O impacto do padrão alimentar na função erétil (ERECTION)
22 de julho de 2026 atualizado por: Montefiore Medical Center
O impacto de uma dieta baseada em vegetais versus uma dieta baseada em animais na função erétil em homens saudáveis com função erétil normal: o estudo ERECTION
O objetivo deste estudo é determinar se a função erétil é afetada por padrões alimentares em homens saudáveis com função erétil normal.
Visão geral do estudo
Status
Recrutamento
Condições
Intervenção / Tratamento
Descrição detalhada
Visita 1:
Depois de revisar e assinar o consentimento, os indivíduos serão triados. A triagem consistirá em:
Complete o IIEF (Índice Internacional de Função Erétil) e um questionário de frequência alimentar.
Registrar histórico médico, medicamentos Medir altura e peso Vitais Coletar sangue para testosterona total, globulina de retenção de hormônio sexual e TSH (hormônio estimulante da tireoide) Os indivíduos serão questionados sobre a presença de erupções ou lesões genitais
Se a pontuação do IIEF for anormal, os indivíduos serão aconselhados a entrar em contato com o PCP (prestador de cuidados primários).
Os indivíduos serão contatados com os resultados dos testes de laboratório. Se anormal, o sujeito será aconselhado a entrar em contato com o PCP.
Se o sujeito não tiver PCP, serão fornecidas as informações de contato de um PCP. Os indivíduos que atendem aos critérios de inclusão e exclusão serão randomizados na sequência um ou na sequência dois. Uma vez inscritos, os indivíduos não modificarão os hábitos alimentares durante a duração do estudo, exceto durante as duas noites e dois dias completos em que a comida é fornecida (ver abaixo).
Sequência Um:
Visita 2:
Os indivíduos retornam ao centro de estudos pela manhã após terem jejuado (além de consumir água) desde as 23h da noite anterior. Os sujeitos não irão escovar os dentes ou usar enxaguatório bucal e/ou outros purificadores de hálito naquela manhã. Serão feitos registros antropomórficos, de pressão arterial e de frequência cardíaca. O sangue será coletado e armazenado. A urina será coletada e armazenada. Os participantes aprenderão como usar o dispositivo Rigiscan™. Os indivíduos receberão um jantar à base de plantas. Os indivíduos então deixarão o centro de estudos e consumirão a dieta habitual até as 17h. No resto da noite, até às 23h, os sujeitos consumirão apenas o jantar fornecido. A água será a única bebida permitida após as 17h. O jantar deve ser consumido às 20h30, EST (horário padrão do leste). Os sujeitos enviarão imagens de texto de tudo o que é consumido (comer ou beber) depois das 17h para o PI ou para um representante do estudo. Um membro da equipe do estudo terá texto ou contato verbal com o sujeito pelo menos uma vez naquela noite. Os indivíduos irão jejuar além da água depois das 23h. Naquela noite, os participantes farão uma avaliação Rigiscan™ durante a noite em casa. A hora em que o sujeito vai para a cama e a hora em que o sujeito acorda durante o dia deve ser registrada. O sujeito concorda em ficar na cama com o Rigiscan™ ativado (exceto para emergências ou idas necessárias ao banheiro) por pelo menos sete horas.
Visita 3:
Os participantes retornam ao centro de estudos na manhã seguinte à avaliação do Rigiscan™ e trazem o dispositivo Rigiscan™. Os indivíduos estarão em jejum, exceto água potável, desde as 23h da noite anterior. Os indivíduos não irão escovar os dentes ou usar enxaguatório bucal e/ou outros purificadores de hálito naquela manhã. Serão feitos registros antropomórficos, de pressão arterial e de frequência cardíaca. O sangue será coletado e armazenado. A urina será coletada e armazenada. Os indivíduos receberão um dia inteiro de refeições à base de plantas. Os indivíduos serão encorajados a tomar café da manhã no centro de estudo depois que as medidas antropomórficas iniciais forem feitas, o sangue for coletado e a urina coletada. Os sujeitos enviarão imagens de texto de tudo o que é consumido durante aquele dia para o PI e/ou para um representante do estudo e um membro da equipe do estudo terá texto ou contato verbal com o sujeito pelo menos duas vezes durante aquele dia. O jantar deve ser consumido às 20h30, EST. Os indivíduos irão jejuar além da água depois das 23h. Naquela noite, os participantes farão uma avaliação Rigiscan™ durante a noite em casa. Café preto e/ou chá são permitidos somente antes do meio-dia. A hora em que o sujeito vai para a cama e a hora em que o sujeito acorda durante o dia deve ser registrada. O sujeito concorda em ficar na cama com o Rigiscan™ ativado (exceto para emergências ou idas necessárias ao banheiro) por pelo menos sete horas.
Visita 4:
Os participantes retornam ao centro de estudos na manhã seguinte à avaliação do Rigiscan™ e trazem o dispositivo Rigiscan™. Os indivíduos não irão escovar os dentes ou usar enxaguatório bucal e/ou outros purificadores de hálito naquela manhã. Serão feitos registros antropomórficos, de pressão arterial e de frequência cardíaca. O sangue será coletado e armazenado. A urina será coletada e armazenada. Haverá então um período de washout de 8 a 12 dias e os indivíduos serão instruídos a retornar aos hábitos alimentares habituais durante esse período de washout.
Visita 5:
Após o período de washout, os indivíduos retornam ao centro de estudo pela manhã após terem jejuado (além de consumir água) desde as 23h da noite anterior. Os indivíduos não irão escovar os dentes ou usar enxaguatório bucal e/ou outros purificadores de hálito naquela manhã. Serão feitos registros antropomórficos, de pressão arterial e de frequência cardíaca. O sangue será coletado e armazenado. A urina será coletada e armazenada. Os indivíduos receberão um jantar à base de animal. Os indivíduos então deixarão o centro de estudos e consumirão a dieta habitual até as 17h. No resto da noite, até às 23h, os sujeitos consumirão apenas o jantar fornecido. A água será a única bebida consumida após as 17h. O jantar deve ser consumido às 20h30, EST. Os sujeitos enviarão imagens de texto de tudo o que é consumido (comer ou beber) depois das 17h para o PI ou para um representante do estudo e um membro da equipe do estudo terá texto ou contato verbal com o sujeito pelo menos uma vez naquela noite. Os indivíduos irão jejuar além da água depois das 23h. Naquela noite, os participantes farão uma avaliação Rigiscan™ durante a noite em casa. A hora em que o sujeito vai para a cama e a hora em que o sujeito acorda durante o dia deve ser registrada. O sujeito concorda em ficar na cama com o Rigiscan™ ativado (exceto para emergências ou idas necessárias ao banheiro) por pelo menos sete horas.
Visita 6:
Os participantes retornam ao centro de estudos na manhã seguinte à avaliação do Rigiscan™ e trazem o dispositivo Rigiscan™. Os indivíduos não irão escovar os dentes ou usar enxaguatório bucal e/ou outros purificadores de hálito naquela manhã. Serão feitos registros antropomórficos, de pressão arterial e EndoPAT™. A saliva será armazenada. O sangue será coletado e armazenado. Os indivíduos receberão um dia inteiro de refeições à base de animais. Os indivíduos serão encorajados a tomar café da manhã no centro de estudo após as medidas antropomórficas iniciais serem feitas, a saliva ser coletada e o sangue coletado. Os sujeitos enviarão imagens de texto de tudo o que é consumido durante aquele dia para o PI e/ou para um representante do estudo e a equipe do estudo terá texto ou contato verbal com o sujeito pelo menos duas vezes durante aquele dia. O jantar deve ser consumido às 20h30, EST. Os indivíduos irão jejuar além da água depois das 23h. Naquela noite, os participantes farão uma avaliação Rigiscan™ durante a noite em casa. Café preto e/ou chá são permitidos somente antes do meio-dia. A hora em que o sujeito vai para a cama e a hora em que o sujeito acorda durante o dia deve ser registrada. O sujeito concorda em ficar na cama com o Rigiscan™ ativado (exceto para emergências ou idas necessárias ao banheiro) por pelo menos sete horas.
Visita 7 (fim do estudo):
Os participantes retornam ao centro de estudos na manhã seguinte à avaliação do Rigiscan™ e trazem o dispositivo Rigiscan™. Os indivíduos não irão escovar os dentes ou usar enxaguatório bucal e/ou outros purificadores de hálito naquela manhã. Serão feitos registros antropomórficos, de pressão arterial e de frequência cardíaca. O sangue será coletado e armazenado. A urina será coletada e armazenada.
Sequência Dois:
A Sequência Dois é idêntica à Sequência Um, exceto que são fornecidas refeições de origem animal em vez de refeições de origem vegetal. Para indivíduos randomizados para refeições à base de animais na Sequência Um e na Sequência Dois, serão idênticos, exceto que refeições à base de plantas serão fornecidas em vez de refeições à base de animais.
Tipo de estudo
Intervencional
Inscrição (Estimado)
46
Estágio
- Não aplicável
Contactos e Locais
Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.
Contato de estudo
- Nome: Robert Ostfeld, MD
- Número de telefone: 718-920-5197
- E-mail: ROSTFELD@montefiore.org
Locais de estudo
-
-
New York
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The Bronx, New York, Estados Unidos, 10467
- Recrutamento
- Montefiore Medical Center, Department of Medicine, Division of Cardiology
-
Contato:
- Robert J Ostfeld, MD, MS
- Número de telefone: 718-920-8011
- E-mail: rostfeld@montefiore.org
-
-
Critérios de participação
Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.
Critérios de elegibilidade
Idades elegíveis para estudo
14 anos a 25 anos (Adulto)
Aceita Voluntários Saudáveis
Sim
Descrição
Critério de inclusão:
- O sujeito fornece consentimento informado por escrito e autorização da HIPAA em inglês antes da realização de qualquer procedimento do estudo;
- Nenhuma terapia médica (exceto prn MDIs (inaladores de dose medida) e nenhuma alteração nos suplementos, se aplicável)
- Pontuação IIEF maior ou igual a 22
- O sujeito terá feito sexo peniano-vaginal dentro de 4 semanas após a inscrição. A pontuação do IIEF utilizada é validada com base nessa janela de tempo.
- Homem de 18 a 29 anos
- Mora perto do Montefiore Health System
- O outro significativo do sujeito (se aplicável) concorda em apoiar o sujeito durante o estudo
- O sujeito concorda em fotografar e compartilhar todos os itens consumidos/bebidos durante a intervenção dietética
- O sujeito concorda em evitar todas as drogas ilícitas, AINEs e álcool por pelo menos dois dias antes da gravação do Rigiscan™ e nos dias e noites da gravação do Rigiscan™
- O sujeito concorda em abster-se de atividade sexual por pelo menos 36 horas antes da colocação do Rigiscan™ e não ter atividade sexual nos dias e noites de gravação do Rigiscan™.
- O sujeito concorda em não ver, ler ou de outra forma consumir material erótico ou pornográfico por pelo menos 36 horas antes dos dias e noites da gravação do Rigiscan™ e nos dias e noites da gravação do Rigiscan™
- O sujeito concorda em vir para Montefiore para se submeter ao treinamento Rigiscan™
- O sujeito concorda em consumir/beber apenas alimentos/bebidas permitidos.
- O sujeito concorda em comparecer a todas as visitas pessoais em Montefiore, em começar o jejum às 23h da noite anterior a cada visita e em fazer todas as coletas de sangue/salivar/outros testes.
- O sujeito concorda em não usar enxaguatório bucal ou enxaguatório bucal ou cuspir intencionalmente durante toda a duração do estudo. Os indivíduos serão solicitados a abster-se de usar enxaguatório bucal por pelo menos 2 dias antes da inscrição. O sujeito concorda em não escovar os dentes na manhã do dia de cada visita do estudo. A escovação dos dentes é permitida de outra forma.
- IMC menor que 30, IMC maior ou igual a 18,5, peso maior que 110 libras.
- O sujeito concorda em cumprir os procedimentos e visitas do estudo.
- Exercícios do sujeito por pelo menos 15 minutos pelo menos duas vezes por semana. O sujeito concorda em evitar exercícios no dia anterior e no dia das medições do Rigiscan™
Critério de exclusão:
- Alergia dietética relevante
- Padrão alimentar vegetariano ou vegano
- História de um distúrbio alimentar; evidência de vício em comida
- Hipertensão e/ou história de hipertensão com ou sem tratamento médico
- IMC maior ou igual a 30, IMC menor que 18,5 ou peso menor ou igual a 110 libras
- Doença médica crônica conhecida, exceto doença musculoesquelética não inflamatória e asma
- História de doença renal ou hipercalemia
- O sujeito recebeu um medicamento experimental dentro de 30 dias antes de assinar o consentimento
- Disfunção erétil
- Tem qualquer condição (por exemplo, doença psiquiátrica) ou situação que, na opinião do investigador, possa confundir os resultados do estudo ou interferir significativamente na capacidade do paciente de aderir aos procedimentos do estudo
- Atualmente em tratamento para a doença de Peyronie
- Nível anormal de testosterona ou hormônio estimulante da tireoide
- Hipogonadismo ou hipotireoidismo tratado
- Viagem planejada durante o estudo
- Histórico de abuso de substâncias nos últimos 12 meses
- Uso de drogas ilícitas, tabagismo ou vaping dentro de 4 semanas
- Doença respiratória superior dentro de duas semanas na triagem
- Se a profissão exigir estar de plantão, sem pernoite ou plantões durante o estudo
- Qualquer doença cutânea ou venérea transmissível. O sujeito relata erupções cutâneas ou lesões no pênis ou na área circundante. Será perguntado ao sujeito: "você tem uma erupção cutânea ou lesão no pênis ou na área circundante?"
Plano de estudo
Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Prevenção
- Alocação: Randomizado
- Modelo Intervencional: Atribuição cruzada
- Mascaramento: Solteiro
Armas e Intervenções
Grupo de Participantes / Braço |
Intervenção / Tratamento |
|---|---|
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Comparador Ativo: Braço à base de plantas
O braço à base de plantas consiste em 3 visitas ao centro de pesquisa clínica, seguindo uma dieta à base de plantas e usando o dispositivo Rigiscan™ para medir a frequência, rigidez e duração das ereções noturnas.
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A alimentação será fornecida pela Montefiore-Einstein Food Services
|
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Comparador Ativo: Braço de origem animal
O braço baseado em animais consiste em 3 visitas ao centro de pesquisa clínica, seguindo uma dieta baseada em animais e usando o dispositivo Rigiscan™ para medir a frequência, rigidez e duração das ereções noturnas.
|
A alimentação será fornecida pela Montefiore-Einstein Food Services
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O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals.
Prazo: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
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The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
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Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Percent of time ≥60% erect during overnight Rigiscan™ use after 1 meal.
Prazo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
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During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
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Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Prazo: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
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During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
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Percent of time ≥60% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Prazo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
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Outras medidas de resultado
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Heart rate
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing heart rate by dietary pattern at both time points (after overnight Rigiscan™ use after consuming the 1 meal and after overnight Rigiscan™ use after consuming the 4 meals) and compared to its respective baseline in beats/minute.
Definition: In regard to the following anthropometric, vital sign, and laboratory data (blood, urine, and saliva) pre-specified outcomes included in this pre-specified outcomes section, at "both time points" is defined as in the sentence above and "respective baseline" refers to either visit 2 or visit 5, as visit 2 is the baseline for one dietary arm (plant or animal) and visit 5 is the baseline for the other dietary arm (plant or animal).
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Blood Pressure
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing blood pressure by dietary pattern at both time points and compared to its respective baseline in mmHg
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Weight
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing weight by dietary pattern at both time points and compared to its respective baseline
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Fibrinogen
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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D-dimer
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Total cholesterol
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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HDL cholesterol
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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HDL efflux capacity
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline.
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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LDL cholesterol
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
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Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Triglyceride
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Oxidized LDL cholesterol
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in U/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Free Fatty Acids
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Myeloperoxidase
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ug/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Factor VII
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in percentage.
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
lysolecithin
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Apolipoprotein B
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Omega 3 index
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in percentage of erythrocyte fatty acid
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Lipoprotein-associated phospholipase-A2 (Lp PLA2) activity
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/min/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
Lipoprotein (a)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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Homocysteine
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
methylmalonic acid (MMA)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Asymmetric Dimethylarginine (ADMA)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
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|
symmetric dimethylarginine (SDMA)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Total testosterone
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Sex Hormone Binding Globulin
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in nmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
cystatin C
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
remnant cholesterol particles
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
uric acid
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
interleukin 1
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in pg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
interleukin 6
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in pg/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
hsCRP
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Blood Urea Nitrogen (BUN)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Carbon Dioxide (CO2)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mmol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
creatinine
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
glucose
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum chloride
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum potassium
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
serum sodium
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in meq/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
alanine aminotransferase (ALT)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in units/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
aspartate aminotransferase (AST)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in units/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
estimated glomerular filtration rate (eGFR)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mL/min/1.73m2
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
vitamin c
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/dL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
reduced glutathione
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
superoxide dismutase
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
vitamin e
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
selenium
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in ng/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
malondialdehyde
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
non coding RNA
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
micro RNA
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Lnc RNA
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in copies/mL
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
trimethylamine-N-oxide (TMAO)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in umol/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
phenylacetylglutamine (PAG)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in uM (micrometers)
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing urine albumin-to-creatinine ratio (UACR)
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in mg/g
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing salivary nitrite level as a correlate of plasma nitric oxide (NO) level
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Comparing salivary nitrate level in as a correlate of plasma nitric oxide (NO) level
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in micromoles/L
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Platelets
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline in cells/ul.
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
FIB-4 Index
Prazo: Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
Comparing it at both time points by dietary pattern and compared to its respective baseline
|
Time zero (Visit 2), at ~24 hours after time zero (Visit 3), at ~48 hours after time zero (Visit 4), after 8-12 day washout (Visit 5), at ~24 hours after 8-12 day washout (Visit 6), at ~48 hours after 8-12 day washout (Visit 7)
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after the 4 meals.
Prazo: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 1 meal.
Prazo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use)
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use)
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals.
Prazo: During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming the 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 1 meal.
Prazo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Prazo: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥60% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Prazo: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 60% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 4 meals versus after 1 meal by dietary pattern.
Prazo: During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming the 4 meals versus overnight Rigiscan™ use directly after consuming the 1 meal by dietary pattern, for each dietary pattern.
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Prazo: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 70% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥70% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Prazo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥70% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 4 meals, where each erection lasts >=5 minutes as measured by Rigiscan™
Prazo: During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 4 meals. (The second night of Rigiscan™ use).
|
|
Percent of time ≥50% erect during overnight Rigiscan™ use after 1 meal, where each erection lasts >=5 minutes as measured by Rigiscan™
Prazo: During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
The first 5 minutes of Rigiscan™ recording is discarded.
Erection time is the total time (in minutes) when penile rigidity is ≥ 50% at both the tip and the base of the penis with a concurrent increase in penile tumescence at both the tip and base of the penis compared to baseline tumescence, and the erection lasts >= 5 minutes, as measured by Rigiscan™ during overnight Rigiscan™ use, divided by the total time (in minutes) of overnight Rigiscan™ use.
Overnight Rigiscan™ use time is defined as starting 5 minutes after the start of the Rigiscan™ recording and the end of Rigiscan™ use is defined as the last time the tip or base was >=10% rigid with a corresponding concurrent increase in penile tumescence at the tip or base compared to baseline tumesence.
This total time window from start to end is the Rigiscan™ use time.
|
During overnight Rigiscan™ use directly after consuming 1 meal. (The first night of Rigiscan™ use).
|
Colaboradores e Investigadores
É aqui que você encontrará pessoas e organizações envolvidas com este estudo.
Patrocinador
Colaboradores
Investigadores
- Investigador principal: Robert Ostfeld, MD, Montefiore Medical Center
Publicações e links úteis
A pessoa responsável por inserir informações sobre o estudo fornece voluntariamente essas publicações. Estes podem ser sobre qualquer coisa relacionada ao estudo.
Publicações Gerais
- Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994 Jan;151(1):54-61. doi: 10.1016/s0022-5347(17)34871-1.
- Chung F, Abdullah HR, Liao P. STOP-Bang Questionnaire: A Practical Approach to Screen for Obstructive Sleep Apnea. Chest. 2016 Mar;149(3):631-8. doi: 10.1378/chest.15-0903. Epub 2016 Jan 12.
- Gupta BP, Murad MH, Clifton MM, Prokop L, Nehra A, Kopecky SL. The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2011 Nov 14;171(20):1797-803. doi: 10.1001/archinternmed.2011.440. Epub 2011 Sep 12.
- Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, Coltman CA. Erectile dysfunction and subsequent cardiovascular disease. JAMA. 2005 Dec 21;294(23):2996-3002. doi: 10.1001/jama.294.23.2996.
- Vogel RA, Corretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol. 1997 Feb 1;79(3):350-4. doi: 10.1016/s0002-9149(96)00760-6.
- Nehra A. Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions. Mayo Clin Proc. 2009 Feb;84(2):139-48. doi: 10.4065/84.2.139.
- Ong PJ, Dean TS, Hayward CS, Della Monica PL, Sanders TA, Collins P. Effect of fat and carbohydrate consumption on endothelial function. Lancet. 1999 Dec 18-25;354(9196):2134. doi: 10.1016/s0140-6736(99)03374-7.
- Esposito K, Nappo F, Giugliano F, Giugliano G, Marfella R, Giugliano D. Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects. Am J Clin Nutr. 2003 Jan;77(1):139-43. doi: 10.1093/ajcn/77.1.139.
- Shimabukuro M, Chinen I, Higa N, Takasu N, Yamakawa K, Ueda S. Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study. Am J Clin Nutr. 2007 Oct;86(4):923-8. doi: 10.1093/ajcn/86.4.923.
- Sakakibara S, Murakami R, Takahashi M, Fushimi T, Murohara T, Kishi M, Kajimoto Y, Kitakaze M, Kaga T. Vinegar intake enhances flow-mediated vasodilatation via upregulation of endothelial nitric oxide synthase activity. Biosci Biotechnol Biochem. 2010;74(5):1055-61. doi: 10.1271/bbb.90953. Epub 2010 May 7.
- Esposito K, Ciotola M, Giugliano F, De Sio M, Giugliano G, D'armiento M, Giugliano D. Mediterranean diet improves erectile function in subjects with the metabolic syndrome. Int J Impot Res. 2006 Jul-Aug;18(4):405-10. doi: 10.1038/sj.ijir.3901447. Epub 2006 Jan 5.
- Wing RR, Rosen RC, Fava JL, Bahnson J, Brancati F, Gendrano Iii IN, Kitabchi A, Schneider SH, Wadden TA. Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial. J Sex Med. 2010 Jan;7(1 Pt 1):156-65. doi: 10.1111/j.1743-6109.2009.01458.x. Epub 2009 Aug 17.
- Cassidy A, Franz M, Rimm EB. Dietary flavonoid intake and incidence of erectile dysfunction. Am J Clin Nutr. 2016 Feb;103(2):534-41. doi: 10.3945/ajcn.115.122010. Epub 2016 Jan 13.
- Yaman O, Tokath Z, Inal T, Anafarta K. Effect of sildenafil on nocturnal erections of potent men. Int J Impot Res. 2003 Apr;15(2):117-21. doi: 10.1038/sj.ijir.3900978.
- Corbin JD, Francis SH. Cyclic GMP phosphodiesterase-5: target of sildenafil. J Biol Chem. 1999 May 14;274(20):13729-32. doi: 10.1074/jbc.274.20.13729. No abstract available.
- Greenstein A, Chen J, Salonia A, Sofer M, Matzkin H, Montorsi F. Does sildenafil enhance quality of nocturnal erections in healthy young men? A NPT-RigiScan study. J Sex Med. 2004 Nov;1(3):314-7. doi: 10.1111/j.1743-6109.04045.x.
- Burris AS, Banks SM, Sherins RJ. Quantitative assessment of nocturnal penile tumescence and rigidity in normal men using a home monitor. J Androl. 1989 Nov-Dec;10(6):492-7. doi: 10.1002/j.1939-4640.1989.tb00148.x.
Datas de registro do estudo
Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.
Datas Principais do Estudo
Início do estudo (Real)
30 de outubro de 2023
Conclusão Primária (Estimado)
1 de dezembro de 2026
Conclusão do estudo (Estimado)
1 de dezembro de 2026
Datas de inscrição no estudo
Enviado pela primeira vez
27 de março de 2020
Enviado pela primeira vez que atendeu aos critérios de CQ
15 de abril de 2020
Primeira postagem (Real)
16 de abril de 2020
Atualizações de registro de estudo
Última Atualização Postada (Real)
24 de julho de 2026
Última atualização enviada que atendeu aos critérios de controle de qualidade
22 de julho de 2026
Última verificação
1 de julho de 2026
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
- Doenças urogenitais
- Doenças Genitais
- Transtornos Mentais, Desordem Mental
- Doenças Genitais, Masculino
- Doenças Urogenitais Masculinas
- Disfunção Sexual Fisiológica
- Disfunções Sexuais, Psicológicas
- Disfunção erétil
- Terapêutica
- Dieta, comida e nutrição
- Fenômenos fisiológicos
- Fenômenos fisiológicos nutricionais
- Dieta terapia
- Terapia nutricional
- Dieta
- Dieta, baseada em plantas
Outros números de identificação do estudo
- 2019-10465
Plano para dados de participantes individuais (IPD)
Planeja compartilhar dados de participantes individuais (IPD)?
NÃO
Informações sobre medicamentos e dispositivos, documentos de estudo
Estuda um medicamento regulamentado pela FDA dos EUA
Não
Estuda um produto de dispositivo regulamentado pela FDA dos EUA
Não
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .