Kochujang, fermented soybean-based red pepper paste, decreases visceral fat and improves blood lipid profiles in overweight adults

Youn-Soo Cha, Soo-Ran Kim, Ji-Ae Yang, Hyang-Im Back, Min-Gul Kim, Su-Jin Jung, Won O Song, Soo-Wan Chae, Youn-Soo Cha, Soo-Ran Kim, Ji-Ae Yang, Hyang-Im Back, Min-Gul Kim, Su-Jin Jung, Won O Song, Soo-Wan Chae

Abstract

Health benefits of Kochujang (KCJ) and its bioactive compounds have been reported in several in vitro and animal studies.

Objective: The aim of this study was to investigate the efficacy of KCJ supplementation on body composition and blood lipid profiles in overweight adults.

Methods: Sixty overweight men and women with BMI ≥23 kg/m2 and waist-hip-ratio (WHR) ≥0.90 for men and ≥0.85 for women were randomly assigned to a KCJ supplement (n=30, 32 g/day) or placebo (n=30, 32 g/day) group for a 12-week, double-blind, placebo controlled study. We measured anthropometric parameters, serum lipid profiles, abdominal fat distribution by computerized tomography and calculated the atherosclerosis indices in 53 subjects (n=26 in KCJ group, n=27 in placebo group) who completed the study.

Results: After 12 weeks, the KCJ group showed a significant reduction in visceral fat (cm2) (p<0.05), although body weight (kg) and WHR did not change. Serum concentration of triglycerides and ApoB were decreased when compared to those of the placebo group.

Conclusion: KCJ supplementation (32 g/day) for 12 weeks in overweight adults showed anti-atherosclerotic and anti-obesogenic effects.

Trial registration: Clinical trials.gov Identifier: NCT01532375.

Figures

Figure 1
Figure 1
The Flow chart of the study.

References

    1. Yu KJ. Analysis of the relationship between dietary fiber intake and food habits in the korean adult population. The Korean J Nutr. 2008;41:19.
    1. Jin EH. A study on health related action rates of dietary guidelines and pattern of dietary in middle-aged women. J Korean Soc Health Inform Health Stat. 2009;34:12.
    1. Park S, Park CH, Jang JS. Antecedent intake of traditional Asian-style diets exacerbates pancreatic beta-cell function, growth and survival after Western-style diet feeding in weaning male rats. J Nutr Biochem. 2006;17:307–318. doi: 10.1016/j.jnutbio.2005.07.002.
    1. Kim J. Biologically active components of soy-fermented foods. Korean Soybean Digest. 2002;17:7.
    1. Oh J, Kim Y, Shin D. Changes in microorganisms, enzyme activities, and gas formation by the addition of mustard power on Kochujang with different salt concentration. Food Sci Biotechnol. 2006;15:298–302.
    1. Kwon DY, Hong SM, Ahn IS, Kim YS, Shin DW, Park S. Kochujang, a Korean fermented red pepper plus soybean paste, improves glucose homeostasis in 90% pancreatectomized diabetic rats. Nutrition. 2009;25:790–799. doi: 10.1016/j.nut.2008.12.006.
    1. Kawada T, Hagihara K, Iwai K. Effects of capsaicin on lipid metabolism in rats fed a high fat diet. J Nutr. 1986;116:1272–1278.
    1. Kang JH, Goto T, Han IS, Kawada T, Kim YM, Yu R. Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet. Obesity (Silver Spring) 2010;18:780–787. doi: 10.1038/oby.2009.301.
    1. Ahn IS, Do MS, Kim SO, Jung HS, Kim YI, Kim HJ, Park KY. Antiobesity effect of Kochujang (Korean fermented red pepper paste) extract in 3T3-L1 adipocytes. J Med Food. 2006;9:15–21. doi: 10.1089/jmf.2006.9.15.
    1. Watanabe T, Kawada T, Kato T, Harada T, Iwai K. Effects of capsaicin analogs on adrenal catecholamine secretion in rats. Life Sci. 1994;54:369–374. doi: 10.1016/0024-3205(94)00793-4.
    1. Ahuja KD, Robertson IK, Geraghty DP, Ball MJ. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am J Clin Nutr. 2006;84:63–69.
    1. Spiller F, Alves MK, Vieira SM, Carvalho TA, Leite CE, Lunardelli A, Poloni JA, Cunha FQ, de Oliveira JR. Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation. J Pharm Pharmacol. 2008;60:473–478. doi: 10.1211/jpp.60.4.0010.
    1. Choo J, Shin H. Body-fat suppressive effects of capsaicin through ß-adrenergic stimulation in rats fed a high-fat diet. Korean J Nutr. 1999;32:533–539.
    1. Cornwell T, Cohick W, Raskin I. Dietary phytoestrogens and health. Phytochemistry. 2004;65:995–1016. doi: 10.1016/j.phytochem.2004.03.005.
    1. Choi YM, Suh HJ. Pharmacological effects of fermented red pepper. Phytother Res. 2004;18:884–888. doi: 10.1002/ptr.1490.
    1. Kwon S, Lee K, Im K, Kim S, Park K. Weight Reduction and Lipid Lowering Effects of Korean Traditional Soybean Fermented Products. J Korean Soc Food Sci Nutr. 2006;35:1194–1199.
    1. Shin D, Kim D, Choi U, Lim D, Lim M. Studies on the physicochemical characteristics of traditional Kochujang. Korean J Food Sic Technol. 1996;28:157–161.
    1. Jeong D, Shin D, Song M. Studies on the physicochemical characteristics of Sunchang traditional Kochujang. Korean J Food Cult. 2001;16:260–267.
    1. Shin D, Kim D, Choi U, Lim M, An E. Taste components of traditional Kochujang prepared with various raw materials. Korean J Food Sci Technol. 1997;29:913–918.
    1. Rhee S, Kong K, Jung K, Park K. Decreasing effects Kochujang on body weight and lipid levels of adipose tissues and serum in rats fed a high-fat diet. J Food Sci Nutr. 2003;32:882–886.
    1. Koo B, Seong SH, Kown DY, Sohn HS, Cha YS. Fermented Kochujang supplement shows anti-obesity effects by controlling lipid metabolism in C57BL/6J mice fed high fat diet. Food Sci Biotechnol. 2008;17:336–342.
    1. Choo J. Anti-obesity effects of Kochujang in rats fed on high fed diet. The Korean J Nutr. 2000;33:787–793.
    1. Back HI, Kim SR, Yang JA, Kim MG, Chae SW, Cha YS. Effects of Chungkookjang supplementation on obesity and atherosclerotic indices in overweight/obese subjects: a 12-week, randomized, double-blind, placebo-controlled clinical trial. J Med Food. 2011;14:532–537. doi: 10.1089/jmf.2010.1199.
    1. Soh JR, Shin DH, Kwon DY, Cha YS. Effect of Cheonggukjang supplementation upon hepatic acyl-CoA synthase, carnitine palmitoyltransferase I, acyl-CoA oxidase and uncoupling protein 2 mRNA levels in C57BL/6J mice fed with high fat diet. Genes Nutr. 2008;2:365–369. doi: 10.1007/s12263-007-0066-x.
    1. Ludy MJ, Mattes RD. The effects of hedonically acceptable red pepper doses on thermogenesis and appetite. Physiol Behav. 2011;102:251–258. doi: 10.1016/j.physbeh.2010.11.018.
    1. Reinbach HC, Smeets A, Martinussen T, Moller P, Westerterp-Plantenga MS. Effects of capsaicin, green tea and CH-19 sweet pepper on appetite and energy intake in humans in negative and positive energy balance. Clin Nutr. 2009;28:260–265. doi: 10.1016/j.clnu.2009.01.010.
    1. Yoshioka M, St-Pierre S, Drapeau V, Dionne I, Doucet E, Suzuki M, Tremblay A. Effects of red pepper on appetite and energy intake. Br J Nutr. 1999;82:115–123.
    1. Lee CH, Choi JH, Hwang IK, Yoo KY, Li H, Park OK, Yan B, Shin HC, Won MH. Immunohistochemical Changes in Orexigenic and Anorexigenic Neuropeptides in the Rat Hypothalamus after Capsaicin Administration. J Vet Med Sci. 2009;71:1337–1342. doi: 10.1292/jvms.001337.
    1. Udani J, Hardy M, Madsen DC. Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract. Altern Med Rev. 2004;9:63–69.
    1. Friedman JH, Dubinsky R. The placebo effect. Neurology. 2008;71:25–26. doi: 10.1212/.
    1. Lee YH, Choi SH, Lee KW, Kim DJ. Apolipoprotein B/A1 ratio is associated with free androgen index and visceral adiposity and may be an indicator of metabolic syndrome in male children and adolescents. Clin Endocrinol (Oxf) 2011;74:579–586. doi: 10.1111/j.1365-2265.2010.03953.x.
    1. Snitker S, Fujishima Y, Shen HQ, Ott S, Pi-Sunyer X, Furuhata Y, Sato H, Takahashi M. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr. 2009;89:45–50.
    1. Chang U, Kim J, Suh H, Oh S. Weight reduction effect of extract of fermented red pepper on female college students. J Korean Soc Food Sci Nutr. 2003;32:479–484.
    1. Gwak JH, Lee JH, Lee SJ, Prak HW, Kim Y, Hyun YJ. The effect of L-carnitine and isoflavone supplementation on weight reduction and visceral fat accumulation in overweight women. Korean J Nutr. 2007;40:9.
    1. Wu J, Oka J, Tabata I, Higuchi M, Toda T, Fuku N, Ezaki J, Sugiyama F, Uchiyama S, Yamada K, Ishimi Y. Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial. J Bone Miner Res. 2006;21:780–789. doi: 10.1359/jbmr.060208.
    1. Lee M, Chae S, Cha Y, Park Y. Supplementation of Korean fermented soy paste doenjang reduces visceral fat in overweight subjects with mutant uncoupling protein-1 allele. Nutr Res. 2012;32:8–14. doi: 10.1016/j.nutres.2011.12.002.
    1. Park JA, Tirupathi Pichiah PB, Yu JJ, Oh SH, Daily JW 3rd, Cha YS. Anti-obesity effect of kimchi fermented with Weissella koreensis OK1-6 as starter in high-fat diet-induced obese C57BL/6J mice. J Appl Microbiol. 2012;113:1507–1516. doi: 10.1111/jam.12017.
    1. Oi Y, Kawada T, Watanabe T, Iwai K. Induction of capsaicin-hydrolyzing enzyme-activity in rat-liver by continuous oral-administration of capsaicin. J Agric Food Chem. 1992;40:467–470. doi: 10.1021/jf00015a021.
    1. Choi S, Kim H, Kwon M, Baek Y, Song Y. The effect of Kimchi pill supplementation on plasma lipid concentration in healthy people. J Korean Soc Food Sci Nutr. 2001;30:913–920.
    1. Kwon DY, Daily JW, Kim HJ, Park S. Antidiabetic effects of fermented soybean products on type 2 diabetes. Nutr Res. 2010;30:1–13.
    1. Kim S, Shin HJ, Kim SY, Kim JH, Lee YS, Kim DH, Lee MO. Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha. Mol Cell Endocrinol. 2004;220:51–58. doi: 10.1016/j.mce.2004.03.011.
    1. Yang JY, Lee SJ, Park HW, Cha YS. Effect of genistein with carnitine administration on lipid parameters and obesity in C57Bl/6J mice fed a high-fat diet. J Med Food. 2006;9:459–467. doi: 10.1089/jmf.2006.9.459.
    1. Jang KHK YS, Lee SW, Lee JW, Kim NY, Jin DR. Korea’s health and Welfare trends. Seoul. 2010;128:128.

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