- ICH GCP
- Registro de ensayos clínicos de EE. UU.
- Ensayo clínico NCT02549872
Dementia Phenotypes in Primary Care, Hospital, and National Mortality Registries
Dementia Phenotypes in Primary Care, Hospital, and National Mortality Registries: a Cohort Study in Linked Electronic Health Records
Most patients with dementia in the UK use their local hospitals and general (family) practices throughout their illness. Linked electronic health records from primary care, hospital and death certificates records therefore provide useful information about the diagnosis and prognosis of patients who develop dementia.
In this study we will assess the validity of dementia diagnoses in linked primary care, hospital and death records, by examining the timing of important health transitions in patients with recorded dementia, and we will estimate the lifetime risk of recorded dementia in different age and sex groups
Descripción general del estudio
Estado
Condiciones
Intervención / Tratamiento
Descripción detallada
Dementia is a clinical syndrome with insidious onset that is difficult to diagnose in its earliest stages. Presentation to healthcare depends not only upon the rates of disease progression, but also on social support, recognition by clinicians, and patients' and carers' fear of diagnosis. Maintaining complete follow up in cohorts of patient with dementia is difficult, because patients with dementia are frequently lost to follow up.
Most patients with dementia in the UK use their local hospitals and general (family) practices throughout their illness. Linked electronic health records from primary care, hospital and death certificates records should therefore provide useful information about the diagnosis and prognosis of patients who develop dementia with minimal loss to follow-up rates and improved completeness of diagnosis.
Demonstrating that patients with recorded dementia have an earlier onset of typical symptoms, functional impairment and death than patients in the general population would support the veracity of diagnosed dementia recorded in electronic health records and its use as an outcome or exposure in cohort studies and for evaluating policy. Previous studies have found that dementia is poorly recorded in routine clinical practice in comparison to face-to-face studies, although this varies by setting and region. However, ascertainment may be improved by examining linked, longitudinal resources. Comparing the lifetime risk of dementia calculated from linked electronic health records with lifetime risks from other sources will also be a useful information to support the use of linked electronic health records in dementia research.
Electronic health records contain information on important health transitions in patients with dementia: from the earliest stage of the illness (depression, anxiety, memory complaints); the development of cognitive impairment that manifest as loss of capacity or missed appointments; and significant functional impairment, with admission to nursing homes or hospital admission. In this study, we will assess the validity of dementia diagnoses in linked primary care, hospital and death records, by examining the timing of important health transitions in patients with recorded dementia, and estimate the lifetime risk of recorded dementia in different age and sex groups.
Tipo de estudio
Inscripción (Anticipado)
Contactos y Ubicaciones
Ubicaciones de estudio
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London, Reino Unido
- London Farr Institute of Health Informatics
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Método de muestreo
Población de estudio
Descripción
Inclusion Criteria:
- Patients aged 18 years and over
- Registered with a participating general practice during the study period
- Minimum one year of records prior to study entry meeting CPRD data quality criteria
- Followed on or after 1 January 1997
Exclusion Criteria:
- Patients without recorded gender
- Less than 1 year of follow-up between study entry and date of administrative censoring
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
Cohortes e Intervenciones
Grupo / Cohorte |
Intervención / Tratamiento |
---|---|
Dementia
Patients with a recorded diagnosis of dementia in primary or secondary care
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This study is based on the retrospective analysis of linked electronic health records.
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Non-dementia
Patients without a recorded diagnosis of dementia in primary or secondary care
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This study is based on the retrospective analysis of linked electronic health records.
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
---|---|---|
Proportion of patients with dementia diagnosis (any type) in primary care that also are recorded in secondary care
Periodo de tiempo: 10 years
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10 years
|
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Factors associated with dementia diagnosis (any type) recording in mortality data only
Periodo de tiempo: 10 years
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These will be estimated from multivariable logistic regression models
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10 years
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Symptoms associated with subsequent diagnosis of dementia
Periodo de tiempo: 10 years
|
These will be estimated from multivariable logistic regression models
|
10 years
|
Lifetime risk of dementia (any type)
Periodo de tiempo: 10 years
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10 years
|
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Lifetime risk of mortality associated with dementia (any time)
Periodo de tiempo: 10 years
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10 years
|
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Factors associated with dementia diagnosis (any type) recording in secondary care only
Periodo de tiempo: 10 years
|
These will be estimated from multivariable logistic regression models
|
10 years
|
Factors associated with dementia diagnosis (any type) recording in primary care only
Periodo de tiempo: 10 years
|
These will be estimated from multivariable logistic regression models
|
10 years
|
Proportion of patients with dementia diagnosis (any type) in primary care that also are recorded in mortality data
Periodo de tiempo: 10 years
|
10 years
|
|
Proportion of patients with dementia diagnosis (any type) in secondary care that also are recorded in mortality data
Periodo de tiempo: 10 years
|
10 years
|
Medidas de resultado secundarias
Medida de resultado |
Periodo de tiempo |
---|---|
Proportion of patients with Alzheimer's disease in primary care that are also diagnosed in secondary care
Periodo de tiempo: 10 years
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10 years
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Proportion of patients with vascular dementia in primary care that are also diagnosed in secondary care
Periodo de tiempo: 10 years
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10 years
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Lifetime risk of Alzheimer's disease
Periodo de tiempo: 10 years
|
10 years
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Lifetime risk of vascular dementia
Periodo de tiempo: 10 years
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10 years
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Lifetime risk of mortality associated with Alzheimer's disease
Periodo de tiempo: 10 years
|
10 years
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Proportion of patients with Alzheimer's disease in primary care that are also diagnosed in mortality data
Periodo de tiempo: 10 years
|
10 years
|
Proportion of patients with Alzheimer's disease in secondary care that are also recorded in mortality data
Periodo de tiempo: 10 years
|
10 years
|
Proportion of patients with vascular dementia in primary care that are also recorded in secondary care
Periodo de tiempo: 10 years
|
10 years
|
Proportion of patients with vascular dementia in secondary care that are also recorded in mortality data
Periodo de tiempo: 10 years
|
10 years
|
Colaboradores e Investigadores
Patrocinador
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio
Finalización primaria (Anticipado)
Finalización del estudio (Anticipado)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Estimar)
Actualizaciones de registros de estudio
Última actualización publicada (Estimar)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- 15_138
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