Interféron alpha-2B recombinant à haute dose, ipilimumab ou pembrolizumab dans le traitement des patients atteints d'un mélanome à haut risque de stade III-IV qui a été retiré par chirurgie
30 septembre 2026 mis à jour par: National Cancer Institute (NCI)
Un essai randomisé de phase III comparant le choix du médecin/patient entre l'interféron à haute dose ou l'ipilimumab et le MK-3475 (pembrolizumab) chez des patients atteints d'un mélanome réséqué à haut risque
This randomized phase III trial studies how well pembrolizumab works compared with the current standard of care, physician/patient choice of either high-dose recombinant interferon alfa-2B or ipilimumab, in treating patients with stage III-IV melanoma that has been removed by surgery but is likely to come back or spread. High-dose recombinant interferon alfa-2B may help shrink or slow the growth of melanoma. Immunotherapy with monoclonal antibodies, such as ipilimumab and pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether pembrolizumab is more effective than the current standard of care in treating patients with melanoma.
Aperçu de l'étude
Statut
Actif, ne recrute pas
Les conditions
Description détaillée
PRIMARY OBJECTIVES:
I. To compare overall survival (OS) of patients with resected stage III and IV melanoma treated with physician/patient choice of either high dose interferon recombinant interferon alfa-2b (alfa-2b) or ipilimumab versus MK-3475 (pembrolizumab).
II. Among patients who are PD-L1 positive, to compare OS of patients with resected stage III and IV melanoma treated with physician/patient choice of either high dose interferon alfa-2b or ipilimumab versus MK-3475 (pembrolizumab).
III. To compare relapse-free survival (RFS) of patients with resected stage III and IV melanoma treated with physician/patient choice of either high dose interferon alfa-2b or ipilimumab to MK-3475 (pembrolizumab).
SECONDARY OBJECTIVES:
I. To estimate OS and RFS for patients who are PD-L1 negative or PD-L1 indeterminate in this population.
II. To compare OS and RFS of patients between the two arms within PD-L1 positive and negative subgroups and to look at the interaction between PD-L1 (positive versus negative) and treatment arm.
III. To assess the safety and tolerability of the regimens.
ADDITIONAL OBJECTIVES:
I. To bank tissue and whole blood in anticipation of future correlative studies in this patient population.
II. To evaluate PD-L1 expression through immunohistochemistry assay. III. To evaluate the effect of treatment-related side effects that may have an impact on the health-related domains of quality of life (QOL) using the Functional Assessment of Cancer Therapy (FACT)-Biological Response Modifiers (BRM), European Quality of Life Five Dimension Three Level Scale (EQ-5D-3L), and Functional Assessment of Chronic Illness Therapy Diarrhea (FACIT-D) between patients treated with physician/patient choice of either high-dose interferon alfa-2b or ipilimumab and MK-3475 (pembrolizumab).
IV. Pharmacokinetic (PK) and anti-drug antibody (ADA) testing will be performed on all patients receiving MK-3475 (pembrolizumab).
TRANSLATIONAL OBJECTIVES RELATED TO T-CELL RECEPTOR BETA CHAIN SEQUENCING:
I. To evaluate the association between TCR beta variable gene (TRBV) haplotype and grade 3-4 immune-related adverse events (irAEs) among stage III melanoma patients treated with adjuvant ipilimumab or pembrolizumab.
II. To describe the TRBV haplotype distribution among this cohort of patients studied.
TRANSLATIONAL MEDICINAL OBJECTIVE RELATED TO ASSOCIATION OF CIRCULATING TUMOR DNA (ctDNA) WITH RELAPSE-FREE SURVIVAL IN HIGH-RISK, RESECTED MELANOMA PATIENTS.
I. To evaluate associations between pretreatment ctDNA (present versus absent) and relapse within 2 years of randomization in a case-control analysis across treatment arms.
II. To evaluate associations between pretreatment ctDNA (present versus absent) and relapse within 2 years of randomization in a case-control analysis across treatment arms.
III. To evaluate associations between pretreatment ctDNA and relapse within 2 years of randomization in a case-control analysis within each treatment arm (after treatment arm data are unblinded to investigators).
IV. To evaluate associations between "early-on treatment" ctDNA levels and relapse within 2 years of randomization.
V. To describe ctDNA levels at end of therapy and time of relapse.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I:
INDUCTION THERAPY: Patients receive high-dose recombinant interferon alfa-2B intravenously (IV) over 20 minutes on days 1-5. Treatment repeats weekly for 4 weeks in the absence of disease progression or unacceptable toxicity. Or patients receive ipilimumab IV over 90 minutes on day 1. Treatment repeats every 3 weeks for a total of 4 cycles in the absence of disease progression or unacceptable toxicity.
MAINTENANCE THERAPY: Patients receive high-dose recombinant interferon alfa-2B subcutaneously (SC) on days 1, 3, and 5. Treatment repeats every 6 weeks for up to 48 weeks in the absence of disease progression or unacceptable toxicity. Or patients receive ipilimumab IV over 90 minutes on day 1. Treatment repeats every 12 weeks for 3 years in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive pembrolizumab IV over 30 minutes on day 1. Treatment repeats every 3 weeks for up to 52 weeks in the absence of disease progression or unacceptable toxicity.
Patients undergo computed tomography (CT) scan, positron emission tomography (PET) scan, magnetic resonance imaging (MRI) and blood sample collection throughout the study.
After completion of study treatment, patients are followed up at 30 days, 6 and 12 weeks, every 3 months for 2 years, every 6 months for 3 years, and then every 12 months for 5 years.
Type d'étude
Interventionnel
Inscription (Réel)
1301
Phase
- Phase 3
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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British Columbia
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Vancouver, British Columbia, Canada, V5Z 4E6
- BCCA-Vancouver Cancer Centre
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New Brunswick
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Moncton, New Brunswick, Canada, E1C 8X3
- The Vitalite Health Network - Dr Leon Richard Oncology Centre
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Ontario
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Barrie, Ontario, Canada, L4M 6M2
- Royal Victoria Regional Health Centre
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Hamilton, Ontario, Canada, L8V 5C2
- Juravinski Cancer Centre at Hamilton Health Sciences
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Kingston, Ontario, Canada, K7L 2V7
- Kingston Health Sciences Centre
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Kitchener, Ontario, Canada, N2G 1G3
- Waterloo Regional Health Network
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London, Ontario, Canada, N6A 4L6
- London Regional Cancer Program
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Mississauga, Ontario, Canada, L5M 2N1
- Trillium Health Partners - Credit Valley Hospital
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Oshawa, Ontario, Canada, L1G 2B9
- Lakeridge Health Oshawa
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Ottawa, Ontario, Canada, K1H 8L6
- Ottawa Hospital and Cancer Center-General Campus
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Sault Ste. Marie, Ontario, Canada, P6B 0A8
- Algoma District Cancer Program Sault Area Hospital
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Thunder Bay, Ontario, Canada, P7B 6V4
- Thunder Bay Regional Health Science Centre
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Toronto, Ontario, Canada, M5G 2M9
- University Health Network-Princess Margaret Hospital
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Toronto, Ontario, Canada, M4N 3M5
- Odette Cancer Centre- Sunnybrook Health Sciences Centre
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Windsor, Ontario, Canada, N8W 2X3
- Windsor Regional Cancer Centre
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Quebec
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Laval, Quebec, Canada, H7M 3L9
- Hopital de la Cite-de-la-Sante
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Montreal, Quebec, Canada, H3H 2R9
- The Research Institute of the McGill University Health Centre (MUHC)
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Québec, Quebec, Canada, G1R 2J6
- CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
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Sherbrooke, Quebec, Canada, J1H 5N4
- Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
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Saskatchewan
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Regina, Saskatchewan, Canada, S4T 7T1
- Allan Blair Cancer Centre
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Saskatoon, Saskatchewan, Canada, S7N 4H4
- Saskatoon Cancer Centre
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Co Dublin
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Dublin, Co Dublin, Irlande, 4
- Saint Vincent's University Hospital
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Co Galway
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Galway, Co Galway, Irlande
- University College Hospital Galway
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Co Waterford
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Waterford, Co Waterford, Irlande, 9
- University Hospital Waterford
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Alabama
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Birmingham, Alabama, États-Unis, 35233
- University of Alabama at Birmingham Cancer Center
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Arizona
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Phoenix, Arizona, États-Unis, 85004
- Cancer Center at Saint Joseph's
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Scottsdale, Arizona, États-Unis, 85258
- Virginia G Piper Cancer Care-Del Camino
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Tucson, Arizona, États-Unis, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, États-Unis, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Little Rock, Arkansas, États-Unis, 72205
- University of Arkansas for Medical Sciences
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Rogers, Arkansas, États-Unis, 72758
- Highlands Oncology Group - Rogers
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California
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Anaheim, California, États-Unis, 92806
- Kaiser Permanente-Anaheim
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Auburn, California, États-Unis, 95602
- Sutter Auburn Faith Hospital
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Baldwin Park, California, États-Unis, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, États-Unis, 90706
- Kaiser Permanente-Bellflower
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Costa Mesa, California, États-Unis, 92627
- UC Irvine Health Cancer Center-Newport
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Duarte, California, États-Unis, 91010
- City of Hope Comprehensive Cancer Center
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Fontana, California, États-Unis, 92335
- Kaiser Permanente-Fontana
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Fremont, California, États-Unis, 94538
- Kaiser Permanente-Fremont
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Fremont, California, États-Unis, 94538
- Palo Alto Medical Foundation-Fremont
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Fresno, California, États-Unis, 93720
- Kaiser Permanente-Fresno
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Harbor City, California, États-Unis, 90710
- Kaiser Permanente South Bay
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Irvine, California, États-Unis, 92618
- Kaiser Permanente-Irvine
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La Jolla, California, États-Unis, 92093
- UC San Diego Moores Cancer Center
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Los Angeles, California, États-Unis, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, États-Unis, 90048
- Cedars-Sinai Medical Center
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Los Angeles, California, États-Unis, 90095
- UCLA / Jonsson Comprehensive Cancer Center
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Los Angeles, California, États-Unis, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, États-Unis, 90034
- Kaiser Permanente West Los Angeles
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Los Angeles, California, États-Unis, 90033
- Los Angeles General Medical Center
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Marysville, California, États-Unis, 95901
- Fremont - Rideout Cancer Center
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Modesto, California, États-Unis, 95355
- Memorial Medical Center
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Modesto, California, États-Unis, 95356
- Kaiser Permanente-Modesto
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Mountain View, California, États-Unis, 94040
- Palo Alto Medical Foundation-Camino Division
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Newport Beach, California, États-Unis, 92663
- USC Norris Oncology/Hematology-Newport Beach
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Novato, California, États-Unis, 94945
- Sutter Cancer Research Consortium
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Oakland, California, États-Unis, 94611
- Kaiser Permanente-Oakland
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Orange, California, États-Unis, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Orange, California, États-Unis, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, États-Unis, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, États-Unis, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, États-Unis, 91402
- Kaiser Permanente - Panorama City
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Redwood City, California, États-Unis, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, États-Unis, 94801
- Kaiser Permanente-Richmond
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Riverside, California, États-Unis, 92505
- Kaiser Permanente-Riverside
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Roseville, California, États-Unis, 95661
- Kaiser Permanente-Roseville
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Roseville, California, États-Unis, 95661
- Sutter Roseville Medical Center
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Sacramento, California, États-Unis, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, États-Unis, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, États-Unis, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, États-Unis, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, États-Unis, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, États-Unis, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, États-Unis, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, États-Unis, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, États-Unis, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, États-Unis, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, États-Unis, 92078
- Kaiser Permanente-San Marcos
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San Rafael, California, États-Unis, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, États-Unis, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, États-Unis, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Rosa, California, États-Unis, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, États-Unis, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, États-Unis, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, États-Unis, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, États-Unis, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Truckee, California, États-Unis, 96161
- Gene Upshaw Memorial Tahoe Forest Cancer Center
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Vacaville, California, États-Unis, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, États-Unis, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, États-Unis, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, États-Unis, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, États-Unis, 80045
- UCHealth University of Colorado Hospital
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Colorado Springs, Colorado, États-Unis, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, États-Unis, 80909
- UCHealth Memorial Hospital Central
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Denver, Colorado, États-Unis, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, États-Unis, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, États-Unis, 80210
- AdventHealth Porter
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Fort Collins, Colorado, États-Unis, 80524
- Poudre Valley Hospital
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Greeley, Colorado, États-Unis, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, États-Unis, 80026
- Kaiser Permanente-Rock Creek
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Littleton, Colorado, États-Unis, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, États-Unis, 80124
- Kaiser Permanente-Lone Tree
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Parker, Colorado, États-Unis, 80138
- AdventHealth Parker
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Connecticut
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Fairfield, Connecticut, États-Unis, 06824
- Smilow Cancer Hospital Care Center-Fairfield
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Hartford, Connecticut, États-Unis, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Haven, Connecticut, États-Unis, 06520
- Yale University
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Stamford, Connecticut, États-Unis, 06904
- Stamford Hospital/Bennett Cancer Center
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Trumbull, Connecticut, États-Unis, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Delaware
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Newark, Delaware, États-Unis, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, États-Unis, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, États-Unis, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, États-Unis, 19971
- Beebe Health Campus
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District of Columbia
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Washington D.C., District of Columbia, États-Unis, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, États-Unis, 20007
- MedStar Georgetown University Hospital
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Florida
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Lakeland, Florida, États-Unis, 33805
- Lakeland Regional Health Hollis Cancer Center
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Miami, Florida, États-Unis, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami Beach, Florida, États-Unis, 33140
- Mount Sinai Medical Center
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Orlando, Florida, États-Unis, 32806
- Orlando Health Cancer Institute
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Tampa, Florida, États-Unis, 33612
- Moffitt Cancer Center
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Weston, Florida, États-Unis, 33331
- Cleveland Clinic-Weston
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Georgia
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Atlanta, Georgia, États-Unis, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, États-Unis, 30342
- Northside Hospital
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Cumming, Georgia, États-Unis, 30041
- Northside Hospital-Forsyth
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Savannah, Georgia, États-Unis, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, États-Unis, 31404
- Memorial Health University Medical Center
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Valdosta, Georgia, États-Unis, 31602
- South Georgia Medical Center/Pearlman Cancer Center
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Hawaii
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Honolulu, Hawaii, États-Unis, 96813
- Queen's Medical Center
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Honolulu, Hawaii, États-Unis, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, États-Unis, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, États-Unis, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, États-Unis, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, États-Unis, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, États-Unis, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, États-Unis, 96813
- Island Urology
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Honolulu, Hawaii, États-Unis, 96859
- Tripler Army Medical Center
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Idaho
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Boise, Idaho, États-Unis, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, États-Unis, 83712
- Saint Luke's Cancer Institute - Boise
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Coeur d'Alene, Idaho, États-Unis, 83814
- Kootenai Health - Coeur d'Alene
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Fruitland, Idaho, États-Unis, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, États-Unis, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, États-Unis, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, États-Unis, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, États-Unis, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, États-Unis, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, États-Unis, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, États-Unis, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, États-Unis, 61520
- Illinois CancerCare-Canton
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Centralia, Illinois, États-Unis, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, États-Unis, 60611
- Northwestern University
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Chicago, Illinois, États-Unis, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, États-Unis, 60612
- Rush MD Anderson Cancer Center
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Danville, Illinois, États-Unis, 61832
- Carle at The Riverfront
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Decatur, Illinois, États-Unis, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, États-Unis, 62526
- Cancer Care Specialists of Illinois - Decatur
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Effingham, Illinois, États-Unis, 62401
- Crossroads Cancer Center
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Effingham, Illinois, États-Unis, 62401
- Carle Physician Group-Effingham
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Elmhurst, Illinois, États-Unis, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, États-Unis, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, États-Unis, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, États-Unis, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, États-Unis, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, États-Unis, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Highland Park, Illinois, États-Unis, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Kewanee, Illinois, États-Unis, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, États-Unis, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, États-Unis, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, États-Unis, 60153
- Loyola University Medical Center
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Naperville, Illinois, États-Unis, 60540
- Edward Hospital/Cancer Center
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New Lenox, Illinois, États-Unis, 60451
- UC Comprehensive Cancer Center at Silver Cross
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O'Fallon, Illinois, États-Unis, 62269
- Cancer Care Center of O'Fallon
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Orland Park, Illinois, États-Unis, 60462
- University of Chicago Medicine-Orland Park
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Ottawa, Illinois, États-Unis, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, États-Unis, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, États-Unis, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, États-Unis, 61354
- Illinois CancerCare-Peru
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Plainfield, Illinois, États-Unis, 60585
- Edward Hospital/Cancer Center?Plainfield
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Princeton, Illinois, États-Unis, 61356
- Illinois CancerCare-Princeton
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Rockford, Illinois, États-Unis, 61114
- UW Health Carbone Cancer Center Rockford
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Springfield, Illinois, États-Unis, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, États-Unis, 62702
- Springfield Clinic
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Springfield, Illinois, États-Unis, 62702
- Central Illinois Hematology Oncology Center
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Springfield, Illinois, États-Unis, 62781
- Springfield Memorial Hospital
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Urbana, Illinois, États-Unis, 61801
- Carle Cancer Center
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Urbana, Illinois, États-Unis, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, États-Unis, 60555
- Northwestern Medicine Cancer Center Warrenville
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Yorkville, Illinois, États-Unis, 60560
- Rush-Copley Healthcare Center
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Indiana
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Indianapolis, Indiana, États-Unis, 46237
- Franciscan Health Indianapolis
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Indianapolis, Indiana, États-Unis, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, États-Unis, 46219
- Community Cancer Center East
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Indianapolis, Indiana, États-Unis, 46227
- Community Cancer Center South
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Indianapolis, Indiana, États-Unis, 46256
- Community Cancer Center North
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Mooresville, Indiana, États-Unis, 46158
- Franciscan Health Mooresville
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Richmond, Indiana, États-Unis, 47374
- Reid Health
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Iowa
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Ames, Iowa, États-Unis, 50010
- Mary Greeley Medical Center
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Ames, Iowa, États-Unis, 50010
- McFarland Clinic - Ames
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Boone, Iowa, États-Unis, 50036
- McFarland Clinic - Boone
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Cedar Rapids, Iowa, États-Unis, 52402
- Physicians' Clinic of Iowa PC
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Clive, Iowa, États-Unis, 50325
- Mercy Cancer Center-West Lakes
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Clive, Iowa, États-Unis, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
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Des Moines, Iowa, États-Unis, 50309
- Iowa Methodist Medical Center
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Des Moines, Iowa, États-Unis, 50314
- Mercy Medical Center - Des Moines
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Des Moines, Iowa, États-Unis, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
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Des Moines, Iowa, États-Unis, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
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Fort Dodge, Iowa, États-Unis, 50501
- McFarland Clinic - Trinity Cancer Center
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Iowa City, Iowa, États-Unis, 52242
- University of Iowa/Holden Comprehensive Cancer Center
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Jefferson, Iowa, États-Unis, 50129
- McFarland Clinic - Jefferson
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Marshalltown, Iowa, États-Unis, 50158
- McFarland Clinic - Marshalltown
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West Des Moines, Iowa, États-Unis, 50266
- Mercy Medical Center-West Lakes
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Kansas
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Chanute, Kansas, États-Unis, 66720
- Cancer Center of Kansas - Chanute
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Dodge City, Kansas, États-Unis, 67801
- Cancer Center of Kansas - Dodge City
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El Dorado, Kansas, États-Unis, 67042
- Cancer Center of Kansas - El Dorado
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Garden City, Kansas, États-Unis, 67846
- Saint Catherine Hospital
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Great Bend, Kansas, États-Unis, 67530
- Central Care Cancer Center - Great Bend
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Great Bend, Kansas, États-Unis, 67530
- Saint Rose Ambulatory and Surgery Center
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Hays, Kansas, États-Unis, 67601
- HaysMed
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Kansas City, Kansas, États-Unis, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, États-Unis, 66112
- University of Kansas Cancer Center-West
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Lawrence, Kansas, États-Unis, 66044
- Lawrence Memorial Hospital
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Lenexa, Kansas, États-Unis, 66219
- Kansas Institute of Medicine Cancer and Blood Center
-
Lenexa, Kansas, États-Unis, 66219
- Minimally Invasive Surgery Hospital
-
Liberal, Kansas, États-Unis, 67905
- Cancer Center of Kansas-Liberal
-
McPherson, Kansas, États-Unis, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, États-Unis, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, États-Unis, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, États-Unis, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, États-Unis, 66209
- Menorah Medical Center
-
Overland Park, Kansas, États-Unis, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, États-Unis, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, États-Unis, 66762
- Mercy Hospital Pittsburg
-
Salina, Kansas, États-Unis, 67401
- Salina Regional Health Center
-
Salina, Kansas, États-Unis, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, États-Unis, 66606
- University of Kansas Health System Saint Francis Campus
-
Wellington, Kansas, États-Unis, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, États-Unis, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, États-Unis, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, États-Unis, 67214
- Cancer Center of Kansas - Wichita
-
Winfield, Kansas, États-Unis, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, États-Unis, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Lexington, Kentucky, États-Unis, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, États-Unis, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
Louisville, Kentucky, États-Unis, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, États-Unis, 40215
- Saints Mary and Elizabeth Hospital
-
Owensboro, Kentucky, États-Unis, 42303
- Owensboro Health Mitchell Memorial Cancer Center
-
-
Louisiana
-
Baton Rouge, Louisiana, États-Unis, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, États-Unis, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, États-Unis, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, États-Unis, 70808
- Our Lady of the Lake Physician Group
-
Covington, Louisiana, États-Unis, 70433
- Northshore Oncology Associates-Covington
-
Monroe, Louisiana, États-Unis, 71202
- Ochsner LSU Health Monroe Medical Center
-
Shreveport, Louisiana, États-Unis, 71103
- LSU Health Sciences Center at Shreveport
-
-
Maine
-
Augusta, Maine, États-Unis, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, États-Unis, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, États-Unis, 04412
- Lafayette Family Cancer Center-EMMC
-
Westbrook, Maine, États-Unis, 04092
- New England Cancer Specialists
-
-
Maryland
-
Baltimore, Maryland, États-Unis, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, États-Unis, 21202
- Mercy Medical Center
-
Frederick, Maryland, États-Unis, 21701
- Frederick Memorial Hospital
-
-
Massachusetts
-
Beverly, Massachusetts, États-Unis, 01915
- Beverly Hospital
-
Boston, Massachusetts, États-Unis, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, États-Unis, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, États-Unis, 02118
- Boston Medical Center
-
Boston, Massachusetts, États-Unis, 02114
- Massachusetts General Hospital Cancer Center
-
Burlington, Massachusetts, États-Unis, 01805
- Lahey Clinic
-
Gloucester, Massachusetts, États-Unis, 01930
- Addison Gilbert Hospital
-
Springfield, Massachusetts, États-Unis, 01199
- Baystate Medical Center
-
-
Michigan
-
Ann Arbor, Michigan, États-Unis, 48109
- University of Michigan Rogel Cancer Center
-
Detroit, Michigan, États-Unis, 48202
- Henry Ford Hospital
-
Detroit, Michigan, États-Unis, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, États-Unis, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, États-Unis, 48054
- Henry Ford River District Hospital
-
Escanaba, Michigan, États-Unis, 49829
- OSF Saint Francis Hospital and Medical Group
-
Flint, Michigan, États-Unis, 48503
- Hurley Medical Center
-
Flint, Michigan, États-Unis, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, États-Unis, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, États-Unis, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grosse Pointe Woods, Michigan, États-Unis, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, États-Unis, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, États-Unis, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, États-Unis, 49201
- Allegiance Health
-
Kalamazoo, Michigan, États-Unis, 49007
- West Michigan Cancer Center
-
Lansing, Michigan, États-Unis, 48912
- University of Michigan Health - Sparrow Lansing
-
Macomb, Michigan, États-Unis, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, États-Unis, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Muskegon, Michigan, États-Unis, 49444
- Trinity Health Muskegon Hospital
-
Reed City, Michigan, États-Unis, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, États-Unis, 48309
- Henry Ford Rochester Hospital
-
Saginaw, Michigan, États-Unis, 48601
- MyMichigan Medical Center Saginaw
-
Traverse City, Michigan, États-Unis, 49684
- Munson Medical Center
-
Warren, Michigan, États-Unis, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, États-Unis, 48093
- Henry Ford Warren Hospital - GLCMS
-
Wyoming, Michigan, États-Unis, 49519
- University of Michigan Health - West
-
-
Minnesota
-
Bemidji, Minnesota, États-Unis, 56601
- Sanford Joe Lueken Cancer Center
-
Burnsville, Minnesota, États-Unis, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, États-Unis, 55433
- Mercy Hospital
-
Duluth, Minnesota, États-Unis, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, États-Unis, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, États-Unis, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, États-Unis, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, États-Unis, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, États-Unis, 55432
- Unity Hospital
-
Maplewood, Minnesota, États-Unis, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, États-Unis, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, États-Unis, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, États-Unis, 55407
- Abbott-Northwestern Hospital
-
Saint Louis Park, Minnesota, États-Unis, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, États-Unis, 55101
- Regions Hospital
-
Saint Paul, Minnesota, États-Unis, 55102
- United Hospital
-
Waconia, Minnesota, États-Unis, 55387
- Ridgeview Medical Center
-
Woodbury, Minnesota, États-Unis, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Jackson, Mississippi, États-Unis, 39216
- University of Mississippi Medical Center
-
-
Missouri
-
Bonne Terre, Missouri, États-Unis, 63628
- Parkland Health Center-Bonne Terre
-
Cape Girardeau, Missouri, États-Unis, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, États-Unis, 63703
- Mercy Cancer Center - Cape Girardeau
-
Independence, Missouri, États-Unis, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, États-Unis, 65109
- MU Health Care Goldschmidt Cancer Center
-
Kansas City, Missouri, États-Unis, 64128
- Kansas City Veterans Affairs Medical Center
-
Kansas City, Missouri, États-Unis, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, États-Unis, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, États-Unis, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, États-Unis, 64132
- Research Medical Center
-
Kansas City, Missouri, États-Unis, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, États-Unis, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, États-Unis, 64064
- University of Kansas Cancer Center - Lee's Summit
-
Lee's Summit, Missouri, États-Unis, 64086
- Saint Luke's East - Lee's Summit
-
Liberty, Missouri, États-Unis, 64068
- Liberty Hospital
-
Saint Joseph, Missouri, États-Unis, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, États-Unis, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, États-Unis, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, États-Unis, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, États-Unis, 63131
- Missouri Baptist Medical Center
-
Sullivan, Missouri, États-Unis, 63080
- Missouri Baptist Sullivan Hospital
-
-
Montana
-
Anaconda, Montana, États-Unis, 59711
- Community Hospital of Anaconda
-
Billings, Montana, États-Unis, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, États-Unis, 59101
- Saint Vincent Healthcare
-
Bozeman, Montana, États-Unis, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, États-Unis, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, États-Unis, 59405
- Great Falls Clinic
-
Great Falls, Montana, États-Unis, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, États-Unis, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, États-Unis, 59901
- Logan Health Medical Center
-
Missoula, Montana, États-Unis, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, États-Unis, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, États-Unis, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Lincoln, Nebraska, États-Unis, 68506
- Nebraska Hematology and Oncology
-
Lincoln, Nebraska, États-Unis, 68516
- Cancer Partners of Nebraska
-
Norfolk, Nebraska, États-Unis, 68701
- Faith Regional Health Services Carson Cancer Center
-
Omaha, Nebraska, États-Unis, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, États-Unis, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, États-Unis, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, États-Unis, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, États-Unis, 68124
- Nebraska Cancer Specialists - Omaha
-
Scottsbluff, Nebraska, États-Unis, 69361
- Regional West Medical Center Cancer Center
-
-
Nevada
-
Henderson, Nevada, États-Unis, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, États-Unis, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, États-Unis, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, États-Unis, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, États-Unis, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, États-Unis, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, États-Unis, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, États-Unis, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, États-Unis, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, États-Unis, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, États-Unis, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, États-Unis, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, États-Unis, 89169
- University Cancer Center
-
Las Vegas, Nevada, États-Unis, 89183
- OptumCare Cancer Care at Fort Apache
-
-
New Hampshire
-
Dover, New Hampshire, États-Unis, 03820
- Wentworth-Douglass Hospital
-
Lebanon, New Hampshire, États-Unis, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Manchester, New Hampshire, États-Unis, 03104
- Dartmouth Cancer Center - Manchester/ DCC Manchester
-
Nashua, New Hampshire, États-Unis, 03060
- Saint Joseph Hospital
-
Nashua, New Hampshire, États-Unis, 03063
- Dartmouth Cancer Center - Nashua
-
-
New Jersey
-
East Orange, New Jersey, États-Unis, 07018-1095
- Veterans Adminstration New Jersey Health Care System
-
Hackensack, New Jersey, États-Unis, 07601
- Hackensack University Medical Center
-
Livingston, New Jersey, États-Unis, 07039
- Cooperman Barnabas Medical Center
-
New Brunswick, New Jersey, États-Unis, 08903
- Rutgers Cancer Institute of New Jersey
-
-
New Mexico
-
Albuquerque, New Mexico, États-Unis, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque, New Mexico, États-Unis, 87106
- Southwest Gynecologic Oncology Associates Inc
-
Albuquerque, New Mexico, États-Unis, 87106
- University of New Mexico Cancer Center
-
-
New York
-
Auburn, New York, États-Unis, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Buffalo, New York, États-Unis, 14263
- Roswell Park Cancer Institute
-
Camillus, New York, États-Unis, 13031
- Hematology Oncology Associates of CNY at Camillus
-
East Syracuse, New York, États-Unis, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, États-Unis, 12801
- Glens Falls Hospital
-
New York, New York, États-Unis, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
Rochester, New York, États-Unis, 14642
- University of Rochester
-
Rochester, New York, États-Unis, 14621
- Rochester General Hospital
-
Stony Brook, New York, États-Unis, 11794
- Stony Brook University Medical Center
-
Syracuse, New York, États-Unis, 13210
- State University of New York Upstate Medical University
-
-
North Carolina
-
Chapel Hill, North Carolina, États-Unis, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, États-Unis, 28328
- Southeastern Medical Oncology Center-Clinton
-
Durham, North Carolina, États-Unis, 27710
- Duke University Medical Center
-
Goldsboro, North Carolina, États-Unis, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, États-Unis, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, États-Unis, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, États-Unis, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
-
North Dakota
-
Bismarck, North Dakota, États-Unis, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, États-Unis, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, États-Unis, 58122
- Sanford Broadway Medical Center
-
Grand Forks, North Dakota, États-Unis, 58201
- Altru Cancer Center
-
-
Ohio
-
Beachwood, Ohio, États-Unis, 44122
- UHHS-Chagrin Highlands Medical Center
-
Belpre, Ohio, États-Unis, 45714
- Strecker Cancer Center-Belpre
-
Centerville, Ohio, États-Unis, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, États-Unis, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, États-Unis, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, États-Unis, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cleveland, Ohio, États-Unis, 44106
- Case Western Reserve University
-
Cleveland, Ohio, États-Unis, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, États-Unis, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, États-Unis, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, États-Unis, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, États-Unis, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, États-Unis, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, États-Unis, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, États-Unis, 43228
- Doctors Hospital
-
Columbus, Ohio, États-Unis, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, États-Unis, 43215
- Grant Medical Center
-
Columbus, Ohio, États-Unis, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, États-Unis, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, États-Unis, 45409
- Miami Valley Hospital
-
Dayton, Ohio, États-Unis, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, États-Unis, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, États-Unis, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, États-Unis, 43015
- Grady Memorial Hospital
-
Findlay, Ohio, États-Unis, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, États-Unis, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, États-Unis, 45840
- Orion Cancer Care
-
Independence, Ohio, États-Unis, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, États-Unis, 45429
- Kettering Medical Center
-
Kettering, Ohio, États-Unis, 45409
- Greater Dayton Cancer Center
-
Mansfield, Ohio, États-Unis, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Mansfield, Ohio, États-Unis, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, États-Unis, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, États-Unis, 43302
- OhioHealth Marion General Hospital
-
Mayfield Heights, Ohio, États-Unis, 44124
- Hillcrest Hospital Cancer Center
-
Mount Vernon, Ohio, États-Unis, 43050
- Knox Community Hospital
-
Newark, Ohio, États-Unis, 43055
- Licking Memorial Hospital
-
Parma, Ohio, États-Unis, 44129
- University Hospitals Parma Medical Center
-
Portsmouth, Ohio, États-Unis, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, États-Unis, 44870
- North Coast Cancer Care
-
Sandusky, Ohio, États-Unis, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Strongsville, Ohio, États-Unis, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Sylvania, Ohio, États-Unis, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, États-Unis, 43614
- University of Toledo
-
Warrensville Heights, Ohio, États-Unis, 44122
- South Pointe Hospital
-
Westerville, Ohio, États-Unis, 43081
- Saint Ann's Hospital
-
Wooster, Ohio, États-Unis, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Zanesville, Ohio, États-Unis, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, États-Unis, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, États-Unis, 73120
- Mercy Hospital Oklahoma City
-
-
Oregon
-
Portland, Oregon, États-Unis, 97239
- Oregon Health and Science University
-
Portland, Oregon, États-Unis, 97213
- Providence Portland Medical Center
-
Portland, Oregon, États-Unis, 97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Abington, Pennsylvania, États-Unis, 19001
- Jefferson Abington Hospital
-
Allentown, Pennsylvania, États-Unis, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, États-Unis, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Danville, Pennsylvania, États-Unis, 17822
- Geisinger Medical Center
-
Ephrata, Pennsylvania, États-Unis, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, États-Unis, 17522
- Ephrata Community Hospital
-
Erie, Pennsylvania, États-Unis, 16505
- UPMC Hillman Cancer Center Erie
-
Gettysburg, Pennsylvania, États-Unis, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, États-Unis, 17331
- WellSpan Medical Oncology and Hematology
-
Hazleton, Pennsylvania, États-Unis, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, États-Unis, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Philadelphia, Pennsylvania, États-Unis, 19111
- Fox Chase Cancer Center
-
Pittsburgh, Pennsylvania, États-Unis, 15212
- Allegheny General Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15224
- West Penn Hospital
-
Pittsburgh, Pennsylvania, États-Unis, 15232
- UPMC Hillman Cancer Center
-
Pottsville, Pennsylvania, États-Unis, 17901
- Geisinger Cancer Services-Pottsville
-
West Reading, Pennsylvania, États-Unis, 19611
- Reading Hospital
-
Wexford, Pennsylvania, États-Unis, 15090
- Wexford Health and Wellness Pavilion
-
Wilkes-Barre, Pennsylvania, États-Unis, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, États-Unis, 17701
- UPMC Susquehanna
-
York, Pennsylvania, États-Unis, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, États-Unis, 17403
- WellSpan Health-York Hospital
-
-
Rhode Island
-
Newport, Rhode Island, États-Unis, 02840
- Newport Hospital
-
Providence, Rhode Island, États-Unis, 02903
- Rhode Island Hospital
-
Providence, Rhode Island, États-Unis, 02906
- Miriam Hospital
-
-
South Carolina
-
Anderson, South Carolina, États-Unis, 29621
- AnMed Health Cancer Center
-
Charleston, South Carolina, États-Unis, 29401
- Roper Hospital
-
Charleston, South Carolina, États-Unis, 29406
- Lowcountry Hematology Oncology PA-North Charleston
-
Charleston, South Carolina, États-Unis, 29414
- Bon Secours Saint Francis Hospital
-
Charleston, South Carolina, États-Unis, 29403
- Charleston Oncology - Roper
-
Charleston, South Carolina, États-Unis, 29414
- Charleston Oncology - Saint Francis
-
Charleston, South Carolina, États-Unis, 29414
- Lowcountry Oncology Associates - West Ashley
-
Greenville, South Carolina, États-Unis, 29607
- Saint Francis Cancer Center
-
Mt. Pleasant, South Carolina, États-Unis, 29464
- Lowcountry Oncology Associates - Mount Pleasant
-
-
South Dakota
-
Rapid City, South Dakota, États-Unis, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, États-Unis, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, États-Unis, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Germantown, Tennessee, États-Unis, 38138
- The West Clinic - Wolf River
-
Memphis, Tennessee, États-Unis, 38163
- University of Tennessee Health Science Center
-
Memphis, Tennessee, États-Unis, 38104
- The West Clinic - Mid-Town
-
Nashville, Tennessee, États-Unis, 37232
- Vanderbilt University/Ingram Cancer Center
-
-
Texas
-
Austin, Texas, États-Unis, 78731
- Texas Oncology - Central Austin Cancer Center
-
Dallas, Texas, États-Unis, 75246
- Baylor University Medical Center
-
Houston, Texas, États-Unis, 77030
- UT MD Anderson Cancer Center
-
-
Utah
-
American Fork, Utah, États-Unis, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, États-Unis, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, États-Unis, 84321
- Logan Regional Hospital
-
Murray, Utah, États-Unis, 84107
- Intermountain Medical Center
-
Ogden, Utah, États-Unis, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, États-Unis, 84604
- Utah Valley Regional Medical Center
-
Salt Lake City, Utah, États-Unis, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, États-Unis, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, États-Unis, 84143
- LDS Hospital
-
South Jordan, Utah, États-Unis, 84009
- South Jordan Health Center
-
St. George, Utah, États-Unis, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Berlin Corners, Vermont, États-Unis, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, États-Unis, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, États-Unis, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Lynchburg, Virginia, États-Unis, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Richmond, Virginia, États-Unis, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, États-Unis, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, États-Unis, 23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen, Washington, États-Unis, 98520
- Providence Regional Cancer System-Aberdeen
-
Centralia, Washington, États-Unis, 98531
- Providence Regional Cancer System-Centralia
-
Everett, Washington, États-Unis, 98201
- Providence Regional Cancer Partnership
-
Lacey, Washington, États-Unis, 98503
- Providence Regional Cancer System-Lacey
-
Longview, Washington, États-Unis, 98632
- PeaceHealth Saint John Medical Center
-
Seattle, Washington, États-Unis, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, États-Unis, 98112
- Kaiser Permanente Washington
-
Shelton, Washington, États-Unis, 98584
- Providence Regional Cancer System-Shelton
-
Vancouver, Washington, États-Unis, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, États-Unis, 99362
- Providence Saint Mary Regional Cancer Center
-
Yelm, Washington, États-Unis, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Bridgeport, West Virginia, États-Unis, 26330
- United Hospital Center
-
Charleston, West Virginia, États-Unis, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
Morgantown, West Virginia, États-Unis, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, États-Unis, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Antigo, Wisconsin, États-Unis, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Burlington, Wisconsin, États-Unis, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, États-Unis, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, États-Unis, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac, Wisconsin, États-Unis, 54937
- Aurora Health Center-Fond du Lac
-
Fond du Lac, Wisconsin, États-Unis, 54935
- Saint Agnes Hospital/Agnesian Cancer Center
-
Germantown, Wisconsin, États-Unis, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, États-Unis, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, États-Unis, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, États-Unis, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, États-Unis, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, États-Unis, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Kenosha, Wisconsin, États-Unis, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, États-Unis, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, États-Unis, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Marinette, Wisconsin, États-Unis, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, États-Unis, 54143
- Bay Area Medical Center
-
Marshfield, Wisconsin, États-Unis, 54449
- Marshfield Medical Center-Marshfield
-
Menomonee Falls, Wisconsin, États-Unis, 53051
- Froedtert Menomonee Falls Hospital
-
Milwaukee, Wisconsin, États-Unis, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, États-Unis, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, États-Unis, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, États-Unis, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, États-Unis, 53210
- Ascension Southeast Wisconsin Hospital-Saint Joseph-Milwaukee
-
Minocqua, Wisconsin, États-Unis, 54548
- Marshfield Medical Center - Minocqua
-
New Richmond, Wisconsin, États-Unis, 54017
- Cancer Center of Western Wisconsin
-
Oconto Falls, Wisconsin, États-Unis, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, États-Unis, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, États-Unis, 53406
- Aurora Cancer Care-Racine
-
Rice Lake, Wisconsin, États-Unis, 54868
- Marshfield Medical Center-Rice Lake
-
Rice Lake, Wisconsin, États-Unis, 54868
- Lakeview Medical Center-Marshfield Clinic
-
Sheboygan, Wisconsin, États-Unis, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, États-Unis, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, États-Unis, 54481
- Aspirus Cancer Care - Stevens Point
-
Sturgeon Bay, Wisconsin, États-Unis, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, États-Unis, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, États-Unis, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Wausau, Wisconsin, États-Unis, 54401
- Marshfield Clinic-Wausau Center
-
Wausau, Wisconsin, États-Unis, 54401
- Aspirus Cancer Care-Wausau
-
Wauwatosa, Wisconsin, États-Unis, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, États-Unis, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, États-Unis, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, États-Unis, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, États-Unis, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cody, Wyoming, États-Unis, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, États-Unis, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, États-Unis, 82801
- Welch Cancer Center
-
-
Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
18 ans et plus (Adulte, Adulte plus âgé)
Accepte les volontaires sains
Non
Sexes éligibles pour l'étude
Tout
La description
Inclusion Criteria:
- STEP 1 REGISTRATION:
- Patients must have completely resected melanoma of cutaneous origin or of unknown primary in order to be eligible for this study; patients must be classified as stage IIIA (N2a), IIIB, IIIC, or stage IV melanoma; patients with non-ulcerated T1b N1a disease are not eligible; patients with melanoma of mucosal or other non-cutaneous origin are eligible; patients with melanoma of ocular origin are not eligible; patients with a history of brain metastases are ineligible
- Patients are eligible for this trial either at initial presentation of their melanoma or at the time of the first detected nodal, satellite/in-transit, distant metastases, or recurrent disease in prior lymphadenectomy basin or distant site; nodal, satellite/in-transit metastasis, distant metastases or disease in a prior complete lymphadenectomy basin must have been confirmed histologically by hematoxylin and eosin (H & E) stained slides
- Patients with multiple regional nodal basin involvement are eligible; gross or microscopic extracapsular nodal extension is permitted
- Patients at initial presentation of melanoma must undergo an adequate wide excision of the primary lesion, if present; patients with previously diagnosed melanoma must have had all current disease resected with pathologically negative margins and must have no evidence of disease at the primary site or must undergo re-resection of the primary site; a full lymphadenectomy meeting the criteria outlined is required for all node-positive patients including those with positive sentinel nodes; patients with recurrent disease who have had a prior complete lymphadenectomy fulfill this requirement as long as all recurrent disease has been resected; for all patients, all disease must have been resected with negative pathological margins and no clinical, radiologic, or pathological evidence of any incompletely resected melanoma; patients must be registered within 98 days of the last surgery performed to render the patient free of disease
- Patients must have available and be willing to submit a minimum of five unstained slides from primary, lymph node, or metastatic site to determine PD-L1 expression; the tumor tissue must be adequate for PD-L1 testing (defined as >= 100 tumor cells as confirmed by the treating institution's local pathologist); this must be documented by having a pathologist sign the S1404 Local Pathology Review form prior to step 1 registration; the specimens may come from an archived block but must be submitted within 20 days from cutting the slides
- Patients must be offered the opportunity to participate in specimen banking as outlined
- Patients must be willing to have blood draws for PK/ADA analysis as outlined, should the patient be randomized to the MK-3475 arm
- Patients may have received prior radiation therapy, including after the surgical resection; all adverse events associated with prior surgery and radiation therapy must have resolved to =< grade 1 prior to registration
- Patients must not have received neoadjuvant treatment for their melanoma; patients must not have had prior immunotherapy including, but not limited to ipilimumab, interferon alfa-2b, high dose IL-2, pegylated (PEG)-IFN, anti-PD-1, anti-PD-L1 intra-tumoral, or vaccine therapies; patients must not be planning to receive any of the prohibited therapies during the screening or treatment phases of the study
- Patients must not be planning to receive concomitant other biologic therapy, radiation therapy, hormonal therapy, other chemotherapy, surgery or other therapy after step 2 registration
- All patients must have disease-free status documented by a complete physical examination and imaging studies within 42 days prior to registration; imaging studies must include a total body positron emission tomography (PET)-computed tomography (CT) scan that is of diagnostic quality (with or without brain) or a CT of the chest, abdomen and pelvis; for patients with melanoma arising from the head and neck, dedicated neck imaging (CT with IV contrast or PET-CT through the region) is required; if the patient has had unknown primary with disease in the axilla, neck imaging is required to assure region is clear of cancer; CT imaging should be done with intravenous contrast if there are no contraindications for it; any other clinically-indicated imaging studies if performed (e.g. bone scan) must show no evidence of disease
- All patients must have a CT or magnetic resonance imaging (MRI) of the brain within 90 days prior to registration; the brain CT or MRI should be performed with intravenous contrast (unless contraindicated)
- Absolute neutrophil count (ANC) >= 1,500 microliter (mcL) (within 42 days prior to registration)
- Platelets >= 100,000 mcL (within 42 days prior to registration)
- Hemoglobin >= 10 g/dL (within 42 days prior to registration)
- Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (except Gilbert's syndrome, who must have a total bilirubin < 3.0 mg/dL) (within 42 days prior to registration)
- Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) and serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 2 x IULN (within 42 days prior to registration)
- Alkaline phosphatase =< 2 x IULN (within 42 days prior to registration)
- Serum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min (within 42 days prior to registration)
- Patients must have lactate dehydrogenase (LDH) performed within 42 days prior to registration
- Patients must have Zubrod performance status =< 1
- Patients must have a baseline electrocardiogram (ECG) performed within 42 days of registration that is normal or considered not clinically significant by the site investigator
- Patients must not have a history of (non-infectious) pneumonitis that required steroids or current pneumonitis
- Patients must not have an active infection requiring systemic therapy
- Patients must not have active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
- Patients must not have received live vaccines within 42 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed
- Patients known to be human immunodeficiency virus (HIV) positive are eligible if they meet the following criteria within 30 days prior to registration: stable and adequate cluster of differentiation 4 (CD4) counts (>= 350 mm^3), and serum HIV viral load of < 25,000 IU/ml; patients may be on or off anti-viral therapy so long as they meet the CD4 count criteria
- Patients must not have known active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection prior to registration
- Patients must not have a history or current evidence of any condition, therapy or laboratory abnormality that might confound the trial results, interfere with the patient's participation for the full duration of the trial, or indicate that participation in the trial is not in the patient's best interests, in the opinion of the treating investigator
- No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, lobular carcinoma of the breast in situ, atypical melanocytic hyperplasia or melanoma in situ, adequately treated stage I or II cancer (including multiple primary melanomas) from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years
- Women of childbearing potential must have a negative urine or serum pregnancy test within 28 days prior to registration; women/men of reproductive potential must have agreed to use an effective contraceptive method for the course of the study through 120 days after the last dose of study medication; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy, or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures, he/she is responsible for beginning contraceptive measures; patients must not be pregnant or nursing due to unknown teratogenic side effects
- Patients who are able to complete questionnaires in English, Spanish or French must participate in the quality of life assessments; (those patients who cannot complete the quality of life questionnaires in English, Spanish or French can be registered to S1404 without contributing to the quality of life studies)
- Patients must be informed of the investigational nature of this study and must sign and give written informed consent for this protocol in accordance with institutional and federal guidelines
- As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
- STEP 2 REGISTRATION (RANDOMIZATION CRITERIA):
- Patients must not be registered until receiving confirmation from the Southwest Oncology Group (SWOG) Statistical Center that the patient's tissue specimen was adequate for PD-L1 testing; patients must be registered within 7 working days of receiving the e-mail notification
- Women of childbearing potential must plan to have a urine or serum pregnancy test within 72 hours prior to receiving the first dose of study medication; if the urine test is positive or cannot be confirmed as negative, a negative serum pregnancy test will be required
- No tests or exams are required to be repeated for step 2 registration (randomization); however, patients who are known to have a change in eligibility status after step 1 registration are not eligible for step 2 registration; for example, ANC is not required to be repeated between step 1 and step 2 registration, but the most recent ANC performed before step 2 registration is required to be >= 1,500 mcL
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Double
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Comparateur actif: Arm I (high-dose recombinant interferon alfa-2B, ipilimumab)
INDUCTION THERAPY: Patients receive high-dose recombinant interferon alfa-2B intravenously (IV) over 20 minutes on days 1-5. Treatment repeats weekly for 4 weeks in the absence of disease progression or unacceptable toxicity. Or patients receive ipilimumab IV over 90 minutes on day 1. Treatment repeats every 3 weeks for a total of 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive high-dose recombinant interferon alfa-2B subcutaneously (SC) on days 1, 3, and 5. Treatment repeats every 6 weeks for up to 48 weeks in the absence of disease progression or unacceptable toxicity. Or patients receive ipilimumab IV over 90 minutes on day 1. Treatment repeats every 12 weeks for 3 years in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, PET scan, MRI and blood sample collection throughout the study. |
Ancillary studies
Autres noms:
Undergo blood sample collection
Autres noms:
Given IV
Autres noms:
Given IV and SC
Autres noms:
Undergo MRI
Autres noms:
Undergo CT scan
Autres noms:
Undergo PET scan
Autres noms:
|
|
Expérimental: Arm II (pembrolizumab)
Patients receive pembrolizumab IV over 30 minutes on day 1. Treatment repeats every 3 weeks for up to 52 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, PET scan, MRI and blood sample collection throughout the study. |
Ancillary studies
Autres noms:
Undergo blood sample collection
Autres noms:
Undergo MRI
Autres noms:
Given IV
Autres noms:
Undergo PET scan
Autres noms:
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Overall Survival (OS)
Délai: 5 years after last randomization
|
Time from date of randomization to date of death due to any cause. Patients known to be alive are censored at date of last contact. The results were presented as 5-year OS estimate. |
5 years after last randomization
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Relapse-free Survival (RFS)
Délai: 5 years after last randomization
|
Time from date of randomization to date of first documentation of relapse or death due to any cause. Patients last known to be alive and relapse-free are censored at date of last contact. |
5 years after last randomization
|
|
Overall Survival (OS) in Participants Who Are PD-L1 Positive
Délai: 94 months; from study start November 10, 2015 to September 15, 2023
|
Time from date of randomization to date of death due to any cause. Patients known to be alive are censored at date of last contact. |
94 months; from study start November 10, 2015 to September 15, 2023
|
|
Relapse-free Survival (RFS) in Participants Who Are PD-L1 Positive
Délai: 5 years after last randomization
|
Time from date of randomization to date of first documentation of relapse or death due to any cause. Patients last known to be alive and relapse-free are censored at date of last contact. |
5 years after last randomization
|
|
Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs
Délai: Randomized patients will be followed until death or 94 months (from study start November 10, 2015 to September 15, 2023), whichever occurs first.
|
Only adverse events that are possibly, probably or definitely related to study drug are reported. CTCAE Version 5.0 was used for all AE reporting. |
Randomized patients will be followed until death or 94 months (from study start November 10, 2015 to September 15, 2023), whichever occurs first.
|
Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Les enquêteurs
- Chercheur principal: Sapna Patel, SWOG Cancer Research Network
Publications et liens utiles
La personne responsable de la saisie des informations sur l'étude fournit volontairement ces publications. Il peut s'agir de tout ce qui concerne l'étude.
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude (Réel)
10 novembre 2015
Achèvement primaire (Réel)
15 septembre 2023
Achèvement de l'étude (Estimé)
23 janvier 2027
Dates d'inscription aux études
Première soumission
22 juillet 2015
Première soumission répondant aux critères de contrôle qualité
22 juillet 2015
Première publication (Estimé)
23 juillet 2015
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
1 octobre 2026
Dernière mise à jour soumise répondant aux critères de contrôle qualité
30 septembre 2026
Dernière vérification
1 août 2026
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
- Tumeurs par site
- Tumeurs
- Tumeurs par type histologique
- Maladies de la peau
- Tumeurs neuroectodermiques
- Tumeurs, cellules germinales et embryonnaires
- Tumeurs, tissu nerveux
- Tumeurs neuroendocrines
- Nevi et mélanomes
- Tumeurs cutanées
- Maladies de la peau et du tissu conjonctif
- Mélanome
- Peptides
- Acides aminés, peptides et protéines
- Protéines
- Techniques d'investigation
- Techniques de laboratoire clinique
- Techniques et procédures de diagnostic
- Diagnostic
- Facteurs biologiques
- Anticorps, monoclonal, humanisé
- Anticorps, monoclonal
- Anticorps
- Immunoglobulines
- Immunoprotéines
- Protéines sanguines
- Globulines sériques
- Globulines
- Techniques de chimie, analytique
- Composants du génome
- Génome
- Structures génétiques
- Phénomènes génétiques
- Analyse du spectre
- Récepteurs, surface cellulaire
- Protéines membranaires
- Peptides de signalisation intercellulaire et protéines
- Cytokines
- Interféron Type I
- Interférons
- Interféron-alpha
- Antigènes
- Antigènes, surface
- Biomarqueurs
- Composants de gènes
- Gènes
- Récepteurs, immunologique
- Antigènes, différenciation, lymphocyte T
- Antigènes, différenciation
- Protéines de point de contrôle immunitaire
- Récepteurs costimulants et inhibiteurs des cellules T
- ADN, intergénique
- Interféron alpha-2
- Ipilimumab
- Manipulation des échantillons
- pembrolizumab
- Spectroscopie de résonance magnétique
- Antigène CTLA-4
- Introns
Autres numéros d'identification d'étude
- NCI-2014-02676
- U10CA180888 (Subvention/contrat des NIH des États-Unis)
- NCI-2014-02676 (Identificateur de registre: CTRP (Clinical Trial Reporting Program))
- S1404 (Autre identifiant: CTEP)
- S1404 (Autre identifiant: SWOG)
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .