Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Calciumgluconat og magnesiumsulfat til forebyggelse af neurotoksicitet hos patienter med tyktarmskræft eller endetarmskræft, der modtager oxaliplatin-baseret kombinationskemoterapi

1. november 2022 opdateret af: Alliance for Clinical Trials in Oncology

Et fase III randomiseret, placebokontrolleret, dobbeltblindt studie af intravenøst ​​calcium/magnesium i to forskellige versioner for at forhindre Oxaliplatin-induceret sensorisk neurotoksicitet

RATIONALE: Kemobeskyttende lægemidler, såsom calciumgluconat og magnesiumsulfat, kan forhindre neurotoksicitet forårsaget af oxaliplatin. Det vides endnu ikke, hvilket administrationsskema for calciumgluconat og magnesiumsulfat, der er mere effektivt til at forhindre neurotoksicitet.

FORMÅL: Dette randomiserede fase III-forsøg studerer forskellige administrationsskemaer for calciumgluconat og magnesiumsulfat og sammenligner, hvor godt de virker i neurotoksicitet hos patienter med tyktarmskræft eller rektalcancer, der får oxaliplatin-baseret kombinationskemoterapi.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

MÅL:

Primær

  • For at bestemme, om 2 skemaer af calciumgluconat og magnesiumsulfat infusioner (givet før og efter kemoterapi eller lige før kemoterapi) kan forebygge eller lindre kronisk, kumulativ oxaliplatin-induceret sensorisk neurotoksicitet hos patienter med tyktarms- eller rektalcancer, der får adjuverende FOLFOX kemoterapi, der omfatter leucovorin calcium, fluorouracil og oxaliplatin.

Sekundær

  • For at bestemme, om disse 2 infusionsskemaer kan øge de kumulative oxaliplatin-doser, der kan leveres uden dosisbegrænsende kronisk neurotoksicitet.
  • For at bestemme, om disse 2 infusionsskemaer kan lindre akut neuropati forbundet med oxaliplatin.
  • For at bestemme, om disse 2 infusionsplaner forårsager uønskede hændelser.
  • At undersøge om disse 2 infusionsskemaer påvirker patientens livskvalitet.
  • At beskrive baseline og post-behandling neurologiske kvantitative sensoriske testabnormiteter hos undersøgelsesdeltagerne.

Tertiære

  • At undersøge, om polymorfismer i GSTP1-, GSTM1-, ERCC2- og XRCC1-generne er forbundet med tidlig indtræden af ​​oxaliplatin-induceret neurotoksicitet.

OVERSIGT: Dette er en multicenterundersøgelse. Patienterne er stratificeret efter alder (< 65 år vs. ≥ 65 år), køn, regime (FOLFOX4 vs. modificeret FOLFOX6 vs. andet) og sygdomsstadium (II vs III vs IV). Patienterne randomiseres til 1 ud af 3 behandlingsarme.

  • Arm I: Patienterne får calciumgluconat IV og magnesiumsulfat IV i løbet af 30 minutter umiddelbart før og efter administration af oxaliplatin (en del af FOLFOX-kemoterapi, der omfatter leucovorin-calcium, fluorouracil og oxaliplatin).
  • Arm II: Patienterne får placebo IV over 30 minutter umiddelbart før og efter administration af oxaliplatin (en del af FOLFOX kemoterapi).
  • Arm III: Patienterne får calciumgluconat og magnesiumsulfat IV over 30 minutter umiddelbart før og placebo IV over 30 minutter umiddelbart efter administration af oxaliplatin (en del af FOLFOX-kemoterapi).

I alle arme gentages kurser hver 14. dag i 6 måneder i fravær af sygdomsprogression eller uacceptabel toksicitet.

Blodprøver udtages før det andet behandlingsforløb til translationel forskning.

Patienter udfylder periodisk spørgeskemaer om bivirkninger, livskvalitet og kemoterapi-induceret perifer neuropati.

Efter afslutning af undersøgelsesbehandlingen følges patienterne op efter 3, 6, 12 og 18 måneder.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

362

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Alaska
      • Fairbanks, Alaska, Forenede Stater, 99701
        • Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
    • California
      • Antioch, California, Forenede Stater, 94531
        • Kaiser Permanente - Deer Valley
      • Fairfield, California, Forenede Stater, 94533
        • North Bay Cancer Center
      • Fremont, California, Forenede Stater, 94538
        • Kaiser Permanente - Fremont
      • Fresno, California, Forenede Stater, 93720
        • Kaiser Permanente Fresno Medical Center
      • Hayward, California, Forenede Stater, 94545
        • Kaiser Permanente Medical Center - Hayward
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente Medical Center - Oakland
      • Pismo Beach, California, Forenede Stater, 93449
      • Redwood City, California, Forenede Stater, 94063
        • Kaiser Permanente Medical Center - Redwood City
      • Richmond, California, Forenede Stater, 94801
        • Kaiser Permanente Medical Center - Richmond
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente Medical Center - Roseville
      • Sacramento, California, Forenede Stater, 95823
        • South Sacramento Kaiser-Permanente Medical Center
      • Sacramento, California, Forenede Stater, 95825
        • Kaiser Permanente Medical Center - Sacramento
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente Medical Center - San Francisco Geary Campus
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente Medical Center - Santa Teresa
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser Foundation Hospital - San Rafael
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara Kiely Campus
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente Medical Center - Santa Rosa
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente Medical Center - South San Francisco
      • Stockton, California, Forenede Stater, 95210
        • Kaiser Permanente Medical Facility - Stockton
      • Vacaville, California, Forenede Stater, 95688
        • Kaiser Permanente Medical Center - Vacaville
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente Medical Center - Vallejo
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente Medical Center - Walnut Creek
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80012
        • Aurora Presbyterian Hospital
      • Boulder, Colorado, Forenede Stater, 80301-9019
        • Boulder Community Hospital
      • Colorado Springs, Colorado, Forenede Stater, 80933
        • Penrose Cancer Center at Penrose Hospital
      • Denver, Colorado, Forenede Stater, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, Forenede Stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Presbyterian - St. Luke's Medical Center
      • Denver, Colorado, Forenede Stater, 80204
        • St. Anthony Central Hospital
      • Denver, Colorado, Forenede Stater, 80218
        • St. Joseph Hospital
      • Denver, Colorado, Forenede Stater, 80224-2522
        • CCOP - Colorado Cancer Research Program
      • Denver, Colorado, Forenede Stater, 80205
        • Kaiser Permanente - Denver
      • Englewood, Colorado, Forenede Stater, 80110
        • Swedish Medical Center
      • Grand Junction, Colorado, Forenede Stater, 81502
        • St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
      • Greeley, Colorado, Forenede Stater, 80631
        • North Colorado Medical Center
      • Lafayette, Colorado, Forenede Stater, 80026
        • Kaiser Permanente - Lafayette
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Sky Ridge Medical Center
      • Longmont, Colorado, Forenede Stater, 80501
        • Hope Cancer Care Center at Longmont United Hospital
      • Loveland, Colorado, Forenede Stater, 80539
        • McKee Medical Center
      • Pueblo, Colorado, Forenede Stater, 81004
        • St. Mary - Corwin Regional Medical Center
      • Thornton, Colorado, Forenede Stater, 80229
        • North Suburban Medical Center
      • Wheat Ridge, Colorado, Forenede Stater, 80033
        • Exempla Lutheran Medical Center
    • Connecticut
      • Hartford, Connecticut, Forenede Stater, 06105
        • Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
      • Norwalk, Connecticut, Forenede Stater, 06856
        • Norwalk Hospital
    • Delaware
      • Lewes, Delaware, Forenede Stater, 19958
        • Tunnell Cancer Center at Beebe Medical Center
      • Newark, Delaware, Forenede Stater, 19713
        • CCOP - Christiana Care Health Services
    • Florida
      • Deerfield Beach, Florida, Forenede Stater, 33064-3596
        • North Broward Medical Center
      • Fort Lauderdale, Florida, Forenede Stater, 33316
        • Broward General Medical Center Cancer Center
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
      • Jupiter, Florida, Forenede Stater, 33458
        • Ella Milbank Foshay Cancer Center at Jupiter Medical Center
      • Miami Beach, Florida, Forenede Stater, 33140
        • CCOP - Mount Sinai Medical Center
      • Orlando, Florida, Forenede Stater, 32803-1273
        • Florida Hospital Cancer Institute at Florida Hospital Orlando
    • Georgia
      • Albany, Georgia, Forenede Stater, 31701
        • Phoebe Cancer Center at Phoebe Putney Memorial Hospital
      • Atlanta, Georgia, Forenede Stater, 30309
        • Piedmont Hospital
      • Atlanta, Georgia, Forenede Stater, 30342-1611
        • Northside Hospital Cancer Center
      • Atlanta, Georgia, Forenede Stater, 30342-1701
        • Saint Joseph's Hospital of Atlanta
      • Atlanta, Georgia, Forenede Stater, 30342
        • CCOP - Atlanta Regional
      • Austell, Georgia, Forenede Stater, 30106
        • WellStar Cobb Hospital
      • Columbus, Georgia, Forenede Stater, 31904
        • John B. Amos Cancer Center
      • Decatur, Georgia, Forenede Stater, 30033
        • Charles B. Eberhart Cancer Center at DeKalb Medical Center
      • Decatur, Georgia, Forenede Stater, 30033
        • Veterans Affairs Medical Center - Atlanta (Decatur)
      • Fayetteville, Georgia, Forenede Stater, 30214
        • Piedmont Fayette Hospital
      • Lawrenceville, Georgia, Forenede Stater, 30045
        • Gwinnett Medical Center
      • Marietta, Georgia, Forenede Stater, 30060
        • Kennestone Cancer Center at Wellstar Kennestone Hospital
      • Riverdale, Georgia, Forenede Stater, 30274-2600
        • Southern Regional Medical Center
      • Rome, Georgia, Forenede Stater, 30165
        • Harbin Clinic Cancer Center - Medical Oncology
      • Savannah, Georgia, Forenede Stater, 31403-3089
        • Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
      • Savannah, Georgia, Forenede Stater, 31405
        • Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
    • Hawaii
      • 'Aiea, Hawaii, Forenede Stater, 96701
        • Kapiolani Medical Center at Pali Momi
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Cancer Research Center of Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96826
        • Kapiolani Medical Center for Women and Children
      • Honolulu, Hawaii, Forenede Stater, 96813
        • OnCare Hawaii, Incorporated - Lusitana
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Cancer Institute at Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Straub Clinic and Hospital, Incorporated
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Hawaii Medical Center - East
      • Honolulu, Hawaii, Forenede Stater, 96817
        • OnCare Hawaii, Incorporated - Kuakini
      • Honolulu, Hawaii, Forenede Stater, 96859
        • Tripler Army Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Kaiser Permanente - Moanalua Medical Center and Clinic
      • Wailuku, Hawaii, Forenede Stater, 96793
        • Maui Memorial Medical Center
      • Wailuku, Hawaii, Forenede Stater, 96793
        • Pacific Cancer Institute - Maui
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
      • Lewiston, Idaho, Forenede Stater, 83501
        • St. Joseph Regional Medical Center
    • Illinois
      • Aurora, Illinois, Forenede Stater, 60504
        • Rush-Copley Cancer Care Center
      • Bloomington, Illinois, Forenede Stater, 61701
        • Illinois CancerCare - Bloomington
      • Canton, Illinois, Forenede Stater, 61520
        • Illinois CancerCare - Canton
      • Canton, Illinois, Forenede Stater, 61520
        • Graham Hospital
      • Carthage, Illinois, Forenede Stater, 62321
        • Memorial Hospital
      • Carthage, Illinois, Forenede Stater, 62321
        • Illinois CancerCare - Carthage
      • Chicago, Illinois, Forenede Stater, 60640
        • Louis A. Weiss Memorial Hospital
      • Chicago, Illinois, Forenede Stater, 60612-7243
        • University of Illinois Cancer Center
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital Cancer Care Institute
      • Eureka, Illinois, Forenede Stater, 61530
        • Illinois CancerCare - Eureka
      • Eureka, Illinois, Forenede Stater, 61530
        • Eureka Community Hospital
      • Galesburg, Illinois, Forenede Stater, 61401
        • Illinois CancerCare - Galesburg
      • Galesburg, Illinois, Forenede Stater, 61401
        • Galesburg Clinic, PC
      • Havana, Illinois, Forenede Stater, 62644
        • Mason District Hospital
      • Havana, Illinois, Forenede Stater, 62644
        • Illinois CancerCare - Havana
      • Kewanee, Illinois, Forenede Stater, 61443
        • Illinois CancerCare - Kewanee Clinic
      • Macomb, Illinois, Forenede Stater, 61455
        • Illinois CancerCare - Macomb
      • Macomb, Illinois, Forenede Stater, 61455
        • Mcdonough District Hospital
      • Moline, Illinois, Forenede Stater, 61265
      • Moline, Illinois, Forenede Stater, 61265
        • Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
      • Monmouth, Illinois, Forenede Stater, 61462
        • Illinois CancerCare - Monmouth
      • Normal, Illinois, Forenede Stater, 61761
        • Bromenn Regional Medical Center
      • Normal, Illinois, Forenede Stater, 61761
        • Community Cancer Center
      • Normal, Illinois, Forenede Stater, 61761
        • Illinois CancerCare - Community Cancer Center
      • Ottawa, Illinois, Forenede Stater, 61350
        • Community Hospital of Ottawa
      • Ottawa, Illinois, Forenede Stater, 61350
        • Oncology Hematology Associates of Central Illinois, PC - Ottawa
      • Pekin, Illinois, Forenede Stater, 61554
        • Cancer Treatment Center at Pekin Hospital
      • Pekin, Illinois, Forenede Stater, 61603
        • Illinois CancerCare - Pekin
      • Peoria, Illinois, Forenede Stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forenede Stater, 61614
        • Proctor Hospital
      • Peoria, Illinois, Forenede Stater, 61615
        • CCOP - Illinois Oncology Research Association
      • Peoria, Illinois, Forenede Stater, 61615
        • Oncology Hematology Associates of Central Illinois, PC - Peoria
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois CancerCare - Peru
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois Valley Community Hospital
      • Princeton, Illinois, Forenede Stater, 61356
        • Perry Memorial Hospital
      • Princeton, Illinois, Forenede Stater, 61356
        • Illinois CancerCare - Princeton
      • River Forest, Illinois, Forenede Stater, 60305
        • West Suburban Center for Cancer Care
      • Spring Valley, Illinois, Forenede Stater, 61362
        • Illinois CancerCare - Spring Valley
      • Springfield, Illinois, Forenede Stater, 62781-0001
        • Regional Cancer Center at Memorial Medical Center
      • Urbana, Illinois, Forenede Stater, 61801
        • CCOP - Carle Cancer Center
    • Indiana
      • Beech Grove, Indiana, Forenede Stater, 46107
        • St. Francis Hospital and Health Centers - Beech Grove Campus
      • Elkhart, Indiana, Forenede Stater, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, Forenede Stater, 46514-2098
        • Elkhart Clinic, LLC
      • Elkhart, Indiana, Forenede Stater, 46514
        • Michiana Hematology-Oncology, PC - Elkhart
      • Kokomo, Indiana, Forenede Stater, 46904
        • Howard Community Hospital
      • La Porte, Indiana, Forenede Stater, 46350
        • Center for Cancer Therapy at LaPorte Hospital and Health Services
      • Lafayette, Indiana, Forenede Stater, 47904
        • Clarian Arnett Cancer Care
      • Michigan City, Indiana, Forenede Stater, 46360
        • Saint Anthony Memorial Health Centers
      • Mishawaka, Indiana, Forenede Stater, 46545-1470
        • Michiana Hematology-Oncology, PC - South Bend
      • Mishawaka, Indiana, Forenede Stater, 46545-1470
        • Saint Joseph Regional Medical Center
      • Plymouth, Indiana, Forenede Stater, 46563
        • Michiana Hematology Oncology PC - Plymouth
      • Richmond, Indiana, Forenede Stater, 47374
        • Reid Hospital & Health Care Services
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, Forenede Stater, 46601
        • CCOP - Northern Indiana CR Consortium
      • Westville, Indiana, Forenede Stater, 46391
        • Michiana Hematology Oncology PC - La Porte
    • Iowa
      • Bettendorf, Iowa, Forenede Stater, 52722
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Cedar Rapids Oncology Associates
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Regional Cancer Center at Mercy Medical Center
      • Clive, Iowa, Forenede Stater, 50325
        • Medical Oncology and Hematology Associates - West Des Moines
      • Clive, Iowa, Forenede Stater, 50325
        • Mercy Cancer Center - West Lakes
      • Des Moines, Iowa, Forenede Stater, 50309
        • CCOP - Iowa Oncology Research Association
      • Des Moines, Iowa, Forenede Stater, 50309
        • John Stoddard Cancer Center at Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Medical Oncology and Hematology Associates at John Stoddard Cancer Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Medical Oncology and Hematology Associates at Mercy Cancer Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Cancer Center at Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forenede Stater, 50316
        • John Stoddard Cancer Center at Iowa Lutheran Hospital
      • Sioux City, Iowa, Forenede Stater, 51101
        • Siouxland Hematology-Oncology Associates, LLP
      • Sioux City, Iowa, Forenede Stater, 51102
        • Mercy Medical Center - Sioux City
      • Sioux City, Iowa, Forenede Stater, 51104
        • St. Luke's Regional Medical Center
      • Waterloo, Iowa, Forenede Stater, 50702
        • Covenant Cancer Treatment Center
      • West Des Moines, Iowa, Forenede Stater, 50266-7700
        • Methodist West Hospital
    • Kansas
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas, PA - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas, PA - Dodge City
      • El Dorado, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas, PA - El Dorado
      • Fort Scott, Kansas, Forenede Stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, Forenede Stater, 67301
        • Cancer Center of Kansas-Independence
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas, PA - Kingman
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, Forenede Stater, 67901
        • Cancer Center of Kansas, PA - Liberal
      • McPherson, Kansas, Forenede Stater, 67460
        • Cancer Center of Kansas, PA - McPherson
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas, PA - Newton
      • Overland Park, Kansas, Forenede Stater, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, Forenede Stater, 66213
        • Saint Luke's Hospital - South
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas, PA - Parsons
      • Prairie Village, Kansas, Forenede Stater, 66208
        • CCOP - Kansas City
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas, PA - Pratt
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas, PA - Salina
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas, PA - Wellington
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas, PA - Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas, PA - Wichita
      • Wichita, Kansas, Forenede Stater, 67214
        • CCOP - Wichita
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Cancer Center at Via Christi Regional Medical Center
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates in Womens Health, PA - North Review
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas, PA - Winfield
    • Louisiana
      • New Orleans, Louisiana, Forenede Stater, 70112
        • MBCCOP - LSU Health Sciences Center
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Medical Center of Louisiana - New Orleans
    • Maine
      • York, Maine, Forenede Stater, 03909
        • York Hospital's Oncology Treatment Center
    • Maryland
      • Easton, Maryland, Forenede Stater, 21601
        • Shore Regional Cancer Center at Memorial Hospital - Easton
      • Elkton, Maryland, Forenede Stater, 21921
        • Union Hospital of Cecil County
    • Massachusetts
      • Attleboro, Massachusetts, Forenede Stater, 02703
        • Sturdy Memorial Hospital
      • Boston, Massachusetts, Forenede Stater, 02118
        • Boston University Cancer Research Center
      • Brighton, Massachusetts, Forenede Stater, 02135-2997
        • Caritas St. Elizabeth's Medical Center
    • Michigan
      • Adrian, Michigan, Forenede Stater, 49221
        • Hickman Cancer Center at Bixby Medical Center
      • Ann Arbor, Michigan, Forenede Stater, 48106-0995
        • Saint Joseph Mercy Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • CCOP - Michigan Cancer Research Consortium
      • Dearborn, Michigan, Forenede Stater, 48123-2500
        • Oakwood Cancer Center at Oakwood Hospital and Medical Center
      • Escanaba, Michigan, Forenede Stater, 49431
        • Green Bay Oncology, Limited - Escanaba
      • Flint, Michigan, Forenede Stater, 48503
        • Hurley Medical Center
      • Flint, Michigan, Forenede Stater, 48503
        • Genesys Hurley Cancer Institute
      • Grand Blanc, Michigan, Forenede Stater, 48439
        • Genesys Regional Medical Center
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Van Elslander Cancer Center at St. John Hospital and Medical Center
      • Iron Mountain, Michigan, Forenede Stater, 49801
        • Dickinson County Healthcare System
      • Jackson, Michigan, Forenede Stater, 49201
        • Foote Memorial Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49001
        • Borgess Medical Center
      • Kalamazoo, Michigan, Forenede Stater, 49007-3731
        • West Michigan Cancer Center
      • Lansing, Michigan, Forenede Stater, 48912-1811
        • Sparrow Regional Cancer Center
      • Livonia, Michigan, Forenede Stater, 48154
        • St. Mary Mercy Hospital
      • Monroe, Michigan, Forenede Stater, 48162
        • Community Cancer Center of Monroe
      • Monroe, Michigan, Forenede Stater, 48162
        • Mercy Memorial Hospital - Monroe
      • Niles, Michigan, Forenede Stater, 49120
        • Michiana Hematology Oncology PC - Niles
      • Pontiac, Michigan, Forenede Stater, 48341-2985
        • St. Joseph Mercy Oakland
      • Port Huron, Michigan, Forenede Stater, 48060
        • Mercy Regional Cancer Center at Mercy Hospital
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital - Royal Oak Campus
      • Saginaw, Michigan, Forenede Stater, 48601
        • Seton Cancer Institute at Saint Mary's - Saginaw
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Lakeside Cancer Specialists, PLLC
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Lakeland Regional Cancer Care Center - St. Joseph
      • Warren, Michigan, Forenede Stater, 48093
        • St. John Macomb Hospital
    • Minnesota
      • Duluth, Minnesota, Forenede Stater, 55805
        • CCOP - Duluth
      • Duluth, Minnesota, Forenede Stater, 55805-1983
        • Duluth Clinic Cancer Center - Duluth
      • Duluth, Minnesota, Forenede Stater, 55805
        • Miller - Dwan Medical Center
      • Mankato, Minnesota, Forenede Stater, 56002
        • Immanuel St. Joseph's
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center - Minneapolis
      • Rochester, Minnesota, Forenede Stater, 55905
        • Mayo Clinic Cancer Center
    • Mississippi
      • Pascagoula, Mississippi, Forenede Stater, 39581
        • Regional Cancer Center at Singing River Hospital
    • Missouri
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Southeast Cancer Center
      • Chesterfield, Missouri, Forenede Stater, 63017
        • Saint Luke's Hospital
      • Jefferson City, Missouri, Forenede Stater, 65109
        • Goldschmidt Cancer Center
      • Kansas City, Missouri, Forenede Stater, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Cancer Institute at Saint Luke's Hospital
      • Kansas City, Missouri, Forenede Stater, 64116
        • Parvin Radiation Oncology
      • Kansas City, Missouri, Forenede Stater, 64118
        • Heartland Hematology Oncology Associates, Incorporated
      • Lee's Summit, Missouri, Forenede Stater, 64086
        • Saint Luke's East - Lee's Summit
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Heartland Regional Medical Center
      • Saint Joseph, Missouri, Forenede Stater, 64507
        • Saint Joseph Oncology, Incorporated
      • Saint Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Cancer Center
      • Saint Louis, Missouri, Forenede Stater, 63110
        • Saint Louis University Cancer Center
      • Saint Louis, Missouri, Forenede Stater, 63141
        • Comprehensive Cancer Care, PC
      • Saint Louis, Missouri, Forenede Stater, 63128
        • St. Anthony's Cancer Center
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • CCOP - Montana Cancer Consortium
      • Billings, Montana, Forenede Stater, 59101
        • St. Vincent Healthcare Cancer Care Services
      • Billings, Montana, Forenede Stater, 59107-7000
        • Billings Clinic - Downtown
      • Billings, Montana, Forenede Stater, 59102
        • Hematology-Oncology Centers of the Northern Rockies - Billings
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Cancer Center
      • Butte, Montana, Forenede Stater, 59701
        • St. James Healthcare Cancer Care
      • Great Falls, Montana, Forenede Stater, 59405
        • Great Falls Clinic - Main Facility
      • Great Falls, Montana, Forenede Stater, 59405-5309
        • Big Sky Oncology
      • Great Falls, Montana, Forenede Stater, 59405
        • Sletten Cancer Institute at Benefis Healthcare
      • Havre, Montana, Forenede Stater, 59501
        • Northern Montana Hospital
      • Helena, Montana, Forenede Stater, 59601
        • St. Peter's Hospital
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Regional Medical Center
      • Kalispell, Montana, Forenede Stater, 59901
        • Glacier Oncology, PLLC
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Medical Oncology at KRMC
      • Missoula, Montana, Forenede Stater, 59807-7877
        • Montana Cancer Specialists at Montana Cancer Center
      • Missoula, Montana, Forenede Stater, 59807
        • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
    • Nebraska
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Cancer Resource Center - Lincoln
      • Omaha, Nebraska, Forenede Stater, 68106
        • CCOP - Missouri Valley Cancer Consortium
      • Omaha, Nebraska, Forenede Stater, 68122
        • Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegant Health Cancer Center at Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68131-2197
        • Creighton University Medical Center
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • CCOP - Nevada Cancer Research Foundation
    • New Hampshire
      • Concord, New Hampshire, Forenede Stater, 03301
        • New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
      • Exeter, New Hampshire, Forenede Stater, 03833
        • Center for Cancer Care at Exeter Hospital
      • Hooksett, New Hampshire, Forenede Stater, 03106
        • New Hampshire Oncology - Hematology, PA - Hooksett
      • Laconia, New Hampshire, Forenede Stater, 03246
        • Lakes Region General Hospital
      • Nashua, New Hampshire, Forenede Stater, 03060
        • Oncology Center at St. Joseph Hospital
    • New Jersey
      • Elizabeth, New Jersey, Forenede Stater, 07207
        • Trinitas Comprehensive Cancer Center at Trinitas Hospital
      • Newark, New Jersey, Forenede Stater, 07112
        • Newark Beth Israel Medical Center
      • Voorhees, New Jersey, Forenede Stater, 08043
        • Cancer Institute of New Jersey at Cooper - Voorhees
    • New York
      • Brooklyn, New York, Forenede Stater, 11203
        • SUNY Downstate Medical Center
      • Brooklyn, New York, Forenede Stater, 11203
        • Kings County Hospital Center
      • Brooklyn, New York, Forenede Stater, 11209
        • Veterans Affairs Medical Center - Brooklyn
      • Cooperstown, New York, Forenede Stater, 13326
        • Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
      • East Syracuse, New York, Forenede Stater, 13057
        • CCOP - Hematology-Oncology Associates of Central New York
      • Lake Success, New York, Forenede Stater, 11042
        • Monter Cancer Center of the North Shore-LIJ Health System
      • Manhasset, New York, Forenede Stater, 11030
        • CCOP - North Shore University Hospital
      • Manhasset, New York, Forenede Stater, 11030
        • Don Monti Comprehensive Cancer Center at North Shore University Hospital
      • New Hyde Park, New York, Forenede Stater, 11040
        • Long Island Jewish Medical Center
      • Plattsburgh, New York, Forenede Stater, 12901
        • Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center
    • North Carolina
      • Asheboro, North Carolina, Forenede Stater, 27203-5400
        • Randolph Hospital
      • Gastonia, North Carolina, Forenede Stater, 28053
        • CaroMont Cancer Center at Gaston Memorial Hospital
      • Goldsboro, North Carolina, Forenede Stater, 27534
        • Wayne Memorial Hospital, Incorporated
      • Greensboro, North Carolina, Forenede Stater, 27403-1198
        • Moses Cone Regional Cancer Center at Wesley Long Community Hospital
      • Hendersonville, North Carolina, Forenede Stater, 28791
        • Pardee Memorial Hospital
      • Pinehurst, North Carolina, Forenede Stater, 28374
        • FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
      • Reidsville, North Carolina, Forenede Stater, 27320
        • Annie Penn Cancer Center
      • Rutherfordton, North Carolina, Forenede Stater, 28139
        • Rutherford Hospital
      • Statesville, North Carolina, Forenede Stater, 28677
        • Iredell Memorial Hospital
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Bismarck Cancer Center
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Medcenter One Hospital Cancer Care Center
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Mid Dakota Clinic, PC
      • Bismarck, North Dakota, Forenede Stater, 58502
        • St. Alexius Medical Center Cancer Center
      • Grand Forks, North Dakota, Forenede Stater, 58201
        • Altru Cancer Center at Altru Hospital
      • Minot, North Dakota, Forenede Stater, 58701
        • Trinity Cancercare Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44307
        • McDowell Cancer Center at Akron General Medical Center
      • Bowling Green, Ohio, Forenede Stater, 43402
        • Wood County Oncology Center
      • Cleveland, Ohio, Forenede Stater, 44109
        • MetroHealth Cancer Care Center at MetroHealth Medical Center
      • Dayton, Ohio, Forenede Stater, 45405
        • Grandview Hospital
      • Dayton, Ohio, Forenede Stater, 45406
        • Good Samaritan Hospital
      • Dayton, Ohio, Forenede Stater, 45409
        • David L. Rike Cancer Center at Miami Valley Hospital
      • Dayton, Ohio, Forenede Stater, 45415
        • Samaritan North Cancer Care Center
      • Dayton, Ohio, Forenede Stater, 45420
        • CCOP - Dayton
      • Elyria, Ohio, Forenede Stater, 44035
        • Community Cancer Center
      • Elyria, Ohio, Forenede Stater, 44035
        • Hematology Oncology Center
      • Findlay, Ohio, Forenede Stater, 45840
        • Blanchard Valley Medical Associates
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Middletown Regional Hospital
      • Greenville, Ohio, Forenede Stater, 45331
        • Wayne Hospital
      • Kettering, Ohio, Forenede Stater, 45429
        • Charles F. Kettering Memorial Hospital
      • Lima, Ohio, Forenede Stater, 45804
        • Lima Memorial Hospital
      • Lima, Ohio, Forenede Stater, 45801
        • St. Rita's Medical Center
      • Maumee, Ohio, Forenede Stater, 43537-1839
        • Northwest Ohio Oncology Center
      • Oregon, Ohio, Forenede Stater, 43616
        • St. Charles Mercy Hospital
      • Oregon, Ohio, Forenede Stater, 43616
        • Toledo Clinic - Oregon
      • Sandusky, Ohio, Forenede Stater, 44870
        • North Coast Cancer Care, Incorporated
      • Sylvania, Ohio, Forenede Stater, 43560
        • Flower Hospital Cancer Center
      • Tiffin, Ohio, Forenede Stater, 44883
        • Mercy Hospital of Tiffin
      • Toledo, Ohio, Forenede Stater, 43608
        • St. Vincent Mercy Medical Center
      • Toledo, Ohio, Forenede Stater, 43606
        • Toledo Hospital
      • Toledo, Ohio, Forenede Stater, 43614
        • Medical University of Ohio Cancer Center
      • Toledo, Ohio, Forenede Stater, 43617
        • CCOP - Toledo Community Hospital
      • Toledo, Ohio, Forenede Stater, 43623
        • Toledo Clinic, Incorporated - Main Clinic
      • Toledo, Ohio, Forenede Stater, 43623
        • St. Anne Mercy Hospital
      • Troy, Ohio, Forenede Stater, 45373-1300
        • UVMC Cancer Care Center at Upper Valley Medical Center
      • Wauseon, Ohio, Forenede Stater, 43567
        • Fulton County Health Center
      • Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
        • United States Air Force Medical Center - Wright-Patterson
      • Xenia, Ohio, Forenede Stater, 45385
        • Ruth G. McMillan Cancer Center at Greene Memorial Hospital
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • Oklahoma University Cancer Institute
      • Tulsa, Oklahoma, Forenede Stater, 74136
        • Natalie Warren Bryant Cancer Center at St. Francis Hospital
      • Tulsa, Oklahoma, Forenede Stater, 74104
        • LaFortune Cancer Center at St. John Medical Center
    • Oregon
      • Portland, Oregon, Forenede Stater, 97227
        • Kaiser Permanente Health Care - Portland
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18105
        • Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
      • Bryn Mawr, Pennsylvania, Forenede Stater, 19010
        • Bryn Mawr Hospital
      • Danville, Pennsylvania, Forenede Stater, 17822-0001
        • Geisinger Cancer Institute at Geisinger Health
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Geisinger Hazleton Cancer Center
      • Paoli, Pennsylvania, Forenede Stater, 19301-1792
        • Cancer Center of Paoli Memorial Hospital
      • State College, Pennsylvania, Forenede Stater, 16801
        • Geisinger Medical Group - Scenery Park
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Lankenau Cancer Center at Lankenau Hospital
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • CCOP - Main Line Health
    • Rhode Island
      • Warwick, Rhode Island, Forenede Stater, 02886
        • Kent County Memorial Hospital
    • South Carolina
      • Anderson, South Carolina, Forenede Stater, 29621
        • AnMed Cancer Center
      • Charleston, South Carolina, Forenede Stater, 29401
        • Roper St. Francis Cancer Center at Roper Hospital
      • Easley, South Carolina, Forenede Stater, 29640
        • Cancer Centers of the Carolinas - Easley
      • Florence, South Carolina, Forenede Stater, 29501
        • McLeod Regional Medical Center
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Hospital Cancer Center
      • Greenville, South Carolina, Forenede Stater, 29605
        • Cancer Centers of the Carolinas - Faris Road
      • Greenville, South Carolina, Forenede Stater, 29605
        • Cancer Centers of the Carolinas - Grove Commons
      • Greenville, South Carolina, Forenede Stater, 29601
        • Bon Secours St. Francis Health System
      • Greenwood, South Carolina, Forenede Stater, 29646
        • Self Regional Cancer Center at Self Regional Medical Center
      • Greer, South Carolina, Forenede Stater, 29650
        • Cancer Centers of the Carolinas - Greer Medical Oncology
      • Lancaster, South Carolina, Forenede Stater, 29720
        • Carolina Blood and Cancer Care Associates, PA
      • Rock Hill, South Carolina, Forenede Stater, 29732
        • Carolina Blood and Cancer Care
      • Seneca, South Carolina, Forenede Stater, 29672
        • Cancer Centers of the Carolinas - Seneca
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • CCOP - Upstate Carolina
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
      • Spartanburg, South Carolina, Forenede Stater, 29307
        • Cancer Centers of the Carolinas - Spartanburg
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Rapid City Regional Hospital
    • Tennessee
      • Kingsport, Tennessee, Forenede Stater, 37662
        • Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
    • Virginia
      • Fredericksburg, Virginia, Forenede Stater, 22401
        • Fredericksburg Oncology, Incorporated
      • Fredericksburg, Virginia, Forenede Stater, 22408
        • Hematology-Oncology Associates of Fredericksburg, Incorporated
      • Martinsville, Virginia, Forenede Stater, 24115
        • Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County
      • Norton, Virginia, Forenede Stater, 24273
        • Southwest Virginia Regional Cancer Center at Wellmonth Health
    • Washington
      • Bellevue, Washington, Forenede Stater, 98004
        • Overlake Cancer Center at Overlake Hospital Medical Center
      • Bellingham, Washington, Forenede Stater, 98225
        • St. Joseph Cancer Center
      • Centralia, Washington, Forenede Stater, 98531-9027
        • Providence Centralia Hospital
      • Everett, Washington, Forenede Stater, 98201
        • Providence Regional Cancer Partnership
      • Federal Way, Washington, Forenede Stater, 98003
        • St. Francis Hospital
      • Kirkland, Washington, Forenede Stater, 98033
        • Cascade Cancer Center at Evergreen Hospital Medical Center
      • Olympia, Washington, Forenede Stater, 98506-5166
        • Providence St. Peter Hospital Regional Cancer Center
      • Puyallup, Washington, Forenede Stater, 98372
        • Good Samaritan Cancer Center
      • Seattle, Washington, Forenede Stater, 98101
        • Virginia Mason Medical Center
      • Seattle, Washington, Forenede Stater, 98101
        • CCOP - Virginia Mason Research Center
      • Seattle, Washington, Forenede Stater, 98104
        • Pacific Medical Center
      • Tacoma, Washington, Forenede Stater, 98405-3004
        • Franciscan Cancer Center at St. Joseph Medical Center
      • Tacoma, Washington, Forenede Stater, 98405
        • Allenmore Hospital
      • Tacoma, Washington, Forenede Stater, 98405
        • CCOP - Northwest
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Regional Cancer Center at Tacoma General Hospital
      • Tacoma, Washington, Forenede Stater, 98499
        • St. Clare Hospital
    • West Virginia
      • Huntington, West Virginia, Forenede Stater, 25701
        • Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
      • Huntington, West Virginia, Forenede Stater, 25702
        • St. Mary's Regional Cancer Center at St. Mary's Medical Center
    • Wisconsin
      • Antigo, Wisconsin, Forenede Stater, 54409
        • Langlade Memorial Hospital
      • Appleton, Wisconsin, Forenede Stater, 54911-3496
        • Fox Valley Hematology and Oncology - East Grant Street
      • Chippewa Falls, Wisconsin, Forenede Stater, 54729
        • Marshfield Clinic - Chippewa Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Clinic Cancer Care at Regional Cancer Center
      • Fond Du Lac, Wisconsin, Forenede Stater, 54935
        • Central Wisconsin Cancer Program at Agnesian HealthCare
      • Green Bay, Wisconsin, Forenede Stater, 54307-3508
        • St. Vincent Hospital Regional Cancer Center
      • Green Bay, Wisconsin, Forenede Stater, 54301-3526
        • Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Green Bay Oncology, Limited at St. Mary's Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • St. Mary's Hospital Medical Center - Green Bay
      • Janesville, Wisconsin, Forenede Stater, 53547
        • Mercy Regional Cancer Center
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Center for Cancer and Blood
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Franciscan Skemp Healthcare - La Crosse Campus
      • Manitowoc, Wisconsin, Forenede Stater, 54221-1450
        • Holy Family Memorial Medical Center Cancer Care Center
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Bay Area Cancer Care Center at Bay Area Medical Center
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Clinic - Marshfield Center
      • Mequon, Wisconsin, Forenede Stater, 53097
        • Columbia Saint Mary's Hospital - Ozaukee
      • Milwaukee, Wisconsin, Forenede Stater, 53211
        • Columbia-Saint Mary's Cancer Care Center
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Clinic - Lakeland Center
      • Oconto Falls, Wisconsin, Forenede Stater, 54154
        • Green Bay Oncology, Limited - Oconto Falls
      • Racine, Wisconsin, Forenede Stater, 53405
        • All Saints Cancer Center at Wheaton Franciscan Healthcare
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Ministry Medical Group at Saint Mary's Hospital
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • St. Nicholas Hospital
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Marshfield Clinic at Saint Michael's Hospital
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235
        • Green Bay Oncology, Limited - Sturgeon Bay
      • Wausau, Wisconsin, Forenede Stater, 54401
        • University of Wisconcin Cancer Center at Aspirus Wausau Hospital
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Oncology Alliance, SC - Milwaukee - West
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Clinic - Weston Center
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Riverview UW Cancer Center at Riverview Hospital
    • Wyoming
      • Sheridan, Wyoming, Forenede Stater, 82801
        • Welch Cancer Center at Sheridan Memorial Hospital
  • Puerto Rico
      • San Juan, Puerto Rico, 00936
        • San Juan City Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

SYGDOMS KARAKTERISTIKA:

  • Histologisk bekræftet adenocarcinom i tyktarmen eller endetarmen
  • Har gennemgået kurativ resektion og anses for at have stadium II eller III sygdom eller fuldstændig resekeret stadium IV sygdom uden tegn på resterende tumor

  • Planlagt at modtage 6 måneders oxaliplatin-baseret adjuverende kemoterapi med 85 mg/m^2 oxaliplatin hver anden uge (dette inkluderer f.eks. FOLFOX4 eller modificeret FOLFOX6)

    • Patienter, der får bevacizumab eller cetuximab i kombination med FOLFOX som en del af et klinisk forsøg eller klinisk praksis, er kvalificerede

PATIENT KARAKTERISTIKA:

  • ECOG ydeevne status 0-2
  • WBC ≥ 3.000/mm^3
  • ANC ≥ 1.500/mm^3
  • Blodpladeantal ≥ 100.000/mm^3
  • Hæmoglobin ≥ 10,0 g/dL
  • Total bilirubin ≤ 1,5 gange øvre normalgrænse (ULN)
  • Serumkreatinin ≤ 1,5 gange ULN
  • Serumcalcium ≤ 1,2 gange ULN
  • Serummagnesium ≤ 1,2 gange ULN
  • Ikke gravid eller ammende
  • Negativ graviditetstest
  • Fertile patienter skal bruge effektiv prævention
  • Kan udfylde spørgeskemaer (alene eller med assistance)
  • I stand til at overholde studiebehandling
  • Er villig til at vende tilbage til indskrivende institution for opfølgning
  • Villig til at give blodprøver til forskningsformål
  • Ingen allerede eksisterende perifer neuropati af nogen grad
  • Ingen familiehistorie med en genetisk/familiær neuropati

  • Ingen anden eller tredje grads AV-hjerteblok eller en historie med anden eller tredje grads hjerteblok

    • Bundle grenblokke er tilladt.
  • Ingen andre medicinske tilstande, som efter den behandlende læges mening ville gøre denne protokol urimelig farlig for patienten

FORUDSÆTNING SAMTYDLIG TERAPI:

  • Se Sygdomskarakteristika
  • Central venøs adgangslinje til stede eller planlagt til at have en central linje placeret før start af kemoterapi og undersøgelsesbehandling
  • Ingen forudgående behandling med neurotoksisk kemoterapi (f.eks. oxaliplatin, cisplatin, taxaner eller vinca-alkaloider)
  • Ingen samtidig digitalis-medicin
  • Ingen samtidig behandling med antikonvulsiva carbamazepin (f.eks. Tegretol®), phenytoin (f.eks. Dilantin®), valproinsyre (f.eks. Depakene®), gabapentin (Neurontin®) eller pregabalin (Lyrica®)
  • Ingen samtidige neurotrope midler, inklusive venlafaxin (Effexor), desvenlafaxin (Pristiq®), milnacipran (Savella®) eller duloxetin (Cymbalta)
  • Ingen samtidige tricykliske antidepressiva (såsom amitryptillin) eller andre lægemidler, der specifikt gives til forebyggelse eller behandling af neuropati
  • Ingen samtidig medicin givet som neurobeskyttende middel

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Støttende pleje
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Dobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Arm I
Patienter får calciumgluconat og magnesiumsulfat IV i løbet af 30 minutter umiddelbart før og efter administration af oxaliplatin (en del af FOLFOX kemoterapi omfattende leucovorin calcium, fluorouracil og oxaliplatin).
Medicin: oxaliplatin
Medicin: calciumgluconat
Givet IV
Medicin: magnesiumsulfat
Givet IV
Placebo komparator: Arm II
Patienter får placebo IV i løbet af 30 minutter umiddelbart før og efter administration af oxaliplatin (en del af FOLFOX kemoterapi).
Medicin: oxaliplatin
Andet: placebo
Givet IV
Eksperimentel: Arm III
Patienterne får calciumgluconat og magnesiumsulfat IV over 30 minutter umiddelbart før og placebo IV over 30 minutter umiddelbart efter administration af oxaliplatin (en del af FOLFOX kemoterapi).
Medicin: oxaliplatin
Medicin: calciumgluconat
Givet IV
Medicin: magnesiumsulfat
Givet IV
Andet: placebo
Givet IV

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Sensorisk område under kurven (AUC) score. Oxaliplatin-induceret sensorisk neuropati som gentagne gange målt ved EORTC QLQ-CIPN20 sensorisk subskala under kemoterapi
Tidsramme: Op til 18 måneder
Den oxaliplatin-inducerede sensoriske neuropati som gentagne gange målt af European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire of Kemotherapy-induced periferal neuropathy (EORTC QLQ-CIPN20) sensorisk subskala under kemoterapien. Dette er en multivariat gentagen måling af CIPN med muligvis variable cyklusser for hver patient. CIPN sensoriske subskala vil blive beregnet ved standard scoringsalgoritme og konverteret til 0-100 skala, hvor højere score repræsenterer en højere livskvalitet. I stedet for at vælge den sensoriske CIPN20-subskala ved en fast kemoterapicyklus, vil vi vedtage et opsummerende mål, areal under kurven (AUC) af CIPN20-sensorisk underskala som det primære endepunkt. Denne AUC vil blive proportionalt med antallet af kemoterapicyklusser, som patienterne har modtaget.
Op til 18 måneder

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Area Under the Curve (AUC) for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire of kemotherapy-induced periferal neuropathy (EORTC QLQ-CIPN20) Autonomic Neuropathy Subscale Scores
Tidsramme: Op til 18 måneder
Den oxaliplatin-inducerede autonome neuropati som gentagne gange målt af European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire of kemotherapy-induced periferal neuropathy (EORTC QLQ-CIPN20) autonom subscale under kemoterapien. Dette er en multivariat gentagen måling af CIPN med muligvis variable cyklusser for hver patient. Den autonome CIPN-underskala vil blive beregnet ved standardscoringsalgoritme og konverteret til 0-100 skala, hvor højere score repræsenterer en højere livskvalitet. I stedet for at vælge den autonome CIPN20-underskala ved en fast kemoterapicyklus, vil vi vedtage et opsummerende mål, areal under kurven (AUC) af CIPN20 autonome underskala som endepunkt. Denne AUC vil blive proportionalt med antallet af kemoterapicyklusser, som patienterne har modtaget.
Op til 18 måneder
Area Under the Curve (AUC) for European Organisation for Research and Treatment of Cancer Quality of Life Spørgeskema for kemoterapi-induceret perifer neuropati (EORTC QLQ-CIPN20) Motor neuropati Subscale Scores
Tidsramme: Op til 18 måneder
Den oxaliplatin-inducerede motoriske neuropati som gentagne gange målt af European Organisation for Research and Treatment of Cancer Quality of Life Spørgeskema over kemoterapi-induceret perifer neuropati (EORTC QLQ-CIPN20) motorisk neuropati underskalaen under kemoterapien. Dette er en multivariat gentagen måling af CIPN med muligvis variable cyklusser for hver patient. CIPN motor neuropati subskalaen vil blive beregnet ved standard scoring algoritme og konverteret til 0-100 skala, hvor højere score repræsenterer en højere livskvalitet. I stedet for at vælge CIPN20-motorneuropati-underskalaen ved en fast kemoterapicyklus, vil vi vedtage et opsummerende mål, areal under kurven (AUC) af CIPN20-motorneuropati-underskalaen som endepunkt. Denne AUC vil blive proportionalt med antallet af kemoterapicyklusser, som patienterne har modtaget.
Op til 18 måneder
Procentdel af patienter, der oplever grad 2+ og grad 3+ kronisk kumulativ neurotoksicitet.
Tidsramme: Op til 18 måneder
Karakterer bestemmes af National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI CTCAE version 4.0) og oxaliplatin-specifik neurotoksicitetsskala under og efter kemoterapi. Højere karakterer symboliserer større alvorlighed af den uønskede hændelse.
Op til 18 måneder
Tid til indtræden af ​​grad 2+ og grad 3+ kronisk kumulativ neurotoksicitet og varigheden af ​​kronisk kumulativ neurotoksicitet under og efter kemoterapi
Tidsramme: Op til 18 måneder
Tid til indtræden af ​​grad 2+ og grad 3+ kronisk kumulativ neurotoksicitet, varigheden af ​​den kroniske kumulative neurotoksicitet under og efter den adjuverende oxaliplatin-baserede kemoterapi. Karakterer bestemmes af National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI CTCAE version 4.0) og oxaliplatin-specifik neurotoksicitetsskala under og efter kemoterapi. Højere karakterer symboliserer større alvorlighed af den uønskede hændelse.
Op til 18 måneder
Kumulative Oxaliplatin-doser, der kan administreres uden dosisbegrænsende kronisk neurotoksicitet
Tidsramme: Op til 18 måneder
En patient har en dosisbegrænsende kronisk neurotoksicitet, når de ophører med oxaliplatin-baseret kemoterapi på grund af neurotoksicitet.
Op til 18 måneder
Procentdel af patienter, der afbryde Oxaliplatin-baseret kemoterapi på grund af neurotoksicitet
Tidsramme: Op til 18 måneder
Op til 18 måneder
Procentdel af patienter med akut neuropati forbundet med oxaliplatin
Tidsramme: Op til 18 måneder
Dette er procentdelen af ​​patienter, der scorede >=50 i alle sekvenser af alle cyklusser efter arm for bivirkning Q1: Følsomhed over for berøring med kulde. Dette er en gentagen måling af CIPN med muligvis variable cyklusser for hver patient. CIPN-underskalaen vil blive beregnet ved hjælp af standardscoringsalgoritme og konverteret til skalaen 0-100. Hvor 0 er ingen følsomhed og 100 er så slemt som det kan være.
Op til 18 måneder
Forekomst af calciumgluconat og magnesiumsulfat-inducerede bivirkninger målt ved CTCAE version 4.0
Tidsramme: Op til 18 måneder
Op til 18 måneder
Area Under the Curve (AUC) for patientrapporteret livskvalitet (QOL) målt ved det supplerende QOL-spørgeskema
Tidsramme: Op til 18 måneder
Dette er en multivariat gentagen måling af CIPN med muligvis variable cyklusser for hver patient. Subskalaen for supplerende livskvalitet (QOL) vil blive beregnet ved standardscoringsalgoritme og konverteret til 0-100 skala, hvor højere score repræsenterer en højere livskvalitet. I stedet for at vælge underskalaen ved en fast kemoterapicyklus, vil vi vedtage et opsummerende mål, area under the curve (AUC) . Denne AUC vil blive proportionalt med antallet af kemoterapicyklusser, som patienterne har modtaget.
Op til 18 måneder

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbejdspartnere

National Cancer Institute (NCI)

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. juni 2010

Primær færdiggørelse (Faktiske)

1. december 2012

Studieafslutning (Faktiske)

1. marts 2013

Datoer for studieregistrering

Først indsendt

6. april 2010

Først indsendt, der opfyldte QC-kriterier

6. april 2010

Først opslået (Skøn)

7. april 2010

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

3. november 2022

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

1. november 2022

Sidst verificeret

1. november 2022

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • N08CB
  • NCCTG-N08CB
  • CDR0000669660 (Registry Identifier: PDQ (Physician Data Query))
  • NCI-2011-02036 (Registry Identifier: CTRP (Clinical Trials Reporting System))

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Kolorektal cancer

Kliniske forsøg med oxaliplatin

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Equatorial Guinea

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Abonner