Principal Scientist In Vivo CNS

Principal Scientist In Vivo CNS Req ID #:  89574 Location: 

Kuopio, FI, 70210 For over 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Principal Scientist In Vivo CNS

We are looking for an organized, proactive and self-driven individual to join our Scientific Team at CRL Kuopio, Finland. The person in this role will be expected to operate in a highly collaborative environment, partnering with peers, operational teams at the site and at other locations and work closely with Clients.

Role Overview

The primary responsibility of Principal Scientist in vivo as a team leader will be to support and develop his/her team in terms of scientific skills, support and troubleshooting of the projects executed by team members.

The candidate will help set program/project strategies and be responsible for designing, interpreting, analyzing and providing steps forward for in vivo experiments executed at the site.

Successful candidate in addition to rigorous scientific thinking must have excellent interpersonal, collaborative and communication skills to achieve above objectives.

Roles and Responsibilities

• Lead a team of in vivo Scientists (4-5 direct reports at Senior Scientists, Scientists, Associate Scientists level)

• Share scientific knowledge/literature and experience to resolve research and operational problems within project teams

• Provides advisory functions designing a program or experiment to address Clients objectives

• Drive the project decision-making process together with Clients, conceptualize and drive research projects to completion

• Introduce new in vivo models, assays, technologies or introduce improvements in existing once as a part of R&D activities of the Company

• In vivo Lead role in Multisite Integrated Drug Discovery Programs - Influence project strategy using timely decision-making to ensure focus and delivery of key objectives

• Representing Company expertise on Scientific Meetings, Webinars etc.

• Support site and global CNS marketing strategy Job Qualifications

Education Required

• PhD degree in pharmacology, neuroscience or a closely related discipline, with at least 5 years of industry experience (pharmaceutical, CRO or related), with a focus on in vivo assay and models development, execution, and analysis in a drug discovery environment

Experience Required

• Proven ability to independently design, develop and implement in vivo pharmacology assays using an array of endpoints including behavioral, imaging, electrophysiological, physiological biochemical, anatomical, etc. in in vivo CNS models

• In-depth knowledge of neurodegenerative diseases and/or psychiatry diseases and/or rare and orphan diseases with CNS implications, and animal models of these diseases

• A good knowledge of a wide range of technologies for the development of efficacy, pharmacodynamic, and mechanism of action assays using animal models

• Proven ability to develop, optimize and validated of in vivo models of CNS diseases and new in vivo endpoints to support efficacy assessment

• Proven ability to establish pharmacokinetic-pharmacodynamic relationships, develop translational biomarkers and in vitro - in vivo correlations to drive compound discovery and development

• Good knowledge of the drug discovery environment, able to establish, maintain and manage effective collaborations with external partners

• Previous experience of effective team leading and line management, experience in training and mentoring team members is highly desirable

• Experience in working as in vivo Lead in Integrated Drug Discovery Programs will be an asset

Skills/Competencies

• Proven ability to work in a team or collaboration-based environment

• Excellent analytical, organizational and communication skills

• Passion for innovation and problem-solving

• Ability to lead, coordinate, prioritize and get things done

• Ability to quickly prioritize deliverables according to team and business requirements

• Ability to work flexibly across projects and adapt to new priorities in fast-paced environment

• Ability to influence the strategy on drug discovery programs

• Fluent spoken and written English, scientific writing skills

About Discovery

Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities.Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 11,000 employees within 70 facilities in 18 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2016, revenue increased by 23.3% to $1.68 billion from $1.36 billion in 2015.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~70% of the drugs approved by the FDA in 2016.

For more information, please visit www.criver.com .

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