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Motion Sickness Severity and Sensorimotor Performance

23 juin 2026 mis à jour par: Yunus Emre Tutuneken, Istinye University

The Relationship of Balance, Proprioception, Coordination, and Reaction Time Measurements With Motion Sickness Severity in Individuals With Motion Sickness: A Cross-Sectional Study

Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).

Aperçu de l'étude

Statut

Pas encore de recrutement

Les conditions

Intervention / Traitement

Autre: Standardized Sensorimotor Assessment and Motion Sickness Provocation Protocol

Type d'étude

Observationnel

Inscription (Estimé)

Critères de participation

Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.

Critère d'éligibilité

Âges éligibles pour étudier

Adulte

Accepte les volontaires sains

Non

Méthode d'échantillonnage

Échantillon non probabiliste

Population étudiée

The study population consists of adult individuals aged between 18 and 40 years who exhibit susceptibility to motion sickness.

La description

Inclusion Criteria:

Individuals aged between 18 and 40 years.
Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).
Normal hearing acuity.
No history of acute or chronic vestibular disease, other than motion sickness.
Normal or corrected-to-normal vision.
Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests.

Exclusion Criteria:

Presence of any physical or orthopedic problem that could interfere with testing.
History of acute or chronic instability, unsteadiness, or vertigo.
Severe visual impairment.
History of prior ear surgery.
Presence of any neurological condition or disorder.
History of migraines.
Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives).
Use of alcohol or psychoactive substances within the last 48 hours prior to testing.

Plan d'étude

Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.

Comment l'étude est-elle conçue ?

Détails de conception

Que mesure l'étude ?

Principaux critères de jugement

Mesure des résultats	Description de la mesure	Délai
Static Balance Délai: 1 hour	Evaluated objectively using the ProKin® computerized balance system. Participants stand on the platform under conditions: double-leg with eyes open.	1 hour
Dynamic Balance Performance Délai: 1 hour	Evaluated using the ProKin® system.	1 hour
Motion Sickness Severity (Graybiel Score) Délai: 1 hour	Used to grade the clinical severity of acute motion sickness symptoms (including nausea, cold sweating, increased salivation, and dizziness) following a randomized chair-rotation provocation protocol. 0 (Minimum) to 50 points (Maximum). Higher scores indicate greater symptom severity, representing a worse clinical outcome (scores of 16 or above designate frank sickness).	1 hour

Mesures de résultats secondaires

Mesure des résultats	Description de la mesure	Délai
Knee Joint Proprioception Délai: 1 hour	Evaluated in supine and prone positions, targeting knee angles of 15°, 30°, 60°, and 90° using the Clinometer digital inclinometer smartphone application.	1 hour
Nine-Hole Peg Test (9HPT) Completion Time Délai: 1 hour	Used to assess upper extremity dexterity and fine motor coordination. Participants place nine pegs into the holes one by one and then remove them as quickly as possible.	1 hour
Tandem Walk Test Error Count Délai: 1 hour	Participants walk barefoot along a straight line for 10 steps, placing the heel of one foot directly against the toe of the other foot with arms relaxed at their sides.	1 hour
Visual Reaction Time Délai: 1 hour	Evaluated using the mobile application-based BlazePod.	1 hour

Collaborateurs et enquêteurs

C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.

Parrainer

Istinye University

Dates d'enregistrement des études

Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.

Dates principales de l'étude

Début de l'étude (Estimé)

1 juin 2026

Achèvement primaire (Estimé)

2 août 2026

Achèvement de l'étude (Estimé)

5 août 2026

Dates d'inscription aux études

Première soumission

26 mai 2026

Première soumission répondant aux critères de contrôle qualité