Effects of Red Panax Ginseng Supplementation on Cognitive Performance and Emotional Well-Being in Young Healthy Adults
Effects of Red Panax Ginseng Supplementation on Cognitive Performance and Emotional Well-Being in Young Healthy Adults, a Randomized Controlled Trial
College students face substantial and persistent mental health challenges that directly affect cognitive performance, stress regulation, and emotional well-being. Neurological functions such as working memory, attention regulation, executive control, and emotional processing are highly sensitive to stressors, leaving young adults vulnerable to daily fluctuations in cognitive efficiency. Recent findings from the Healthy Minds Network (2025) indicate that although rates of moderate to severe depression among college students declined from 44% in 2022 to 37% in 2025, and anxiety symptoms fell from 37% to 32%, levels of psychological flourishing also dropped, falling to 36% despite these improvements.
Ginseng contains bioactive compounds known as ginsenosides that favorably influence brain function and inflammatory cascades. Studies in stressed and moderately stressed adults demonstrated reduced perceived stress, improved emotional processing, enhanced cognitive performance, and beneficial changes to biomarkers with ginseng supplementation. In addition, randomized controlled trials reported improvements in mood regulation, fatigue resistance, and aspects of working memory and attention following short-term ginseng supplementation. This study will examine the effects of daily red panax ginseng supplementation (3000 mg/day; two 1500 mg Red Panax gummies) on cognitive performance and emotional well-being in healthy young adults.
Studieöversikt
Status
Betingelser
Intervention / Behandling
Detaljerad beskrivning
College students face substantial and persistent mental health challenges that directly affect cognitive performance, stress regulation, and emotional well-being. Neurological functions such as working memory, attention regulation, executive control, and emotional processing are highly sensitive to stressors, leaving young adults vulnerable to daily fluctuations in cognitive efficiency. Recent findings from the Healthy Minds Network (2025) indicate that although rates of moderate to severe depression among college students declined from 44% in 2022 to 37% in 2025, and anxiety symptoms fell from 37% to 32%, levels of psychological flourishing also dropped, falling to 36% despite these improvements.
Ginseng contains bioactive compounds known as ginsenosides that favorably influence multiple neurobiological pathways such as neurotrophic signaling, neurotransmitter regulation, oxidative balance, and inflammatory cascades. Studies in stressed and moderately stressed adults demonstrated reduced perceived stress, improved emotional processing, enhanced cognitive performance, and modulated biomarkers related to the hypothalamic-pituitary-adrenal axis with ginseng supplementation. In addition, randomized controlled trials reported improvements in mood regulation, fatigue resistance, and aspects of working memory and attention following short-term ginseng supplementation. This study will examine the effects of daily red panax ginseng supplementation (3000 mg/day; two 1500 mg Red Panax gummies) on cognitive performance and emotional well-being in healthy young adults.
Studietyp
Inskrivning (Beräknad)
Fas
- Inte tillämpbar
Kontakter och platser
Studiekontakt
- Namn: Carol Johnston
- Telefonnummer: 6024963463
- E-post: carol.johnston@asu.edu
Studieorter
-
-
Arizona
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Phoenix, Arizona, Förenta staterna, 85004
- Rekrytering
- Health North ASU Downtown Campus
-
Kontakt:
- Carol Johnston, PhD
- Telefonnummer: 6024962539
- E-post: carol.johnston@asu.edu
-
-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Beskrivning
Inclusion Criteria:
- Healthy young adults
- 18-30 years of age
Exclusion Criteria:
- medication/drug use that has not been consistent for the previous 3 months or will be discontinued during the trial
- unresolved chronic medical conditions (e.g., presence of persistent symptomology)
- diagnosed clinical depression
- acute illness
- regular use of cigarettes or marijuana
- pregnant or lactating women
- not fluent in English
- currently competing in sports or unusually high-intensity exercise protocols (e.g., high-intensity exercise greater than 30 minutes most days of the week)
- current use of ginseng or adaptogenic supplements, or allergy to ginseng
- any significant food allergies
- not willing to attend two in-person lab visits in downtown Phoenix and follow study protocol (including abstaining from caffeine in the 12 hours prior to testing)
Studieplan
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Grundläggande vetenskap
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Dubbel
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Experimentell: ginseng
ginseng |
This study will test the efficacy of ginseng on health compared to placebo treatment. |
|
Placebo-jämförare: Placebo
strawberry gummy (2) |
This study will test the efficacy of ginseng on health compared to placebo treatment. |
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
cognitive performance
Tidsram: 2 hours post ingestion
|
Trail Making Test: measures cognitive flexibility; visual attention, and executive function, with interpretation based on completion times (in seconds) |
2 hours post ingestion
|
|
cognitive performance
Tidsram: 2 weeks
|
Trail Making Test measures cognitive flexibility; visual attention, and executive function, with interpretation based on completion times (in seconds) |
2 weeks
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
stress
Tidsram: 2 weeks
|
Perceived Stress Scale: higher scores indicate higher stress |
2 weeks
|
|
mental well being
Tidsram: 2 weeks
|
Warwick-Edinburgh Mental Well-Being Scale: higher scores indicating greater positive mental wellbeing |
2 weeks
|
Andra resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
cognitive performance
Tidsram: 2 hours post ingestion
|
Stroop test: measures attention span, reaction time, and ability to resist distractions |
2 hours post ingestion
|
|
cognitive performance
Tidsram: 2 hours post ingestion
|
reaction time test: measured by the elapsed time between stimulus onset and an individual's response |
2 hours post ingestion
|
Samarbetspartners och utredare
Sponsor
Utredare
- Huvudutredare: Carol Johnston, Arizona State University
Studieavstämningsdatum
Studera stora datum
Studiestart (Faktisk)
Primärt slutförande (Beräknad)
Avslutad studie (Beräknad)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Faktisk)
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- STUDY00024361
Plan för individuella deltagardata (IPD)
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