Symptoms of anxiety and depression among colorectal cancer survivors from the population-based, longitudinal PROFILES Registry: Prevalence, predictors, and impact on quality of life

Floortje Mols, Dounya Schoormans, Ignace de Hingh, Simone Oerlemans, Olga Husson, Floortje Mols, Dounya Schoormans, Ignace de Hingh, Simone Oerlemans, Olga Husson

Abstract

Background: The aims of this study were to prospectively assess symptoms of anxiety and depression among survivors of colorectal cancer (CRC), to compare these survivors with a normative population, and to identify subgroups at risk for experiencing symptoms of anxiety and/or depression across a 4-year time period. Also, the impact on health-related quality of life (HRQOL) was studied.

Methods: The population-based Eindhoven Cancer Registry was used to select patients diagnosed with CRC between 2000 and 2009. The Hospital Anxiety and Depression Scale and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (HRQOL) were completed by patients in 2010 (n = 2625 [73% response rate]), 2011, 2012, and 2013 and by an age- and sex-matched normative sample (n = 315) in 2011.

Results: Patients reported a significantly higher prevalence of depression (19.0% vs 12.8%) and anxiety (20.9% vs 11.8%) in comparison with the norm. Anxiety was stable, whereas depression scores changed over time, although this was not clinically relevant. A longer time since diagnosis was associated with fewer depressive symptoms over time, whereas older age and being male were associated with less anxiety and more depression. Being married was associated with less anxiety and depression, and a low education level and comorbid conditions were associated with more anxiety and depression. Higher levels of symptoms of depression and anxiety were associated with a lower global quality of life and lower physical, role, cognitive, emotional, and social functioning over time.

Conclusions: Because of the increased prevalence of depression and anxiety among patients with CRC and their negative effect on HRQOL, screening and referral are of the utmost importance, especially among those who are single, have a low educational level, and have comorbid conditions, even years after diagnosis and treatment. Cancer 2018;124:2621-8. © 2018 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Keywords: anxiety; colorectal cancer; depression; normative population; quality of life.

© 2018 American Cancer Society.

References

    1. Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017;67:177‐193.
    1. Jansen L, Koch L, Brenner H, Arndt V. Quality of life among long‐term (>/=5 years) colorectal cancer survivors—systematic review. Eur J Cancer. 2010;46:2879‐2888.
    1. Denlinger CS, Barsevick AM. The challenges of colorectal cancer survivorship. J Natl Compr Canc Netw. 2009;7:883‐893.
    1. Numico G, Longo V, Courthod G, Silvestris N. Cancer survivorship: long‐term side‐effects of anticancer treatments of gastrointestinal cancer. Curr Opin Oncol. 2015;27:351‐357.
    1. Mosher CE, Winger JG, Given BA, Helft PR, O'Neil BH. Mental health outcomes during colorectal cancer survivorship: a review of the literature. Psychooncology. 2016;25:1261‐1270.
    1. Janssen‐Heijnen MLG, Louwman WJ, Van de Poll‐Franse LV, Coebergh JWW. Results of 50 Years Cancer Registry in the South of the Netherlands: 1955‐2004 [in Dutch]. Eindhoven, the Netherlands: Eindhoven Cancer Registry; 2005.
    1. van de Poll‐Franse LV, Horevoorts N, Eenbergen MV, et al. The Patient Reported Outcomes Following Initial Treatment and Long Term Evaluation of Survivorship registry: scope, rationale and design of an infrastructure for the study of physical and psychosocial outcomes in cancer survivorship cohorts. Eur J Cancer. 2011;47:2188‐2194.
    1. Sangha O, Stucki G, Liang MH, Fossel AH, Katz JN. The self‐administered comorbidity questionnaire: a new method to assess comorbidity for clinical and health services research. Arthritis Rheum. 2003;49:156‐163.
    1. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand. 1983;67:361‐370.
    1. Olsson I, Mykletun A, Dahl AA. The Hospital Anxiety and Depression Rating Scale: a cross‐sectional study of psychometrics and case finding abilities in general practice. BMC Psychiatry. 2005;5:46.
    1. Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 2002;52:69‐77.
    1. Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ‐C30: a quality‐of‐life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365‐376.
    1. Fayers PM, Aaronson NK, Bjordal K, Groenvold M, Curran D, Bottomley A; EORTC Quality of Life Group . The EORTC QLQ‐C30 Scoring Manual. 3rd ed. Brussels, Belgium: European Organisation for Research and Treatment of Cancer; 2001.
    1. Hedeker DR, Gibbons RD. Longitudinal Data Analysis. Hoboken, NJ: Wiley; 2006:101‐112.
    1. Cohen J, Cohen P, West SG, Aiken LS. Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences. Mahwah, NJ: Erlbaum; 2003:255‐301.
    1. Cocks K, King MT, Velikova G, Martyn St‐James M, Fayers PM, Brown JM. Evidence‐based guidelines for determination of sample size and interpretation of the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30. J Clin Oncol. 2011;29:89‐96.
    1. Norman GR, Sloan JA, Wyrwich KW. Interpretation of changes in health‐related quality of life: the remarkable universality of half a standard deviation. Med Care. 2003;41:582‐592.
    1. Norman GR, Sridhar FG, Guyatt GH, Walter SD. Relation of distribution‐ and anchor‐based approaches in interpretation of changes in health‐related quality of life. Med Care. 2001;39:1039‐1047.
    1. Dunn J, Ng SK, Holland J, et al. Trajectories of psychological distress after colorectal cancer. Psychooncology. 2013;22:1759‐1765.
    1. Goldzweig G, Andritsch E, Hubert A, et al. How relevant is marital status and gender variables in coping with colorectal cancer? A sample of middle‐aged and older cancer survivors. Psychooncology. 2009;18:866‐874.
    1. Lynch BM, Steginga SK, Hawkes AL, Pakenham KI, Dunn J. Describing and predicting psychological distress after colorectal cancer. Cancer. 2008;112:1363‐1370.
    1. Tsunoda A, Nakao K, Hiratsuka K, Yasuda N, Shibusawa M, Kusano M. Anxiety, depression and quality of life in colorectal cancer patients. Int J Clin Oncol. 2005;10:411‐417.
    1. Aminisani N, Nikbakht H, Asghari Jafarabadi M, Shamshirgaran SM. Depression, anxiety, and health related quality of life among colorectal cancer survivors. J Gastrointest Oncol. 2017;8:81‐88.
    1. Baker‐Glenn EA, Park B, Granger L, Symonds P, Mitchell AJ. Desire for psychological support in cancer patients with depression or distress: validation of a simple help question. Psychooncology. 2011;20:525‐531.
    1. Mols F, Husson O, Roukema JA, van de Poll‐Franse LV. Depressive symptoms are a risk factor for all‐cause mortality: results from a prospective population‐based study among 3,080 cancer survivors from the PROFILES registry. J Cancer Surviv. 2013;7:484‐492.
    1. Caruso R, Nanni MG, Riba M, et al. Depressive spectrum disorders in cancer: prevalence, risk factors and screening for depression: a critical review. Acta Oncol. 2017;56:146‐155.
    1. Caruso R, GiuliaNanni M, Riba MB, Sabato S, Grassi L. Depressive spectrum disorders in cancer: diagnostic issues and intervention. A critical review. Curr Psychiatry Rep. 2017;19:33.
    1. Pinquart M, Duberstein PR. Depression and cancer mortality: a meta‐analysis. Psychol Med. 2010;40:1797‐1810.

Source: PubMed

Szponzorok és közreműködők

Egészségi állapot

Kábítószer-beavatkozások

3
Iratkozz fel