Effects of Red Panax Ginseng Supplementation on Cognitive Performance and Emotional Well-Being in Young Healthy Adults
Effects of Red Panax Ginseng Supplementation on Cognitive Performance and Emotional Well-Being in Young Healthy Adults, a Randomized Controlled Trial
College students face substantial and persistent mental health challenges that directly affect cognitive performance, stress regulation, and emotional well-being. Neurological functions such as working memory, attention regulation, executive control, and emotional processing are highly sensitive to stressors, leaving young adults vulnerable to daily fluctuations in cognitive efficiency. Recent findings from the Healthy Minds Network (2025) indicate that although rates of moderate to severe depression among college students declined from 44% in 2022 to 37% in 2025, and anxiety symptoms fell from 37% to 32%, levels of psychological flourishing also dropped, falling to 36% despite these improvements.
Ginseng contains bioactive compounds known as ginsenosides that favorably influence brain function and inflammatory cascades. Studies in stressed and moderately stressed adults demonstrated reduced perceived stress, improved emotional processing, enhanced cognitive performance, and beneficial changes to biomarkers with ginseng supplementation. In addition, randomized controlled trials reported improvements in mood regulation, fatigue resistance, and aspects of working memory and attention following short-term ginseng supplementation. This study will examine the effects of daily red panax ginseng supplementation (3000 mg/day; two 1500 mg Red Panax gummies) on cognitive performance and emotional well-being in healthy young adults.
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
College students face substantial and persistent mental health challenges that directly affect cognitive performance, stress regulation, and emotional well-being. Neurological functions such as working memory, attention regulation, executive control, and emotional processing are highly sensitive to stressors, leaving young adults vulnerable to daily fluctuations in cognitive efficiency. Recent findings from the Healthy Minds Network (2025) indicate that although rates of moderate to severe depression among college students declined from 44% in 2022 to 37% in 2025, and anxiety symptoms fell from 37% to 32%, levels of psychological flourishing also dropped, falling to 36% despite these improvements.
Ginseng contains bioactive compounds known as ginsenosides that favorably influence multiple neurobiological pathways such as neurotrophic signaling, neurotransmitter regulation, oxidative balance, and inflammatory cascades. Studies in stressed and moderately stressed adults demonstrated reduced perceived stress, improved emotional processing, enhanced cognitive performance, and modulated biomarkers related to the hypothalamic-pituitary-adrenal axis with ginseng supplementation. In addition, randomized controlled trials reported improvements in mood regulation, fatigue resistance, and aspects of working memory and attention following short-term ginseng supplementation. This study will examine the effects of daily red panax ginseng supplementation (3000 mg/day; two 1500 mg Red Panax gummies) on cognitive performance and emotional well-being in healthy young adults.
Type d'étude
Inscription (Estimé)
Phase
- N'est pas applicable
Contacts et emplacements
Coordonnées de l'étude
- Nom: Carol Johnston
- Numéro de téléphone: 6024963463
- E-mail: carol.johnston@asu.edu
Lieux d'étude
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Arizona
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Phoenix, Arizona, États-Unis, 85004
- Recrutement
- Health North ASU Downtown Campus
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Contact:
- Carol Johnston, PhD
- Numéro de téléphone: 6024962539
- E-mail: carol.johnston@asu.edu
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-
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Inclusion Criteria:
- Healthy young adults
- 18-30 years of age
Exclusion Criteria:
- medication/drug use that has not been consistent for the previous 3 months or will be discontinued during the trial
- unresolved chronic medical conditions (e.g., presence of persistent symptomology)
- diagnosed clinical depression
- acute illness
- regular use of cigarettes or marijuana
- pregnant or lactating women
- not fluent in English
- currently competing in sports or unusually high-intensity exercise protocols (e.g., high-intensity exercise greater than 30 minutes most days of the week)
- current use of ginseng or adaptogenic supplements, or allergy to ginseng
- any significant food allergies
- not willing to attend two in-person lab visits in downtown Phoenix and follow study protocol (including abstaining from caffeine in the 12 hours prior to testing)
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Science basique
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Double
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Expérimental: ginseng
ginseng |
This study will test the efficacy of ginseng on health compared to placebo treatment. |
|
Comparateur placebo: Placebo
strawberry gummy (2) |
This study will test the efficacy of ginseng on health compared to placebo treatment. |
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
cognitive performance
Délai: 2 hours post ingestion
|
Trail Making Test: measures cognitive flexibility; visual attention, and executive function, with interpretation based on completion times (in seconds) |
2 hours post ingestion
|
|
cognitive performance
Délai: 2 weeks
|
Trail Making Test measures cognitive flexibility; visual attention, and executive function, with interpretation based on completion times (in seconds) |
2 weeks
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
stress
Délai: 2 weeks
|
Perceived Stress Scale: higher scores indicate higher stress |
2 weeks
|
|
mental well being
Délai: 2 weeks
|
Warwick-Edinburgh Mental Well-Being Scale: higher scores indicating greater positive mental wellbeing |
2 weeks
|
Autres mesures de résultats
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
cognitive performance
Délai: 2 hours post ingestion
|
Stroop test: measures attention span, reaction time, and ability to resist distractions |
2 hours post ingestion
|
|
cognitive performance
Délai: 2 hours post ingestion
|
reaction time test: measured by the elapsed time between stimulus onset and an individual's response |
2 hours post ingestion
|
Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chercheur principal: Carol Johnston, Arizona State University
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Réel)
Achèvement primaire (Estimé)
Achèvement de l'étude (Estimé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- STUDY00024361
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
Étudie un produit d'appareil réglementé par la FDA américaine
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