injury | STEMI

United States, Hungary, Germany, Poland
Artimplant AB

Unknown

Artelon Metatarsophalangeal (MTP) Spacer

Osteoarthritis | Hallux Rigidus

Sweden
Stealth BioTherapeutics Inc.

Completed

A Phase 1 Study Investigating the Safety and Pharmacokinetics of Repeat-dose Intravenous Infusion of MTP-131 in Subjects With Impaired Renal Function

Normal and Impaired Renal Function

United States
Stealth BioTherapeutics Inc.

Available

An Intermediate Size Expanded Access Protocol of Elamipretide

Mitochondrial Diseases | Barth Syndrome
Stealth BioTherapeutics Inc.

Completed

A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome (TAZPOWER)

Barth Syndrome

United States
Children's Hospital of Philadelphia
Friedreich's Ataxia Research Alliance; Stealth BioTherapeutics Inc.

Active, not recruiting

FRDA Investigator Initiated Study (IIS) With Elamipretide (ELViS-FA)

Friedreich Ataxia

United States
Stealth BioTherapeutics Inc.

Terminated

Effects of Intravenous Bendavia™ on Reperfusion Injury in Patients Undergoing Angioplasty of the Renal Artery (EVOLVE)

Renal Artery Obstruction | Ischemia Reperfusion Injury | Hypertension, Renovascular

United States
Stealth BioTherapeutics Inc.

Completed

Safety and Pharmacokinetic (PK) Study of Oral Bendavia Administered for 7 Days

Healthy Volunteers

United States
Stealth BioTherapeutics Inc.

Completed

A Study Investigating the Safety, Tolerability, and Pharmacokinetics of MTP-131 in Subjects With Congestive Heart Failure

Congestive Heart Failure

Bulgaria
Stealth BioTherapeutics Inc.

Withdrawn

A Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of Bendavia™ (MTP-131) in Patients With Heart Failure

Heart Failure

Bulgaria
Stealth BioTherapeutics Inc.

Completed

An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects With Intermediate Age-Related Macular Degeneration

Age-Related Macular Degeneration

United States
National Institute of Allergy and Infectious Diseases...
Biocine

Completed

A Phase I Clinical Trial to Evaluate: Part A. The Safety of MTP-PE/MF59 Adjuvant Emulsion. Part B. The Safety and Immunogenicity of Env 2-3, a Yeast Derived Recombinant Envelope Protein of Human Immunodeficiency Virus-1, in Combination With MTP-PE/MF59

HIV Infections | HIV Seronegativity

United States
National Institute of Allergy and Infectious Diseases...
Biocine

Completed

A Placebo-Controlled, Phase I, Pilot Clinical Trial to Evaluate the Safety and Immunogenicity of ENV 2-3, a Yeast-Derived Recombinant Envelope Protein of Human Immunodeficiency Virus-1, in Combination With MTP-PE/MF59 in Individuals With HIV Infection (Placebo Patients Receive MF59 Emulsion Only)

HIV Infections

United States
Stealth BioTherapeutics Inc.

Completed

Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of Intravenous (IV) Infusion of MTP-131 (Bendavia™) in Healthy Adults

Healthy

United States
Nova Scotia Health Authority

Not yet recruiting

The Effect of Weight Bearing on Patient Outcomes Following 1st MTP Joint Fusion

Hallux Valgus | Hallux Rigidus
National Institute of Allergy and Infectious Diseases...
Biocine

Completed

Safety of and Immune Response to an HIV Vaccine (SF-2 gp120) With or Without MTP-PE/MF59 Adjuvant

HIV Infections

United States
Stealth BioTherapeutics Inc.

Completed

A Phase 2 Study to Evaluate the Cardiac and Renal Effects of Short Term Treatment With Elamipretide in Patients Hospitalized With Congestion Due to Heart Failure

Heart Failure

Spain, Hungary, Netherlands, United Kingdom, Serbia, France, Latvia, Belgium, Bulgaria, Poland
Stealth BioTherapeutics Inc.

Completed

Safety, Tolerability, Efficacy of MTP-131 for Treatment of Mitochondrial Disease in Subjects From the MMPOWER Study (MMPOWER-2)

Primary Mitochondrial Disease

United States
Stealth BioTherapeutics Inc.
Charite University, Berlin, Germany; SCIRENT Clinical Research and Science...

Completed

A Study to Evaluate the Effects of 4 Weeks Treatment With Subcutaneous Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Preserved Ejection Fraction

Chronic Heart Failure

Germany, Serbia
Stealth BioTherapeutics Inc.

Completed

A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendavia™) on Skeletal Muscle Function in Elderly (MOTION)

Skeletal Muscle Mitochondrial Dysfunction in the Elderly

United States
Stealth BioTherapeutics Inc.

Completed

A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for Treatment of Leber's Hereditary Optic Neuropathy

Leber's Hereditary Optic Neuropathy

United States
Huazhong University of Science and Technology

Recruiting

The Effects of Three Different Ultrasound-guided Nerve Blocks in VATS

Pain, Acute | Nerve Block | Thoracic Anesthesia

China
Stealth BioTherapeutics Inc.

Completed

Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction

Heart Failure

Netherlands, Italy, United Kingdom
National Institute of Allergy and Infectious Diseases...

Recruiting

Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis

Chronic Granulomatous Disease-associated Colitis

United States
University of Wisconsin, Madison
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Fecal Microbiota Transplantation for C. Difficile Infection in Solid Organ Transplant Recipients

Clostridium Difficile Infection Recurrence

United States
Massachusetts General Hospital
VKTRY Gear

Completed

Managing Pain in Patients With MTP Arthritis

Hallux Rigidus

United States
Stealth BioTherapeutics Inc.

Terminated

A Trial to Evaluate Safety and Efficacy of Elamipretide Primary Mitochondrial Myopathy Followed by Open-Label Extension (MMPOWER-3)

Primary Mitochondrial Myopathy

United States, Germany, Canada, Italy, United Kingdom, Denmark, Hungary
US Department of Veterans Affairs

Completed

Multi-Site Evaluation of Progressive Tinnitus Management

Tinnitus

United States
Aegerion Pharmaceuticals, Inc.
University of Pennsylvania; Doris Duke Charitable Foundation

Completed

Safety, Tolerability and Efficacy of Microsomal Triglyceride Protein (MTP) Inhibitor

Homozygous Familial Hypercholesterolemia

United States
Paul Fortin, MD
Musculoskeletal Transplant Foundation

Completed

Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe (MTP)

Osteoarthritis

United States
Stealth BioTherapeutics Inc.

Completed

A Study of MTP-131 Topical Ophthalmic Solution in Subjects With Diabetic Macular Edema and Non-Exudative Intermediate Age-related Macular Degeneration (SPIOC-101)

Age-related Macular Degeneration | Diabetic Macular Edema

United States
Cartiva, Inc.

Completed

A Study to Evaluate the Effectiveness and Safety of an Implant in the Treatment of Osteoarthritis of the Great Toe

Osteoarthritis of First Metatarsalphalangeal Joint

Canada, United Kingdom
Stealth BioTherapeutics Inc.

Completed

Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial Myopathy (MMPOWER)

Mitochondrial Myopathy

United States
Cartiva, Inc.

Completed

Post Approval Study to Evaluate the Effectiveness and Safety of Cartiva Implant in the Treatment of OA of the Great Toe (MOTION)

Osteoarthritis of First Metatarsalphalangeal Joint
Memorial Sloan Kettering Cancer Center

Available

Expanded Access Use of L-MTP-PE for the Treatment of Osteosarcoma

Osteosarcoma

United States
Stealth BioTherapeutics Inc.

Completed

ReCLAIM-2 Study to Evaluate Safety,Efficacy & Pharmacokinetics of Elamipretide in Subjects With AMD With Non-central GA (ReCLAIM-2)

Age-related Macular Degeneration

United States
Hospital District of Helsinki and Uusimaa

Active, not recruiting

Risk for Reoperation After First MTP Joint Arthrodesis

Surgery | Complication of Surgical Procedure | Orthopedic Disorder | Hallux Valgus | Hallux Rigidus

Finland
UConn Health
National Institute on Drug Abuse (NIDA)

Completed

Marijuana Treatment Project - 3 (MTP-3)

Marijuana Dependence

United States
Tanta University

Not yet recruiting

Mid-transverse Process to Pleura Block in Pediatric Thoracotomy

Analgesia | Ultrasound Guided Block | Pediatric Surgery
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

PTK787/ZK 222584 in Treating Patients With Unresectable Malignant Mesothelioma

Malignant Mesothelioma

United States
Stealth BioTherapeutics Inc.

Completed

A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED) (SPIFD-101)

Fuchs' Corneal Endothelial Dystrophy (FCED)

United States
Millennium Pharmaceuticals, Inc.

Completed

Mifamurtide (L-MTP-PE) for High-Risk Osteosarcoma

Osteosarcoma

United States
Istanbul University - Cerrahpasa (IUC)

Completed

The Turkish Version of the AOFAS Hallux MTP-IP

Orthopedic Disorder | Assessment, Self | Hallux Deformity | Foot Deformity

Turkey
Ain Shams University

Recruiting

US-Guided PECS II Block Versus MTP Block For Postoperative Analgesia Of MRM Sugery

Analgesia | Anesthesia, Local | Post Operative Pain | Neuromuscular Blockade

Egypt
Stealth BioTherapeutics Inc.

Active, not recruiting

Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD) (NuPower)

Mitochondrial Diseases | Mitochondrial Myopathies | Mitochondrial Complex I Deficiency | Mitochondrial Pathology | Mitochondrial DNA Depletion | Mitochondrial DNA Mutation | Mitochondrial DNA Deletion | Mitochondrial Metabolism Defect

Spain, United States, Italy, Netherlands, Australia, Germany, Hungary, New Zealand, Norway, United Kingdom
University of Rochester

Completed

Evaluating URMC's Massive Transfusion Protocol (MTP-TEG)

Blood Coagulation Disorders | Trauma | Acute Coagulopathy

United States
Midwest Bunion Center, LLC

Completed

Patient Reported Function Following Combined First MTP and First TMT Arthrodesis.

Hallux Valgus

United States
Dana-Farber Cancer Institute
Novartis; Brigham and Women's Hospital

Completed

Protein Tyrosine Kinases (PTK) in Multiple Myeloma

Multiple Myeloma

United States
Aerie Pharmaceuticals

Completed

Study Evaluating Techniques for Measuring Tear Production (MTP)

Dry Eye Disease

United States

Search clinical trials for: or trifunctional protein (MTP).

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