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Research on the Possible Relationship Between Sarcopenia and Oral Muscle Function (GSOM)

15. juni 2026 opdateret af: Chang Gung University of Science and Technology

A Study on the Correlation Between the Genetic Polymorphisms of Elderly Individuals in the Community and Possible Sarcopenia and Oral Muscle Function

This study will focus on community-dwelling elderly individuals and will follow the community screening process recommended by AWGS.

It is expected to recruit 100 individuals who may have sarcopenia and 300 healthy or sub-healthy elderly individuals who are not likely to have sarcopenia, totaling 400 participants.Basic data such as age and body composition will be collected, as well as dietary records (three days), nutritional status assessments (Mini Nutritional Assessment, MNA), and oral health status records (including records of missing teeth, the number of opposing teeth, and whether participants wear fixed or removable dentures).

Chewing and swallowing abilities will be recorded using the Eating Assessment Tool (EAT-10). In a non-invasive manner, saliva samples will be collected for genomic DNA (gDNA) extraction, followed by quantitative gDNA typing analysis of seven gene loci (shown in Table 3).

Genotype data will be statistically analyzed along with participants' basic information, relevant sarcopenia screening data, and parameters related to oral health and swallowing function. This study adopts a case-control experimental design with the following objectives:

  1. to explore the incidence of possible sarcopenia in community-dwelling elderly.
  2. to investigate the relationship between oral function and possible sarcopenia in community-dwelling elderly using tongue pressure measurements.
  3. to understand the correlation between sarcopenia risk in community-dwelling elderly and seven specific genes.
  4. to examine the relationship between oral function and seven specific genes in community-dwelling elderly.
  5. to investigate the relationship between tongue pressure measurements and the values measured using edible chewing gum.
  6. to establish a standard test for evaluating oral chewing function using edible chewing gum.

By examining the possible mechanisms of the different genes involved in the causes of sarcopenia, we aim to find prevention strategies that are suitable for participants with different gene types.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

251

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Taiwan
      • Taoyuan, Taiwan
        • Chang Gung University of Science and Technology

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ja

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

The research locations are the multimedia classroom on the 5th floor of the Department of Health and Nutrition at Chang Gung University, as well as community care centers in various districts of Taoyuan City and New Taipei City.

Beskrivelse

Case group - Inclusion Criteria:

  • aged 60 years (inclusive) or older
  • general public or residing in an institution for 3 months (inclusive) or more
  • willing to participate in the experimental design and sign the consent form
  • able to eat independently by mouth
  • identified by researchers as possibly having sarcopenia

Control group-Inclusion Criteria:

  • aged 60 years (inclusive) or older
  • general public or residing in an institution for 3 months (inclusive) or more ●willing to participate in the experimental design and sign the consent form
  • able to eat independently by mouth
  • identified by researchers as not possibly having sarcopenia

Case group 、Control group- Exclusion Criteria:

  • having comorbidities, critical illnesses, undergoing major surgeries, cancer, renal failure, liver failure, kidney diseases, liver diseases, having malignant tumors in the past five years, inflammation symptoms (C-reactive protein >10mg/dl)
  • severely malnourished individuals (GNRI < 82)
  • long-term tube-fed individuals.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
Case group
Possible sarcopenia
Andet: Non interventional study
NON
Control group
Non-possible sarcopenia
Andet: Non interventional study
NON

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Based on the results of empirical research on sarcopenia in Asian countries, a diagnostic consensus was established.
Tidsramme: baseline
  • The cut-off point for abnormal grip strength is less than 28 kg for men and less than 18 kg for women
  • 6-meter walking speed less than 1.0 second/meter
  • 5-time chair stand test greater than or equal to 12 seconds
  • Short physical performance battery, SPPB greater than or equal to 9 points The above data will be combined to determine whether sarcopenia is possible
baseline

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Chang Gung University of Science and Technology

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

14. november 2025

Primær færdiggørelse (Faktiske)

4. juni 2026

Studieafslutning (Faktiske)

4. juni 2026

Datoer for studieregistrering

Først indsendt

10. juni 2026

Først indsendt, der opfyldte QC-kriterier

15. juni 2026

Først opslået (Faktiske)

22. juni 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

22. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

15. juni 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 202402045B0
  • NMRPF3Q0291 (Anden identifikator: Chang Gung University of Science and Technology)

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

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Kliniske forsøg med Non interventional study

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Taiwan

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Abonner