Epidemiology of Neonatal Sepsis in Neonatal Intensive Care Unit in Assiut University Children Hospital
Epidemiology of Neonatal Sepsis in Infants Admitted to Neonatal Intensive Care Unit in Assiut University Children Hospital
Studieoversigt
Detaljeret beskrivelse
More than 40% of under-five deaths globally occur in the neonatal period, resulting in 3.1 million newborn death each year.
The majority of these deaths usually occur in low income countries . On the other hand, the survivors of neonatal sepsis are vulnerable to short- and long term neurodevelopmental morbidity .
Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteremia in the first month of life. It includes various systemic infections of the newborn such as septicemia, meningitis, pneumonia, arthritis, osteomyelitis, and urinary tract infections. Superficial infections like conjunctivitis and oral thrush are usually not included under neonatal sepsis.
Diagnosis of sepsis in neonates is challenging due to nonspecific signs and symptoms. The salient clinical features include systemic signs of infection such as fever, hypothermia, tachycardia, failure to thrive, lethargy, irritability, restlessness In addition, laboratory diagnosis until recently was time-consuming. This, therefore, necessitates the initiation of empirical antibiotic therapy pending a definitive diagnosis .
Neonatal sepsis is caused by Gram-positive and Gram-negative bacteria and Candida. The diversity of organisms causing sepsis varies from region to another and changes over time even in the same place .
Undersøgelsestype
Tilmelding (Forventet)
Kontakter og lokationer
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
• All admitted inborn and out born neonates during this study period will be screened for sepsis
Exclusion Criteria:
• All cases that mimic neonatal sepsis such as;
- Inborn errors of metabolism
- Congestive heart failure
- Hemolytic Disease of Newborn
- Hypoxic ischemic encephalopathy
- Congenital Diaphragmatic Hernia
- Intra cranial hemorrhage
- Respiratory Distress Syndrome
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
|
complete blood count
blood sample is collected from infant to detect presence of sepsis
|
blood culture to determine causative organisms of neonatal sepsis
Andre navne:
|
|
c reactive protein
measuring c reactive protein in blood sample to determine neonatal sepsis
|
blood culture to determine causative organisms of neonatal sepsis
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Incidence of neonatal sepsis
Tidsramme: up to 4 months
|
by measuring the incidence of neonatal sepsis helping to know the size of the problem of neonatal sepsis
|
up to 4 months
|
|
prevalence of neonatal sepsis
Tidsramme: up to 4 months
|
by measuring the prevalence of neonatal sepsis this help us to manage neonatal sepsis accordingly
|
up to 4 months
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
risk factors and causative organisms of neonatal sepsis
Tidsramme: up to 4 months
|
by determining the relation between risk factors and incidence of neonatal sepsis and by determining the causative organisms this help in prevention and management of neonatal sepsis
|
up to 4 months
|
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Studiestol: Gehan Mo Kamal El_Din, Professor, Assiut University
Datoer for undersøgelser
Studer store datoer
Studiestart (Forventet)
Primær færdiggørelse (Forventet)
Studieafslutning (Forventet)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- EONI
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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