En undersøgelse for at evaluere effekten af langtidsbehandling med BELVIQ (Lorcaserin HCl) på forekomsten af alvorlige uønskede kardiovaskulære hændelser og konvertering til type 2 diabetes mellitus hos fede og overvægtige personer med hjerte-kar-sygdomme eller flere kardiovaskulære risikofaktorer (CAMELLIA-TIMI)
27. juni 2019 opdateret af: Eisai Inc.
Et randomiseret, dobbeltblindt, placebokontrolleret, parallelgruppestudie til evaluering af virkningen af langtidsbehandling med BELVIQ (Lorcaserin HCl) på forekomsten af alvorlige uønskede kardiovaskulære hændelser og konvertering til type 2-diabetes mellitus hos fede og overvægtige personer Med hjerte-kar-sygdom eller flere kardiovaskulære risikofaktorer
Dette er et multicenter, randomiseret, dobbeltblindt, placebokontrolleret, parallelgruppestudie i overvægtige og fede personer med kardiovaskulær (CV) sygdom og/eller flere CV-risikofaktorer.
Studieoversigt
Status
Afsluttet
Intervention / Behandling
Detaljeret beskrivelse
Cirka 12.000 forsøgspersoner vil blive randomiseret til to behandlingsgrupper i forholdet 1:1, stratificeret efter tilstedeværelsen af etableret CV-sygdom (ca. 80 %) eller CV-risikofaktorer uden etableret CV-sygdom (ca. 20 %).
Forsøgspersonerne vil modtage lorcaserin HCl 10 mg BID eller placebo BID.
Undersøgelsen vil bestå af 2 faser: Prærandomisering og Randomisering.
Prærandomiseringsfasen vil vare op til 30 dage og bestå af ét besøg, hvor forsøgspersoner vil blive screenet for berettigelse.
Randomiseringsfasen vil bestå af to perioder: Behandling og Opfølgning.
Behandlingsperioden vil vare i cirka 5 år med cirka 18 besøg, og opfølgningsperioden er 30 (+ eller - 10 dage) fra afslutningen af behandlingsbesøget.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
14673
Fase
- Fase 4
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
-
Adelaide, Australien, 5000
- South Australian Medical Research Inst, Centre for Clinical Research
-
-
New South Wales
-
Coffs Harbour, New South Wales, Australien, 2450
- Coffs Harbour Health Campus
-
Gosford, New South Wales, Australien, 2250
- Gosford Hospital, Cardiology Clinical Trials
-
Liverpool, New South Wales, Australien, 2170
- Liverpool Hospital
-
Wollongong, New South Wales, Australien, 2500
- Wollongong Hospital
-
Wollongong, New South Wales, Australien, 2500
- Illawarra Shoalhaven Local Health District, Clinical Trial and Research Unit
-
-
Queensland
-
Brisbane, Queensland, Australien, 4064
- Core Research Group
-
Brisbane, Queensland, Australien, 4102
- Princess Alexandra Hospital, Cardiology Research Department
-
Herston, Queensland, Australien, 4029
- Royal Brisbane and Women's Hospital, Endocrinology Department
-
Milton, Queensland, Australien, 4064
- HeartCare Partners Clinical Research Unit
-
Sherwood, Queensland, Australien, 4075
- AusTrials Pty Ltd
-
Southport, Queensland, Australien, 4215
- Gold Coast Hospital, Cardiovascular Research Centre
-
-
South Australia
-
Adelaide, South Australia, Australien, 5000
- New Royal Adelaide Hospital, Cardiology Department
-
Ashford, South Australia, Australien, 5035
- Adelaide Medical Research
-
Elizabeth Vale, South Australia, Australien, 5112
- Lyell McEwin Hospital, Department of Cardiology
-
Fullarton, South Australia, Australien, SA 5063
- Heart and Vascular Institute
-
Woodville South, South Australia, Australien, 5011
- The Queen Elizabeth Hospital
-
-
Victoria
-
Ballarat, Victoria, Australien, 3353
- Ballarat Health Services
-
Geelong, Victoria, Australien, 3220
- Geelong Cardiology Research Unit, Barwon Health
-
Heidelberg Heights, Victoria, Australien, 3081
- Austin Health - Heidelberg Repatriation Hospital, Department of Medicine, Boronia Centre
-
Saint Kilda East, Victoria, Australien, 3183
- Avenue Cardiovascular Centre
-
-
Western Australia
-
Joondalup, Western Australia, Australien, 6027
- Joondalup Cardiovascular Trials Foundation Inc
-
Murdoch, Western Australia, Australien, 6150
- Fiona Stanley Hospital, Cardiology Research Department,CDO11
-
-
-
-
-
Nassau, Bahamas
- The Partners Clinical Research Centre
-
-
-
-
Alberta
-
Calgary, Alberta, Canada, T2H 2G4
- LMC Clinical Research Inc. (Calgary)
-
-
British Columbia
-
Vancouver, British Columbia, Canada, V5Z 1M9
- Gordon and Leslie Diamond Health Care Centre
-
-
Nova Scotia
-
Halifax, Nova Scotia, Canada, B3H 3A7
- Nova Scotia Health Authority /QEII Health Sciences Centre
-
-
Ontario
-
Brampton, Ontario, Canada, L6S0C9
- LMC Diabetes & Endocrinology - Brampton
-
Brampton, Ontario, Canada, L6Z 4N5
- McMaster University
-
Burlington, Ontario, Canada, L7M 4Y1
- JBN Medical Diagnostic Services Inc.
-
Burlington, Ontario, Canada, L7R 1E2
- Aviva Clinical Trial Group In.
-
Cambridge, Ontario, Canada, N1R 6V6
- Cambridge Cardiac Care Centre
-
Cambridge, Ontario, Canada, N1R 7L6
- Joanne F. Liutkus Medicine Professional Corp.
-
Cambridge, Ontario, Canada, N1R 7R1
- Saul Vizel Professional Medicine Corporation, Vizel Cardiac Research
-
Etobicoke, Ontario, Canada, M9R4E1
- LMC Diabetes & Endocrinology (Etobicoke)
-
Hamilton, Ontario, Canada, L8L 5G8
- Wharton Medical Clinic Clinical Trials Group Inc.
-
London, Ontario, Canada, N6A 4V2
- Saint Josephs Health Care London
-
Markham, Ontario, Canada, L6B0P9
- LMC Diabetes & Endocrinoly
-
Newmarket, Ontario, Canada, L3Y 8C3
- New Market Cardiology Research Group
-
Oakville, Ontario, Canada, L6K 3W7
- Dr. Michael Heffernan
-
Oakville, Ontario, Canada, L6M 4H8
- LMC Clinical Research Inc. (Oakville)
-
Oshawa, Ontario, Canada, L1J 2K1
- Dr. Cha
-
Ottawa, Ontario, Canada, K1Y 4W7
- University of Ottawa Heart Institute
-
Peterborough, Ontario, Canada, K9J 0B2
- Kawartha Cardiology Clinical Trials
-
Sudbury, Ontario, Canada, P3E 6C3
- Dr. Dinkar Shukla Professional Medicine Corporation
-
Sudbury, Ontario, Canada, P3E3B8
- Dr Roger Labonte Professional Medicine Corp
-
Thornhill, Ontario, Canada, L4J8L7
- Lmc Diabetes & Endocrinology (Thornhill)
-
Toronto, Ontario, Canada, M4G 3E8
- LMC Clinical Research Inc. (Bayview)
-
Toronto, Ontario, Canada, M3M 3E5
- Keele Medical Place
-
Toronto, Ontario, Canada, M3J 1N2
- JJ DIG Research Ltd.
-
Toronto, Ontario, Canada, M5C 2T2
- St Michael's Hospital Health Centre
-
-
Quebec
-
Brossard, Quebec, Canada, J4X 1S4
- Viacar Recherche Clinique
-
Gatineau, Quebec, Canada, J8Y 6S8
- Q&T Research Outaouais Inc.
-
Greenfield Park, Quebec, Canada, J4V 2G8
- Viacar Recherche Clinique Inc.
-
Levis, Quebec, Canada, G6W 0M6
- Manna Research Inc
-
Montreal, Quebec, Canada, H1T 3Y7
- Clinique Sante Cardio MC
-
Quebec City, Quebec, Canada, G1V 4G5
- Universitaire de Cardiologie et de Pneumologie de Quebec
-
Saint-Charles-Borromee, Quebec, Canada, J6E 6J2
- Centre hospitalier régional de Lanaudière
-
Sherbrooke, Quebec, Canada, J1J 2E3
- Recherche Clinique London
-
St Jean sur Richelieu, Quebec, Canada, J3A1C3
- CardioVasc HR, Inc.
-
St-Lambert, Quebec, Canada, J4P 2H4
- Viacar Recherche Clinique Inc.
-
Ville Saint-Laurent, Quebec, Canada, H4T 1Z9
- LMC Clinical Research Inc. (Montreal)
-
-
-
-
-
Concepcion, Chile, 4070038
- Hospital Regional Concepción
-
Santiago, Chile, 7500520
- Cardiocob
-
Santiago, Chile, 7500710
- Servicios Medicos Godoy Ltda.
-
Santiago, Chile, 8331143
- Ccbr Cecim
-
Temuco, Chile, 4781156
- Centro Investigacion Clinica Del Sur
-
Temuco, Chile, 4813299
- CECMI Ltda.
-
-
Santiago
-
Providencia, Santiago, Chile, 7500710
- BioMedica Research Group
-
San Miguel, Santiago, Chile, 8910259
- Sociedad Medica Cardiologica El Llano
-
-
-
-
Alabama
-
Alexander City, Alabama, Forenede Stater, 35010
- Advanced Cardiovascular, LLC
-
Athens, Alabama, Forenede Stater, 35611
- North Alabama Research Center, LLC
-
Birmingham, Alabama, Forenede Stater, 35294
- UAB Medical Center
-
Mobile, Alabama, Forenede Stater, 36608
- Coastal Clinical Research, Inc.
-
Mobile, Alabama, Forenede Stater, 36608
- Mobile Heart Specialists, PC
-
-
Alaska
-
Anchorage, Alaska, Forenede Stater, 99508
- Alaska Heart Institute
-
-
Arizona
-
Chandler, Arizona, Forenede Stater, 85224
- Connect Clinical Research Center, LCC
-
Glendale, Arizona, Forenede Stater, 85306
- Arrowhead Health Centers
-
Glendale, Arizona, Forenede Stater, 85306
- Phoenix Heart, PLLC
-
Tucson, Arizona, Forenede Stater, 85745
- Eclipse Clinical Research
-
-
Arkansas
-
Jonesboro, Arkansas, Forenede Stater, 72401
- NEA Baptist Clinic
-
Little Rock, Arkansas, Forenede Stater, 72211
- Preferred Research Partners
-
Little Rock, Arkansas, Forenede Stater, 72205
- Central Arkansas Veterans Healthcare System
-
Little Rock, Arkansas, Forenede Stater, 72205
- Arkansas Cardiology Clinic
-
-
California
-
Alhambra, California, Forenede Stater, 91801
- Clinical Research Alliance
-
Bakersfield, California, Forenede Stater, 93308
- Central Cardiology
-
Beverly Hills, California, Forenede Stater, 90210
- Cardiovascular Research Foundation of Southern Cal
-
Carmichael, California, Forenede Stater, 95608
- Capitol Interventional Cardiology
-
Chula Vista, California, Forenede Stater, 91911 3813
- San Diego Costal Endocrinology Group AMC
-
Concord, California, Forenede Stater, 94520
- John Muir Physician Network Clinical Research Cent
-
Encino, California, Forenede Stater, 91436
- Medical Group of Encino
-
Greenbrae, California, Forenede Stater, 94904
- Marin Endocrine Care & Research, Inc.
-
Huntington Beach, California, Forenede Stater, 92648
- California Heart Specialists
-
Huntington Park, California, Forenede Stater, 90255
- Del Rosario Medical Clinic, Inc.
-
La Mesa, California, Forenede Stater, 91942
- Diabetes and Endocrine Associates
-
La Mesa, California, Forenede Stater, 91942
- La Mesa Cardiac Center
-
Laguna Hills, California, Forenede Stater, 92653
- Alliance Research Centers
-
Lomita, California, Forenede Stater, 90717
- Torrance Clinical Research Institute, Inc.
-
Long Beach, California, Forenede Stater, 90807
- Long Beach Center For Clinical Research
-
Los Angeles, California, Forenede Stater, 90033
- Metabolic Clinic and Research Center
-
Los Angeles, California, Forenede Stater, 90073
- VA Greater Los Angeles Health Care System
-
Los Angeles, California, Forenede Stater, 90067
- Beverly Hills Cardiology
-
Mission Viejo, California, Forenede Stater, 92692
- Clinical Interventions Research Institute
-
Murrieta, California, Forenede Stater, 92563
- Brigid Freyne MD Inc
-
Northridge, California, Forenede Stater, 91325
- Valley Clinical Trials Inc
-
Oceanside, California, Forenede Stater, 92056
- Carr Cardiology
-
Redding, California, Forenede Stater, 96001
- Northern California Clinical Research Center
-
San Diego, California, Forenede Stater, 92103
- University of California San Diego
-
San Diego, California, Forenede Stater, 92101
- Sharp Rees-Stealy Medical Group, Inc.
-
San Diego, California, Forenede Stater, 92117
- Ritchken and First MD's
-
San Ramon, California, Forenede Stater, 94582
- West Coast Research LLC
-
Santa Ana, California, Forenede Stater, 92704
- Coastal Multi-Specialty Research
-
Thousand Oaks, California, Forenede Stater, 91360
- Westlake Medical Research
-
Torrance, California, Forenede Stater, 90509
- Harbor - UCLA Medical Center
-
Ventura, California, Forenede Stater, 93003
- Ventura Cardiology Consultants
-
Ventura, California, Forenede Stater, 93003
- Ronald Chochinov, MD
-
West Hills, California, Forenede Stater, 91307
- Infosphere Clinical Research
-
-
Colorado
-
Colorado Springs, Colorado, Forenede Stater, 80909
- UCH-MHS Cardiac Research
-
Denver, Colorado, Forenede Stater, 80209
- Creekside Endocrine Associates PC
-
Golden, Colorado, Forenede Stater, 80401
- New West Physicians, PC
-
Loveland, Colorado, Forenede Stater, 80538
- University of Colorado Health
-
-
Connecticut
-
Bridgeport, Connecticut, Forenede Stater, 06610
- Bridgeport Hospital
-
Bridgeport, Connecticut, Forenede Stater, 06606
- Connecticut Clinical Research, Llc
-
Bristol, Connecticut, Forenede Stater, 06010-5103
- Clinical Research Works, Bristol
-
Norwalk, Connecticut, Forenede Stater, 06851
- Cardiology Associates of Fairfield County, Norwalk
-
Stamford, Connecticut, Forenede Stater, 06905
- Stamford Therapeutics Consortium
-
Stamford, Connecticut, Forenede Stater, 06905
- Cardiology Associates of Fairfield County, P.C.
-
Trumbull, Connecticut, Forenede Stater, 06611
- Cardiology Associates of Fairfield County, P.C.
-
Trumbull, Connecticut, Forenede Stater, 06611
- Connecticut Heart and Vascular Center
-
Waterbury, Connecticut, Forenede Stater, 06708
- Chase Medical Research, LLC
-
-
Delaware
-
Newark, Delaware, Forenede Stater, 19713
- Red Clay Research
-
Wilmington, Delaware, Forenede Stater, 19803-3733
- Alfieri Cardiology
-
-
Florida
-
Aventura, Florida, Forenede Stater, 33180
- Aventura Heart Center
-
Boynton Beach, Florida, Forenede Stater, 33427
- Zasa Clinical Research
-
Bradenton, Florida, Forenede Stater, 34201
- Meridien Research
-
Bradenton, Florida, Forenede Stater, 34209
- Nova Southeastern University
-
Brandon, Florida, Forenede Stater, 33511
- Bay Area Cardiology
-
Brooksville, Florida, Forenede Stater, 34601
- Meridien Research, Brooksville
-
Clearwater, Florida, Forenede Stater, 33756
- Clearwater Cardiovascular and Interventional Cons.
-
Coral Gables, Florida, Forenede Stater, 33143
- Clinical Research of South Florida
-
Coral Springs, Florida, Forenede Stater, 33065
- Holy Cross Medical Group
-
Daytona Beach, Florida, Forenede Stater, 32117
- International Medical Research
-
Daytona Beach, Florida, Forenede Stater, 32117
- Cardiology Research Associates
-
Doral, Florida, Forenede Stater, 33166
- Asclepius Medical Research
-
Fleming Island, Florida, Forenede Stater, 32003
- Fleming Island Center for Clinical Research
-
Fort Lauderdale, Florida, Forenede Stater, 33316
- M & O Clinical Research, LLC
-
Fort Lauderdale, Florida, Forenede Stater, 33312
- Integrative Research Associates, Inc.
-
Fort Myers, Florida, Forenede Stater, 33907
- Primary Care Associates
-
Gainesville, Florida, Forenede Stater, 32605
- Florida Research Network, LLC
-
Green Cove Springs, Florida, Forenede Stater, 32043
- George E. Platt, M.D.
-
Hialeah, Florida, Forenede Stater, 33013
- Eastern Research, Inc.
-
Hollywood, Florida, Forenede Stater, 33021
- Research Physicians Network Alliance
-
Hollywood, Florida, Forenede Stater, 33021
- Larry K. Levinson, D.O., P.A.
-
Hudson, Florida, Forenede Stater, 34667
- Pasco Cardiology Center
-
Inverness, Florida, Forenede Stater, 34452
- Nature Coast Clinical Research
-
Jacksonville, Florida, Forenede Stater, 32216
- Jacksonville Center for Clinical Research
-
Jacksonville, Florida, Forenede Stater, 32209
- University of Florida- Jacksonville
-
Jacksonville, Florida, Forenede Stater, 32216
- Westside Center for Clinical Research
-
Lakeland, Florida, Forenede Stater, 33805
- Meridien Research
-
Miami, Florida, Forenede Stater, 33173
- Cardiovascular Research Center of South Florida
-
Miami, Florida, Forenede Stater, 33134
- Life Spring Research Foundation
-
Miami, Florida, Forenede Stater, 33126-2956
- Pharmax Research Clinic, Inc
-
Miami, Florida, Forenede Stater, 33155
- United Clinical Research Corp.
-
Miami, Florida, Forenede Stater, 33176
- South Florida Research Group LLC
-
Miramar, Florida, Forenede Stater, 33025
- South Florida Research Solutions
-
Naples, Florida, Forenede Stater, 34102
- Southwest Florida Research
-
Ocala, Florida, Forenede Stater, 34471
- Ocala Research Institute, Inc
-
Oviedo, Florida, Forenede Stater, 32765
- Oviedo Medical Research
-
Palm Beach Gardens, Florida, Forenede Stater, 33410-4304
- Cardiology Partners Clinical Research Institute
-
Palm Beach Gardens, Florida, Forenede Stater, 33410
- Palm Beach Gardens Research Center
-
Pembroke Pines, Florida, Forenede Stater, 33028
- South Florida Research Solutions
-
Pembroke Pines, Florida, Forenede Stater, 33025
- Research Physicians Network Alliance, Pembrok
-
Pensacola, Florida, Forenede Stater, 32501 6335
- Cardiology Consultants
-
Plant City, Florida, Forenede Stater, 33563
- Clinical Research of Central Florida
-
Plantation, Florida, Forenede Stater, 33324
- Columbia Primary Care, LLC d/b/a Heart and Health Institute
-
Ponte Vedra, Florida, Forenede Stater, 32081
- St Johns Center for Clinical Research
-
Port Charlotte, Florida, Forenede Stater, 33952
- Charlotte Heart Group Research Center
-
Port Orange, Florida, Forenede Stater, 32127
- Progressive Medical Research
-
Rockledge, Florida, Forenede Stater, 32955
- Brevard Cardiovascular Research Associates Inc
-
Safety Harbor, Florida, Forenede Stater, 34695
- Clearwater Cardiovascular and Interventional Cons.
-
Saint Petersburg, Florida, Forenede Stater, 33709
- Meridien Research - St. Petersburg
-
Saint Petersburg, Florida, Forenede Stater, 33701
- Bayfront Health St. Petersburg, Research
-
Saint Petersburg, Florida, Forenede Stater, 33713
- Professional Health Care of Pinellas, INC
-
Sarasota, Florida, Forenede Stater, 34239
- Intercoastal Medical Group
-
Springfield, Florida, Forenede Stater, 32401
- Springfield Medical Center
-
Stuart, Florida, Forenede Stater, 34996
- Advanced Clinical Research Group
-
Tampa, Florida, Forenede Stater, 33613
- Stedman Clinical Trials
-
Tampa, Florida, Forenede Stater, 33614
- Healthpoint Medical Group, Inc
-
Tampa, Florida, Forenede Stater, 33606
- Meridien Research - Tampa
-
Trinity, Florida, Forenede Stater, 34655
- Interventional Cardiac Consultants
-
Venice, Florida, Forenede Stater, 34292
- Lovelace Scientific Research
-
Vero Beach, Florida, Forenede Stater, 32960-3296
- Indian River Medical Center-Cardiology
-
Wellington, Florida, Forenede Stater, 33449
- Cardiology Partners Clinical Research Institute
-
West Palm Beach, Florida, Forenede Stater, 33401
- Metabolic Research Institute
-
West Palm Beach, Florida, Forenede Stater, 33401
- Cleveland Clinic Foundation
-
Winter Haven, Florida, Forenede Stater, 33880
- Clinical Research of Central Florida
-
-
Georgia
-
Atlanta, Georgia, Forenede Stater, 30318
- Atlanta Diabetes Associates, Endocrinology
-
Conyers, Georgia, Forenede Stater, 30094
- Rockdale Medical-Research Associates
-
Cumming, Georgia, Forenede Stater, 30041
- Atlanta Heart Specialists
-
Marietta, Georgia, Forenede Stater, 30067
- Urban Family Practice Associates/Clinical Research Advantage
-
Roswell, Georgia, Forenede Stater, 30076
- Endocrine Research Solutions, Inc.
-
Suwanee, Georgia, Forenede Stater, 30024
- Herman Clinical Research LLC
-
Tucker, Georgia, Forenede Stater, 30084
- Atlanta Heart Specialists
-
-
Illinois
-
Arlington Heights, Illinois, Forenede Stater, 60005
- Northwest Heart Clinical Research, LLC
-
Chicago, Illinois, Forenede Stater, 60637
- University of Chicago
-
Chicago, Illinois, Forenede Stater, 60611
- Northwestern University Feinberg School of Medicine
-
Chicago, Illinois, Forenede Stater, 60607
- Cedar-Crosse Research Center
-
Elmhurst, Illinois, Forenede Stater, 60126
- Consultants in Cardiovascular Medicine
-
Gurnee, Illinois, Forenede Stater, 60031
- Clinical Investigation Specialists, Inc. in Gurnee
-
Rock Island, Illinois, Forenede Stater, 61201
- Advanced CardioVascular Consultants, SC
-
-
Indiana
-
Anderson, Indiana, Forenede Stater, 46011
- Community Clinical Research Center
-
Avon, Indiana, Forenede Stater, 46123
- American Health Network of IN, LLC, Avon
-
Bloomington, Indiana, Forenede Stater, 47403 3239
- Premier Healthcare, Llc
-
Evansville, Indiana, Forenede Stater, 47713
- Deaconess Clinic, Inc.
-
Franklin, Indiana, Forenede Stater, 46131
- American Health Network of IN, LLC, Franklin
-
Greenfield, Indiana, Forenede Stater, 46140
- American Health Network of IN, LLC, Greenfield
-
Indianapolis, Indiana, Forenede Stater, 46254-5471
- American Health Network - Thomas Moretto, MD
-
Muncie, Indiana, Forenede Stater, 47304
- American Health Network of IN, LLC
-
Muncie, Indiana, Forenede Stater, 47303
- Medical Consultants PC
-
Munster, Indiana, Forenede Stater, 46321
- Cardiology Associates of Northwest Indiana, P.C
-
-
Iowa
-
Iowa City, Iowa, Forenede Stater, 52242
- The University of Iowa, College of Public Health
-
-
Kansas
-
Wichita, Kansas, Forenede Stater, 67203
- Professional Research Network of Kansas, LLC
-
-
Kentucky
-
Louisville, Kentucky, Forenede Stater, 40213
- L-MARC Research Center
-
Louisville, Kentucky, Forenede Stater, 40205 3338
- Norton Heart Specialists
-
Louisville, Kentucky, Forenede Stater, 40205-3338
- Norton Heart Specialists
-
Owensboro, Kentucky, Forenede Stater, 42303
- Research Integrity LLC
-
-
Maine
-
Auburn, Maine, Forenede Stater, 04210
- Central Maine Medical Center
-
Bangor, Maine, Forenede Stater, 04401
- Acadia Clinical Research, LLC
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center Northeast Cardiology Associates
-
Biddeford, Maine, Forenede Stater, 04005
- Southern Maine Health Care/Maine Medical Center Research Ins
-
Portland, Maine, Forenede Stater, 04101
- Intermed, PA
-
-
Maryland
-
Annapolis, Maryland, Forenede Stater, 21401
- Medstar Cardiology Associates
-
Baltimore, Maryland, Forenede Stater, 21218
- MedStar Union Memorial Hospital
-
Baltimore, Maryland, Forenede Stater, 21236
- Overlea Personal Physicians
-
Baltimore, Maryland, Forenede Stater, 21218
- Medstar Union Memorial Heart Specialists
-
Baltimore, Maryland, Forenede Stater, 21204
- Chesapeake Cardiovascular Associates, GBMC
-
Baltimore, Maryland, Forenede Stater, 21204
- Clinical Research, Inc
-
Baltimore, Maryland, Forenede Stater, 21229
- Spectrum Clinical Research
-
Baltimore, Maryland, Forenede Stater, 21237
- Shahid Saeed MD, PC
-
Glen Burnie, Maryland, Forenede Stater, 21061
- Maryland Heart Associates, LLC
-
Hagerstown, Maryland, Forenede Stater, 21740
- Klein & Associates, MD, PA
-
Hyattsville, Maryland, Forenede Stater, 20782
- Medstar Health Research Institute
-
Lutherville, Maryland, Forenede Stater, 21093
- Lutherville Personal Physicians
-
Oxon Hill, Maryland, Forenede Stater, 20745
- MD Medical Research
-
Rockville, Maryland, Forenede Stater, 20852
- Endocrine & Metabolic Consultants
-
Towson, Maryland, Forenede Stater, 21204
- Lutherville Personal Physicians
-
Towson, Maryland, Forenede Stater, 21204
- Overlea Personal Physicians
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02115
- Brigham and Women's Hospital
-
Boston, Massachusetts, Forenede Stater, 02111
- Tufts Medical Center
-
Boston, Massachusetts, Forenede Stater, 02114
- MGH Weight Center
-
Fall River, Massachusetts, Forenede Stater, 02720
- New England Center for Clinical Research, IMCA
-
Haverhill, Massachusetts, Forenede Stater, 01830
- Pentucket Medical Associates
-
Methuen, Massachusetts, Forenede Stater, 01844
- ActivMed Practices
-
Natick, Massachusetts, Forenede Stater, 01760
- Partners Community Physicians Organization
-
Needham, Massachusetts, Forenede Stater, 02494
- Partners Community Physicians Organization
-
-
Michigan
-
Alpena, Michigan, Forenede Stater, 49707
- Endeavor Medical Research PLC
-
Cadillac, Michigan, Forenede Stater, 49601
- Cadillac Clinical Research, LLC
-
Kalamazoo, Michigan, Forenede Stater, 49009
- Westside Family Medical Center, Pc
-
Lapeer, Michigan, Forenede Stater, 48446
- Cardiology Consultants of East Michigan
-
Marquette, Michigan, Forenede Stater, 49855
- Marquette General Heart and Vascular Institute
-
Midland, Michigan, Forenede Stater, 48670
- MidMichigan Medical Center
-
Petoskey, Michigan, Forenede Stater, 49770
- Nisus Research at McLaren Northern Michigan Hospital
-
Pontiac, Michigan, Forenede Stater, 48341-2985
- Saint Joseph Mercy Oakland Hospital
-
Rochester, Michigan, Forenede Stater, 48307
- Remedica LLC
-
Saginaw, Michigan, Forenede Stater, 48601 1423
- Michigan Cardiovascular Institute
-
Southfield, Michigan, Forenede Stater, 48034
- American Center for Clinical Trials
-
Traverse City, Michigan, Forenede Stater, 49684-2386
- Medical Research Associates, Inc.
-
Ypsilanti, Michigan, Forenede Stater, 48197
- Michigan Heart
-
-
Minnesota
-
Baxter, Minnesota, Forenede Stater, 56425
- Minneapolis Heart Institute Foundation
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Institute of Rural Health
-
Eagan, Minnesota, Forenede Stater, 55123
- MNCOME Clinic
-
Edina, Minnesota, Forenede Stater, 55435
- Radiant Research, Inc.
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Minneapolis Heart Institute
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
-
Mississippi
-
Gulfport, Mississippi, Forenede Stater, 39501
- Coast Cardiovascular Consultants PLLC
-
Tupelo, Mississippi, Forenede Stater, 38801
- Cardiology Associates Research, Llc
-
-
Missouri
-
Chesterfield, Missouri, Forenede Stater, 63017
- Diabetes & Endocrinology Specialists, Inc.
-
Washington, Missouri, Forenede Stater, 63090
- BodyAesthetic Research Center
-
-
Montana
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Research Center
-
Billings, Montana, Forenede Stater, 59102
- Montana Health Research Institute, Inc.
-
Kalispell, Montana, Forenede Stater, 59901
- Glacier View Cardiology PC
-
-
Nebraska
-
Grand Island, Nebraska, Forenede Stater, 68803
- Internal Medical Associates of Grand Island, PC
-
-
Nevada
-
Henderson, Nevada, Forenede Stater, 89052
- Clinical Research Advantage / Rita Chuang, M.D.
-
Las Vegas, Nevada, Forenede Stater, 89121
- Clinical Research of South Nevada
-
Las Vegas, Nevada, Forenede Stater, 89117
- Clinical Research Advantage, Inc.
-
-
New Jersey
-
Bridgewater, New Jersey, Forenede Stater, 08807-3060
- Medicor Cardiology, PA
-
Bridgewater, New Jersey, Forenede Stater, 08807
- Advanced Heart Care
-
East Brunswick, New Jersey, Forenede Stater, 08816
- UmiMed Center LLC
-
Elmer, New Jersey, Forenede Stater, 08318-1715
- Cardiovascular Associates of the Delaware Valley
-
Haddon Heights, New Jersey, Forenede Stater, 08035
- Advocare Heights Primary Care
-
Haddon Heights, New Jersey, Forenede Stater, 08035
- Cardiovascular Associates of the Delaware Valley P
-
Linden, New Jersey, Forenede Stater, 07036
- NJ Heart
-
Mine Hill, New Jersey, Forenede Stater, 07103
- Rutgers New Jersey Medical School
-
Sewell, New Jersey, Forenede Stater, 08080-1715
- Cardiovascular Associates Delaware Valley Sewell
-
Somerset, New Jersey, Forenede Stater, 08873
- Cardio Metabolic Institute
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87102
- New Mexico Heart Institute, PA
-
-
New York
-
Albany, New York, Forenede Stater, 12211
- Capital Cardiology Associates
-
Albany, New York, Forenede Stater, 12206
- Albany College of Medicine, Division of Endocrinology
-
Binghamton, New York, Forenede Stater, 13901
- United Medical Associates, PC
-
Bronx, New York, Forenede Stater, 10468
- James J. Peters VA Medical Center, Bronx, NY
-
Buffalo, New York, Forenede Stater, 14215
- Buffalo Heart group
-
Endwell, New York, Forenede Stater, 13760
- Regional Clinical Research, Inc.
-
Great Neck, New York, Forenede Stater, 11023
- Long Island Gastrointestinal Research Group LLP
-
Mineola, New York, Forenede Stater, 11501
- Long Island Heart Associates
-
New Hyde Park, New York, Forenede Stater, 11042
- North Shore Diabetes and Endocrine Associates
-
New York, New York, Forenede Stater, 10065
- Weill Cornell Medical College
-
North Massapequa, New York, Forenede Stater, 11758
- Digiovanna Institute For Medical Education
-
Poughkeepsie, New York, Forenede Stater, 12601
- Hudson Valley Heart Center
-
Rochester, New York, Forenede Stater, 14609
- Rochester Clinical Research, Inc.
-
Southampton, New York, Forenede Stater, 11968
- Northwell Health Physician Partners Cardiology
-
Troy, New York, Forenede Stater, 12180
- Capital Cardiology Associates
-
Westfield, New York, Forenede Stater, 14787
- Great Lakes Medical Research
-
-
North Carolina
-
Burlington, North Carolina, Forenede Stater, 27215
- Kernodle Clinic
-
Cary, North Carolina, Forenede Stater, 27518
- Clinical Trials of America Inc.
-
Charlotte, North Carolina, Forenede Stater, 28209
- PMG Research of Charlotte, LLC
-
Charlotte, North Carolina, Forenede Stater, 28204
- Metrolina Internal Medicine
-
Greensboro, North Carolina, Forenede Stater, 27401
- Bland Clinic, PA
-
Hickory, North Carolina, Forenede Stater, 28601
- Clinical Trials of America, Inc.
-
Hickory, North Carolina, Forenede Stater, 28601
- Clinical Trials of America Inc. Hickory
-
High Point, North Carolina, Forenede Stater, 27262
- Peters Medical Research
-
Lenoir, North Carolina, Forenede Stater, 28645
- Clinical Trials of America, Inc.
-
Morehead City, North Carolina, Forenede Stater, 28557
- Diabetes & Endocrinology Consultants
-
Morganton, North Carolina, Forenede Stater, 28655
- Burke Primary Care
-
Pinehurst, North Carolina, Forenede Stater, 28374-8798
- Pinehurst Medical Clinic, INC.
-
Raleigh, North Carolina, Forenede Stater, 27612
- Wake Research Associates, LLC
-
Rocky Mount, North Carolina, Forenede Stater, 27804
- PMG Research of Rocky Mount
-
Salisbury, North Carolina, Forenede Stater, 28144
- PMG Research of Salisbury
-
Sanford, North Carolina, Forenede Stater, 27330
- Sanford Cardiology
-
Statesville, North Carolina, Forenede Stater, 28625
- Piedmont Healthcare
-
Wilmington, North Carolina, Forenede Stater, 28401
- PMG Research of Wilmington
-
Winston-Salem, North Carolina, Forenede Stater, 27103
- PMG Research of Winston-Salem, LLC
-
-
North Dakota
-
Fargo, North Dakota, Forenede Stater, 58103
- Lillestol Research LLC
-
-
Ohio
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Hospital
-
Cincinnati, Ohio, Forenede Stater, 45219
- The Lindner Research Center
-
Cincinnati, Ohio, Forenede Stater, 45236
- Sentral Clinical Research
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Research Group, LLC
-
Marion, Ohio, Forenede Stater, 43302
- Awasty Research Network, LLC
-
Massillon, Ohio, Forenede Stater, 44646
- Community Health care
-
Springfield, Ohio, Forenede Stater, 45505
- Apex Medical Research Inc.
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Memorial Clinical Research
-
Oklahoma City, Oklahoma, Forenede Stater, 73135
- South Oklahoma Heart Research, LLC
-
Oklahoma City, Oklahoma, Forenede Stater, 73112
- Integris Cardiovascular Physicians LLC
-
Tulsa, Oklahoma, Forenede Stater, 74104
- Oklahoma Heart Institute
-
Tulsa, Oklahoma, Forenede Stater, 74136 7028
- Vital Prospects Clinical Research Institute PC
-
-
Pennsylvania
-
Altoona, Pennsylvania, Forenede Stater, 16602
- Clinical Research Associates of Central PA, LLC
-
Altoona, Pennsylvania, Forenede Stater, 16602
- Blair Medical Associates
-
Camp Hill, Pennsylvania, Forenede Stater, 17011
- Capital Area Research, LLC
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Health System
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Health Clinic
-
Doylestown, Pennsylvania, Forenede Stater, 18901
- Doylestown Health Cardiology a Division of Doylestown Health
-
Duncansville, Pennsylvania, Forenede Stater, 16635
- Altoona Center for Clinical Research
-
Erie, Pennsylvania, Forenede Stater, 16508
- Liberty Family Practice
-
Feasterville, Pennsylvania, Forenede Stater, 19053
- Endocrine Clinical Research LLC
-
Indiana, Pennsylvania, Forenede Stater, 15701
- Joseph Lamantia, DO
-
Jenkintown, Pennsylvania, Forenede Stater, 19046
- The Clinical Trial Center, LLC
-
Jersey Shore, Pennsylvania, Forenede Stater, 17740
- Lycoming Internal Medicine, Inc.
-
Johnstown, Pennsylvania, Forenede Stater, 15905-3443
- Berkley Hills Clinicals
-
Johnstown, Pennsylvania, Forenede Stater, 15905
- Ilumina Clinical Associates, Johnstown
-
Johnstown, Pennsylvania, Forenede Stater, 15905
- Joseph Lamantia, DO
-
Langhorne, Pennsylvania, Forenede Stater, 19047
- Comprehensive Cardiology Consultants
-
Lansdale, Pennsylvania, Forenede Stater, 19446
- Detweiler Family Medicine and Associates PC
-
Lansdale, Pennsylvania, Forenede Stater, 19446
- Green & Seidner Family Practice Associates
-
Newport, Pennsylvania, Forenede Stater, 17074
- Capital Area Research LLC
-
Philadelphia, Pennsylvania, Forenede Stater, 19114
- Endocrine Metabolic Associates
-
Pottstown, Pennsylvania, Forenede Stater, 19464
- Pottstown Medical Specialists, Inc. (PMSI)
-
Scranton, Pennsylvania, Forenede Stater, 18508
- Geisinger Clinic
-
-
Rhode Island
-
Cumberland, Rhode Island, Forenede Stater, 02864
- Partners in Clinical Research
-
-
South Carolina
-
Greer, South Carolina, Forenede Stater, 29650
- Radiant Research, Inc.
-
Greer, South Carolina, Forenede Stater, 29651
- Mountain View Clinical Research
-
Spartanburg, South Carolina, Forenede Stater, 29302
- Palmetto Research Center, LLC
-
-
South Dakota
-
Watertown, South Dakota, Forenede Stater, 57201
- Brown Clinic, PLLP
-
-
Tennessee
-
Bristol, Tennessee, Forenede Stater, 37620
- PMG Research of Bristol, LLC
-
Chattanooga, Tennessee, Forenede Stater, 37421
- WR-ClinSearch, LLC
-
Chattanooga, Tennessee, Forenede Stater, 37404
- Chattanooga Research and Medicine (CHARM)
-
Greeneville, Tennessee, Forenede Stater, 37745-5810
- Wellmont CVA Heart Institute
-
Jackson, Tennessee, Forenede Stater, 38305
- The Jackson Clinic, PA
-
Jackson, Tennessee, Forenede Stater, 38305
- Kore Cardiovascular Research
-
Jackson, Tennessee, Forenede Stater, 38301-3930
- Research Associates Of Jackson
-
Johnson City, Tennessee, Forenede Stater, 37604
- Wellmont CVA Heart Institute
-
Kingsport, Tennessee, Forenede Stater, 37660
- Holston Medical Group
-
Kingsport, Tennessee, Forenede Stater, 37660
- Wellmont CVA Heart Institute
-
Memphis, Tennessee, Forenede Stater, 38119
- The Endocrine Clinic
-
Nashville, Tennessee, Forenede Stater, 37203
- Cardiology Wellness Center
-
-
Texas
-
Austin, Texas, Forenede Stater, 78731
- Texas Diabetes & Endocrinology
-
Austin, Texas, Forenede Stater, 78705
- Central Texas Clinical Research, LLC
-
Carrollton, Texas, Forenede Stater, 75007
- Texas Health Physicians Group
-
Corpus Christi, Texas, Forenede Stater, 78404
- Adriana Pop-Moody MD Clinic, PA
-
Dallas, Texas, Forenede Stater, 75231
- Research Institute of Dallas
-
Dallas, Texas, Forenede Stater, 75218
- Texas Health Physicians Group
-
Dallas, Texas, Forenede Stater, 75024
- Baylor Research Institute
-
Dallas, Texas, Forenede Stater, 75220
- Texas Health Physicians Group, Dallas
-
Fort Worth, Texas, Forenede Stater, 76104
- Odilon Alvarado, M.D.
-
Fort Worth, Texas, Forenede Stater, 76107
- Texas Health Physicians Group Fort Worth
-
Fort Worth, Texas, Forenede Stater, 76117
- Tand R Clinic, PA
-
Georgetown, Texas, Forenede Stater, 78626
- San Gabriel Clinical Research, LLC
-
Houston, Texas, Forenede Stater, 77095
- Endocrine And Psychiatry Center
-
Houston, Texas, Forenede Stater, 77074
- Oxford Clinical Research, LLC
-
Houston, Texas, Forenede Stater, 77025 5253
- Angiocardiac Care of Texas PA
-
Houston, Texas, Forenede Stater, 77094
- West Houston Area Clinical Trial Consultants, LLC
-
Irving, Texas, Forenede Stater, 75039
- Texas Health Physicians Group
-
Kingwood, Texas, Forenede Stater, 77339
- Texas Cardiology Associates of Houston
-
Lewisville, Texas, Forenede Stater, 75067
- Jalil Aziz Khan M.D., P.A.
-
Midland, Texas, Forenede Stater, 79707
- Midland Clinical Research Center
-
Odessa, Texas, Forenede Stater, 79761
- Permian Research Foundation
-
Plano, Texas, Forenede Stater, 75075
- Clinical Investigations of Texas, LLC
-
Plano, Texas, Forenede Stater, 75023
- Medical Clinic of North Texas
-
Round Rock, Texas, Forenede Stater, 78681
- Texas Diabetes
-
San Antonio, Texas, Forenede Stater, 78229
- Cardiology Clinic of San Antonio
-
San Antonio, Texas, Forenede Stater, 78229
- Radiant Research San Antonio
-
San Antonio, Texas, Forenede Stater, 78228
- Physician PrimeCare Research Institute, PLLC
-
Tomball, Texas, Forenede Stater, 77375
- Martin Diagnostic Clinic
-
Tyler, Texas, Forenede Stater, 75701
- Cardiovascular Associates of East Texas
-
Webster, Texas, Forenede Stater, 77598
- Bay Area Total Health Medical Group
-
-
Utah
-
Ogden, Utah, Forenede Stater, 84405
- Advanced Research Institute
-
Salt Lake City, Utah, Forenede Stater, 84124
- Jean Brown Research
-
-
Virginia
-
Alexandria, Virginia, Forenede Stater, 22304
- Alexandria Clinical Research, LLC
-
Arlington, Virginia, Forenede Stater, 22201
- Washington Center for Weight Management and Resear
-
Burke, Virginia, Forenede Stater, 22015
- Burke Internal Medicine and Research
-
Danville, Virginia, Forenede Stater, 24541
- Cardiology Consultants of Danville, Inc.
-
Danville, Virginia, Forenede Stater, 24541
- Danville Internal Medicine, Inc
-
Falls Church, Virginia, Forenede Stater, 22044
- Seven Corners Medical Research Center
-
Falls Church, Virginia, Forenede Stater, 22042-1262
- Virginia Heart
-
Manassas, Virginia, Forenede Stater, 20110
- Manassas Clinical Research Center
-
Manassas, Virginia, Forenede Stater, 20109
- Inova Health Care Services
-
Manassas, Virginia, Forenede Stater, 20110
- Burke Internal Medicine and Research
-
Norfolk, Virginia, Forenede Stater, 23507
- Clinical Research Associates of Tidewater
-
Norfolk, Virginia, Forenede Stater, 23502
- Health Research of Hampton Roads - Norfolk, Inc.
-
Richmond, Virginia, Forenede Stater, 23229
- Virginia Cardiovascular Specialists
-
Richmond, Virginia, Forenede Stater, 23220
- Clinical Research Partners
-
Richmond, Virginia, Forenede Stater, 23294
- National Clinical Research-Richmond, Inc
-
Winchester, Virginia, Forenede Stater, 22601
- Selma Medical Associates
-
-
Washington
-
Federal Way, Washington, Forenede Stater, 98003
- Larry D. Stonesifer, MD, Inc PS
-
Seattle, Washington, Forenede Stater, 98105
- Seattle Women's
-
Spokane, Washington, Forenede Stater, 99218
- Rowan Research Inc.
-
Tacoma, Washington, Forenede Stater, 98405
- Universal Research Group
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Research Institute
-
Wenatchee, Washington, Forenede Stater, 98801
- Wenatchee Valley Hospital & Clinics
-
-
Wisconsin
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Cardiology Associates of Bellin Health
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Prevea Clinic, Inc
-
Kenosha, Wisconsin, Forenede Stater, 53142
- Clinical Investigation Specialists, Inc.
-
Madison, Wisconsin, Forenede Stater, 53713
- Meriter hospital Inc., DBA: UnityPoint Health-Meriter Heart
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Clinic
-
Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Research Institute
-
-
-
-
-
Aguascalientes, Mexico, 20230
- Hospital Cardiologica Aguascalientes
-
Aguascalientes, Mexico, 20230
- Fundacion Cardiovascular de Aguascalientes
-
Distrito Federal, Mexico, 06700
- Mentrials S.A.de C.V.
-
-
Jalisco
-
Guadalajara, Jalisco, Mexico, 44600
- ICLE
-
Guadalajara, Jalisco, Mexico, 44657
- Private Medical Practice
-
-
Nuevo Leon
-
Monterrey, Nuevo Leon, Mexico, 64620
- Centro de Estudios Clínicos y Especialidades Médicas S.C.
-
Monterrey, Nuevo Leon, Mexico, 64020
- IMED Clin Trials
-
Monterrey, Nuevo Leon, Mexico, 64060
- Cardiolink ClinTrials S.C.
-
-
Veracruz
-
Xalapa, Veracruz, Mexico, 91193
- Hospital de Angeles Xalapa
-
-
-
-
-
Auckland, New Zealand, 1148
- Auckland City Hospital
-
Hastings, New Zealand, 4120
- Hawkes Bay Regional Hospital
-
Nelson, New Zealand, 7010
- Nelson Hospital, Cardiology Department
-
Rotorua, New Zealand, 3010
- Lakeland Clinical Trials, Rotorua
-
Tauranga, New Zealand, 3112
- Tauranga Hospital
-
-
Auckland
-
Milford, Auckland, New Zealand, 0622
- North Shore Hospital-Cardiology Research
-
Papatoetoe, Auckland, New Zealand, 2025
- Middlemore Hospital
-
Takapuna, Auckland, New Zealand, 0740
- North Shore Hospital - Diabetes Clinic
-
-
Canterbury
-
Christchurch, Canterbury, New Zealand, 8011
- Christchurch Hospital, Lipids
-
Christchurch, Canterbury, New Zealand, 8811
- Christchurch Hospital, Cardiology Research
-
-
Otago
-
Dunedin, Otago, New Zealand, 9016
- Dunedin Hospital
-
-
Taranaki
-
New Plymouth, Taranaki, New Zealand, 4310
- Taranaki Base Hospital
-
-
Wellington
-
Lower Hutt, Wellington, New Zealand, 5010
- Hutt Hospital, Cardiology Dept
-
-
-
-
-
Bezrzecze, Polen, 72-003
- Indywidualna Specjalistyczna Praktyka Lekarska
-
Biala Rawska, Polen, 96-230
- NZOZ "Eskulap"
-
Białystok, Polen, 15-875
- Podlaski Osrodek Kardiologii Janusz Korecki
-
Bydgoszcz, Polen, 85-681
- 10 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ
-
Bydgoszcz, Polen, 85-231
- Centrum Medyczne Kermed
-
Chorzów, Polen, 41-500
- Nzoz "Mada-Med"
-
Chrzanów, Polen, 32-500
- DIABET Centrum Medyczne s. c.
-
Gdynia, Polen, 81-157
- ISPL w Dziedzinie Kardiologii lek.med. Krzysztof Cymerman
-
Gdynia, Polen, 81-423
- NZOZ SCBK ProCordis
-
Gdynia, Polen, 81-472
- Gabinet Kardiologiczno-Internistyczny
-
Inowroclaw, Polen, 88-100
- Praktyka Lekarska dr n. med. Marek Bronisz
-
Kamieniec Ząbkowicki, Polen, 57-230
- Piotr Mader Diabetic Clinic NZOZ PD-I
-
Koluszki, Polen, 95-040
- NZOZ Eskulap SC
-
Kraków, Polen, 30-082
- Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
-
Kraków, Polen, 31-156
- LANDA' Specjalistyczne Gabinety Lekarskie
-
Kraków, Polen, 31-261
- Medyczne Centrum Diabetologiczno Endokrynologiczno
-
Legnica, Polen, 59-220
- Nzoz Cardiamed
-
Lublin, Polen, 20-044
- "CenterMed Lublin" Sp. z o.o.
-
Mrągowo, Polen, 11-700
- Indywidualna Praktyka Lekarska
-
Olsztyn, Polen, 10-010
- Zechowicz MEDEUSZ-PLUS
-
Poznań, Polen, 61-655
- Praktyka Lekarska Ewa Krzyzagorska
-
Poznań, Polen, 61-853
- NZOZ NEURO-KARD "Ilkowski i Partnerzy"
-
Płock, Polen, 09-402
- Specjalistyczna Przychodnia Lekarska MEDIKARD (SPL Medikard)
-
Tarnów, Polen, 33-100
- Specjalistyczny Gabinet Lekarski
-
Toruń, Polen, 87-100
- Lecznice Citomed Sp. z o.o.
-
Toruń, Polen, 87-100
- Praktyka Lekarska Pawlowicz Lidia
-
Warszawa, Polen, 01-518
- Centrum Medyczne AMED
-
Warszawa, Polen, 02-679
- Centrum Badawcze Wspolczesnej Terapii
-
Warszawa, Polen, 03-973
- SNZOZ Fundacji PROCLINICA
-
Wierzchosławice, Polen, 33-122
- Centrum Zdrowia Wierzchoslawice
-
Wroclaw, Polen, 50-127
- Regionalna Poradnia Diabetologiczna
-
Włocławek, Polen, 87-800
- Specjalistyczne Gabinety Lekarskie "Medicor PLUS"
-
Łódź, Polen, 94-048
- NZOZ All-Med Centrum Medyczne
-
Łęczna, Polen, 21-010
- SP ZOZ w Lecznej
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
40 år og ældre (VOKSEN, OLDER_ADULT)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inklusionskriterier
- BMI større end eller lig (>=) til 27 kilogram pr. kvadratmeter (kg/m^2)
- Forsøgspersoner, der er i stand til og villige til at overholde en kaloriefattig diæt og et øget fysisk aktivitetsprogram
Alder >= til 40 år med etableret CV-sygdom som defineret ved en af følgende:
- Anamnese med dokumenteret MI eller iskæmisk slagtilfælde
- Historie om perifer arteriesygdom
- Anamnese med revaskularisering (koronar, carotis eller perifer arterie)
- Betydelig ikke-revaskulariseret koronar arteriel stenose
ELLER
Alder >= til 55 år for kvinder eller >= til 50 år for mænd, der har type 2-diabetes mellitus (T2DM) uden etableret CV-sygdom plus mindst én af følgende CV-risikofaktorer:
- Hypertension, eller i øjeblikket i behandling for dokumenteret hypertension
- Dyslipidæmi, eller i øjeblikket tager receptpligtig lipidsænkende behandling for dokumenteret dyslipidæmi
- Estimeret glomerulær filtrationshastighed >= til 30 til mindre end lig (<=) til 60 milliliter pr. minut pr. 1,73 kvadratmeter (mL/min/1,73 m^) ifølge Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) ligningen
- Højfølsomt C-reaktivt protein (hsCRP)
- Urinalbumin-til-kreatinin-forhold (ACR) >= 30 ug/mg
Forsøgspersoner med T2DM kan have en allerede eksisterende eller ny diagnose af T2DM. En ny diagnose af T2DM (dvs. opdaget ved screening) bør baseres på 2013 American Diabetes Association (ADA) retningslinjer.
Alle T2DM-personer skal have en HbA[1c] mindre (<) end 10 % ved screening. Hvis forsøgspersoner er under behandling, eller efter diagnose skal behandles med antidiabetika, skal T2DM-behandlingsregimet være stabilt i mindst 3 måneder før randomisering.
Eksklusionskriterier
- Moderate eller større symptomer på kongestivt hjertesvigt (New York Heart Association [NYHA] klasse III eller IV)
- Kendt venstre ventrikel (LV) ejektionsfraktion < end 20 %
- Moderate eller større symptomer på pulmonal hypertension (PH)
- Kendt alvorlig klapsygdom
- Moderat nedsat nyrefunktion, alvorligt nedsat nyrefunktion (estimeret glomerulær filtrationshastighed < 30 ml/min/1,73 m^ ifølge CKD-EPI-ligningen baseret på ideel kropsvægt) eller nyresygdom i slutstadiet (ESRD)
- Svært nedsat leverfunktion
- Brug af andre produkter beregnet til vægttab, herunder receptpligtig medicin, håndkøbsmedicin (OTC) og urtepræparater
- Brug af mere end ét andet serotonergt lægemiddel
- Brug af lægemidler, der vides at øge risikoen for hjerteklapklap inden for 6 måneder før screening, herunder, men ikke begrænset til: pergolid, ergotamin, methysergid, cabergolin
- Anamnese eller tegn på klinisk signifikant sygdom (f.eks. malignitet, hjerte-, luftvejs-, gastrointestinal, nyre- eller psykiatrisk sygdom)
- Brug af lorcaserin HCl før screening eller overfølsomhed over for lorcaserin HCl eller et eller flere af hjælpestofferne
- Planlagt fedmekirurgi
- Kvinder må ikke være gravide eller amme
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: BEHANDLING
- Tildeling: TILFÆLDIGT
- Interventionel model: PARALLEL
- Maskning: DOBBELT
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
EKSPERIMENTEL: Lorcaserin hydrochlorid (HCL) 10 mg
APD356 10 mg to gange dagligt
|
APD356 10 mg to gange dagligt
Andre navne:
|
|
PLACEBO_COMPARATOR: Placebo
Placebo to gange dagligt
|
Placebo to gange dagligt
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Tid fra randomisering til første forekomst af større uønskede kardiovaskulære hændelser (MACE) ved interimanalyse
Tidsramme: Baseline op til måned 42
|
MACE-hændelserne involverede myokardieinfarkt (MI), slagtilfælde eller kardiovaskulær (CV) død.
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline op til måned 42
|
|
Tid fra randomisering til første forekomst af MACE+
Tidsramme: Baseline frem til slutningen af studiet (måned 56)
|
MACE+-hændelserne involverede MI, slagtilfælde eller CV-død eller hospitalsindlæggelse for ustabil angina eller hjertesvigt (HF) eller enhver koronar revaskularisering.
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline frem til slutningen af studiet (måned 56)
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Tid fra randomisering til konvertering til type 2-diabetes mellitus (T2DM) for deltagere med prædiabetes ved baseline
Tidsramme: Baseline frem til slutningen af studiet (måned 56)
|
Tid fra randomisering til konvertering til T2DM blev defineret som første forekomst af en komponent i 2013 American Diabetes Association (ADA) Diagnostic Criteria (ADA, 2013) hos deltagere med prædiabetes ved baseline.
De diagnostiske kriterier var opfyldt, hvis en deltager havde utvetydig hyperglykæmi (tilfældig plasmaglukose større end eller lig med (>=) 200 milligram pr. deciliter (mg/dL) (11,1 millimol pr. liter [mmol/L]) med klassiske symptomer på hyperglykæmi eller hyperglykæmisk krise) eller et af de følgende kriterier blev observeret og efterfølgende bekræftet ved gentagne laboratorietests, såsom: glycosyleret hæmoglobin (HbA1c) >=til 6,5%; fastende plasmaglucose (FPG) >=126 mg/dL (7,0 mmol/L); 2-timers plasmaglukose >=200 mg/dL (11,1 mmol/L) ved en oral glucosetolerancetest (OGTT).
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline frem til slutningen af studiet (måned 56)
|
|
Tid fra randomisering til første forekomst af de individuelle komponenter i MACE+
Tidsramme: Baseline frem til slutningen af studiet (måned 56)
|
MACE+-hændelserne involverede MI, slagtilfælde eller CV-død eller hospitalsindlæggelse for ustabil angina eller HF eller enhver koronar revaskularisering.
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline frem til slutningen af studiet (måned 56)
|
|
Tid fra randomisering til hændelse af dødelighed af alle årsager
Tidsramme: Baseline frem til slutningen af studiet (måned 56)
|
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline frem til slutningen af studiet (måned 56)
|
|
Tid fra randomisering til konvertering til normal glukosehomeostase hos deltagere med prædiabetes ved baseline
Tidsramme: Baseline frem til slutningen af studiet (måned 56)
|
Normal glucosehomeostase blev defineret som HbA1c mindre end eller lig med (<=) 5,6 % og FPG < 100 mg/dL uden nogen antidiabetisk behandling.
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline frem til slutningen af studiet (måned 56)
|
|
Tid fra randomisering til konvertering til T2DM for deltagere uden nogen form for diabetes ved baseline
Tidsramme: Baseline frem til slutningen af studiet (måned 56)
|
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline frem til slutningen af studiet (måned 56)
|
|
Ændring fra baseline i HbA1c ved 6. måned i deltagere med T2DM ved baseline
Tidsramme: Baseline og måned 6
|
Baseline og måned 6
|
|
|
Tid fra randomisering til hændelse af nyopstået nyreinsufficiens eller forværring af eksisterende nedsat nyrefunktion hos alle deltagere
Tidsramme: Baseline frem til slutningen af studiet (måned 56)
|
Ny indtræden/forværring af eksisterende nyreinsufficiens var den første forekomst af nogen hændelser: mikroalbuminuri og makroalbuminuri (albumin-til-kreatinin ratio [ACR] >=30 mcg/mg og ACR>=300 mcg/mg i pleturin), forværring af albuminuri (mikroalbuminuri) ved baseline udviklet makroalbuminuri, ACR steg >=30 % fra baseline under behandling), nyudviklet kronisk nyresygdom (CKD) (eGFR >=90 milliliter pr. minut pr. 1,73 [ml/min/1,73]krop
overfladeareal (BSA) og uden nyreskade ved baseline ændret til CKD Stage 1/højere i henhold til National Kidney Foundation [NKF] retningslinjer [2002]) eller forværring af CKD (CKD Stage 1/højere i henhold til NKF Guidelines [2002] forværret til højere CKD-stadier under behandling), eller fordobling af serumkreatinin (kreatininværdi mindst 2 gange basisværdi og >=1,5 mg/dL under behandling).
eller et af følgende: nyresygdom i slutstadiet, nyretransplantation, nyredød.
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline frem til slutningen af studiet (måned 56)
|
|
Tid fra randomisering til tilfælde af nyopstået nyreinsufficiens eller forværring af eksisterende nedsat nyrefunktion hos deltagere med prædiabetes ved baseline
Tidsramme: Baseline frem til slutningen af studiet (måned 56)
|
Ny indtræden/forværring af eksisterende nyreinsufficiens var den første forekomst af nogen hændelser: mikroalbuminuri og makroalbuminuri (ACR >=30mcg/mg og ACR >=300 mcg/mg i pleturin), forværring af albuminuri (mikroalbuminuri ved baseline udviklet makroalbuminuri, ACR øget > =30 % fra baseline under behandling), CKD (eGFR >=90 ml/min/1,73
BSA og uden nyreskade ved baseline ændret til CKD trin 1/højere i henhold til NKF retningslinjer [2002]) eller forværring af CKD (CKD trin 1/højere i henhold til NKF retningslinjer [2002] forværret til højere CKD stadier under behandling) eller fordobling af serumkreatinin (kreatininværdi mindst 2 gange baselineværdien og >=1,5 mg/dL under behandlingen).
eller et af følgende: nyresygdom i slutstadiet, nyretransplantation, nyredød.
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline frem til slutningen af studiet (måned 56)
|
|
Tid fra randomisering til hændelse af nystartet nedsat nyrefunktion eller forværring af eksisterende nedsat nyrefunktion hos deltagere med T2DM ved baseline
Tidsramme: Baseline frem til slutningen af studiet (måned 56)
|
Ny indtræden/forværring af eksisterende nedsat nyrefunktion var den første forekomst af nogen hændelser: mikroalbuminuri og makroalbuminuri (ACR >=30 mcg/mg og ACR >=300 mcg/mg i pleturin), forværring af albuminuri (mikroalbuminuri ved baseline udviklet makroalbuminuri, ACR øget >=30 % fra baseline under behandling), CKD (eGFR >=90 ml/min/1,73
BSA og uden nyreskade ved baseline ændret til CKD trin 1/højere i henhold til NKF retningslinjer [2002]) eller forværring af CKD (CKD trin 1/højere i henhold til NKF retningslinjer [2002] forværret til højere CKD stadier under behandling) eller fordobling af serumkreatinin (kreatininværdi mindst 2 gange baselineværdien og >=1,5 mg/dL under behandlingen).
eller et af følgende: nyresygdom i slutstadiet, nyretransplantation, nyredød.
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline frem til slutningen af studiet (måned 56)
|
|
Tid fra randomisering til hændelse af forbedring af nyrefunktionen hos deltagere med T2DM ved baseline
Tidsramme: Baseline frem til slutningen af studiet (måned 56)
|
Forbedring af nyrefunktionen blev defineret som den første forekomst af regression af albuminuri eller regression af CKD.
Regression af albuminuri blev defineret som når deltagere med makroalbuminuri ved baseline udviklede mikroalbuminuri eller nonalbuminuri (ACR <30 mcg/mg i pleturin), eller deltagere med mikroalbuminuri ved baseline blev nonalbuminuri, og ACR-værdien faldt >= 30 % fra tidligere vurdering under behandlingen .
Regression af CKD defineret som når deltagere med CKD trin 1 eller højere ved baseline forbedrede til normale eller lavere stadier ifølge NKF-retningslinjer (eGFR >=90 med albuminuri ved baseline forbedret til eGFR >=90 uden albuminuri, eller eGFR 60 til 89 ved baseline blev eGFR >=90 med eller uden albuminuri, eller eGFR mellem 30 og 59 ved baseline forbedret til >60 ml/min/1,73
BSA) under behandlingen.
Resultatdataene blev vurderet ved hjælp af Kaplan-Meier-estimat og Greenwood Formula.
|
Baseline frem til slutningen af studiet (måned 56)
|
|
Procentdel af deltagere, der mødte FDA-defineret valvulopati i ekkokardiografisk bestemte hjerteklapændringer
Tidsramme: Måned 6 og 12
|
Måned 6 og 12
|
|
|
Procentdel af deltagere med FDA-defineret valvulopati ved baseline, som påviste forværret FDA-defineret valvulopati
Tidsramme: Måned 6 og 12
|
Måned 6 og 12
|
|
|
Ændring fra baseline i ekkokardiografisk bestemt pulmonalt arterielt systolisk tryk
Tidsramme: Baseline, måned 12
|
Baseline, måned 12
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Scirica BM, Bohula EA, Dwyer JP, Qamar A, Inzucchi SE, McGuire DK, Keech AC, Smith SR, Murphy SA, Im K, Leiter LA, Gupta M, Patel T, Miao W, Perdomo C, Bonaca MP, Ruff CT, Sabatine MS, Wiviott SD; CAMELLIA-TIMI 61 Steering Committee and Investigators. Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial. Circulation. 2019 Jan 15;139(3):366-375. doi: 10.1161/CIRCULATIONAHA.118.038341.
- Bohula EA, Scirica BM, Inzucchi SE, McGuire DK, Keech AC, Smith SR, Kanevsky E, Murphy SA, Leiter LA, Dwyer JP, Corbalan R, Hamm C, Kaplan L, Nicolau JC, Ophuis TO, Ray KK, Ruda M, Spinar J, Patel T, Miao W, Perdomo C, Francis B, Dhadda S, Bonaca MP, Ruff CT, Sabatine MS, Wiviott SD; CAMELLIA-TIMI 61 Steering Committee Investigators. Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial. Lancet. 2018 Nov 24;392(10161):2269-2279. doi: 10.1016/S0140-6736(18)32328-6. Epub 2018 Oct 4.
- Bohula EA, Wiviott SD, McGuire DK, Inzucchi SE, Kuder J, Im K, Fanola CL, Qamar A, Brown C, Budaj A, Garcia-Castillo A, Gupta M, Leiter LA, Weissman NJ, White HD, Patel T, Francis B, Miao W, Perdomo C, Dhadda S, Bonaca MP, Ruff CT, Keech AC, Smith SR, Sabatine MS, Scirica BM; CAMELLIA-TIMI 61 Steering Committee and Investigators. Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients. N Engl J Med. 2018 Sep 20;379(12):1107-1117. doi: 10.1056/NEJMoa1808721. Epub 2018 Aug 26.
- Bohula EA, Scirica BM, Fanola C, Inzucchi SE, Keech A, McGuire DK, Smith SR, Abrahamsen T, Francis BH, Miao W, Perdomo CA, Satlin A, Wiviott SD, Sabatine MS. Design and rationale for the Cardiovascular and Metabolic Effects of Lorcaserin in Overweight and Obese Patients-Thrombolysis in Myocardial Infarction 61 (CAMELLIA-TIMI 61) trial. Am Heart J. 2018 Aug;202:39-48. doi: 10.1016/j.ahj.2018.03.012. Epub 2018 Mar 29.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (FAKTISKE)
24. januar 2014
Primær færdiggørelse (FAKTISKE)
14. maj 2018
Studieafslutning (FAKTISKE)
14. maj 2018
Datoer for studieregistrering
Først indsendt
18. december 2013
Først indsendt, der opfyldte QC-kriterier
18. december 2013
Først opslået (SKØN)
24. december 2013
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (FAKTISKE)
16. juli 2019
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
27. juni 2019
Sidst verificeret
1. november 2017
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- APD356-G000-401
- 2013-000324-34 (EUDRACT_NUMBER)
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ja
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Placebo
-
SamA Pharmaceutical Co., LtdUkendtAkut bronkitis | Akut øvre luftvejsinfektionKorea, Republikken
-
National Institute on Drug Abuse (NIDA)AfsluttetBrug af cannabisForenede Stater
-
AkesoIkke rekrutterer endnuAtopisk dermatitisKina
-
CellmedisMedical Network Sp. z o.o.Ikke rekrutterer endnu
-
Texas A&M UniversityNutraboltAfsluttetGlukose og insulinrespons
-
AstraZenecaParexel; Spandauer Damm 130; 14050; Berlin, GermanyAfsluttetMandlige forsøgspersoner med type II-diabetes (T2DM)Tyskland
-
Heptares Therapeutics LimitedAfsluttetFarmakokinetik | SikkerhedsproblemerDet Forenede Kongerige
-
LifeMine TherapeuticsRekruttering
-
Longeveron Inc.AfsluttetHypoplastisk venstre hjerte syndromForenede Stater