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Motion Sickness Severity and Sensorimotor Performance

23 juni 2026 bijgewerkt door: Yunus Emre Tutuneken, Istinye University

The Relationship of Balance, Proprioception, Coordination, and Reaction Time Measurements With Motion Sickness Severity in Individuals With Motion Sickness: A Cross-Sectional Study

Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).

Studie Overzicht

Toestand

Nog niet aan het werven

Conditie

Interventie / Behandeling

Ander: Standardized Sensorimotor Assessment and Motion Sickness Provocation Protocol

Studietype

Observationeel

Inschrijving (Geschat)

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

Volwassen

Accepteert gezonde vrijwilligers

Nee

Bemonsteringsmethode

Niet-waarschijnlijkheidssteekproef

Studie Bevolking

The study population consists of adult individuals aged between 18 and 40 years who exhibit susceptibility to motion sickness.

Beschrijving

Inclusion Criteria:

Individuals aged between 18 and 40 years.
Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).
Normal hearing acuity.
No history of acute or chronic vestibular disease, other than motion sickness.
Normal or corrected-to-normal vision.
Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests.

Exclusion Criteria:

Presence of any physical or orthopedic problem that could interfere with testing.
History of acute or chronic instability, unsteadiness, or vertigo.
Severe visual impairment.
History of prior ear surgery.
Presence of any neurological condition or disorder.
History of migraines.
Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives).
Use of alcohol or psychoactive substances within the last 48 hours prior to testing.

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat	Maatregel Beschrijving	Tijdsspanne
Static Balance Tijdsspanne: 1 hour	Evaluated objectively using the ProKin® computerized balance system. Participants stand on the platform under conditions: double-leg with eyes open.	1 hour
Dynamic Balance Performance Tijdsspanne: 1 hour	Evaluated using the ProKin® system.	1 hour
Motion Sickness Severity (Graybiel Score) Tijdsspanne: 1 hour	Used to grade the clinical severity of acute motion sickness symptoms (including nausea, cold sweating, increased salivation, and dizziness) following a randomized chair-rotation provocation protocol. 0 (Minimum) to 50 points (Maximum). Higher scores indicate greater symptom severity, representing a worse clinical outcome (scores of 16 or above designate frank sickness).	1 hour

Secundaire uitkomstmaten

Uitkomstmaat	Maatregel Beschrijving	Tijdsspanne
Knee Joint Proprioception Tijdsspanne: 1 hour	Evaluated in supine and prone positions, targeting knee angles of 15°, 30°, 60°, and 90° using the Clinometer digital inclinometer smartphone application.	1 hour
Nine-Hole Peg Test (9HPT) Completion Time Tijdsspanne: 1 hour	Used to assess upper extremity dexterity and fine motor coordination. Participants place nine pegs into the holes one by one and then remove them as quickly as possible.	1 hour
Tandem Walk Test Error Count Tijdsspanne: 1 hour	Participants walk barefoot along a straight line for 10 steps, placing the heel of one foot directly against the toe of the other foot with arms relaxed at their sides.	1 hour
Visual Reaction Time Tijdsspanne: 1 hour	Evaluated using the mobile application-based BlazePod.	1 hour

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Istinye University

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Geschat)

1 juni 2026

Primaire voltooiing (Geschat)

2 augustus 2026

Studie voltooiing (Geschat)

5 augustus 2026

Studieregistratiedata

Eerst ingediend

26 mei 2026

Eerst ingediend dat voldeed aan de QC-criteria