El impacto del patrón dietético en la función eréctil (ERECTION)
22 de julio de 2026 actualizado por: Montefiore Medical Center
El impacto de una dieta basada en plantas frente a una dieta basada en animales sobre la función eréctil en hombres sanos con función eréctil normal: el estudio ERECTION
El objetivo de este estudio es determinar si la función eréctil se ve afectada por los patrones dietéticos en hombres sanos con una función eréctil normal.
Descripción general del estudio
Estado
Reclutamiento
Condiciones
Intervención / Tratamiento
Descripción detallada
Visita 1:
Después de revisar y firmar el consentimiento, los sujetos serán evaluados. La proyección consistirá en:
Complete IIEF (Índice Internacional de Función Eréctil) y un cuestionario de frecuencia de alimentos.
Registrar el historial médico, los medicamentos. Medir la altura y el peso. Signos vitales. Extraer sangre para determinar la testosterona total, la globulina fijadora de hormonas sexuales y la TSH (hormona estimulante de la tiroides). Se preguntará a los sujetos sobre la presencia de erupciones o lesiones genitales.
Si la puntuación del IIEF es anormal, se recomendará a los sujetos que se comuniquen con el PCP (proveedor de atención primaria).
Los sujetos serán contactados con los resultados de las pruebas de laboratorio. Si es anormal, se recomendará al sujeto que se comunique con el PCP.
Si el sujeto no tiene PCP, se proporcionará la información de contacto de un PCP. Los sujetos que cumplan con los criterios de inclusión y exclusión serán aleatorizados en la secuencia uno o en la secuencia dos. Una vez inscritos, los sujetos no modificarán los hábitos dietéticos durante la duración del estudio, excepto durante las dos noches y los dos días completos en los que se proporciona comida (ver más abajo).
Secuencia uno:
Visita 2:
Los sujetos regresan al centro de estudio por la mañana después de haber ayunado (aparte de consumir agua) desde las 23:00 horas de la noche anterior. Los sujetos no se cepillarán los dientes ni usarán enjuague bucal u otros refrescantes del aliento esa mañana. Se realizarán registros antropomórficos, de presión arterial y de frecuencia cardiaca. Se extraerá sangre y se almacenará. La orina será recolectada y almacenada. A los sujetos se les enseñará cómo usar el dispositivo Rigiscan™. Los sujetos recibirán una cena a base de plantas. Luego, los sujetos abandonarán el centro de estudio y consumirán la dieta habitual hasta las 5:00 p. m. Durante el resto de la noche hasta las 23:00, los sujetos consumirán solo la cena proporcionada. El agua será la única bebida permitida después de las 5:00 p. m. La cena debe consumirse a las 8:30 p. m., EST (hora estándar del este). Los sujetos enviarán imágenes de todo lo que se consume (comer o beber) después de las 5:00 p. m. al IP o a un representante del estudio. Un miembro del equipo del estudio tendrá contacto verbal o de texto con el sujeto al menos una vez esa noche. Los sujetos ayunarán aparte del agua después de las 11 p.m. Esa noche, los sujetos harán una evaluación Rigiscan™ durante la noche en casa. Se debe registrar la hora a la que el sujeto se acuesta y la hora a la que se despierta para el día. El sujeto acepta estar en la cama con Rigiscan™ activado (excepto en casos de emergencia o necesarios para ir al baño) durante al menos siete horas.
Visita 3:
Los sujetos regresan al centro de estudio la mañana después de la evaluación Rigiscan™ y traen el dispositivo Rigiscan™. Los sujetos habrán estado en ayunas que no hayan bebido agua desde las 11 p. m. de la noche anterior. Los sujetos no se cepillarán los dientes ni usarán enjuague bucal u otros refrescantes del aliento esa mañana. Se realizarán registros antropomórficos, de presión arterial y de frecuencia cardiaca. Se extraerá sangre y se almacenará. La orina será recolectada y almacenada. Luego, los sujetos recibirán un día completo de comidas a base de plantas. Se alentará a los sujetos a desayunar en el centro de estudio después de que se realicen las medidas antropomórficas iniciales, se extraiga sangre y se recolecte la orina. Los sujetos enviarán por mensaje de texto imágenes de todo lo que se consume durante ese día al PI y/o a un representante del estudio y un miembro del equipo de estudio tendrá contacto verbal o de texto con el sujeto al menos dos veces durante ese día. La cena debe consumirse a las 8:30 p. m., EST. Los sujetos ayunarán aparte del agua después de las 11 p.m. Esa noche, los sujetos harán una evaluación Rigiscan™ durante la noche en casa. El café solo y/o el té solo están permitidos antes del mediodía. Se debe registrar la hora a la que el sujeto se acuesta y la hora a la que se despierta para el día. El sujeto acepta estar en la cama con Rigiscan™ activado (excepto en casos de emergencia o necesarios para ir al baño) durante al menos siete horas.
Visita 4:
Los sujetos regresan al centro de estudio la mañana después de la evaluación Rigiscan™ y traen el dispositivo Rigiscan™. Los sujetos no se cepillarán los dientes ni usarán enjuague bucal u otros refrescantes del aliento esa mañana. Se realizarán registros antropomórficos, de presión arterial y de frecuencia cardiaca. Se extraerá sangre y se almacenará. La orina será recolectada y almacenada. Luego habrá un período de lavado de 8 a 12 días y se indicará a los sujetos que vuelvan a sus hábitos dietéticos habituales durante este período de lavado.
Visita 5:
Después del período de lavado, los sujetos regresan al centro de estudio por la mañana después de haber ayunado (aparte de consumir agua) desde las 11:00 p. m. de la noche anterior. Los sujetos no se cepillarán los dientes ni usarán enjuague bucal u otros refrescantes del aliento esa mañana. Se realizarán registros antropomórficos, de presión arterial y de frecuencia cardiaca. Se extraerá sangre y se almacenará. La orina será recolectada y almacenada. Los sujetos recibirán una cena basada en animales. Luego, los sujetos abandonarán el centro de estudio y consumirán la dieta habitual hasta las 5:00 p. m. Durante el resto de la noche hasta las 23:00, los sujetos consumirán solo la cena proporcionada. El agua será la única bebida consumida después de las 17:00 horas. La cena debe consumirse a las 8:30 p. m., EST. Los sujetos enviarán imágenes de todo lo que se consume (comer o beber) después de las 5:00 p. m. al IP o a un representante del estudio y un miembro del equipo del estudio tendrá contacto verbal o de texto con el sujeto al menos una vez esa noche. Los sujetos ayunarán aparte del agua después de las 11 p.m. Esa noche, los sujetos harán una evaluación Rigiscan™ durante la noche en casa. Se debe registrar la hora a la que el sujeto se acuesta y la hora a la que se despierta para el día. El sujeto acepta estar en la cama con Rigiscan™ activado (excepto en casos de emergencia o necesarios para ir al baño) durante al menos siete horas.
Visita 6:
Los sujetos regresan al centro de estudio la mañana después de la evaluación Rigiscan™ y traen el dispositivo Rigiscan™. Los sujetos no se cepillarán los dientes ni usarán enjuague bucal u otros refrescantes del aliento esa mañana. Se realizarán registros antropomórficos, de presión arterial y EndoPAT™. La saliva se almacenará. Se extraerá sangre y se almacenará. Luego, los sujetos recibirán un día completo de comidas basadas en animales. Se alentará a los sujetos a desayunar en el centro de estudio después de que se realicen las medidas antropomórficas iniciales, se obtenga saliva y se extraiga sangre. Los sujetos enviarán por mensaje de texto imágenes de todo lo que se consume durante ese día al PI y/o a un representante del estudio y el equipo del estudio tendrá contacto verbal o de texto con el sujeto al menos dos veces durante ese día. La cena debe consumirse a las 8:30 p. m., EST. Los sujetos ayunarán aparte del agua después de las 11 p.m. Esa noche, los sujetos harán una evaluación Rigiscan™ durante la noche en casa. El café solo y/o el té solo están permitidos antes del mediodía. Se debe registrar la hora a la que el sujeto se acuesta y la hora a la que se despierta para el día. El sujeto acepta estar en la cama con Rigiscan™ activado (excepto en casos de emergencia o necesarios para ir al baño) durante al menos siete horas.
Visita 7 (fin del estudio):
Los sujetos regresan al centro de estudio la mañana después de la evaluación Rigiscan™ y traen el dispositivo Rigiscan™. Los sujetos no se cepillarán los dientes ni usarán enjuague bucal u otros refrescantes del aliento esa mañana. Se realizarán registros antropomórficos, de presión arterial y de frecuencia cardiaca. Se extraerá sangre y se almacenará. La orina será recolectada y almacenada.
Secuencia dos:
La Secuencia dos es idéntica a la Secuencia uno, excepto que se proporcionan comidas a base de animales en lugar de comidas a base de plantas. Para los sujetos asignados al azar a comidas de origen animal en la Secuencia Uno y la Secuencia Dos, será idéntico excepto que se proporcionarán comidas de origen vegetal en lugar de comidas de origen animal.
Tipo de estudio
Intervencionista
Inscripción (Estimado)
46
Fase
- No aplica
Contactos y Ubicaciones
Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.
Estudio Contacto
- Nombre: Robert Ostfeld, MD
- Número de teléfono: 718-920-5197
- Correo electrónico: ROSTFELD@montefiore.org
Ubicaciones de estudio
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New York
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The Bronx, New York, Estados Unidos, 10467
- Reclutamiento
- Montefiore Medical Center, Department of Medicine, Division of Cardiology
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Contacto:
- Robert J Ostfeld, MD, MS
- Número de teléfono: 718-920-8011
- Correo electrónico: rostfeld@montefiore.org
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Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
14 años a 25 años (Adulto)
Acepta Voluntarios Saludables
Sí
Descripción
Criterios de inclusión:
- El sujeto proporciona el consentimiento informado por escrito y la autorización HIPAA en inglés antes de realizar cualquier procedimiento del estudio;
- Sin terapia médica (aparte de MDI prn (inhaladores de dosis medida) y sin cambios en los suplementos, si corresponde)
- Puntaje IIEF mayor o igual a 22
- El sujeto habrá tenido sexo pene-vaginal dentro de las 4 semanas posteriores a la inscripción. La puntuación del IIEF utilizada se valida en función de esta ventana de tiempo.
- Hombre de 18 a 29 años
- Vive a poca distancia del sistema de salud de Montefiore
- La pareja del sujeto (si corresponde) acepta apoyar al sujeto durante el estudio
- El sujeto acepta fotografiar y compartir todos los artículos consumidos/bebidos durante la intervención dietética
- El sujeto acepta evitar todas las drogas ilícitas, AINE y alcohol durante al menos dos días antes de la grabación con Rigiscan™ y en los días y noches de la grabación con Rigiscan™
- El sujeto acepta abstenerse de actividad sexual durante al menos 36 horas antes de la colocación de Rigiscan™ y no tener actividad sexual en los días y noches de grabación de Rigiscan™.
- El sujeto acepta no ver, leer o consumir material erótico o pornográfico durante al menos 36 horas antes de los días y noches de grabación Rigiscan™ y en los días y noches de grabación Rigiscan™
- El sujeto acepta venir a Montefiore para someterse a la formación Rigiscan™
- El sujeto acepta consumir/beber únicamente alimentos/bebidas permitidas.
- El sujeto acepta asistir a todas las visitas en persona en Montefiore, comenzar a ayunar a las 11 p. m. la noche anterior a cada visita y someterse a todas las extracciones de sangre, saliva u otras pruebas.
- El sujeto acepta no usar enjuagues bucales o enjuagues bucales ni escupir intencionalmente durante toda la duración del estudio. Se les pedirá a los sujetos que se abstengan de usar enjuague bucal durante al menos 2 días antes de la inscripción. El sujeto acepta no cepillarse los dientes en la mañana del día de cada visita de estudio. De lo contrario, se permite el cepillado de dientes.
- IMC menor a 30, IMC mayor o igual a 18.5, peso mayor a 110 lbs.
- El sujeto acepta cumplir con los procedimientos y visitas del estudio.
- Ejercicios de sujetos durante al menos 15 minutos al menos dos veces por semana. El sujeto acepta evitar el ejercicio el día anterior y el día de las mediciones Rigiscan™
Criterio de exclusión:
- Alergia dietética relevante
- Patrón dietético vegetariano o vegano
- Antecedentes de un trastorno alimentario; evidencia de adicción a la comida
- Hipertensión o antecedentes de hipertensión con o sin tratamiento médico
- IMC mayor o igual a 30, IMC menor a 18.5 o peso menor o igual a 110 libras
- Enfermedad médica crónica conocida distinta de la enfermedad musculoesquelética no inflamatoria y el asma
- Antecedentes de enfermedad renal o hiperpotasemia
- El sujeto ha recibido un fármaco en investigación dentro de los 30 días anteriores a la firma del consentimiento
- Disfunción eréctil
- Tiene cualquier condición (p. ej., enfermedad psiquiátrica) o situación que, en opinión del investigador, pueda confundir los resultados del estudio o pueda interferir significativamente con la capacidad del paciente para cumplir con los procedimientos del estudio.
- Actualmente en tratamiento para la enfermedad de Peyronie
- Nivel anormal de testosterona o hormona estimulante de la tiroides
- Hipogonadismo o hipotiroidismo tratados
- Viajes planificados durante el estudio.
- Historial de abuso de sustancias en los últimos 12 meses
- Uso de drogas ilícitas, fumar o vapear dentro de las 4 semanas
- Enfermedad de las vías respiratorias superiores dentro de las dos semanas posteriores a la detección
- Si la profesión requiere estar de guardia, no debe pasar la noche o estar de guardia durante el estudio.
- Cualquier enfermedad transmisible de la piel o venérea. El sujeto informa sarpullido o lesiones en el pene o el área circundante. Se le preguntará al sujeto: "¿Tiene un sarpullido o una lesión en el pene o en el área circundante?"
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Prevención
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación cruzada
- Enmascaramiento: Único
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
|---|---|
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Comparador activo: Brazo a base de plantas
El brazo basado en plantas consta de 3 visitas al centro de investigación clínica, siguiendo una dieta basada en plantas y utilizando el dispositivo Rigiscan™ para medir la frecuencia, la rigidez y la duración de las erecciones nocturnas.
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Los alimentos serán proporcionados por Montefiore-Einstein Food Services
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Comparador activo: Brazo basado en animales
El grupo basado en animales consta de 3 visitas al centro de investigación clínica, siguiendo una dieta basada en animales y utilizando el dispositivo Rigiscan™ para medir la frecuencia, la rigidez y la duración de las erecciones nocturnas.
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Los alimentos serán proporcionados por Montefiore-Einstein Food Services
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals.
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
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Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Percent of time ≥60% erect during overnight Rigiscan™ use after 1 meal.
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
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During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
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Percent of time ≥60% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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Otras medidas de resultado
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Heart rate
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing heart rate by dietary pattern at both time points (after overnight Rigiscan™ use after consuming the 1 meal and after overnight Rigiscan™ use after consuming the 4 meals) and compared to its respective baseline in beats/minute.
Definition: In regard to the following anthropometric, vital sign, and laboratory data (blood, urine, and saliva) pre-specified outcomes included in this pre-specified outcomes section, at "both time points" is defined as in the sentence above and "respective baseline" refers to either visit 2 or visit 5, as visit 2 is the baseline for one dietary arm (plant or animal) and visit 5 is the baseline for the other dietary arm (plant or animal).
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Blood Pressure
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing blood pressure by dietary pattern at both time points and compared to its respective baseline in mmHg
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Weight
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing weight by dietary pattern at both time points and compared to its respective baseline
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Fibrinogen
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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D-dimer
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Total cholesterol
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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HDL cholesterol
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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HDL efflux capacity
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline.
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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LDL cholesterol
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Triglyceride
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Oxidized LDL cholesterol
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in U/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Free Fatty Acids
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Myeloperoxidase
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ug/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Factor VII
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in percentage.
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
lysolecithin
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Apolipoprotein B
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Omega 3 index
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in percentage of erythrocyte fatty acid
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Lipoprotein-associated phospholipase-A2 (Lp PLA2) activity
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/min/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Lipoprotein (a)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Homocysteine
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
methylmalonic acid (MMA)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Asymmetric Dimethylarginine (ADMA)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
symmetric dimethylarginine (SDMA)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Total testosterone
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Sex Hormone Binding Globulin
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
cystatin C
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
remnant cholesterol particles
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
uric acid
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
interleukin 1
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in pg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
interleukin 6
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in pg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
hsCRP
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Blood Urea Nitrogen (BUN)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Carbon Dioxide (CO2)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
creatinine
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
glucose
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum chloride
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum potassium
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum sodium
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
alanine aminotransferase (ALT)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in units/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
aspartate aminotransferase (AST)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in units/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
estimated glomerular filtration rate (eGFR)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mL/min/1.73m2
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
vitamin c
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
reduced glutathione
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
superoxide dismutase
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
vitamin e
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
selenium
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
malondialdehyde
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
non coding RNA
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
micro RNA
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Lnc RNA
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
trimethylamine-N-oxide (TMAO)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
phenylacetylglutamine (PAG)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in uM (micrometers)
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing urine albumin-to-creatinine ratio (UACR)
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/g
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Comparing salivary nitrite level as a correlate of plasma nitric oxide (NO) level
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing salivary nitrate level in as a correlate of plasma nitric oxide (NO) level
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Platelets
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in cells/ul.
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
FIB-4 Index
Periodo de tiempo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
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Percent of time ≥50% erect during overnight Rigiscan™ use after the 4 meals.
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 1 meal.
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use)
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use)
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals.
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 1 meal.
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥70% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Periodo de tiempo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Colaboradores
Investigadores
- Investigador principal: Robert Ostfeld, MD, Montefiore Medical Center
Publicaciones y enlaces útiles
La persona responsable de ingresar información sobre el estudio proporciona voluntariamente estas publicaciones. Estos pueden ser sobre cualquier cosa relacionada con el estudio.
Publicaciones Generales
- Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994 Jan;151(1):54-61. doi: 10.1016/s0022-5347(17)34871-1.
- Chung F, Abdullah HR, Liao P. STOP-Bang Questionnaire: A Practical Approach to Screen for Obstructive Sleep Apnea. Chest. 2016 Mar;149(3):631-8. doi: 10.1378/chest.15-0903. Epub 2016 Jan 12.
- Gupta BP, Murad MH, Clifton MM, Prokop L, Nehra A, Kopecky SL. The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2011 Nov 14;171(20):1797-803. doi: 10.1001/archinternmed.2011.440. Epub 2011 Sep 12.
- Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, Coltman CA. Erectile dysfunction and subsequent cardiovascular disease. JAMA. 2005 Dec 21;294(23):2996-3002. doi: 10.1001/jama.294.23.2996.
- Vogel RA, Corretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol. 1997 Feb 1;79(3):350-4. doi: 10.1016/s0002-9149(96)00760-6.
- Nehra A. Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions. Mayo Clin Proc. 2009 Feb;84(2):139-48. doi: 10.4065/84.2.139.
- Ong PJ, Dean TS, Hayward CS, Della Monica PL, Sanders TA, Collins P. Effect of fat and carbohydrate consumption on endothelial function. Lancet. 1999 Dec 18-25;354(9196):2134. doi: 10.1016/s0140-6736(99)03374-7.
- Esposito K, Nappo F, Giugliano F, Giugliano G, Marfella R, Giugliano D. Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects. Am J Clin Nutr. 2003 Jan;77(1):139-43. doi: 10.1093/ajcn/77.1.139.
- Shimabukuro M, Chinen I, Higa N, Takasu N, Yamakawa K, Ueda S. Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study. Am J Clin Nutr. 2007 Oct;86(4):923-8. doi: 10.1093/ajcn/86.4.923.
- Sakakibara S, Murakami R, Takahashi M, Fushimi T, Murohara T, Kishi M, Kajimoto Y, Kitakaze M, Kaga T. Vinegar intake enhances flow-mediated vasodilatation via upregulation of endothelial nitric oxide synthase activity. Biosci Biotechnol Biochem. 2010;74(5):1055-61. doi: 10.1271/bbb.90953. Epub 2010 May 7.
- Esposito K, Ciotola M, Giugliano F, De Sio M, Giugliano G, D'armiento M, Giugliano D. Mediterranean diet improves erectile function in subjects with the metabolic syndrome. Int J Impot Res. 2006 Jul-Aug;18(4):405-10. doi: 10.1038/sj.ijir.3901447. Epub 2006 Jan 5.
- Wing RR, Rosen RC, Fava JL, Bahnson J, Brancati F, Gendrano Iii IN, Kitabchi A, Schneider SH, Wadden TA. Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial. J Sex Med. 2010 Jan;7(1 Pt 1):156-65. doi: 10.1111/j.1743-6109.2009.01458.x. Epub 2009 Aug 17.
- Cassidy A, Franz M, Rimm EB. Dietary flavonoid intake and incidence of erectile dysfunction. Am J Clin Nutr. 2016 Feb;103(2):534-41. doi: 10.3945/ajcn.115.122010. Epub 2016 Jan 13.
- Yaman O, Tokath Z, Inal T, Anafarta K. Effect of sildenafil on nocturnal erections of potent men. Int J Impot Res. 2003 Apr;15(2):117-21. doi: 10.1038/sj.ijir.3900978.
- Corbin JD, Francis SH. Cyclic GMP phosphodiesterase-5: target of sildenafil. J Biol Chem. 1999 May 14;274(20):13729-32. doi: 10.1074/jbc.274.20.13729. No abstract available.
- Greenstein A, Chen J, Salonia A, Sofer M, Matzkin H, Montorsi F. Does sildenafil enhance quality of nocturnal erections in healthy young men? A NPT-RigiScan study. J Sex Med. 2004 Nov;1(3):314-7. doi: 10.1111/j.1743-6109.04045.x.
- Burris AS, Banks SM, Sherins RJ. Quantitative assessment of nocturnal penile tumescence and rigidity in normal men using a home monitor. J Androl. 1989 Nov-Dec;10(6):492-7. doi: 10.1002/j.1939-4640.1989.tb00148.x.
Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio (Actual)
30 de octubre de 2023
Finalización primaria (Estimado)
1 de diciembre de 2026
Finalización del estudio (Estimado)
1 de diciembre de 2026
Fechas de registro del estudio
Enviado por primera vez
27 de marzo de 2020
Primero enviado que cumplió con los criterios de control de calidad
15 de abril de 2020
Publicado por primera vez (Actual)
16 de abril de 2020
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
24 de julio de 2026
Última actualización enviada que cumplió con los criterios de control de calidad
22 de julio de 2026
Última verificación
1 de julio de 2026
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
- Enfermedades urogenitales
- Enfermedades Genitales
- Desordenes mentales
- Enfermedades Genitales Masculinas
- Enfermedades urogenitales masculinas
- Disfunción Sexual Fisiológica
- Disfunciones Sexuales Psicológicas
- Disfuncion erectil
- Terapéutica
- Dieta, alimentos y nutrición
- Fenómeno fisiológico
- Fenómenos fisiológicos nutricionales
- Terapia de dieta
- Terapia nutricional
- Dieta
- Dieta, a base de plantas
Otros números de identificación del estudio
- 2019-10465
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
NO
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
No
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
No
Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .