Search clinical trials for: therapeutic toxicity

Total 13939 results

National Cancer Institute (NCI)

Not yet recruiting

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

B Acute Lymphoblastic Leukemia | Acute Leukemia of Ambiguous Lineage
Therapeutic Advances in Childhood Leukemia Consortium

Recruiting

Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

Lymphoma, B-Cell | Hodgkin Lymphoma | Lymphoblastic Lymphoma | Lymphoma, T-Cell | AML | Hematologic Malignancy | MDS | Acute Undifferentiated Leukemia | ALL | Mixed Phenotype Acute Leukemia | BPDCN

United States, Australia
Centre Francois Baclesse, Luxembourg
BIONEXT; NEOLYS DIAGNOSTICS - ALARA GROUP

Not yet recruiting

Pre-therapeutic Analysis of the Individual Radiosensitivity of Cancer Patients in Luxembourg (APRI-Lux): Prospective National Interventional Study With Minimal Risk

Cancer | Radiation Toxicity | Radiosensitivity
Protara Therapeutics

Recruiting

Safety and Toxicity Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer (Phase 1a) (ADVANCED-1)

Non-muscle Invasive Bladder Cancer

United States, Moldova, Republic of, Romania, Ukraine
Protara Therapeutics

Recruiting

Safety and Toxicity Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer (ADVANCED-1)

Non-muscle Invasive Bladder Cancer

United States
Superficial Siderosis Research Alliance Inc.

Not yet recruiting

Therapeutic Antioxidant Supplementation (TAS-SS21)

Superficial Siderosis
National Science Centre, Poland
Medical University of Warsaw

Recruiting

The New LC-MS/MS Method for Determination of Unbound Tacrolimus in Plasma (FreeTAC)

Kidney Transplant Rejection | Liver Transplant; Complications | Immunosuppression | Metabolism Medication Toxicity | Genetic Predisposition | Kidney Transplant; Complications | Liver Transplant Rejection

Poland
Centre Hospitalier Universitaire, Amiens

Recruiting

Ofloxacin Concentration-toxicity Relationship in the Elderly (ROSCO)

Therapeutic Drug Monitoring | Bone and Joint Infection | Adverse Drug Reactions | Ofloxacin

France
University of Geneva, Switzerland
University Hospital, Geneva

Recruiting

The OPTIMAL TDM Study: Determining Optimal Beta-lactam Plasma Concentrations Through Therapeutic Drug Monitoring (OPTIMAL TDM)

Efficacy | Toxicity | Beta-lactam Antibiotics | Therapeutic Drug Monitoring | Ceftazidime | Amoxicillin | Meropenem | Imipenem | Piperacillin | Flucloxacillin | Cefepime

Switzerland
Universidad de Granada

Recruiting

Attenuating Cancer Treatment-related Toxicity in Oncology Patients With a Tailored Physical Exercise Program (ATOPE)

Breast Neoplasms

Spain
Dana-Farber Cancer Institute
National Cancer Institute (NCI)

Completed

Treatment of Acute Lymphoblastic Leukemia in Children

Leukemia | Drug/Agent Toxicity by Tissue/Organ

United States, Canada
Therapeutic Advances in Childhood Leukemia Consortium
Takeda; Children's Hospital Los Angeles

Active, not recruiting

PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Lymphoblastic Leukemia, Acute, Childhood | ALL, Childhood | Lymphoblastic Lymphoma, Childhood

United States, Australia
Baylor Research Institute
The Methodist Hospital Research Institute; International Urogynecological Association

Completed

Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive Bladder

Overactive Bladder | Lower Urinary Tract Symptoms | Dementia | Incontinence, Urge

United States
InterveXion Therapeutics, LLC
National Institute on Drug Abuse (NIDA)

Terminated

Meth-OD: A Study of IXT-m200 in Patients With Toxicity From Methamphetamine Overdose (Meth-OD)

Methamphetamine Intoxication (Disorder)

United States
Institut Cancerologie de l'Ouest

Active, not recruiting

Impact of Therapeutic Patient Education on the Toxicity of Immune Checkpoint Inhibitors in Oncology (EDHITO)

Melanoma | Renal Cell Carcinoma | Head and Neck Cancer | Advanced Non-small Cell Lung Cancer | Immune Checkpoint Inhibitors | Therapeutic Patient Education | Immune-related Adverse Event

France
GenFleet Therapeutics (Australia) Pty Ltd.

Completed

A Study of GFH312 in Healthy Subjects

Healthy | Toxicity

Australia
National Cancer Institute (NCI)

Completed

Phase II Study of Dose-Adjusted EPOCH-Rituximab in Adults With Untreated Burkitt Lymphoma and c-MYC+ Diffuse Large B-Cell Lymphoma

Burkitt Lymphoma | Plasmablastic Lymphoma | Diffuse Large B-cell Lymphoma, c-MYC Positive

United States
G1 Therapeutics, Inc.

Terminated

Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving FOLFOXIRI/Bevacizumab for Metastatic Colorectal Cancer (mCRC): (PRESERVE1)

Colorectal Cancer Metastatic | Chemotherapeutic Toxicity | Myelosuppression-Adult

China, Spain, United States, Hungary, United Kingdom, Poland, Ukraine, Italy
Optimi Health Corporation
University of Calgary

Withdrawn

Mood and Cognitive Effects of Psilocybin in Healthy Participants (MELO)

Health, Subjective | Anxiety | Sleep Disturbance | Drug Effect | Psychedelic Experiences | Mood Change | Mood Disturbance | Psilocin Toxicity | Psilocybin Toxicity | Psilocybin Causing Adverse Effects in Therapeutic Use
University of Bologna

Active, not recruiting

Design of New Personalized Therapeutic Approaches for Diffuse Large B-cell Lymphoma

Diffuse Large B Cell Lymphoma

Italy
101 Therapeutics

Active, not recruiting

Study to Evaluate Pharmacokinetics, Safety & Tolerability of 101-PGC-005 in Healthy, Adult, Human Subjects

Virus Diseases | COVID-19 | Infectious Disease | Glucocorticoids Toxicity

India
National Institute of Allergy and Infectious Diseases...
Protein Sciences Corporation

Completed

Active Immunization of Asymptomatic, HIV-Infected Individuals With Recombinant GP160 HIV-1 Antigen: A Phase I/II Study of Immunogenicity and Toxicity

HIV Infections

United States
G1 Therapeutics, Inc.
Bionical Emas

Approved for marketing

Expanded Access to Trilaciclib for Patients Receiving Chemotherapy for Small Cell Lung Cancer

Small Cell Lung Cancer | Chemotherapeutic Toxicity | Myelosuppression Adult
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Completed

Melatonin and Radiation Therapy in Treating Patients With Brain Metastases

Unspecified Adult Solid Tumor, Protocol Specific | Metastatic Cancer | Radiation Toxicity

United States, Canada
Central Hospital, Nancy, France

Completed

Target Attainment of TDM-guided Infusion of Piperacillin/Tazobactam and Cefepim in Critically Ill Patients (DOSATB)

Sepsis | Critical Illness | Septic Shock | Antibiotic Toxicity

France
NovoCure GmbH

Unknown

Effect of Tumor Treating Fields (TTFields, 150kHz) Concomitant With Sorafenib For Advanced Hepatocellular Carcinoma (HCC) (HEPANOVA)

Hepatocellular Carcinoma

Italy, Czechia, France, Germany, Poland, Spain
Case Comprehensive Cancer Center

Completed

Treating Patients With Prostate Cancer That Did Not Respond to Hormone Therapy

Prostate Cancer

United States
Shanghai Zhongshan Hospital
Wu Jieping Medical Foundation

Unknown

A Randomized Open-labeled Study for Comparing Methods of Using Imrecoxib to Treat AS

Ankylosing Spondylitis | Therapeutic Agent Toxicity

China
Institut Cancerologie de l'Ouest

Terminated

Pre-therapeutic Identification of Dihydropyrimidine Dehydrogenase Gene (DPD) Deficiency for Predicting Toxicity to Fluoropyrimidines (DPD côlon)

Colorectal Cancer | Intravenous 5 Fluorouracile

France
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant

Acute Myeloid Leukemia | Hodgkin Lymphoma | Waldenstrom Macroglobulinemia | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Non-Hodgkin Lymphoma | Plasma Cell Myeloma | Myelodysplastic/Myeloproliferative Neoplasm | Graft Versus Host Disease | Chronic Myelogenous Leukemia, BCR-ABL1 Positive

United States, Italy
Erasmus Medical Center
Gilead Sciences

Unknown

Switching From Tenofovir Disoproxil Fumarate to Abacavir or Tenofovir Alafenamide (BACTAF)

Hiv | Renal Insufficiency,Chronic | Therapeutic Agent Toxicity

Netherlands
M.D. Anderson Cancer Center

Unknown

Understanding Patient's Knowledge and Use of Acetaminophen

Liver Failure

United States
Hannover Medical School

Unknown

Northern Survey on Therapeutic Oxygen Prescription (NONSTOP)

Oxygen Toxicity

Germany
Akebia Therapeutics

Completed

Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin

Drug Interaction Potentiation

Canada
Masaryk Memorial Cancer Institute

Unknown

Acupuncture as the Therapeutic Modalities of Acute Toxicity in the Radiotherapy of Head and Neck Tumors

Malignant Tumor of Soft Tissue of Head, Face and Neck

Czechia
William Lee
Medical University of South Carolina; National Institute of Diabetes and Digestive... and other collaborators

Completed

Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury (STOP-ALF)

Acute Liver Failure | Acute Liver Injury

United States
University Hospital, Geneva

Unknown

APAP Hepatotoxicity After Therapeutic Doses

Malnutrition | Paracetamol Toxicity | Hepatotoxicity

Switzerland
Aminex Therapeutics, Inc.
Iqvia Pty Ltd; Novella Clinical

Withdrawn

Study of Orally-Administered AMXT 1501 Dicaprate in Normal Healthy Volunteers

Neoplasms | Tolerance | Medication Toxicity

United States
Vyne Therapeutics Inc.

Completed

Safety, Tolerability and Efficacy Study of Doxycycline Foam for the Prevention of EGFRI Skin Toxicity in Cancer Patients

Rash Due to Epidermal Growth Factor Receptor Inhibitors

Israel
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, II, or IIIA Breast Cancer Undergoing Chemo

Breast Cancer | Fatigue | Neurotoxicity | Neuropathy | Chemotherapeutic Agent Toxicity

United States
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Terminated

Chemo/XRT +/- Amifostine to Assess Outcomes Related to Xerostomia, Mucositis, & Dysphagia

Head and Neck Cancer | Dysphagia | Mucositis | Xerostomia

United States
First Affiliated Hospital Xi'an Jiaotong University

Unknown

Therapies on Newly Diagnosed Type 2 Diabetes Patients With High Glucose Toxicity Which Protect Islet β Cell (TOND)

Type 2 Diabetes Mellitus

China
Maastricht University Medical Center

Unknown

Everolimus TDM to Predict Long Term Toxicity (Foresight)

Renal Cell Carcinoma | Breast Cancer | Neuroendocrine Neoplasm of Lung | Pancreatic Neuroendocrine Tumour | Gastrointestinal Neuroendocrine Tumour

Netherlands
Third Military Medical University

Completed

Prospective Study of Stereotactic Body Radiation Therapy for Thymoma Inoma: Therapeutic Effect and Toxicity Assessment

Thymoma | Thymic Tumor

China
The HIV Netherlands Australia Thailand Research...
University of California, San Francisco; amfAR, The Foundation for AIDS Research and other collaborators

Completed

Second-line Therapy (TASER-P)

Treatment Failure of Second-line ART in Asian HIV-infected Children

Thailand, Malaysia, Indonesia, Vietnam
Wellstat Therapeutics

Approved for marketing

Uridine Triacetate as Antidote for Patients at Excess Risk of 5-FU Toxicity Due to Overdosage or Impaired Elimination

Toxicity Due to Chemotherapy
AIDS Malignancy Consortium
National Cancer Institute (NCI)

Withdrawn

Peripheral Stem Cell Transplantation Followed By Infusion of White Blood Cells in Treating Patients With AIDS-Related Lymphoma

Lymphoma
Cantonal Hospital of St. Gallen
University of Bern

Completed

Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients (FLOXTOX2)

Colorectal Cancer

Switzerland
Providence Health & Services

Terminated

The Effects of Whole Food Intervention on Mucositis in Patients Treated for Head and Neck Cancer

Mucositis

United States
Providence Health & Services

Terminated

The Effects of Whole Food Intervention on Mucositis in Patients Treated for Thoracic Cancer

Esophagitis

United States

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