The Relationship Between Clotting Factor VIII and Bleeding Adverse Reactions in Patients Under the Therapies of Thrombolysis, Anticoagulation and Anti-platelet

Inclusion Criteria:

• Guidelines prepared by the diagnostic criteria(according to the diagnostic criteria of the Fourth National Stroke Conference prepared,have been more than one times skull CT and/or MRI)was confirmed for ischemic stroke,and requires the use of antithrombotic therapy(including thrombolysis, anticoagulation, antiplatelet) patients
• Willing and able to comply with the study protocol and visits planned

Exclusion Criteria:

• At the same time the presence of other active malignancy.
• There is known brain metastases or leptomeningeal metastases
• Systemic active infection ( ie infection leads to body temperature ≥38 ℃)
• The last 4 weeks there is a need drainage ascites, pleural effusion or pericardial fluid .
• Clinically significant obstruction , pulmonary fibrosis , kidney failure , liver failure and other diseases.
• Uncontrolled diabetes.
• Severe / unstable angina, New York Heart Association (NYHA) class III or IV symptoms of congestive heart failure
• there is other reason (not the antithrombotic drugs) caused by bleeding.
• The presence of an autoimmune disease or a history of organ transplant patients require immunosuppressive therapy
• Psychiatric presence may increase the risks associated with study participation or study drug , or may interfere with the interpretation of study results
• Pregnant and lactating women
• Bleeding disorders may exist on admission
• The researchers added that the study is not appropriate to the circumstances