Research on the Possible Relationship Between Sarcopenia and Oral Muscle Function (GSOM)
A Study on the Correlation Between the Genetic Polymorphisms of Elderly Individuals in the Community and Possible Sarcopenia and Oral Muscle Function
This study will focus on community-dwelling elderly individuals and will follow the community screening process recommended by AWGS.
It is expected to recruit 100 individuals who may have sarcopenia and 300 healthy or sub-healthy elderly individuals who are not likely to have sarcopenia, totaling 400 participants.Basic data such as age and body composition will be collected, as well as dietary records (three days), nutritional status assessments (Mini Nutritional Assessment, MNA), and oral health status records (including records of missing teeth, the number of opposing teeth, and whether participants wear fixed or removable dentures).
Chewing and swallowing abilities will be recorded using the Eating Assessment Tool (EAT-10). In a non-invasive manner, saliva samples will be collected for genomic DNA (gDNA) extraction, followed by quantitative gDNA typing analysis of seven gene loci (shown in Table 3).
Genotype data will be statistically analyzed along with participants' basic information, relevant sarcopenia screening data, and parameters related to oral health and swallowing function. This study adopts a case-control experimental design with the following objectives:
- to explore the incidence of possible sarcopenia in community-dwelling elderly.
- to investigate the relationship between oral function and possible sarcopenia in community-dwelling elderly using tongue pressure measurements.
- to understand the correlation between sarcopenia risk in community-dwelling elderly and seven specific genes.
- to examine the relationship between oral function and seven specific genes in community-dwelling elderly.
- to investigate the relationship between tongue pressure measurements and the values measured using edible chewing gum.
- to establish a standard test for evaluating oral chewing function using edible chewing gum.
By examining the possible mechanisms of the different genes involved in the causes of sarcopenia, we aim to find prevention strategies that are suitable for participants with different gene types.
Descripción general del estudio
Estado
Intervención / Tratamiento
Tipo de estudio
Inscripción (Actual)
Contactos y Ubicaciones
Ubicaciones de estudio
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-
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Taoyuan, Taiwán
- Chang Gung University of Science and Technology
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-
Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
- Adulto
- Adulto Mayor
Acepta Voluntarios Saludables
Método de muestreo
Población de estudio
Descripción
Case group - Inclusion Criteria:
- aged 60 years (inclusive) or older
- general public or residing in an institution for 3 months (inclusive) or more
- willing to participate in the experimental design and sign the consent form
- able to eat independently by mouth
- identified by researchers as possibly having sarcopenia
Control group-Inclusion Criteria:
- aged 60 years (inclusive) or older
- general public or residing in an institution for 3 months (inclusive) or more ●willing to participate in the experimental design and sign the consent form
- able to eat independently by mouth
- identified by researchers as not possibly having sarcopenia
Case group 、Control group- Exclusion Criteria:
- having comorbidities, critical illnesses, undergoing major surgeries, cancer, renal failure, liver failure, kidney diseases, liver diseases, having malignant tumors in the past five years, inflammation symptoms (C-reactive protein >10mg/dl)
- severely malnourished individuals (GNRI < 82)
- long-term tube-fed individuals.
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
Cohortes e Intervenciones
Grupo / Cohorte |
Intervención / Tratamiento |
|---|---|
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Case group
Possible sarcopenia
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NON
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Control group
Non-possible sarcopenia
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NON
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Based on the results of empirical research on sarcopenia in Asian countries, a diagnostic consensus was established.
Periodo de tiempo: baseline
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baseline
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Colaboradores e Investigadores
Patrocinador
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Actual)
Finalización del estudio (Actual)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- 202402045B0
- NMRPF3Q0291 (Otro identificador: Chang Gung University of Science and Technology)
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
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