The Effects of Three Different Ultrasound-guided Nerve Blocks in VATS

April 13, 2022 updated by: Wenlong Yao, Huazhong University of Science and Technology

The Effects of Ultrasound-guided Mid-point Transverse Process to Pleura Block, Erector Spinae Plane Block and Paravertebral Block on Postoperative Pain in Video-assisted Thoracic Surgery

Ultrasound-guided mid-point transverse process to pleura block, erector spinae plane block and paravertebral block are three different methods of nerve block, used for relieving postoperative pain in thoracic anesthesia. This study is to compare them on block effects, postoperative pain and analgesic consumption in video-assisted thoracic surgery.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Ultrasound-guided nerve block is an important part of multi-mode analgesia to decrease the consumption of opioids. Thoracic paravertebral block is considered as an ideal regional analgesic choice for video-assisted thoracic surgery, but it still has some side effects, such as pneumothorax, vascular injury, especially for novices. Recent years, ultrasound-guided mid-point transverse process to pleura block and erector spinae plane block are reported for thoracic surgery. The insertion depth in these two methods is more superficial than traditional paravertebral block. They could have less side effects. Therefore, we design a randomised control study to compare them on block effects, postoperative pain and analgesic consumption in video-assisted thoracic surgery.

Study Type

Interventional

Enrollment (Anticipated)

90

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Wenlong Yao, MD
  • Phone Number: 86-27-83663173
  • Email: wlyao82@126.com

Study Locations

  • China
    • Hubei
      • Wuhan, Hubei, China, 430030
        • Recruiting
        • Tongji Hospital, Huazhong University of Science and Technology
        • Contact:
        • Principal Investigator:
          • Wenlong Yao, Ph.D.,M.D.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 70 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • selective lobetomy under VATS
  • ASA classfication 1-3

Exclusion Criteria:

  • history of thoracic surgery
  • double lateral VATS
  • allergy to local anesthetics
  • coagulation disorders
  • severe heart diseases, hepatic or renal insufficiency
  • a history of chronic pain or chronic opioid use
  • psychiatric disease or uncooperative
  • BMI>28 kg/m2
  • VATS transfered to open thoractomy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: paravertebral block
Patients receive ultrasound-guided paravertebral block
Procedure: Paravertebral block
Patients receive ultrasound-guided paravertebral block
Active Comparator: ESP block
Patients receive ultrasound-guided erector spinae plane (ESP) block
Procedure: ESP block
Patients receive ultrasound-guided erector spinae plane (ESP) block
Experimental: MTP block
Patients receive ultrasound-guided mid-point transverse process to pleura (MTP) block
Procedure: MTP block
Patients receive ultrasound-guided mid-point transverse process to pleura (MTP) block

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
postoperative morphine consumption
Time Frame: postoperative 24 hours
The dose is according to the record from PCA pump
postoperative 24 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Pain score at rest
Time Frame: at 0, 8, 24 hour after surgery
measured by VAS (0-10)
at 0, 8, 24 hour after surgery
Pain score while coughing
Time Frame: at 0, 8, 24 hour after surgery
measured by VAS (0-10)
at 0, 8, 24 hour after surgery

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
block level
Time Frame: 20 minutes after block
measured by pin-prick at clavicle midline
20 minutes after block
intraoperative analgesic comsumption
Time Frame: intraoperative, from induction to emergence from anesthesia
the dose of sufentanil, remifentanil
intraoperative, from induction to emergence from anesthesia

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Huazhong University of Science and Technology

Investigators

  • Study Chair: Ailin Luo, MD,PhD, Tongji Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 5, 2021

Primary Completion (Anticipated)

October 1, 2022

Study Completion (Anticipated)

December 1, 2022

Study Registration Dates

First Submitted

March 30, 2021

First Submitted That Met QC Criteria

April 1, 2021

First Posted (Actual)

April 2, 2021

Study Record Updates

Last Update Posted (Actual)

April 14, 2022

Last Update Submitted That Met QC Criteria

April 13, 2022

Last Verified

April 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • TJMZK20210301

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Subscribe