Search clinical trials for: proof of concept

Total 428554 results

EmeraMed
NBMI Science AB

Completed

Pilot Proof of Concept Study of NBMI Treatment of Mercury Intoxication (NBMI)

Mercury Poisoning

Ecuador
Novartis Pharmaceuticals

Completed

Proof of Concept Study to Determine the Safety and Antiviral Effect of BZF961 With or Without Ritonavir Boosting in Hepatitis C Virus Infected Patients (CBZF961X2201)

Hepatitis C

United States
ViiV Healthcare

Completed

A Proof of Concept Study of GSK3640254 in Human Immunodeficiency Virus-1 (HIV-1) Infected Treatment-naive Adults

HIV Infections

Spain, France, United States, Germany, Italy, South Africa
Bayer

Completed

Repeat Doses of BAY1902607 in Healthy Males and Proof of Concept in Chronic Cough Patients

Cough

Netherlands, United Kingdom
University College, London

Unknown

Group CST Using Zoom: A Proof of Concept Study

Dementia

United Kingdom
Children's Hospital Medical Center, Cincinnati

Completed

A Proof-of-Concept Study of Minocycline in Autism

Autism Spectrum Disorder | Autism

United States
Rabin Medical Center
Harvard University; DreaMed

Terminated

Determination of Automated Multiple Insulin Dose Injections Settings Using the MDI/SMBG Advisor for Patients With Type 1 Diabetes -Data Collection, Observational & Proof of Concept Study

Type 1 Diabetes | Multiple Daily Injections

Israel
UCB Celltech
PRA Health Sciences

Terminated

UCB Proof of Concept Study in Patients With Primary Sjögren's Syndrome

Primary Sjögren's Syndrome

France, Italy, Spain, Sweden, United Kingdom
9 Meters Biopharma, Inc.

Unknown

Proof of Concept Study in Patients With Short Bowel Syndrome

Short Bowel Syndrome

United States
Hoffmann-La Roche

Completed

A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) (AVENUE)

Choroidal Neovascularization

United States
Unity Health Toronto
University of Toronto; Li Ka Shing Knowledge Institute

Unknown

Proof-of-Concept: A Pilot, Randomized, Double-Blind Study of Oseltamivir Versus Placebo for Immune Thrombocytopenia

Immune Thrombocytopenia

Canada
Bioquark Inc.
Revita Life Sciences; Anupam Hospital

Completed

Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury

Brain Death

India
ReveraGen BioPharma, Inc.

Withdrawn

Proof of Concept Trial of Vamorolone in Pediatric Ulcerative Colitis

Pediatric Ulcerative Colitis
Mayo Clinic

Completed

Proof of Concept: "Bottom's Up" Seat to Treat Constipation

Constipation Aggravated | Pelvic Floor; Incompetency

United States
McMaster University

Withdrawn

Psychoeducational Video Series - Proof of Concept

Psychoeducation
Hull University Teaching Hospitals NHS Trust

Completed

Exercise In Critical Limb Ischaemia Patients Having Surgery Proof of Concept (EXERCISE)

Critical Limb Ischemia

United Kingdom
Mark Gallardo, MD

Unknown

A Single Center Proof Of Concept Study To Assess Intra And Perioperative Safety Profile Of OMNI Surgical System

Open Angle Glaucoma

United States
The University of Hong Kong

Completed

A Proof of Concept for All-ceramic Zirconia Resin Bonded Bridges for Canine, Premolar and Short Span Posterior Teeth

Missing Teeth

China
Nicole Lindenblatt
University Hospital, Zürich; Swiss Federal Institute of Technology; Zurich University... and other collaborators

Completed

Proof-of-concept Study of LymphMonitor 1.0 to Assess the Lymphatic Vessel Function

Lymphedema | Secondary Lymphedema

Switzerland
The Leeds Teaching Hospitals NHS Trust

Unknown

Cubital Tunnel Syndrome and Diffusion MRI: A Proof of Concept Study

Cubital Tunnel Syndrome

United Kingdom
Miltenyi Biotec B.V. & Co. KG

Completed

Proof of Concept Study of IMMUNOadsorption Therapy in Patients With Idiopathic Pulmonary Arterial Hypertension

Idiopathic Pulmonary Arterial Hypertension

Germany
TWi Biotechnology, Inc.

Completed

A Proof-of-Concept Study of AC-201 Controlled-Release Tablet (CR Tablet) in Patients With Hemophilic Arthropathy

Hemophilic Arthropathy

Taiwan
Danone Asia Pacific Holdings Pte, Ltd.
Techobserver

Completed

A Proof of Concept Study to Investigate the Use and Relevance of a Digital Platform for Infant Crying and Fussing (COOL)

Healthy

Singapore
Instituto de Investigación Hospital Universitario...

Unknown

Antiretroviral Treatment Guided by Proviral Genotype: Pilot Trial of Proof of Concept.

HIV-1-infection

Spain
Chinese University of Hong Kong

Unknown

Esophagogastroduodenoscopy (EGD) is an Aerosol-generating Procedure: Proof of Concept Study

Aerosol-generating Procedure, Esophagogastroduodenoscopy

Hong Kong
NYU Langone Health

Terminated

A Proof of Concept Study of the Prevention of Mild Cognitive Impairment and Eventual Alzheimer's Disease Using F18 Flutemetamol

Alzheimer Disease

United States
Vendsyssel Hospital
Charite University, Berlin, Germany; Umeå University; Leiden University Medical... and other collaborators

Completed

Treatment of Female Genital Schistosomiasis (FGS) With Praziquantel: A Proof-of-Concept Study

Schistosomiasis

Madagascar
Massachusetts General Hospital

Completed

Developing a Positive Psychology Intervention to Promote Health Behaviors in Metabolic Syndrome: Proof-of Concept Trial (MAPP-II)

Metabolic Syndrome

United States
University Hospital, Clermont-Ferrand

Completed

A Role for RAGE/TXNIP/Inflammasome Axis in Alveolar Macrophage Activation During ARDS (RIAMA): a Proof-of-concept Clinical Study

Acute Respiratory Distress Syndrome | Mechanical Ventilation

France
Cairo University

Unknown

Intravenous Tranexamic Acid Versus IV Carbetocin in Abdominal Myomectomy

Myomectomy
Reha Rheinfelden

Completed

TONEFITreha: Proof of Concept and Usability Study. (TONFITreha)

Orthopedic Disorder | Neurological Disorder

Switzerland
University Hospital, Grenoble
University Grenoble Alps; Linksium

Completed

Treprostinil Iontophoresis in Systemic Sclerosis Digital UlcErations. A Proof of Concept Study (TISSUE-PoC)

Scleroderma, Systemic

France
University of the West of England

Completed

Promoting Engagement in Physical Activity in Early Rheumatoid Arthritis: Proof of Concept Study (PEPA-RA)

Rheumatoid Arthritis

United Kingdom
AegisCN LLC
Duke Clinical Research Institute; PharPoint Research, Inc.

Completed

A Proof of Concept Study to Evaluate CN-105 in ICH Patients (CATCH)

Intracerebral Hemorrhage

United States
Ottawa Hospital Research Institute

Completed

Safety and Efficacy of Intravenous Autologous Mesenchymal Stem Cells for MS: a Phase 2 Proof of Concept Study (MESCAMS)

Multiple Sclerosis

Canada
NHS Tayside

Completed

Proof of Concept ELectro-Stimulation of Muscles to resolVe Insulin Resistance in NASH (ELVIS)

Insulin Sensitivity | NASH - Nonalcoholic Steatohepatitis

United Kingdom
Western Norway University of Applied Sciences
Haukeland University Hospital; University of Dublin, Trinity College

Unknown

Exercise to Improve Balance in Older Adults With Hearing Impairment - a Proof-of-concept Study

Hearing Loss | Old Age; Debility | Gait, Unsteady | Balance; Distorted
Gustave Roussy, Cancer Campus, Grand Paris
Innovative Therapies For Children with Cancer Consortium

Unknown

Proof -of -Concept Study To Stratify Targeted Therapies Adapted To Molecular Profiling (MAPPYACTS)

Relapsed or Refractory Pediatric Tumor

France, Ireland, Israel, Italy, Spain
U.S. Army Medical Research and Development Command

Completed

Safety and Tolerability of Antiplaque Chewing Gum in a Gingivitis Population (APCG)

Gingivitis | Plaque

United States
Biotest

Completed

Proof-of-Concept Study With BT063 in Subjects With Systemic Lupus Erythematosus (BT063 in SLE)

Systemic Lupus Erythematosus

Belarus, Georgia, Poland, Serbia
Judson Brandeis

Unknown

A Proof of Concept Top Evaluate a Novel Penile Lengthening Protocol

Penile Elongation

United States
Summit Therapeutics

Terminated

Proof of Concept Study to Assess Activity and Safety of SMT C1100 (Ezutromid) in Boys With Duchenne Muscular Dystrophy (DMD)

Duchenne Muscular Dystrophy

United States, United Kingdom
Ipsen

Terminated

A Proof of Concept Study of Maintenance Therapy With Tasquinimod in Patients With Metastatic Castrate-resistant Prostate Cancer Who Are Not Progressing After a First Line Docetaxel Based Chemotherapy

Metastatic Castrate Resistant Prostate Cancer

France, Spain, Poland, Belgium, Germany, Italy, Denmark, Lithuania, United Kingdom, Czechia, Hungary
Gregory Jicha, 323-5550
University of Kentucky; Kentucky Alzheimer's Center

Completed

Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study (VPA)

Alzheimer's Disease

United States
TWi Biotechnology, Inc.

Terminated

A Proof-of-Concept Study of Topical AC-203 in Patients With Bullous Pemphigoid

Bullous Pemphigoid

Taiwan
Royal Marsden NHS Foundation Trust
Janssen, LP

Unknown

Proof-of-concept Study of Ibrutinib in c-MYC and HER2 Amplified Oesophagogastric Carcinoma (iMYC)

Gastrooesophageal Cancer

United Kingdom
Tools4Patient
International Drug Development Institute

Completed

A Proof of Concept Study to Investigate the Effect of a New Treatment in Patient With Chronic Pain

Osteoarthritis | Peripheral Neuropathies

France, Belgium
Centre Hospitalier Universitaire de Nice

Unknown

Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura (APAM)

Migraine With Aura

France
HaEmek Medical Center, Israel
AbbVie

Completed

Proof of Concept Study To Evaluate the Efficacy and Justification Of OBV/PTV/r and DSV In Adults With Chronic Hepatitis C Virus Genotype 2K/1B

HCV Coinfection

Israel
The Christie NHS Foundation Trust
University of Manchester

Withdrawn

A Proof of Concept, Window Trial of the IMmunological Effects of AveLumab and Aspirin in Triple-Negative Breast Cancer (IMpALA)

Breast Cancer

3

Subscribe