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Using Artificial Intelligence To Improve Ventilator Settings For Intensive Care Patients

15. maj 2026 opdateret af: Wu Rongzhou

Research on Intelligent Optimization of Ventilator Parameters for Intensive Care Patients Based on Multimodal Large Models

This observational study aims to determine whether an AI-assisted decision support system can improve clinical outcomes for mechanically ventilated pediatric patients (aged 1 month to 18 years) in the PICU, compared to standard care provided by medical staff. The primary question addressed is: Do patients whose ventilator parameter optimization decisions are guided by AI assistance achieve a greater number of ventilator-free days within 28 days than those managed by medical staff? By utilizing clinical data collected following tracheal intubation to generate AI-driven recommendations-and comparing these against the actual adjustments made by physicians-this study seeks to assess whether the AI-assisted decision support system can effectively improve clinical outcomes for mechanically ventilated patients in the PICU.

Studieoversigt

Status

Afsluttet

Betingelser

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

2000

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Kina
    • Zhejiang
      • Wenzhou, Zhejiang, Kina, 325000
        • The Second Affiliated Hospital of Wenzhou Medical University and Yuying Children's Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Barn
  • Voksen

Tager imod sunde frivillige

Ingen

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

Pediatric patients aged 1 month to 18 years admitted to the Pediatric Intensive Care Unit (PICU) of the Second Affiliated Hospital of Wenzhou Medical University and Yuying Children's Hospital, who are receiving mechanical ventilation.

Beskrivelse

Inclusion Criteria:

  1. PICU patients aged 1 month to 18 years.
  2. Receiving invasive mechanical ventilation, expected to last ≥ 48 hours.
  3. Informed consent signed prior to enrollment.

Exclusion Criteria:

  1. Expected survival < 24 hours
  2. Irreversible brain injury (GCS = 3 + absence of brainstem reflexes)
  3. Severe congenital cardiopulmonary malformations affecting ventilation assessment
  4. Pregnancy (must be ruled out in adolescent girls)
  5. Currently participating in other ventilation intervention trials
  6. Guardian refusal to participate

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
AI-Assisted Ventilator Parameter Optimization in Pediatric ICU
Clinical data from key time points following tracheal intubation in each pediatric patient were input into an AI system to generate recommendations. These recommendations were then compared against the actual adjustments made by physicians, enabling a counterfactual assessment to determine whether-had the AI's suggestions been adopted-the number of ventilator-free days within a 28-day period would have been superior.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Number of ventilator-free days within 28 days
Tidsramme: From the start of tracheal intubation until 28 days after tracheal intubation.
Days survived and free from invasive ventilation
From the start of tracheal intubation until 28 days after tracheal intubation.

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
mortality rate
Tidsramme: 28 and 90 days after the initiation of tracheal intubation
All-cause mortality at 28 and 90 days following tracheal intubation
28 and 90 days after the initiation of tracheal intubation
Mechanical Ventilation-Related Complications
Tidsramme: From the start of tracheal intubation to Day 28
Cumulative duration of mechanical ventilation, reintubation rate (within 48 hours of extubation), ventilator-associated pneumonia (VAP), barotrauma.
From the start of tracheal intubation to Day 28
Length of Hospital Stay
Tidsramme: The duration from the time of admission to discharge for pediatric patients-up to a maximum of three months.
PICU Length of Stay, Total Hospital Length of Stay
The duration from the time of admission to discharge for pediatric patients-up to a maximum of three months.
Artificial Intelligence System Evaluation
Tidsramme: From the start of tracheal intubation to Day 28
Physician Adoption Rates and Outcomes of Cases Involving Discrepancies Between AI Recommendations and Physician Decisions
From the start of tracheal intubation to Day 28
Health Economics
Tidsramme: The duration from the time of admission to discharge for pediatric patients-up to a maximum of three months.
PICU Hospitalization Costs
The duration from the time of admission to discharge for pediatric patients-up to a maximum of three months.

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Wu Rongzhou

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. januar 2021

Primær færdiggørelse (Faktiske)

31. december 2025

Studieafslutning (Faktiske)

31. december 2025

Datoer for studieregistrering

Først indsendt

10. maj 2026

Først indsendt, der opfyldte QC-kriterier

15. maj 2026

Først opslået (Faktiske)

18. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

18. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

15. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 2026-K-78-01

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

IPD-planbeskrivelse

Individual participant data will not be shared, the study's ethical approvals and consent agreements do not permit public data sharing. Access may be considered upon reasonable request to the corresponding author, subject to institutional review and data use agreements to ensure patient privacy and compliance with regulations.

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

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