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Motion Sickness Severity and Sensorimotor Performance

23. juni 2026 oppdatert av: Yunus Emre Tutuneken, Istinye University

The Relationship of Balance, Proprioception, Coordination, and Reaction Time Measurements With Motion Sickness Severity in Individuals With Motion Sickness: A Cross-Sectional Study

Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).

Studieoversikt

Status

Har ikke rekruttert ennå

Forhold

Intervensjon / Behandling

Annen: Standardized Sensorimotor Assessment and Motion Sickness Provocation Protocol

Studietype

Observasjonsmessig

Registrering (Antatt)

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Voksen

Tar imot friske frivillige

Nei

Prøvetakingsmetode

Ikke-sannsynlighetsprøve

Studiepopulasjon

The study population consists of adult individuals aged between 18 and 40 years who exhibit susceptibility to motion sickness.

Beskrivelse

Inclusion Criteria:

Individuals aged between 18 and 40 years.
Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).
Normal hearing acuity.
No history of acute or chronic vestibular disease, other than motion sickness.
Normal or corrected-to-normal vision.
Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests.

Exclusion Criteria:

Presence of any physical or orthopedic problem that could interfere with testing.
History of acute or chronic instability, unsteadiness, or vertigo.
Severe visual impairment.
History of prior ear surgery.
Presence of any neurological condition or disorder.
History of migraines.
Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives).
Use of alcohol or psychoactive substances within the last 48 hours prior to testing.

Studieplan

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Designdetaljer

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Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Static Balance Tidsramme: 1 hour	Evaluated objectively using the ProKin® computerized balance system. Participants stand on the platform under conditions: double-leg with eyes open.	1 hour
Dynamic Balance Performance Tidsramme: 1 hour	Evaluated using the ProKin® system.	1 hour
Motion Sickness Severity (Graybiel Score) Tidsramme: 1 hour	Used to grade the clinical severity of acute motion sickness symptoms (including nausea, cold sweating, increased salivation, and dizziness) following a randomized chair-rotation provocation protocol. 0 (Minimum) to 50 points (Maximum). Higher scores indicate greater symptom severity, representing a worse clinical outcome (scores of 16 or above designate frank sickness).	1 hour

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Knee Joint Proprioception Tidsramme: 1 hour	Evaluated in supine and prone positions, targeting knee angles of 15°, 30°, 60°, and 90° using the Clinometer digital inclinometer smartphone application.	1 hour
Nine-Hole Peg Test (9HPT) Completion Time Tidsramme: 1 hour	Used to assess upper extremity dexterity and fine motor coordination. Participants place nine pegs into the holes one by one and then remove them as quickly as possible.	1 hour
Tandem Walk Test Error Count Tidsramme: 1 hour	Participants walk barefoot along a straight line for 10 steps, placing the heel of one foot directly against the toe of the other foot with arms relaxed at their sides.	1 hour
Visual Reaction Time Tidsramme: 1 hour	Evaluated using the mobile application-based BlazePod.	1 hour

Samarbeidspartnere og etterforskere

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Sponsor

Istinye University

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Antatt)

1. juni 2026

Primær fullføring (Antatt)

2. august 2026

Studiet fullført (Antatt)

5. august 2026

Datoer for studieregistrering

Først innsendt

26. mai 2026

Først innsendt som oppfylte QC-kriteriene