Search clinical trials for: phase 1a study for healthy normals

Total 393249 results

NanoSHIFT LLC

Completed

A Single-Dose Study of an Investigational Capsule Formulation of 2 mg/0.5 mg Buprenorphine/Naloxone

Healthy

United States
ProMis Neurosciences, Inc

Recruiting

A Phase 1a Study of PMN310 In Healthy Volunteers

Healthy Participants

United States
CohBar, Inc.

Completed

A Phase 1a/1b Study of CB4211 in Healthy Non-obese Subjects and Subjects With Nonalcoholic Fatty Liver Disease

Nonalcoholic Fatty Liver Disease

United States
ImevaX

Completed

Phase 1a/b Study on Safety of IMX101 in H. Pylori-negative and H. Pylori-infected Healthy Volunteers (IMX-02)

Helicobacter Pylori Infected Subjects | Helicobacter Pylori Naive Subjects

Germany
University of Michigan

Completed

Phase 1A Study of the Safety of KSP/QRH Dimer

Healthy Adults

United States
Moerae Matrix, Inc.

Unknown

Phase 1a Study in Healthy Smokers to Investigate the Effect With MMI-0100 on Airway Inflammation in Induced Sputum After Challenge With Inhaled Lipopolysaccharide (LPS)

Acute Inflammatory Response to Non-antigenic Stimulus

United Kingdom
Lpath, Inc.

Completed

A Phase 1a, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate Lpathomab in Healthy Volunteers

Healthy Subjects

United States
Presidio Pharmaceuticals, Inc.

Completed

A Phase 1a/1b Study of PPI-383 in Healthy Adults and Hepatitis C Patients

Hepatitis C, Chronic

United Kingdom, Mauritius
AstraZeneca

Completed

Assessment of Relative Bioavailability of NKTR-118 in Three Formulations in Healthy Subjects

Healthy

United States
Biogen

Completed

A Multiple-Dose, Open-Label, Phase 1, Pharmacokinetic, Pharmacodynamic, and Safety Study of Avonex® in Chinese Healthy Volunteer Subjects

Healthy

China
Link Medicine Corporation

Completed

An Escalating Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of LNK 754 in Elderly Volunteers and in Subjects With Mild Alzheimer's Disease

Mild Alzheimer's Disease

United States
National Institute of Allergy and Infectious Diseases...
KBio Inc

Not yet recruiting

Phase 1, Randomized, Double-Blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of an Enterovirus D68-specific Monoclonal Antibody in Healthy Adults

Enterovirus Infection

United States
Rallybio IPA, LLC

Not yet recruiting

Phase 2 Study on the Pharmacokinetics and Safety of RLYB212 in Pregnant Women at Higher Risk for HPA-1a Alloimmunization

Fetal and Neonatal Alloimmune Thrombocytopenia
GE Healthcare
PPD; Fortrea

Not yet recruiting

A Phase 1, Dose-Escalation, Positron Emission Tomography Study to Assess the Safety, Pharmacokinetics, Dosimetry and Biodistribution of GEH200521 (18F) Injection Co-Administered With GEH200520 Injection in Healthy Volunteers

Healthy Volunteers

United States
Vertex Pharmaceuticals Incorporated

Recruiting

A Phase 1 Dose Escalation Study of Intravenous VX-993 in Healthy Adults

Pain

United States
Vertex Pharmaceuticals Incorporated

Recruiting

A Phase 1, Open-label Study Evaluating the Pharmacokinetics and Drug-drug Interaction of VX-993 in Healthy Adults

Pain

United Kingdom
Modern Biosciences Ltd

Recruiting

Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects

Pharmacokinetics

United Kingdom
Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Not yet recruiting

A Single Dose Escalation Study of HHT201 in Healthy Subjects

Alzheimer Disease

China
Eli Lilly and Company

Recruiting

A Drug-Drug Interaction (DDI) Study of Orforglipron With Carbamazepine in Healthy Participants

Healthy

United States
PMV Pharmaceuticals, Inc

Recruiting

A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of PC14586 in Healthy Participants

Healthy Volunteers

United States
Mage Biologics
Alimentiv Inc.

Recruiting

A Phase 1 Study to Evaluate the Safety of an Oral Biologic in Healthy Participants

Ulcerative Colitis

Australia
InnoCare Pharma Inc.

Not yet recruiting

A Global Phase 3 Study of Orelabrutinib+BR vs.BR in Pts With TN MCL

Mantle Cell Lymphoma
Haisco Pharmaceutical Group Co., Ltd.

Recruiting

A Phase I Study to Assess the Safety,Tolerability, PK, PD, and Food Effect of HSK39297 in Healthy Subjects

Healthy

China
Vertex Pharmaceuticals Incorporated

Recruiting

A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of VX-407 in Healthy Participants

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

United States
Valneva Austria GmbH

Recruiting

Phase 1 Trial to Assess the Safety and Immunogenicity of an Inactivated, Adjuvanted Whole Zika Virus Vaccine Candidate (VLA1601) in Healthy Adults

Zika | Zika Virus Infection

United States
Actym Therapeutics, Inc.

Not yet recruiting

A Phase 1a/1b Study of ACTM-838 in Patients With Advanced Solid Tumors

Solid Tumor

Australia
Bayer

Recruiting

A Study to Learn About How BAY2927088 Affects the Level of Dabigatran or Rosuvastatin in the Blood When These Drugs Are Taken Together in Healthy Participants

Healthy Volunteers | Advanced Non-small Cell Lung Cancer | EGFR Mutation | HER2 Mutation

United Kingdom
Celgene

Not yet recruiting

A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment

Renal Impairment

United States
Xi'an Xintong Pharmaceutical Research Co.,Ltd.

Recruiting

Safety, Tolerability Phase Ia Study of XT1061 in Single and Multiple Doses in Healthy Subjects (XT1061)

Chronic Hepatitis b

China
Denali Therapeutics Inc.

Recruiting

A Phase 1, Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-DNL343 Following a Single Oral Dose in Healthy Male Participants

Healthy Volunteers

United States
Guangzhou Lupeng Pharmaceutical Company LTD.

Recruiting

Phase Ib Study of Rocbrutinib in Combination With R-CHOP in Patients With Newly Diagnosed B-cell Non-Hodgkin Lymphoma

B-cell Non-Hodgkin Lymphoma

China
Alzheimer's Disease Expert Lab (ADEL), Inc.
Oscotec Inc.

Recruiting

A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01

Alzheimer Disease

United States
ReCode Therapeutics

Recruiting

A Phase 1 Study Evaluating Safety and Tolerability of RCT2100 in Healthy Participants

Cystic Fibrosis

New Zealand
Kynexis B.V.
Parexel

Recruiting

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of KYN-5356 in Healthy Subjects Aged 18 to 55 Years

Schizophrenia | Cognitive Dysfunction

United States
Drug Delivery Company, LLC DBA Akyso Pharmaceuticals
National Institute on Drug Abuse (NIDA); Laboratory Corporation of America; Cognitive...

Not yet recruiting

A Phase 1, Placebo-controlled, Single-Ascending-Dose, Study of BIOPIN 6 in Healthy Adults

Opioid Use Disorder
M.D. Anderson Cancer Center

Recruiting

A Phase I/II Study of Intraperitoneal Paclitaxel in Patients With Metastatic Appendiceal Adenocarcinoma

Intraperitoneal Paclitaxel | Metastatic Appendiceal Adenocarcinoma

United States
Odyssey Therapeutics

Recruiting

Phase 1 Study to Investigate OD-07656 in Healthy Adult Participants

Inflammatory Bowel Diseases | Crohn Disease | Ulcerative Colitis | Spondyloarthritis | Blau Syndrome

Australia
Almirall, S.A.

Recruiting

A Single and Multiple Ascending Dose Study of LAD603 in Healthy Subjects

Healthy Volunteers

United States
International Bio service

Not yet recruiting

Bioequivalence Study of Amlodipine/Valsartan 10/160 mg Film Coated Tablets

Healthy Volunteer
AbbVie
Genmab

Recruiting

Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma (EPCORE™FL-2)

Follicular Lymphoma (FL)

United States, Puerto Rico
Wave Life Sciences Ltd.

Recruiting

A Phase 1 Research Study to Evaluate Safety, Tolerability, and Pharmacokinetics of WVE-006 in Healthy Participants With Wild-type AAT Expression (RestorAATion-1) (RestorAATion-1)

Alpha-1 Antitrypsin Deficiency

United Kingdom
Agomab Spain S.L.

Recruiting

Phase I Study to Assess Safety, Tolerability, PK and PD of AGMB-447 in Healthy Participants and Participants With IPF

IPF

United Kingdom
GlaxoSmithKline

Not yet recruiting

A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

United Kingdom
Eli Lilly and Company

Recruiting

A Study of LY3971297 in Healthy Participants and Participants With Obesity and Hypertension

Hypertension | Healthy | Obesity

United States, Singapore
National Institute of Allergy and Infectious Diseases...

Recruiting

Safety Study of SLV213 for the Treatment of COVID-19.

COVID-19

United States
Lantern Pharma Inc.

Recruiting

A Study of LP-284 in Relapsed or Refractory Lymphomas and Solid Tumors

Advanced Solid Tumor | Relapsed or Refractory Lymphomas

United States
The University of Hong Kong

Recruiting

KeySteps@JC Phase Two Study

Lifestyle Modification

Hong Kong
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

Phase 3 Study of Toripalimab Alone or in Combination With Tifcemalimab as Consolidation Therapy in Patients With Limited-stage Small Cell Lung Cancer (LS-SCLC)

Limited-stage Small Cell Lung Cancer (LS-SCLC)

China, France, United States, Spain, Taiwan, Korea, Republic of, Turkey, Italy, Netherlands, Georgia, Germany, Belgium, Poland, Romania
Shanghai Leadingtac Pharmaceutical Co., Ltd.

Not yet recruiting

A Phase 1 Study of LT-002-158 Intended for the Treatment of Skind Disorder in Healthy Adult Volunteers

Atopic Dermatitis | Healthy Volunteer | Hidradenitis Suppurativa
University of Kansas Medical Center
National Cancer Institute (NCI); Children's Mercy Hospital Kansas City

Recruiting

A Healthy Weight Intervention for Family Stress During the Early Phases of ALL Treatment: NOURISH-ALL (NOURISH-ALL)

Behavior, Health | ALL, Childhood

United States

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