Search clinical trials for: smoothened
Total 21 results
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Mayo ClinicNational Cancer Institute (NCI)RecruitingMetastatic Lung Non-Small Cell Carcinoma | Refractory Lung Non-Small Cell Carcinoma | Metastatic Melanoma | Stage IV Lung Cancer AJCC v8 | Unresectable Malignant Solid Neoplasm | Recurrent Head and Neck Squamous Cell Carcinoma | Metastatic Malignant Solid Neoplasm | Unresectable Melanoma | Clinical... and other conditionsUnited States
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National Cancer Institute (NCI)Active, not recruitingAdvanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma | Hematopoietic and Lymphatic System NeoplasmUnited States
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St. Jude Children's Research HospitalNovartis PharmaceuticalsActive, not recruitingGlioma | Neoplasms | Glioblastoma | Neoplasms, Neuroepithelial | Central Nervous System Neoplasms | Brain Cancer | Brain Tumor | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Pineoblastoma | Recurrent Medulloblastoma | CNS Tumor | Pediatric... and other conditionsUnited States
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Endeavor Biomedicines, Inc.CompletedIdiopathic Pulmonary FibrosisCanada, Malaysia, Australia, Mexico, Korea, Republic of
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Endeavor Biomedicines, Inc.Active, not recruitingSolid Tumors With PTCH1 Loss-of-function MutationsUnited States
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Endeavor Biomedicines, Inc.CompletedIdiopathic Pulmonary FibrosisAustralia
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Mayo ClinicNational Cancer Institute (NCI); Novartis PharmaceuticalsCompletedRefractory Plasma Cell Myeloma | Recurrent Plasma Cell MyelomaUnited States
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H. Lee Moffitt Cancer Center and Research InstitutePfizerCompletedChronic Myelomonocytic Leukemia (CMML) | Myelodysplastic Syndrome (MDS)United States
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Novartis PharmaceuticalsCompletedMedulloblastoma | Basal Cell Carcinoma | Advanced Solid Tumor CancersSpain, Switzerland, United Kingdom, United States
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Novartis PharmaceuticalsCompletedMedulloblastoma | Basal Cell Carcinoma | Advanced Solid Tumor CancersTaiwan, Hong Kong, Japan
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Novartis PharmaceuticalsCompletedMetastatic Colorectal Cancer | Gastric Cancer | Advanced Solid Tumors | Metastatic Breast Cancer | Gastroesophageal Junction Cancer | Recurrent Glioblastoma Multiforme | Advanced Pancreatic Adenocarcinoma | Safety | Triple Negative Metastatic Breast Cancer | Dose Escalation | Preliminary Efficacy | Hormone Receptor...Canada, United Kingdom, Spain, Germany, Italy, Belgium, Australia, United States
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Novartis PharmaceuticalsCompletedBone Marrow Diseases | Hematologic Diseases | Blood Coagulation Disorders | Hemorrhagic Disorders | Primary Myelofibrosis | Myeloproliferative Disorders | Polycythemia Vera | Thrombocytosis | Essential Thrombocythemia | Blood Platelet DisordersUnited Kingdom, Belgium, Canada, France, Australia, Netherlands, Spain, Denmark, Ireland, Italy, Germany
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Mayo ClinicNational Cancer Institute (NCI)CompletedPrimary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Chronic Myelomonocytic Leukemia | Previously Treated Myelodysplastic Syndrome | Recurrent Adult Acute Myeloid Leukemia | Untreated Adult Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Childhood Acute Myeloid Leukemia and other conditionsUnited States
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PfizerTerminatedPrimary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia MyelofibrosisUnited States, Japan
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Novartis PharmaceuticalsWithdrawnBasal Cell CarcinomaGreece, Switzerland, Germany, United Kingdom, Belgium, Canada, Czechia, Finland, Italy, Spain
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Bristol-Myers SquibbTerminatedLeukemiaFrance, United States, Spain, Poland, Finland, Argentina, Canada, Belgium
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SCRI Development Innovations, LLCNovartisTerminated
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Anne ChangNovartisCompletedBasal Cell CarcinomaUnited States
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Bristol-Myers SquibbCompletedLeukemiaUnited States, Canada, Finland, Italy, United Kingdom, France, Germany
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Washington University School of MedicineWithdrawn
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Bristol-Myers SquibbExelixisCompletedBasal Cell Carcinoma (BCC) | Hedgehog Pathway | Smoothened | Basal Cell Nevoid Syndrome (BCNS)United States, Canada