The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Osamu Nishida, Hiroshi Ogura, Moritoki Egi, Seitaro Fujishima, Yoshiro Hayashi, Toshiaki Iba, Hitoshi Imaizumi, Shigeaki Inoue, Yasuyuki Kakihana, Joji Kotani, Shigeki Kushimoto, Yoshiki Masuda, Naoyuki Matsuda, Asako Matsushima, Taka-Aki Nakada, Satoshi Nakagawa, Shin Nunomiya, Tomohito Sadahiro, Nobuaki Shime, Tomoaki Yatabe, Yoshitaka Hara, Kei Hayashida, Yutaka Kondo, Yuka Sumi, Hideto Yasuda, Kazuyoshi Aoyama, Takeo Azuhata, Kent Doi, Matsuyuki Doi, Naoyuki Fujimura, Ryota Fuke, Tatsuma Fukuda, Koji Goto, Ryuichi Hasegawa, Satoru Hashimoto, Junji Hatakeyama, Mineji Hayakawa, Toru Hifumi, Naoki Higashibeppu, Katsuki Hirai, Tomoya Hirose, Kentaro Ide, Yasuo Kaizuka, Tomomichi Kan'o, Tatsuya Kawasaki, Hiromitsu Kuroda, Akihisa Matsuda, Shotaro Matsumoto, Masaharu Nagae, Mutsuo Onodera, Tetsu Ohnuma, Kiyohiro Oshima, Nobuyuki Saito, So Sakamoto, Masaaki Sakuraya, Mikio Sasano, Norio Sato, Atsushi Sawamura, Kentaro Shimizu, Kunihiro Shirai, Tetsuhiro Takei, Muneyuki Takeuchi, Kohei Takimoto, Takumi Taniguchi, Hiroomi Tatsumi, Ryosuke Tsuruta, Naoya Yama, Kazuma Yamakawa, Chizuru Yamashita, Kazuto Yamashita, Takeshi Yoshida, Hiroshi Tanaka, Shigeto Oda, Osamu Nishida, Hiroshi Ogura, Moritoki Egi, Seitaro Fujishima, Yoshiro Hayashi, Toshiaki Iba, Hitoshi Imaizumi, Shigeaki Inoue, Yasuyuki Kakihana, Joji Kotani, Shigeki Kushimoto, Yoshiki Masuda, Naoyuki Matsuda, Asako Matsushima, Taka-Aki Nakada, Satoshi Nakagawa, Shin Nunomiya, Tomohito Sadahiro, Nobuaki Shime, Tomoaki Yatabe, Yoshitaka Hara, Kei Hayashida, Yutaka Kondo, Yuka Sumi, Hideto Yasuda, Kazuyoshi Aoyama, Takeo Azuhata, Kent Doi, Matsuyuki Doi, Naoyuki Fujimura, Ryota Fuke, Tatsuma Fukuda, Koji Goto, Ryuichi Hasegawa, Satoru Hashimoto, Junji Hatakeyama, Mineji Hayakawa, Toru Hifumi, Naoki Higashibeppu, Katsuki Hirai, Tomoya Hirose, Kentaro Ide, Yasuo Kaizuka, Tomomichi Kan'o, Tatsuya Kawasaki, Hiromitsu Kuroda, Akihisa Matsuda, Shotaro Matsumoto, Masaharu Nagae, Mutsuo Onodera, Tetsu Ohnuma, Kiyohiro Oshima, Nobuyuki Saito, So Sakamoto, Masaaki Sakuraya, Mikio Sasano, Norio Sato, Atsushi Sawamura, Kentaro Shimizu, Kunihiro Shirai, Tetsuhiro Takei, Muneyuki Takeuchi, Kohei Takimoto, Takumi Taniguchi, Hiroomi Tatsumi, Ryosuke Tsuruta, Naoya Yama, Kazuma Yamakawa, Chizuru Yamashita, Kazuto Yamashita, Takeshi Yoshida, Hiroshi Tanaka, Shigeto Oda

Abstract

Background and purpose: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English-language version of these guidelines was created based on the contents of the original Japanese-language version.

Methods: Members of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ), and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two-thirds (>66.6%) majority vote of each of the 19 committee members.

Results: A total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J-SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for 5 CQs.

Conclusions: Based on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

Keywords: Medical Information Network Distribution Service (Minds); Sepsis; evidence‐based medicine; guidelines; septic shock; systematic review.

References

    1. Sepsis Registry Committee of The Japanese Society of Intensive Care Medicine . The Japanese Guidelines for Management of Sepsis. J. Jpn. Soc. Intensive Care Med. 2013; 20: 124–73.
    1. Oda S, Aibiki M, Ikeda T et al The Japanese guidelines for the management of sepsis. J. Intensive Care. 2014; 2: 55.
    1. Committee for the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016). J. Jpn. Soc. Intensive Care Med. 2017;24: s1–232.
    1. Committee for the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016). JJAAM 2017; 28:s1–232
    1. Singer M, Deutschman CS, Seymour CW et al The third international consensus definitions for sepsis and septic shock (Sepsis‐3). JAMA 2016; 315: 801–10.
    1. Shankar‐Hari M, Phillips GS, Levy ML et al Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis‐3). JAMA 2016; 315: 775–87.
    1. Seymour CW, Liu VX, Iwashyna TJ et al Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis‐3). JAMA 2016; 315(762–74): 2.
    1. Levy MM, Fink MP, Marshall JC et al SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit. Care Med. 2001; 2003(31): 1250–6.
    1. Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta‐analysis. Lancet Infect Dis. 2013; 13: 426–35.
    1. Zhang X, Liu D, Liu YN, Wang R, Xie LX. The accuracy of presepsin (sCD14‐ST) for the diagnosis of sepsis in adults: a meta‐analysis. Crit. Care 2015; 19: 323.
    1. Hou T, Huang D, Zeng R, Ye Z, Zhang Y. Accuracy of serum interleukin (IL)‐6 in sepsis diagnosis: a systematic review and meta‐analysis. Int. J. Clin. Exp. Med. 2015; 8: 15238–45.
    1. Simon L, Gauvin F, Amre DK, Saint‐Louis P, Lacroix J. Serum procalcitonin and C‐reactive protein levels as markers of bacterial infection: a systematic review and meta‐analysis. Clin. Infect. Dis. 2004; 39: 206–17.
    1. Chandrasekar PH, Brown WJ. Clinical issues of blood cultures. Arch. Intern. Med. 1994; 154: 841–9.
    1. Caldeira D, David C, Sampaio C. Skin antiseptics in venous puncture‐site disinfection for prevention of blood culture contamination: systematic review with meta‐analysis. J. Hosp. Infect. 2011; 77: 223–32.
    1. Murray PR, Masur H. Current approaches to the diagnosis of bacterial and fungal bloodstream infections in the intensive care unit. Crit. Care Med. 2012; 40: 3277–82.
    1. Kiyoyama T, Tokuda Y, Shiiki S et al Isopropyl alcohol compared with isopropyl alcohol plus povidone‐iodine as skin preparation for prevention of blood culture contamination. J. Clin. Microbiol. 2009; 47: 54–8.
    1. Cockerill FR III, Wilson JW, Vetter EA et al Optimal testing parameters for blood cultures. Clin. Infect. Dis. 2004; 38: 1724–30.
    1. Li J, Plorde JJ, Carlson LG. Effects of volume and periodicity on blood cultures. J. Clin. Microbiol. 1994; 32: 2829–31.
    1. Lee A, Mirrett S, Reller LB et al Detection of bloodstream infections in adults: how many blood cultures are needed? J. Clin. Microbiol. 2007; 45: 3546–8.
    1. Baddour LM, Wilson WR, Bayer AS et al Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. Circulation 2005; 111: e394–434.
    1. Blot F, Nitenberg G, Chachaty E et al Diagnosis of catheter‐related bacteraemia: a prospective comparison of the time to positivity of hub‐blood versus peripheral‐blood cultures. Lancet 1999; 354: 1071–7.
    1. Blot F, Schmidt E, Nitenberg G et al Earlier positivity of central‐venous‐ versus peripheral‐blood cultures is highly predictive of catheter‐related sepsis. J. Clin. Microbiol. 1998; 36: 105–9.
    1. Dellinger RP, Levy MM, Rhodes A et al Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013; 39: 165–228.
    1. Mandell LA, Wunderink RG, Anzueto A et al Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community‐acquired pneumonia in adults. Clin. Infect. Dis. 2007; 44(Suppl 2): S27–72.
    1. American Thoracic Society; Infectious Diseases Society of America . Guidelines for the management of adults with hospital‐acquired, ventilator‐associated, and healthcare‐associated pneumonia. Am. J. Respir. Crit. Care Med. 2005; 171: 388–416.
    1. Hooton TM, Bradley SF, Cardenas DD et al Diagnosis, prevention, and treatment of catheter‐associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin. Infect. Dis. 2010; 50: 625–63.
    1. Tunkel AR, Hartman BJ, Kaplan SL et al Practice guidelines for the management of bacterial meningitis. Clin. Infect. Dis. 2004; 39: 1267–84.
    1. Chaudhuri A, Martinez‐Martin P, Kennedy PG et al EFNS guideline on the management of community‐acquired bacterial meningitis: report of an EFNS Task Force on acute bacterial meningitis in older children and adults. Eur. J. Neurol. 2008; 15: 649–59.
    1. Dellinger RP, Levy MM, Rhodes A et al Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit. Care Med. 2013; 41: 580–637.
    1. De Waele JJ. Early source control in sepsis. Langenbecks Arch Surg 2010; 395: 489–94.
    1. Hasburn R, Abrahams J, Jekel J et al Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N. Engl. J. Med. 2001; 345: 1727–33.
    1. Tsuchiya K, Katase S, Yoshino A et al Pre and postcontrast FLAIR MR imaging in the diagnosis of intracranial meningeal pathology. Radiat. Med. 2000; 18: 363–8.
    1. Baddour LM, Wilson WR, Bayer AS et al Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications. a scientific statement for healthcare professionals from the american heart association. Circulation 2015; 132: 1435–86.
    1. Nonaka M, Kadokura M. Descending necrotizing mediastinitis: its early detection and acceptable approach. J. Jpn. Soc. Intensive Care Med. 2008; 15: 41–8.
    1. Ferguson ND, Fan E, Camporota L et al The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med. 2012; 38: 1573–82.
    1. Sartelli M, Viale P, Catena F et al 2013 WSES guidelines for management of intra‐abdominal infections. World J. Emerg. Surg. 2013; 8: 3.
    1. Kiriyama S, Takada T, Strasberg SM et al TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos). J. Hepatobiliary Pancreat. Sci. 2013; 20: 24–34.
    1. Yamamoto S, Ishikawa K, Hayami H et al JAID/JSC guidelines for the treatment of urinary tract infectious diseases and male genital infections. Jpn. J. Chemother. 2016; 64: 2–30.
    1. Wan YL, Lee TY, Bullard MJ et al Acute gas‐producting bacterial renal infection: correlation between imaging findings and clinical outcome. Radiology 1996; 198: 433–8.
    1. Yanagawa Y, Aihara K, Watanabe S et al Whole body CT for a patient with sepsis. Int. Sch. Sci. Res. Innov. 2013; 7: 318–21.
    1. Just KS, Defosse JM, Grensemann J et al Computed tomography for the identification of a potential infectious source in critically ill surgical patients. J. Crit. Care 2015; 30: 386–9.
    1. McDonald JS, McDonald RJ, Comin J et al Frequency of acute kidney injury following intravenous contrast medium administration: a systematic review and meta‐analysis. Radiology 2013; 267: 119–28.
    1. Ng CS, Shaw AD, Bell CS et al Effect of IV contrast medium on renal function in oncologic patients undergoing CT in ICU. AJR Am. J. Roentgenol. 2010; 195: 414–22.
    1. Polena S, Yang S, Alam R et al Nephropathy in critically ill patients without preexisting renal disease. Proc. West. Pharmacol. Soc. 2005; 48: 134–5.
    1. Tokyo Igakusha . Clinical Guideline for the Use of Iodine Contrast Medium in Patients with Kidney Injury 2012. Tokyo: Tokyo Igakusha, 2012.
    1. Wacha H, Hau T, Dittmer R, Ohmann C. Risk factors associated with intraabdominal infections: a prospective multicenter study. Langenbecks Arch. Surg. 1999; 384: 24–32.
    1. Solomkin JS, Mazuski JE, Bradley JS et al Diagnosis and management of complicated intra‐abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin. Infect. Dis. 2010; 50: 133–64.
    1. Koperna T, Schulz F. Relaparotomy in peritonitis: prognosis and treatment of patients with persisting intraabdominal infection. World J. Surg. 2000; 24: 32–7.
    1. Buck DL, Vester‐Andersen M, Moller MH. Surgical delay is a critical determinant of survival in perforated peptic ulcer. Br. J. Surg. 2013; 100: 1045–9.
    1. Azuhata T, Kinoshita K, Kawano D et al Time from admission to initiation of surgery for source control is a critical determinant of survival in patients with gastrointestinal perforation with associated septic shock. Crit. Care 2014; 18: R87.
    1. Banks PA, Bollen TL, Dervenis C et al Classification of acute pancreatitis ‐ 2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62: 102–11.
    1. Mermel LA, Allon M, Bouza E et al Clinical practice guidelines for the diagnosis and management of intravascular catheter‐related infection: 2009 Update by the Infectious Diseases Society of America. Clin. Infect. Dis. 2009; 49: 1–45.
    1. Pearle MS, Goldfarb DS, Assimos DG et al Medical management of kidney stones: AUA guideline. J. Urol. 2014; 192: 316–24.
    1. Tuürk C, Knoll T, Petrik A et al Guidelines on Urolithiasis. [cited 15 Dec 2017]. Available from:
    1. Ziemba JB, Matlaga BR. Guideline of guidelines: kidney stones. BJU Int. 2015; 116: 184–9.
    1. Pearle MS, Pierce HL, Miller GL et al Optimal method of urgent decompression of the collecting system for obstruction and infection due to ureteral calculi. J. Urol. 1998; 160: 1260–4.
    1. Stevens DL, Bisno AL, Chambers HF et al Practice guidelines for the diagnosis and management of skin and soft tissue infections. Clin. Infect. Dis. 2014; 59: 147–59.
    1. Sartelli M, Malangoni MA, May AK et al World Society of Emergency Surgery (WSES) guidelines for management of skin and soft tissue infections. World J Emergency Surg 2014; 9: 57.
    1. Goh T, Goh LG, Ang CH et al Early diagnosis of necrotizing fasciitis. Br. J. Surg. 2014; 101: e119–5.
    1. Mier J, León EL, Castillo A et al Early versus late necrosectomy in severe necrotizing pancreatitis. Am. J. Surg. 1997; 173: 71–5.
    1. van Santvoort HC, Besselink MG, Bakker OJ et al A step‐up approach or open necrosectomy for necrotizing pancreatitis. N. Engl. J. Med. 2010; 362: 1491–502.
    1. Bakker OJ, van Santvoort HC, van Brunschot S et al Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis: a randomized trial. JAMA 2012; 307: 1053–61.
    1. Rijnders BJ, Peetermans WE, Verwaest C et al Watchful waiting versus immediate catheter removal in ICU patients with suspected catheter‐related infection: a randomized trial. Intensive Care Med. 2004; 30: 1073–80.
    1. Garnacho‐Montero J, Aldabó‐Pallás T, Palomar‐Martínez M et al Risk factors and prognosis of catheter‐related bloodstream infection in critically ill patients: a multicenter study. Intensive Care Med. 2008; 34: 2185–93.
    1. Kumar A, Roberts D, Wood KE et al Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit. Care Med. 2006; 34: 1589–96.
    1. Jalili M, Barzegari H, Pourtabatabaei N et al Effect of door‐to‐antibiotic time on mortality of patients with sepsis in emergency department: a prospective cohort study. Acta Med. Iran 2013; 51: 454–60.
    1. Sterling SA, Miller WR, Pryor J, Puskarich MA, Jones AE. The impact of timing of antibiotics on outcomes in severe sepsis and septic shock: a systematic review and meta‐analysis. Crit. Care Med. 2015; 43: 1907–15.
    1. Ostrosky‐Zeichner L, Pappas PG. Invasive candidiasis in the intensive care unit. Crit. Care Med. 2006; 34: 857–63.
    1. Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin. Microbiol. Rev. 2007; 20: 133–63.
    1. Muskett H, Shahin J, Eyres G et al Risk factors for invasive fungal disease in critically ill adult patients: a systematic review. Crit. Care Lond. Engl. 2011; 15: R287.
    1. Yang S‐P, Chen Y‐Y, Hsu H‐S et al A risk factor analysis of healthcare‐associated fungal infections in an intensive care unit: a retrospective cohort study. BMC Infect. Dis. 2013; 13: 10.
    1. Abdul‐Aziz MH, Sulaiman H, Mat‐Nor MB et al Beta‐Lactam Infusion in Severe Sepsis (BLISS): a prospective, two‐centre, open‐labelled randomised controlled trial of continuous versus intermittent beta‐lactam infusion in critically ill patients with severe sepsis. Intensive Care Med. 2016; 42: 1535–45.
    1. Abdul‐Aziz MH, Dulhunty JM, Bellomo R et al Continuous beta‐lactam infusion in critically ill patients: the clinical evidence. Ann. Intensive Care 2012; 2: 37.
    1. Leone M, Bechis C, Baumstarck K et al De‐escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non‐blinded randomized noninferiority trial. Intensive Care Med. 2014; 40: 1399–408.
    1. Karlsson S, Heikkinen M, Pettilä V et al Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study. Crit. Care 2010; 14: R205.
    1. de Azevedo JRA, Torres OJM, Czeczko NG et al Procalcitonin as a prognostic biomarker of severe sepsis and septic shock. Rev. Colégio Bras. Cir. 2012; 39: 456–61.
    1. Charles PE, Tinel C, Barbar S et al Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and the outcome. Crit. Care 2009; 13: R38.
    1. Shehabi Y, Sterba M, Garrett PM et al Procalcitonin algorithm in critically ill adults with undifferentiated infection or suspected sepsis. A randomized controlled trial. Am. J. Respir. Crit. Care Med. 2014; 190: 1102–10.
    1. Oliveira CF, Botoni FA, Oliveira CR et al Procalcitonin versus C‐reactive protein for guiding antibiotic therapy in sepsis: a randomized trial. Crit. Care Med. 2013; 41: 2336–43.
    1. Deliberato RO, Marra AR, Sanches PR et al Clinical and economic impact of procalcitonin to shorten antimicrobial therapy in septic patients with proven bacterial infection in an intensive care setting. Diagn. Microbiol. Infect. Dis. 2013; 76: 266–71.
    1. Annane D, Maxime V, Faller JP et al Procalcitonin levels to guide antibiotic therapy in adults with non‐microbiologically proven apparent severe sepsis: a randomised controlled trial. BMJ Open 2013; 3: e002186.
    1. Bouadma L, Luyt CE, Tubach F et al Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial. Lancet 2010; 375: 463–74.
    1. Schroeder S, Hochreiter M, Koehler T et al Procalcitonin (PCT)‐guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study. Langesbecks Arch. Surg. 2009; 394: 221–6.
    1. Nobre V, Harbarth S, Graf JD et al Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. Am. J. Respir. Crit. Care Med. 2008; 177: 498–505.
    1. Svoboda P, Kantorová I, Scheer P et al Can procalcitonin help us in timing of re‐intervention in septic patients after multiple trauma or major surgery? Hepatogastroenterology 2007; 54: 359–63.
    1. de Jong E, van Oers JA, Beishuizen A et al Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open‐label trial. Lancet Infect. Dis. 2016; 16: 819–27.
    1. Roberts JA, Lipman J. Pharmacokinetic issues for antibiotics in the critically ill patient. Crit. Care Med. 2009; 37: 840–51.
    1. Paul M, Lador A, Grozinsky‐Glasberg S et al Beta lactam antibiotic monotherapy versus beta lactam‐aminoglycoside antibiotic combination therapy for sepsis. Cochrane Database Syst. Rev. 2014; 1: CD003344.
    1. Brunkhorst FM, Oppert M, Marx G et al Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis‐related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA 2012; 307: 2390–9.
    1. Chytra I, Stepan M, Benes J et al Clinical and microbiological efficacy of continuous versus intermittent application of meropenem in critically ill patients: a randomized open‐label controlled trial. Crit. Care 2012; 16: R113.
    1. Dulhunty JM, Roberts JA, Davis JS et al Continuous infusion of beta‐lactam antibiotics in severe sepsis: a multicenter double‐blind, randomized controlled trial. Clin. Infect. Dis. 2013; 56: 236–244.
    1. Dulhunty JM, Roberts JA, Davis JS et al A multicenter randomized trial of continuous versus intermittent beta‐lactam infusion in severe sepsis. Am. J. Respir. Crit. Care Med. 2015; 192: 1298–1305.
    1. Negi VS, Elluru S, Sibéril S et al Intravenous immunoglobulin:an update on the clinical use and mechanisms of action. J. Clin. Immunol. 2007; 27: 233–45.
    1. Nimmerjahn F, Ravetch JV. Anti‐inflammatory actions of intravenous immunoglobulin. Annu. Rev. Immunol. 2008; 26: 513–33.
    1. Venet F, Gebeile R, Bancel J et al Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients. Int. Immunopharmacol. 2011; 11: 2086–90.
    1. Taccone FS, Stordeur P, De Becker D et al Gammaglobulin levels in patients with community‐acquired septic shock. Shock 2009; 32: 379–85.
    1. Rodríguez A, Rello J, Neira J et al Effects of high‐dose of intravenous immunoglobulin and antibiotics on survival for severe sepsis undergoing surgery. Shock 2005; 23: 298–304.
    1. Masaoka T, Hasegawa H, Takaku F et al The efficacy of intravenous immunoglobulin in combination therapy with antibiotics for severe infections. Jpn. J. Chemother. 2000; 48: 199–217.
    1. Kotani J, Saito T, Gando S et al Analysis of the therapies for severe sepsis patients. JJAAM 2013; 24: 291–6.
    1. Tagami T, Matsui H, Fushimi K et al Intravenous immunoglobulin use in septic shock patients after emergency laparotomy. J. Infect. 2015; 71: 158–66.
    1. Tagami T, Matsui H, Fushimi K et al Intravenous immunoglobulin and mortality in pneumonia patients with septic shock: an observational nationwide study. Clin. Infect. Dis. 2015; 61: 385–92.
    1. Werdan K, Pilz G, Bujdoso O et al Score‐based immunoglobulin G therapy of patients with sepsis: the SBITS study. Crit. Care Med. 2007; 35: 2693–701.
    1. Darenberg J, Ihendyane N, Sjölin J et al Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double‐blind, placebo‐controlled trial. Clin. Infect. Dis. 2003; 37: 333–40.
    1. De Simone C, Delogu G, Corbetta G. Intravenous immunoglobulins in association with antibiotics: a therapeutic trial in septic intensive care unit patients. Crit. Care Med. 1988; 16: 23–6.
    1. Dominioni L, Bianchi V, Imperatori A et al High‐dose intravenous IgG for treatment of severe surgical infections. Dig. Surg. 1996; 13: 430–4.
    1. Grundmann R, Hornung M. Immunoglobulin therapy in patients with endotoxemia and postoperative sepsis ‐ a prospective randomized study. Prog. Clin. Biol. Res. 1988; 272: 339–49.
    1. Alejandria MM, Lansang MA, Dans LF et al Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. Cochrane Database Syst. Rev. 2013; 9: CD001090.
    1. Gu WJ, Wang F, Bakker J et al The effect of goal‐directed therapy on mortality in patients with sepsis ‐ earlier is better: a meta‐analysis of randomized controlled trials. Crit. Care 2014; 18: 570.
    1. Rivers E, Nguyen B, Havstad S et al Early goal‐directed therapy in the treatment of severe sepsis and septic shock. N. Engl. J. Med. 2001; 345: 1368–77.
    1. ProCESS Investigators , Yealy DM, Kellum JA et al A randomized trial of protocol‐based care for early septic shock. N. Engl. J. Med. 2014; 370: 1683–93.
    1. ARISE Investigators; ANZICS Clinical Trials Group , Peake SL, Delaney A et al Goal‐directed resuscitation for patients with early septic shock. N. Engl. J. Med. 2014; 371: 1496–506.
    1. Mouncey PR, Osborn TM, Power GS et al Trial of early, goal‐directed resuscitation for septic shock. N. Engl. J. Med. 2015; 372: 1301–11.
    1. Parker MM, Shelhamer JH, Bacharach SL et al Profound but reversible myocardial depression in patients with septic shock. Ann. Intern. Med. 1984; 100: 483–90.
    1. Landesberg G, Gilon D, Meroz Y et al Diastolic dysfunction and mortality in severe sepsis and septic shock. Eur. Heart J. 2012; 33: 895–903.
    1. Reuter DA, Felbinger TW, Moerstedt K et al Intrathoracic blood volume index measured by thermodilution for preload monitoring after cardiac surgery. J. Cardiothorac. Vasc. Anesth. 2002; 16: 191–5.
    1. Marik PE, Cavallazzi R, Vasu T et al Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature. Crit. Care Med. 2009; 37: 2642–7.
    1. Mahjoub Y, Touzeau J, Airapetian N et al The passive leg‐raising maneuver cannot accurately predict fluid responsiveness in patients with intra‐abdominal hypertension. Crit. Care Med. 2010; 38: 1824–9.
    1. Jones AE, Shapiro NI, Trzeciak S et al Emergency Medicine Shock Research Network (EMShockNet) Investigators. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 2010; 303: 739–46.
    1. Landry DW, Oliver JA. The pathogenesis of vasodilatory shock. N. Engl. J. Med. 2001; 345: 588–95.
    1. Cariou A, Pinsky MR, Monchi M et al Is myocardial adrenergic responsiveness depressed in human septic shock? Intensive Care Med. 2008; 34: 917–22.
    1. Rudiger A, Singer M. Mechanisms of sepsis‐induced cardiac dysfunction. Crit. Care Med. 2007; 35: 1599–608.
    1. Annane D, Vignon P, Renault A et al Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomized trial. Lancet 2007; 370: 676–84.
    1. Mahmoud KM, Ammar AS. Norepinephrine supplemented with dobutamine or epinephrine for the cardiovascular support of patients with septic shock. Indian J. Crit. Care Med. 2012; 16: 75–80.
    1. Gordon AC, Perkins GD, Singer M et al Levosimendan for the prevention of acute organ dysfunction in sepsis. N. Engl. J. Med. 2016; 375: 1638–48.
    1. Morelli A, Ertmer C, Westphal M et al Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA 2013; 310: 1683–91.
    1. Wang Z, Wu Q, Nie X et al Combination therapy with milrinone and esmolol for heart protection in patients with severe sepsis: a prospective, randomized trial. Clin. Drug Investig. 2015; 35: 707–16.
    1. Chacko CJ, Gopal S. Systematic review of use of β‐blockers in sepsis. J. Anaesthesiol. Clin. Pharmacol. 2015; 31: 460–5.
    1. Brunkhorst FM, Engel C, Bloos F et al Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N. Engl. J. Med. 2008; 358: 125–39.
    1. McIntyre LA, Fergusson D, Cook DJ et al Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trial. Can. J. Anaesth. 2008; 55: 819–26.
    1. Perner A, Haase N, Guttormsen AB et al Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N. Engl. J. Med. 2012; 367: 124–34.
    1. Dubin A, Pozo MO, Casabella CA et al Comparison of 6% hydroxyethyl starch 130/0.4 and saline solution for resuscitation of the microcirculation during the early goal‐directed therapy of septic patients. J. Crit. Care 2010; 25: 659.e1–659.e8
    1. Guidet B, Martinet O, Boulain T et al Assessment of hemody‐ namic efficacy and safety of 6% hydroxyethylstarch 130/0.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis: the CRYSTMAS study. Crit. Care 2012; 16: R94.
    1. Myburgh JA, Finfer S, Bellomo R et al Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N. Engl. J. Med. 2012; 367: 1901–11.
    1. Lv J, Zhao HY, Liu F et al The influence of lactate Ringer solution versus hydroxyethyl starch on coagulation and fibrinolytic system in patients with septic shock. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2012; 24: 38–41.
    1. Zhu GC, Quan ZY, Shao YS et al The study of hypertonic saline and hydroxyethyl starch treating severe sepsis. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2011; 23: 150–3.
    1. Basel Starch Evaluation in Sepsis (BaSES) . Last vertified January 2013. [cited 15 Dec 2017]. Available from: ; 2012.
    1. Serpa Neto A, Veelo DP, Peireira VG et al Fluid resuscitation with hydroxyethyl starches in patients with sepsis is associated with an increased incidence of acute kidney injury and use of renal replacement therapy: a systematic review and meta‐analysis of the literature. J. Crit. Care 2014; 29: 185.e1–185.e7.
    1. Annane D, Siami S, Jaber S et al Effect of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial. JAMA 2013; 310: 1809–17.
    1. Patel A, Laffan MA, Waheed U et al Randomized trials of human albumin for adults with sepsis: systematic review and meta‐ analysis with trial sequential analysis of all‐cause mortality. BMJ 2014; 349: g4561.
    1. SAFE Study Investigators , Finfer S, McEvoy S et al Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis. Intensive Care Med. 2011; 37: 86–96.
    1. Kuan WS, Ibrahim I, Leong BS et al Emergency department management of sepsis patients: a randomized, goal‐oriented, noninvasive sepsis trial. Ann. Emerg. Med. 2016; 67(367–78): e3.
    1. Chen C, Kollef MH. Targeted fluid minimization following initial resuscitation in septic shock: a pilot study. Chest 2015; 148: 1462–9.
    1. Zhang Z, Ni H, Qian Z. Effectiveness of treatment based on PiCCO parameters in critically ill patients with septic shock and/or acute respiratory distress syndrome: a randomized controlled trial. Intensive Care Med. 2015; 41: 444–51.
    1. Richard JC, Bayle F, Bourdin G et al Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial. Crit. Care 2015; 19: 5.
    1. Xu Q, Yan J, Cai G et al Effect of two volume responsiveness evaluation methods on fluid resuscitation and prognosis in septic shock patients. Chin. Med. J. (Engl.) 2014; 127: 483–7.
    1. Jansen TC, van Bommel J, Schoonderbeek FJ et al Early lactate‐guided therapy in intensive care unit patients: a multicenter, open‐label, randomized controlled trial. Am. J. Respir. Crit. Care Med. 2010; 182: 752–61.
    1. Avni T, Lador A, Lev S et al Vasopressors for the treatment of septic shock: systematic review and meta‐analysis. PLoS ONE 2015; 10: e0129305.
    1. Vieillard‐Baron A. Septic cardiomyopathy. Ann. Intensive Care 2011; 1: 6.
    1. Le Tulzo Y, Seguin P, Gacouin A et al Effects of epinephrine on right ventricular function in patients with severe septic shock and right ventricular failure: a preliminary descriptive study. Intensive Care Med. 1997; 23: 664–70.
    1. Russell JA, Walley KR, Singer J et al Vasopressin versus norepi‐ nephrine infusion in patients with septic shock. N. Engl. J. Med. 2008; 358: 877–87.
    1. Morelli A, Ertmer C, Rehberg S et al Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study. Crit. Care 2009; 13: R130.
    1. Marik PE, Pastores SM, Annane D et al Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit. Care Med. 2008; 36: 1937–49.
    1. Dellinger RP, Carlet JM, Masur H et al Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit. Care Med. 2004; 32: 858–73.
    1. Dellinger RP, Levy MM, Carlet JM et al Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit. Care Med. 2008; 36: 296–327.
    1. Annane D, Bellissant E, Bollaert PE et al Corticosteroids for severe sepsis and septic shock: a systematic review and meta‐analysis. BMJ 2004; 329: 480–4.
    1. Sprung CL, Annane D, Keh D et al Hydrocortisone therapy for patients with septic shock. N. Engl. J. Med. 2008; 358: 111–24.
    1. Keh D, Trips E, Marx G et al Effect of hydrocortisone on development of shock among patients with severe sepsis. The HYPRESS Randomized Clinical Trial. JAMA 2016; 316: 1775–85.
    1. Bone RC, Fisher CJ Jr, Clemmer TP et al A controlled clinical trial of high‐dose methylpredonisolone in the treatment of severe sepsis and septic shock. N. Engl. J. Med. 1987; 317: 653–8.
    1. The Veterans Administration Systemic Sepsis Cooperative Study Group . Effect of high‐dose glucocorticoid therapy on mortality in patients with clinical signs of sepsis. N. Engl. J. Med. 1987; 317: 659–65.
    1. Wang C, Sun J, Zheng J et al Low‐dose hydrocortisone therapy attenuates septic shock in adult patients but does not reduce 28‐day mortality: a meta‐analysis of randomized controlled trials. Anesth. Analg. 2014; 118: 346–57.
    1. Gordon AC, Mason AJ, Perkins GD et al The interaction of vasopressin and corticosteroids in septic shock: a pilot randomized controlled trial. Crit. Care Med. 2014; 42: 1325–33.
    1. Bollaert PE, Charpentier C, Levy B et al Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit. Care Med. 1998; 26: 645–50.
    1. Briegel J, Forst H, Haller M et al Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double‐blind, single‐center study. Crit. Care Med. 1999; 27: 723–32.
    1. Chawla K, Kupfer Y, Goldman I et al Hydrocortisone reverses refractory septic shock (abstract). Am. J. Respir. Crit. Care Med. 1999; 27: A33.
    1. Annane D, Sébille V, Charpentier C et al Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288: 862–71.
    1. Oppert M, Schindler R, Husung C et al Low‐dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit. Care Med. 2005; 33: 2457–64.
    1. Mussack T, Briegel J, Schelling G et al Effect of stress doses of hydrocortisone on S‐100B vs. interleukin‐8 and polymorphonuclear elastase levels in human septic shock. Clin. Chem. Lab. Med. 2005; 43: 259–68.
    1. Arabi YM, Aljumah A, Dabbagh O et al Low‐dose hydrocortisone in patients with cirrhosis and septic shock: a randomized controlled trial. CMAJ 2010; 182: 1971–7.
    1. Park HY, Suh GY, Song JU et al Early initiation of low‐dose corticosteroid therapy in the management of septic shock: a retrospective observational study. Crit. Care 2012; 16: R3.
    1. Katsenos CS, Antonopoulou AN, Apostolidou EN et al Early administration of hydrocortisone replacement after the advent of septic shock: impact on survival and immune response. Crit. Care Med. 2014; 42: 1651–7.
    1. Annane D, Bellissant E, Bollaert PE et al Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. JAMA 2009; 301: 2362–75.
    1. Annane D, Bellisant E, Bollaert PE et al Corticosteroids for treating sepsis (Review). The Cochrane Collaboration, The Cochrane Library, 2015; issue 12, Wiley.
    1. Meduri GU, Golden E, Freire AX et al Methylpredonisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 2007; 131: 954–63.
    1. Moran JL, Graham PL, Rockliff S et al Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta‐analytic perspective. Crit. Care 2010; 14: R134.
    1. Yu TJ, Liu YC, Yu CC et al Comparing hydrocortisone and methylprednisolone in patients with septic shock. Adv. Ther. 2009; 26: 728–35.
    1. Ministry of Health, Labour and Welfare . The guideline for the use of blood products. [cited 15 Dec 2017]. Available from:
    1. Holst LB, Haase N, Wetterslev J et al Lower versus higher hemoglobin threshold for transfusion in septic shock. N. Engl. J. Med. 2014; 371: 1381–91.
    1. Mazza BF, Freitas FG, Barros MM et al Blood transfusions in septic shock: is 7.0 g/dL really the appropriate threshold? Rev. Bras. Ter. Intensiva 2015; 27: 36–43.
    1. Shaz BH, Stowell SR, Hillyer CD. Transfusion‐related acute lung injury: from bedside to bench and back. Blood 2011; 117: 1463–71.
    1. Ware LB, Matthay MA. Medical progress: the acute respiratory distress syndrome. N. Engl. J. Med. 2000; 342: 1334–49.
    1. Rubenfeld GD, Caldwell E, Peabody E et al Incidence and outcomes of acute lung injury. N. Engl. J. Med. 2005; 353: 1685–93.
    1. Pierrakos C, Vincent JL. The changing pattern of acute respiratory distress syndrome over time: a comparison of two periods. Eur. Respir. J. 2012; 40: 589–95.
    1. Gajic O, Dabbagh O, Park PK et al Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am. J. Respir. Crit. Care Med. 2011; 183: 462–70.
    1. Mikkelsen ME, Shah CV, Meyer NJ et al The epidemiology of acute respiratory distress syndrome in patients presenting to the emergency department with severe sepsis. Shock 2013; 40: 375–81.
    1. Ranieri VM, Rubenfeld GD, Thompson BT et al Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012; 307: 2526–33.
    1. Nishimura M. High‐flow nasal cannula oxygen therapy in adults. J. Intensive Care 2015; 3: 15.
    1. Frat JP, Brugiere B, Ragot S et al Sequential application of oxygen therapy via high‐flow nasal cannula and noninvasive ventilation in acute respiratory failure: an observational pilot study. Respir. Care 2015; 60: 170–1.
    1. Agarwal R, Aggarwal AN, Gupta D. Role of noninvasive ventilation in acute lung injury/acute respiratory distress syndrome: a proportion meta‐analysis. Respir. Care 2010; 55: 1653–60.
    1. Nava S, Schreiber A, Domenighetti G. Noninvasive ventilation for patients with acute lung injury or acute respiratory distress syndrome. Respir. Care 2011; 56: 1583–8.
    1. Japanese Society of Intensive Care Medicine/Japanese Society of Respiratory Care Medicine/Japanese Respiratory Society . Clinical guideline for acute respiratory distress syndrome 2016; Sogoigakusha, Tokyo Japan:
    1. Network The Acute Respiratory Distress Syndrome. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N. Engl. J. Med. 2000; 342: 1301–8.
    1. Esteban A, Ferguson ND, Meade MO et al Evolution of mechanical ventilation in response to clinical research. Am. J. Respir. Crit. Care Med. 2008; 177: 170–7.
    1. Artigas A, Bernard GR, Carlet J et al The American‐European Consensus Conference on ARDS, part 2: ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 1998; 157: 1332–47.
    1. Feihl F, Perret C. Permissive hypercapnia. How permissive should we be? Am. J. Respir. Crit. Care Med. 1994; 150: 1722–37.
    1. Dreyfuss D, Saumon G. Ventilator‐induced lung injury: lessons from experimental studies. Am. J. Respir. Crit. Care Med. 1998; 157: 294–323.
    1. Gattinoni L, Caironi P. Refining ventilatory treatment for acute lung injury and acute respiratory distress syndrome. JAMA 2008; 299: 691–3.
    1. Amato MB, Meade MO, Slutsky AS et al Driving pressure and survival in the acute respiratory distress syndrome. N. Engl. J. Med. 2015; 372: 747–55.
    1. Mauri T, Yoshida T, Bellani G et al PLeUral pressure working Group (PLUG—Acute Respiratory Failure section of the European Society of Intensive Care Medicine): esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives. Intensive Care Med. 2016; 42: 1360–73.
    1. Mauri T, Bellani G, Grasselli G et al Patient‐ventilator interaction in ARDS patients with extremely low compliance undergoing ECMO: a novel approach based on diaphragm electrical activity. Intensive Care Med. 2013; 39: 282–91.
    1. Rosenberg AL, Dechert RE, Park PK et al Review of a large clinical series: association of cumulative fluid balance on outcome in acute lung injury: a retrospective review of the ARDSnet tidal volume study cohort. J. Intensive Care Med. 2009; 24: 35–46.
    1. Martin GS, Eaton S, Mealer M et al Extravascular lung water in patients with severe sepsis: a prospective cohort study. Crit. Care 2005; 9: R74–82.
    1. Petrucci N, De Feo C. Lung protective ventilation strategy for the acute respiratory distress syndrome. Cochrane Database Syst. Rev. 2013; 2: CD003844.
    1. Amato MB, Barbas CS, Medeiros DM et al Effect of a protective‐ventilation strategy on mortality in the acute respiratory distress syndrome. N. Engl. J. Med. 1998; 338: 347–54.
    1. Brochard L, Roudot‐Thoraval F, Roupie E et al Tidal volume reduction for prevention of ventilator‐induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS. Am. J. Respir. Crit. Care Med. 1998; 158: 1831–8.
    1. Brower RG, Shanholtz CB, Fessler HE et al Prospective, randomized controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit. Care Med. 1999; 27: 1492–8.
    1. Stewart TE, Meade MO, Cook DJ et al Evaluation of a ventilation strategy to prevent barotrauma in patient at high risk for acute respiratory distress syndrome. Pressure and volume limited ventilation strategy group. N. Engl. J. Med. 1998; 338: 355–61.
    1. Villar J, Kacmarek RM, Perez‐Mendez L et al A high positive end‐expiration pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Crit. Care Med. 2006; 34: 1311–8.
    1. Brower RG, Lanken PN, MacIntyre N et al Higher versus lower positive end‐expiratory pressures in patients with the acute respiratory distress syndrome. N. Engl. J. Med. 2004; 351: 327–36.
    1. Meade MO, Cook DJ, Guyatt GH et al Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end‐expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008; 299: 637–45.
    1. Mercat A, Richard JC, Vielle B et al Positive end‐expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008; 299: 646–55.
    1. Talmor D, Sarge T, Malhotra A et al Mechanical ventilation guided by esophageal pressure in acute lung injury. N. Engl. J. Med. 2008; 359: 2095–104.
    1. Huh JW, Jung H, Choi HS et al Efficacy of positive end‐expiratory pressure titration after the alveolar recruitment manoeuvre in patients with acute respiratory distress syndrome. Crit. Care 2009; 13: R22.
    1. Wiedemann HP, Wheeler AP, Bernard GR et al Comparison of two fluid‐management strategies in acute lung injury. N. Engl. J. Med. 2006; 354: 2564–75.
    1. Martin GS, Mangialardi RJ, Wheeler AP et al Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. Crit. Care Med. 2002; 30: 2175–82.
    1. Mojtahedzadeh M, Vazin A, Najafi A et al The effect of furosemide infusion on serum epidermal growth factor concentration after acute lung injury. J. Infus. Nurs. 2005; 28: 188–93.
    1. Hu W, Lin CW, Liu BW et al Extravascular lung water and pulmonary arterial wedge pressure for fluid management in patients with acute respiratory distress syndrome. Multidiscip. Respir. Med. 2014; 9: 3.
    1. Peterson JF, Pun BT, Dittus RS et al Delirium and its motor subtypes: a study of 614 critically ill patients. J. Am. Geriatr. Soc. 2006; 54: 479–84.
    1. Ely EW, Inouye SK, Bernard GR et al Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM‐ICU). JAMA 2001; 286: 2703–10.
    1. Stevens RD, Nyquist PA. Types of brain dysfunction in critical illness. Neurol. Clin. 2008; 26: 469–86.
    1. Pandharipande PP, Girard TD, Jackson JC et al Long‐term cognitive impairment after critical illness. N. Engl. J. Med. 2013; 369: 1306–16.
    1. Vasilevskis EE, Ely EW, Speroff T et al Reducing iatrogenic risks: ICU‐acquired delirium and weakness–crossing the quality chasm. Chest 2010; 138: 1224–33.
    1. Girard TD, Pandharipande PP, Carson SS et al Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo‐controlled trial. Crit. Care Med. 2010; 38: 428–37.
    1. van Eijk MM, Roes KC, Honing ML et al Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double‐blind, placebo‐controlled randomised trial. Lancet 2010; 376: 1829–37.
    1. Kalisvaart KJ, de Jonghe JF, Bogaards MJ et al Haloperidol prophylaxis for elderly hip‐surgery patients at risk for delirium: a randomized placebo‐controlled study. J. Am. Geriatr. Soc. 2005; 53: 1658–66.
    1. Larsen KA, Kelly SE, Stern TA et al Administration of olanzapine to prevent postoperative delirium in elderly joint‐replacement patients: a randomized, controlled trial. Psychosomatics 2010; 51: 409–18.
    1. Marcantonio ER, Palihnich K, Appleton P et al Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture. J. Am. Geriatr. Soc. 2011; 59: S282–8.
    1. Gamberini M, Bolliger D, Lurati Buse GA et al Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery–a randomized controlled trial. Crit. Care Med. 2009; 37: 1762–8.
    1. Devlin JW, Roberts RJ, Fong JJ et al Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double‐blind, placebo‐controlled pilot study. Crit. Care Med. 2010; 38: 419–27.
    1. Gilmore ML, Wolfe DJ. Antipsychotic prophylaxis in surgical patients modestly decreases delirium incidence–but not duration–in high‐incidence samples: a meta‐analysis. Gen. Hosp. Psychiatry 2013; 35: 370–5.
    1. Litton E, Carnegie V, Elliott R et al The efficacy of earplugs as a sleep hygiene strategy for reducing delirium in the ICU: a systematic review and meta‐analysis. Crit. Care Med. 2016; 44: 992–9.
    1. Schweickert WD, Pohlman MC, Pohlman AS et al Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 2009; 373: 1874–82.
    1. Needham DM, Korupolu R, Zanni JM et al Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch. Phys. Med. Rehabil. 2010; 91: 536–42.
    1. Brook AD, Ahrens TS, Schaiff R et al Effect of a nursing‐implemented sedation protocol on the duration of mechanical ventilation. Crit. Care Med. 1999; 27: 2609–15.
    1. Kress JP, Pohlman AS, O'Connor MF et al Daily interruption ofsedative infusions in critically ill patients undergoing mechanicalventilation. N. Engl. J. Med. 2000; 342: 1471–7.
    1. Girard TD, Kress JP, Fuchs BD et al Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a radomised controlled trial. Lancet 2008; 371: 126–34.
    1. Shehabi Y, Bellomo R, Reade MC et al . Early goal‐directed sedation versus standard sedation in mechanically ventilated critically Ill patients: a pilot study. Crit. Care Med. 2013; 41: 1983–91.
    1. Pohlman MC, Schweickert WD, Pohlman AS et al Feasibility of physical and occupational therapy beginning from initiation of mechanical ventilation. Crit. Care Med. 2010; 38: 2089–94.
    1. Berney SC, Harrold M, Webb SA et al Intensive care unit mobility practices in Australia and New Zealand: a point prevalence study. Crit. Care Resusc. 2013; 15: 260–5.
    1. Nydahl P, Ruhl AP, Bartoszek G et al Early mobilization of mechanically ventilated patients: a 1‐day point‐prevalence study in Germany. Crit. Care Med. 2014; 42: 1178–86.
    1. Strøm T, Martinussen T, Toft P. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 2010; 375: 475–80.
    1. Committee for the development of Japanese guidelines for the management of Pain, Agitation, and Delirium in intensive care unit, Japanese Society of Intensive Care Medicine . Japanese guidelines for the management of Pain, Agitation, and Delirium in intensive care unit (J‐PAD). J. Jpn. Soc. Intensive Care Med. 2014;21:539–579.
    1. Barr J, Fraser GL, Puntillo K et al Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit. Care Med. 2013; 41: 263–306.
    1. Chlan LL, Weinert CR, Heiderscheit A et al Effects of patient‐directed music intervention on anxiety and sedative exposure in critically ill patients receiving mechanical ventilatory support: a randomized clinical trial. JAMA 2013; 309: 2335–44.
    1. Bellomo R, Ronco C, Kellum JA et al Acute renal failure ‐ definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit. Care 2004; 8: R204–12.
    1. Ricci Z, Cruz D, Ronco C. The RIFLE criteria and mortality in acute kidney injury: a systematic review. Kidney Int. 2008; 73: 538–46.
    1. Lassnigg A, Schmidlin D, Mouhieddine M et al Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study. J. Am. Soc. Nephrol. 2004; 15: 1597–605.
    1. Mehta RL, Kellum JA, Shah SV et al Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit. Care 2007; 11: R31.
    1. Improving Global Outcomes . (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int. Suppl. 2012; 2: 1–138.
    1. Bagshaw SM, Uchino S, Bellomo R et al Beginning and Ending Supportive Therapy for the Kidney(BEST KIDNEY) Investigators. Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin. J. Am. Soc. Nephrol. 2007; 2: 431–9.
    1. Ostermann M, Chang RW. Acute kidney injury in the intensive care unit according to RIFLE. Crit. Care Med. 2007; 35: 1837–43.
    1. Luo X, Jiang L, Du B et al A comparison of different diagnostic criteria of acute kidney injury in critically ill patients. Crit. Care 2014; 18: R144.
    1. Fujii T, Uchino S, Takinami M et al Validation of the kidney disease improving global outcomes criteria for AKI and comparison of three criteria in hospitalized patients. Clin. J. Am. Soc. Nephrol. 2014; 9: 848–54.
    1. Levi TM, de Souza SP, de Magalhães JG et al Comparison of the RIFLE, AKIN and KDIGO criteria to predict mortality in critically ill patients. Rev. Bras. Ter Intensiva 2013; 25: 290–6.
    1. Shinjo H, Sato W, Imai E et al Comparison of kidney disease: improving global outcomes and acute kidney injury network criteria for assessing patients in intensive care units. Clin. Exp. Nephrol. 2014; 18: 737–45.
    1. Zeng X, McMahon GM, Brunelli SM et al Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals. Clin. J. Am. Soc. Nephrol. 2014; 9: 12–20.
    1. Nisula S, Kaukonen KM, Vaara ST et al Incidence, risk factors and 90‐day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study. Intensive Care Med. 2013; 39: 420–8.
    1. Peng Q, Zhang L, Ai Y et al Epidemiology of acute kidney injury in intensive care septic patients based on the KDIGO guidelines. Chin. Med. J. 2014; 127: 1820–6.
    1. National Institute for Health and Clinical Excellence . Acute Kidney Injury: Prevention, Detection and Management Up to the Point of Renal Replacement Therapy. UK: National Clinical Guideline Centre, 2013.
    1. Bouman CS, Oudemans‐Van Straaten HM, Tijssen JG et al Effects of early high‐volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: a prospective, randomized trial. Crit. Care Med. 2002; 30: 2205–11.
    1. Gaudry S, Hajage D, Schortgen F et al Initiation strategies for renal‐replacement therapy in the intensive care unit. N. Engl. J. Med. 2016; 375: 122–33.
    1. Zarbock A, Kellum JA, Schmidt C et al Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA 2016; 315: 2190–9.
    1. Smith OM, Wald R, Adhikari NK et al Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT‐AKI): study protocol for a randomized controlled trial. Trials 2013; 14: 320.
    1. Rabindranath K, Adams J, Macleod AM et al Intermittent versus continuous renal replacement therapy for acute renal failure in adults. Cochrane Database Syst. Rev. 2007; 3: 3773.
    1. Augustine JJ, Sandy D, Seifert TH et al A randomized controlled trial comparing intermittent with continuous dialysis in patients with ARF. Am. J. Kidney Dis. 2004; 44: 1000–7.
    1. Gasparovic V, Filipovic‐Grcic I, Merkler M et al Continuous renal replacement therapy (CRRT) or intermittent hemodialysis (IHD) ‐ what is the procedure of choice in critically III patients? Ren. Fail. 2003; 25: 855–62.
    1. Mehta R, McDonald B, Gabbai FB et al A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure. Kidney Int. 2001; 60: 1154–63.
    1. Noble JS, Simpson K, Allison ME. Long‐term quality of life and hospital mortality in patients treated with intermittent or continuous hemodialysis for acute renal and respiratory failure. Ren. Fail. 2006; 28: 323–30.
    1. Lins RL, Elseviers MM, Van der Niepen P et al Intermittent versus continuous renal replacement therapy for acute kidney injury patients admitted to the intensive care unit: results of a randomized clinical trial. Nephrol. Dial. Transplant. 2009; 24: 512–8.
    1. Uehlinger DE, Jakob SM, Ferrari P et al Comparison of continuous and intermittent renal replacement therapy for acute renal failure. Nephrol. Dial. Transplant. 2005; 20: 1630–7.
    1. Vinsonneau C, Camus C, Combes A et al Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple‐organ dysfunction syndrome: a multicentre randomised trial. Lancet 2006; 368: 379–85.
    1. John S, Griesbach D, Baumgartel M et al Effects of continuous haemofiltration vs intermittent haemodialysis on systemic haemodynamics and splanchnic regional perfusion in septic shock patients: a prospective, randomized clinical trial. Nephrol. Dial. Transplant. 2001; 16: 320–27.
    1. Jun M, Heerspink HJ, Ninomiya T et al Intensities of renal replacement therapy in acute kidney injury: a systematic review and meta‐analysis. Clin. J. Am. Soc. Nephrol. 2010; 5: 956–63.
    1. Vincent JL, Laterre PF, Cohen J et al A pilot‐controlled study of a polymyxin B‐immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra‐abdominal infection. Shock 2005; 23: 400–5.
    1. Cruz DN, Antonelli M, Fumagalli R et al Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA 2009; 301: 2445–52.
    1. Payen DM, Guilhot J, Launey Y et al Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial. Intensive Care Med. 2015; 41: 975–84.
    1. Klein DJ, Foster D, Schorr CA et al The EUPHRATES trial (Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock): study protocol for a randomized controlled trial. Trials 2014; 15: 218.
    1. Ho KM, Power BM. Benefits and risks of furosemide in acute kidney injury. Anaesthesia 2010; 65: 283–93
    1. Ho KM, Sheridan DJ. Meta‐analysis of frusemide to prevent or treat acute renal failure. BMJ 2006; 333: 420.
    1. De Backer D, Aldecoa C, Njimi H et al Dopamine versus norepinephrine in the treatment of septic shock: a meta‐analysis. Crit. Care Med. 2012; 40: 725–30.
    1. Friedrich JO, Adhikari N, Herridge MS et al Meta‐analysis: low‐dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann. Intern. Med. 2005; 142: 510–24.
    1. Nigwekar SU, Navaneethan SD, Parikh CR et al Atrial natriuretic peptide for preventing and treating acute kidney injury. Cochrane Database Syst. Rev. 2009; CD006028.
    1. Hasselgren PO. Catabolic response to stress and injury: implications for regulation. World J. Surg. 2000; 24: 1452–1459.
    1. Demling RH, Seigne P. Metabolic management of patients with severe burns. World J. Surg. 2000; 24: 673–680.
    1. Hill AG, Hill GL. Metabolic response to severe injury. Br. J. Surg. 1998; 85: 884–890.
    1. Ali NA, O'Brien JM Jr, Hoffmann SP et al Acquired weakness, handgrip strength, and mortality in critically ill patients. Am. J. Respir. Crit. Care Med. 2008; 178: 261–268.
    1. Elamin EM, Camporesi E. Evidence‐based nutritional support in the intensive care unit. Int. Anesthesiol. Clin. 2009; 47: 121–138.
    1. The Committee on Japanese Guidelines for Nutrition Support Therapy in the Adult and Pediatric Critically Ill Patients, Japanese Society of Intensive Care Medicine. Japanese Guidel ines for Nutrition Support Therapy in the Adult and Pediatric Critically Ill Patients. . J. Jpn. Soc. Intensive Care Med. 2016; 23: 185–281.
    1. Doig GS, Heighes PT, Simpson F et al Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: a meta‐analysis of randomised controlled trials. Intensive Care Med. 2009; 35: 2018–2027.
    1. Doig GS, Heighes PT, Simpson F et al Early enteral nutrition reduces mortality in trauma patients requiring intensive care: a meta‐analysis of randomised controlled trials. Injury 2011; 42: 50–56.
    1. Heyland DK, Dhaliwal R, Drover JW. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J. Parenter. Enteral Nutr. 2003; 27: 355–373.
    1. Marik PE, Zaloga GP. Early enteral nutrition in acutely ill patients: a systematic review. Crit. Care Med. 2001; 29: 2264–2270.
    1. Koretz RL, Lipman TO. The presence and effect of bias in trials of early enteral nutrition in critical care. Clin. Nutr. 2014; 33: 240–245.
    1. Rice TW, Wheeler AP, Thompson BT, deBoisblanc BP, Steingrub J, Rock P. Enteral omega‐3 fatty acid, gamma‐linolenic acid, and antioxidant supplementation in acute lung injury. JAMA 2011; 306: 1574–1581.
    1. Villet S, Chiolero RL, Bollmann MD et al Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin. Nutr. 2005; 24: 502–509.
    1. Rapp RP, Young B, Twyman D et al The favorable effect of early parenteral feeding on survival in head‐injured patients. J. Neurosurg. 1983; 58: 906–12.
    1. Adams S, Dellinger EP, Wertz MJ et al Enteral versus parenteral nutritional support following laparotomy for trauma: a randomized prospective trial. J. Trauma 1986; 26: 882–91.
    1. Young B, Ott L, Twyman D et al The effect of nutritional support on outcome from severe head injury. J. Neurosurg. 1987; 67: 668–76.
    1. Peterson VM, Moore EE, Jones TN et al Total enteral nutrition versus total parenteral nutrition after major torso injury: attenu‐ ation of hepatic protein reprioritization. Surgery 1988; 104: 199–207.
    1. Cerra FB, McPherson JP, Konstantinides FN et al Enteral nutrition does not prevent multiple organ failure syndrome (MOFS) after sepsis. Surgery 1988; 104: 727–33.
    1. Moore FA, Moore EE, Jones TN et al TEN versus TPN following major abdominal trauma–reduced septic morbidity. J. Trauma 1989; 29: 916–23.
    1. Kudsk KA, Croce MA, Fabian TC et al Enteral versus parenteral feeding. Effects on septic morbidity after blunt and penetrating abdominal trauma. Ann. Surg. 1992; 215: 503–13.
    1. Dunham CM, Frankenfield D, Belzberg H et al Gut failure–predictor of or contributor to mortality in mechanically ventilated blunt trauma patients? J. Trauma 1994; 37: 30–4.
    1. Borzotta AP, Pennings J, Papasadero B et al Enteral versus parenteral nutrition after severe closed head injury. J. Trauma 1994; 37: 459–68.
    1. Hadfield RJ, Sinclair DG, Houldsworth PE et al Effects of enteral and parenteral nutrition on gut mucosal permeability in the critically ill. Am. J. Respir. Crit. Care Med. 1995; 152: 1545–8.
    1. McClave SA, Greene LM, Snider HL et al Comparison of the safety of early enteral vs parenteral nutrition in mild acute pancreatitis. JPEN J. Parenter. Enteral Nutr. 1997; 21: 14–20.
    1. Harvey SE, Parrott F, Harrison DA et al Trial of the route of early nutritional support in critically ill adults. N. Engl. J. Med. 2014; 371: 1673–84.
    1. Doig GS, Chevrou‐Séverac H, Simpson F. Early enteral nutrition in critical illness: a full economic analysis using US costs. Clinicoecon Outcomes Res. 2013; 5: 429–36.
    1. Chiarelli A, Enzi G, Casadei A et al Very early nutrition supplementation in burned patients. Am. J. Clin. Nutr. 1990; 51: 1035–9.
    1. Eyer SD, Micon LT, Konstantinides FN et al Early enteral feeding does not attenuate metabolic response after blunt trauma. J. Trauma 1993; 34: 639–43.
    1. Minard G, Kudsk KA, Melton S et al Early versus delayed feeding with an immune‐enhancing diet in patients with severe head injuries. JPEN J. Parenter. Enteral Nutr. 2000; 24: 145–9.
    1. Peck MD, Kessler M, Cairns BA et al Early enteral nutrition does not decrease hypermetabolism associated with burn injury. J. Trauma 2004; 57: 1143–8.
    1. Kompan L, Vidmar G, Spindler‐Vesel A et alIs early enteral nutrition a risk factor for gastric intolerance and pneumonia? Clin. Nutr. 2004; 23: 527–32.
    1. Dvorak MF, Noonan VK, Bélanger L et al Early versus late enteral feeding in patients with acute cervical spinal cord injury: a pilot study. Spine (Phila Pa 1976) 2004; 29: 175–80.
    1. Nguyen NQ, Fraser RJ, Bryant LK et al The impact of delaying enteral feeding on gastric emptying, plasma cholecystokinin, and peptide YY concentrations in critically ill patients. Crit. Care Med. 2008; 36: 1469–74.
    1. Chourdakis M, Kraus MM, Tzellos T et al Effect of early compared with delayed enteral nutrition on endocrine function in patients with traumatic brain injury: an open‐labeled randomized trial. JPEN J. Parenter. Enteral Nutr. 2012; 36: 108–16.
    1. Nguyen NQ, Besanko LK, Burgstad C et al Delayed enteral feeding impairs intestinal carbohydrate absorption in critically ill patients. Crit. Care Med. 2012; 40: 50–4.
    1. Rice TW, Mogan S, Hays MA et al Randomized trial of initial trophic versus full‐energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit. Care Med. 2011; 39: 967–974.
    1. Rice TW, Wheeler AP, Thompson BT et al Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA 2012; 307: 795–803.
    1. Desachy A, Clavel M, Vuagnat A et al Initial efficacy and tolerability of early enteral nutrition with immediate or gradual introduction in intubated patients. Intensive Care Med. 2008; 34: 1054–9.
    1. Taylor SJ, Fettes SB, Jewkes C et al Prospective, randomized, controlled trial to determine the effect of early enhanced enteral nutrition on clinical outcome in mechanically ventilated patients suffering head injury. Crit. Care Med. 1999; 27: 2525–31.
    1. Arabi YM, Tamim HM, Dhar GS et al Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial. Am. J. Clin. Nutr. 2011; 93: 569–77.
    1. Arabi YM, Aldawood AS, Haddad SH et al Permissive underfeeding or standard enteral feeding in critically ill adults. N. Engl. J. Med. 2015; 372: 2398–408.
    1. Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ et al Early parenteral nutrition in critically ill patients with short‐term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA 2013; 309: 2130–8.
    1. Langouche L, Vander Perre S, Marques M, Boelen A, Wouters PJ et al Impact of early nutrient restriction during critical illness on the nonthyroidal illness syndrome and its relation with outcome: a randomized, controlled clinical study. J. Clin. Endocrinol. Metab. 2013; 98: 1006–13.
    1. Heidegger CP, Berger MM, Graf S, Zingg W, Darmon P et al Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet 2013; 381: 385–93.
    1. Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M et al Early versus late parenteral nutrition in critically ill adults. N. Engl. J. Med. 2011; 365: 506–17.
    1. Singer P, Anbar R, Cohen J, Shapiro H, Shalita‐Chesner M et al The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients. Intensive Care Med. 2011; 37: 601–9.
    1. Bauer P, Charpentier C, Bouchet C, Nace L, Raffy F et al Parenteral with enteral nutrition in the critically ill. Intensive Care Med. 2000; 26: 893–900.
    1. Owais AE, Kabir SI, Mcnaught C et al A single‐blinded randomised clinical trial of permissive underfeeding in patients requiring parenteral nutrition. Clin. Nutr. 2014; 33: 997–1001.
    1. van den Berghe G, Wouters P, Weekers F et al Intensive insulin therapy in critically ill patients. N. Engl. J. Med. 2001; 345: 1359–67.
    1. Van den Berghe G, Wilmer A, Hermans G et al Intensive insulin therapy in the medical ICU. N. Engl. J. Med. 2006; 354: 449–61.
    1. Finfer S, Chittock DR, Su SY et al Intensive versus conventional glucose control in critically ill patients. N. Engl. J. Med. 2009; 360: 1283–97.
    1. Friedrich JO, Chant C, Adhikari NK. Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta‐analytic data. Crit. Care 2010; 14: 324.
    1. Song F, Zhong LJ, Han L et al Intensive insulin therapy for septic patients: a meta‐analysis of randomized controlled trials. Biomed. Res. Int. 2014; 2014: 698265.
    1. Kanji S, Buffie J, Hutton B et al Reliability of point‐of‐care testing for glucose measurement in critically ill adults. Crit. Care Med. 2005; 33: 2778–85.
    1. Inoue S, Egi M, Kotani J et al Accuracy of blood‐glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review. Crit. Care 2013; 17: R48.
    1. Grey NJ, Perdrizet GA. Reduction of nosocomial infections in the surgical intensive‐care unit by strict glycemic control. Endocr. Pract. 2004; 10(Suppl 2): 46–52.
    1. Bilotta F, Spinelli A, Giovannini F et al The effect of intensive insulin therapy on infection rate, vasospasm, neurologic outcome, and mortality in neurointensive care unit after intracranial aneurysm clipping in patients with acute subarachnoid hemorrhage: a randomized prospective pilot trial. J. Neurosurg. Anesthesiol. 2007; 19: 156–60.
    1. Bilotta F, Caramia R, Cernak I et al Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial. Neurocrit. Care 2008; 9: 159–66.
    1. Bland DK, Fankhanel Y, Langford E et al Intensive versus modified conventional control of blood glucose level in medical intensive care patients: a pilot study. Am. J. Crit. Care 2005; 14: 370–6.
    1. Walters MR, Weir CJ, Lees KR. A randomised, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycaemic acute ischaemic stroke patients. Cerebrovasc. Dis. 2006; 22: 116–22.
    1. Bruno A, Kent TA, Coull BM et al Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial. Stroke 2008; 39: 384–9.
    1. Mitchell I, Knight E, Gissane J et al A phase II randomised controlled trial of intensive insulin therapy in general intensive care patients. Crit. Care Resusc. 2006; 8: 289–93.
    1. Iapichino G, Albicini M, Umbrello M et al Tight glycemic control does not affect asymmetric‐dimethylarginine in septic patients. Intensive Care Med. 2008; 34: 1843–50.
    1. De La Rosa Gdel C, Donado JH, Restrepo AH et al Strict glycaemic control in patients hospitalised in a mixed medical and surgical intensive care unit: a randomised clinical trial. Crit. Care 2008; 12: R120.
    1. Arabi YM, Dabbagh OC, Tamim HM et al Intensive versus conventional insulin therapy: a randomized controlled trial in medical and surgical critically ill patients. Crit. Care Med. 2008; 36: 3190–7.
    1. Chan RP, Galas FR, Hajjar LA et al Intensive perioperative glucose control does not improve outcomes of patients submitted to open‐heart surgery: a randomized controlled trial. Clinics 2009;64:51–60
    1. Gray CS, Hildreth AJ, Sandercock PA et al Glucose‐potassium‐insulin infusions in the management of post‐stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST‐UK). Lancet Neurol. 2007; 6: 397–406.
    1. Farah R, Samokhvalov A, Zviebel F et al Insulin therapy of hyperglycemia in intensive care. Isr. Med. Assoc. J. 2007; 9: 140–2.
    1. Henderson WR, Dhingra V, Chittock D et al The efficacy and safety of glucose control algorithms in intensive care: a pilot study of the Survival Using Glucose Algorithm Regulation (SUGAR) trial. Pol. Arch. Med. Wewn. 2009; 119: 439–46.
    1. Annane D, Cariou A, Maxime V et al Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. JAMA 2010; 303: 341–8.
    1. Savioli M, Cugno M, Polli F et al Tight glycemic control may favor fibrinolysis in patients with sepsis. Crit. Care Med. 2009; 37: 424–31.
    1. Cappi SB, Noritomi DT, Velasco IT et al Dyslipidemia: a prospective controlled randomized trial of intensive glycemic control in sepsis. Intensive Care Med. 2012; 38: 634–41.
    1. Preiser JC, Devos P, Ruiz‐Santana S et al A prospective randomised multi‐centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med. 2009; 35: 1738–48.
    1. McMullin J, Brozek J, McDonald E et al Lowering of glucose in critical care: a randomized pilot trial. J. Crit. Care 2007; 22: 112–8; discussion 118‐9.
    1. Oksanen T, Skrifvars MB, Varpula T et al Strict versus moderate glucose control after resuscitation from ventricular fibrillation. Intensive Care Med. 2007; 33: 2093–100.
    1. de Azevedo JR, de Araujo LO, da Silva WS et al A carbohydrate‐restrictive strategy is safer and as efficient as intensive insulin therapy in critically ill patients. J. Crit. Care 2010; 25: 84–9.
    1. Mackenzie IM, Ercole A, Ingle S et al Glycaemic control and outcome in general intensive care: the East Anglian GLYCOGENIC study. Br. J. Intensive Care 2008; 18: 121–126.
    1. Davies RR, Newton RW, McNeill GP et al Metabolic control in diabetic subjects following myocardial infarction: difficulties in improving blood glucose levels by intravenous insulin infusion. Scott. Med. J. 1991; 36: 74–6.
    1. Grady NP, Barie PS, Bartlett JG et al Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Crit. Care Med. 2008; 36: 1330–49.
    1. Boulant JA. Role of the preoptic‐anterior hypothalamus in thermoregulation and fever. Clin. Infect. Dis. 2000; 31(Suppl 5): S157–61.
    1. Badillo AT, Sarani B, Evans SR. Optimizing the use of blood cultures in the febrile postoperative patient. J. Am. Coll. Surg. 2002; 194: 477–87; quiz 554‐6.
    1. Kennedy LD, Case LD, Hurd DD et al A prospective, randomized, double‐blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. Transfusion 2008; 48: 2285–91.
    1. Roush MK, Nelson KM. Understanding drug‐induced febrile reactions. Am. Pharm. 1993; NS33: 39–42.
    1. Tabor PA. Drug‐induced fever. Drug Intell. Clin. Pharm. 1986; 20: 413–20.
    1. Hawksworth JS, Leeser D, Jindal RM et al New directions for induction immunosuppression strategy in solid organ transplantation. Am. J. Surg. 2009; 197: 515–24.
    1. Lee BH, Inui D, Suh GY et al Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi‐centered prospective observational study. Crit. Care 2012; 16: R33.
    1. Laupland KB. Fever in the critically ill medical patient. Crit. Care Med. 2009; 37: S273–8.
    1. Plaisance KI, Mackowiak PA. Antipyretic therapy: physiologic rationale, diagnostic implications, and clinical consequences. Arch. Intern. Med. 2000; 160: 449–56.
    1. Knaus WA, Draper EA, Wagner DP et al APACHE II: a severity of disease classification system. Crit. Care Med. 1985; 13: 818–29.
    1. Bone RC, Balk RA, Cerra FB et al Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992. Chest 2009; 136: e28.
    1. Magill SS, Klompas M, Balk R et al Developing a new, national approach to surveillance for ventilator‐associated events*. Crit. Care Med. 2013; 41: 2467–75.
    1. Kushimoto S, Gando S, Saitoh D et al The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis. Crit. Care 2013; 17: R271.
    1. Bernard GR, Wheeler AP, Russell JA et al The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N. Engl. J. Med. 1997; 336: 912–8.
    1. Gozzoli V, Schottker P, Suter PM et al Is it worth treating fever in intensive care unit patients? Preliminary results from a randomized trial of the effect of external cooling. Arch. Intern. Med. 2001; 161: 121–3.
    1. Schortgen F, Clabault K, Katsahian S et al Fever control using external cooling in septic shock: a randomized controlled trial. Am. J. Respir. Crit. Care Med. 2012; 185: 1088–95.
    1. Schulman CI, Namias N, Doherty J et al The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study. Surg. Infect. (Larchmt) 2005; 6: 369–75.
    1. Yang YL, Liu DW, Wang XT et al Body temperature control in patients with refractory septic shock: too much may be harmful. Chin. Med. J. (Engl) 2013; 126: 1809–13.
    1. Young P, Saxena M, Bellomo R et al Acetaminophen for fever in critically ill patients with suspected infection. N. Engl. J. Med. 2015; 373: 2215–24.
    1. Valeri CR, MacGregor H, Cassidy G et al Effects of temperature on bleeding time and clotting time in normal male and female volunteers. Crit. Care Med. 1995; 2: 698–704.
    1. Watts DD, Trask A, Soeken K et al Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. J. Trauma 1998; 44: 846–54.
    1. Gando S, Iba T, Eguchi Y et al Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit. Care Med. 2006; 34: 625–31.
    1. Ogura H, Gando S, Saitoh D et al Epidemiology of severe sepsis in Japanese intensive care units: a prospective multicenter study. J. Infect. Chemother. 2014; 20: 157–62.
    1. Levi M, van der Poll T. A short contemporary history of disseminated intravascular coagulation. Semin. Thromb. Hemost. 2014; 40: 874–80.
    1. Asakura H. Classifying types of disseminated intravascular coagulation: clinical and animal models. J. Intensive Care 2014; 2: 20.
    1. Wada H, Matsumoto T, Yamashita Y. Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines. J. Intensive Care 2014; 2: 15.
    1. Fujishima S, Gando S, Saitoh D et al A multicenter, prospective evaluation of quality of care and mortality in Japan based on the Surviving Sepsis Campaign guidelines. J. Infect. Chemother. 2014; 20: 115–20.
    1. Umemura Y, Yamakawa K, Ogura H et al Efficacy and safety of anticoagulant therapy in three specific populations with sepsis: a meta‐analysis of randomized controlled trials. J. Thromb. Haemost. 2016; 14: 518–30.
    1. Levi M, van der Poll T. Coagaulaton in patients with severe sepsis. Semin. Thromb. Hemost. 2015; 41: 9–15.
    1. Warren BL, Eid A, Singer P et al Caring for the critically ill patient. High‐dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA 2001; 286: 1869–78.
    1. Ranieri VM, Thompson BT, Barie PS et al PROWESS‐SHOCK Study Group. Drotrecogin alfa (activated) in adults with septic shock. N. Engl. J. Med. 2012; 366: 2055–64.
    1. Kobayashi N, Maegawa T, Takada M et al Criteria for diagnosis of DIC based on the analysis of clinical and laboratory findings in 345 DIC patients collected by the research committee on DIC in Japan. Bibl. Haemotol. 1983; 49: 265–75.
    1. Taylor FB Jr, Toh CH, Hoots WK et al Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation ‐ On behalf of the Scientific Subcommittee on disseminated intravascular coagulation(DIC)of the International Society on Thrombosis and Haemostasis(ISTH). Thromb. Haemost. 2001; 86: 1327–30.
    1. Gando S, Saitoh D, Ogura H et al Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: results of a multicenter, prospective survey. Crit. Care Med. 2008; 36: 145–50.
    1. Gando S, Saitoh D, Ishikura H et al A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis. Crit. Care 2013; 17: R297.
    1. Gando S, Saitoh D, Ogura H et al A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis. Crit. Care 2013; 17: R111.
    1. Saito H, Maruyama I, Shimazaki S et al Efficacy and safety of recombinant human soluble thrombomodulin (ART‐123) in disseminated intravascular coagulation: results of a phase III, randomized, double‐blind clinical trial. J. Thromb. Haemost. 2007; 5: 31–41.
    1. Vincent JL, Ramesh MK, Ernest D et al A randomized, double‐blind, placebo‐controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART–123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit. Care Med. 2013; 41: 2069–79.
    1. Yamakawa K, Aihara M, Ogura H et al Recombinant human soluble thrombomodulin in severe sepsis: a systematic review and meta‐analysis. J. Thromb. Haemost. 2015; 13: 508–19.
    1. Aikawa N, Shimazaki S, Yamamoto Y et al Thrombomodulin alfa in the treatment of infectious patients complicated by disseminated intravascular coagulation: subanalysis from the phase 3 trial. Shock 2011; 35: 349–54.
    1. Takahashi H, Isotani E, Usizawa H et al Effect of recombinant thrombomodulin for sepsis‐induced disseminated intravascular coagulation. ICU & CCU 2011; 35: 581–4.
    1. Kienast J, Juers M, Wiedermann CJ et al Treatment effects of high‐dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation. J. Thromb. Haemost. 2006; 4: 90–7.
    1. Fourrier F, Chopin C, Huart JJ et al Double‐blind, placebo‐controlled trial of antithrombin III concentrates in septic shock with disseminated intravascular coagulation. Chest 1993; 104: 882–8.
    1. Nishiyama T, Kohno Y, Koishi K. Effects of antithrombin and gabexate mesilate on disseminated intravascular coagulation: a preliminary study. Am. J. Emerg. Med. 2012; 30: 1219–23.
    1. Hsu JT, Chen HM, Chiu DF et al Efficacy of gabexate mesilate on disseminated intravascular coagulation as a complication of infection developing after abdominal surgery. J. Formos. Med. Assoc. 2004; 103: 678–84.
    1. Nishiyama T, Matsukawa T, Hanaoka K. Is protease inhibitor a choice for the treatment of pre‐ or mild disseminated intravascular coagulation? Crit. Care Med. 2000; 28: 1419–22.
    1. Aoki N, Matsuda T, Saito H et al CTC‐111‐IM Clinical Research Group. A comparative double‐blind randomized trial of activated protein C and unfractionated heparin in the treatment of disseminated intravascular coagulation. Int. J. Hematol. 2002; 75: 540–7.
    1. Liu XL, Wang XZ, Liu XX et al Low‐dose heparin as treatment for early disseminated intravascular coagulation during sepsis: a prospective clinical study. Exp. Ther. Med. 2014; 7: 604–8.
    1. Guidelines for the Diagnosis, Treatment and Prevention of Pulmonary Thromboembolism and Deep Vein Thrombosis. [cited 15 Dec 2017]. Available from:
    1. Kaplan D, Casper TC, Elliott CG et al VTE incidence and risk factors in patients with severe sepsis and septic shock. Chest 2015; 148: 1224–30.
    1. Cade JF. High risk of the critically ill for venous thromboembolism. Crit. Care Med. 1982; 10: 448–50.
    1. Violi F, Perri L, Loffredo L. Should all acutely ill medical patients be treated with antithrombotic drugs? A review of the interventional trials. Thromb. Haemost. 2013; 109: 589–95.
    1. Tichelaar YI, Kluin‐Nelemans HJ, Meijer K. Infections and inflammatory diseases as risk factors for venous thrombosis. A systematic review. Thromb. Haemost. 2012; 107: 827–37.
    1. Donze JD, Ridker PM, Finlayson SR et al Impact of sepsis on risk of postoperative arterial and venous thromboses: large prospective cohort study. BMJ (Clin. Res. ed). 2014; 349: g5334.
    1. Japanese Guideline for Prevention of Venous Thromboembolism: Digest . [cited 15 Dec 2017]. Available from:
    1. Bates SM, Jaeschke R, Stevens AM et al Diagnosis of DVT. Antithrombotic therapy and prevention of thrombosis. Chest 2012; 41: e351S–e418S.
    1. Needham DM, Davidson J, Cohen H et al Improving long‐term outcomes after discharge from intensive care unit: report from a stakeholders’ conference. Crit. Care Med. 2012; 40: 502–9.
    1. Kress JP, Hall JB. ICU‐acquired weakness and recovery from critical illness. N. Engl. J. Med. 2014; 370: 1626–35.
    1. Stevens RD, Dowdy DW, Michaels RK et al Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med. 2007; 33: 1876–91.
    1. Koch S, Spuler S, Deja M et al Critical illness myopathy is frequent: accompanying neuropathy protracts ICU discharge. J. Neurol. Neurosurg. Psychiatry 2011; 82: 287–93.
    1. Koch S, Wollersheim T, Bierbrauer J et al Long‐term recovery In critical illness myopathy is complete, contrary to polyneuropathy. Muscle Nerve 2014; 50: 431–6.
    1. Deconinck N, Van Parijs V, Beckers‐Bleukx G et al Critical illness myopathy unrelated to corticosteroids or neuromuscular blocking agents. Neuromuscul. Disord. 1998; 8: 186–92.
    1. Callahan LA, Supinski GS. Sepsis‐induced myopathy. Crit. Care Med. 2009; 37: S354–67.
    1. Fan E, Cheek F, Chlan L et al An Official American Thoracic Society Clinical Practice Guideline: the diagnosis of intensive care unit–acquired weakness in adults. Am. J. Respir. Crit. Care Med. 2014; 190: 1437–46.
    1. Kleyweg RP, van der Meche FG, Meulstee J. Treatment of Guillain–Barre syndrome with high‐dose gammaglobulin. Neurology 1988; 38: 1639–41.
    1. Schefold JC, Bierbrauer J, Weber‐Carstens S. Intensive care unit‐acquired weakness (ICU‐AW) and muscle wasting in critically ill patients with severe sepsis and septic shock. J. Cachexia Sarcopenia Muscle 2010; 1: 147–57.
    1. Elliott D, Davidson JE, Harvey MA et al Exploring the scope of post‐intensive care syndrome therapy and care: engagement of non‐critical care providers and survivors in a second stakeholders meeting. Crit. Care Med. 2014; 42: 2518–26.
    1. Nelson BJ, Weinert CR, Bury CL et al Intensive care unit drug use and subsequent quality of life in acute lung injury patients. Crit. Care Med. 2000; 28: 3626–30.
    1. Jones C, Backman C, Capuzzo M et al Intensive care diaries reduce new onset post traumatic stress disorder following critical illness: a randomised, controlled trial. Crit. Care 2010; 14: R168.
    1. Prescott HC, Langa KM, Liu V et al Increased 1‐year healthcare use in survivors of severe sepsis. Am. J. Respir. Crit. Care Med. 2014; 190: 62–9.
    1. Vivodtzev I, Pépin JL, Vottero G et al Improvement in quadriceps strength and dyspnea in daily tasks after 1 month of electrical stimulation in severely deconditioned and malnourished COPD. Chest 2006; 129: 1540–8.
    1. Nuhr MJ, Pette D, Berger R et al Beneficial effects of chronic low‐frequency stimulation of thigh muscles in patients with advanced chronic heart failure. Eur. Heart J. 2004; 25: 136–43.
    1. Sillen MJ, Speksnijder CM, Eterman RM, et al Effects of neuromuscular electrical stimulation of muscles of ambulation in patients with chronic heart failure or COPD: a systematic review of the English‐language literature. Chest 2009; 136: 44–61.
    1. Routsi C, Gerovasili V, Vasileieiadis I et al Electrical muscle stimulation prevents critical illness polyneuromyopathy: a randomized parallel intervention trial. Crit. Care 2010; 14: R74.
    1. Kho ME, Truong AD, Zanni JM et al Neuromuscular electrical stimulation in mechanically ventilated patients: a randomized, sham‐controlled pilot trial with blinded outcome assessment. J. Crit. Care 2015; 30: 32–9.
    1. Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G. Interventions for preventing critical illness polyneuropathy and critical illness myopathy. Cochrane Database Syst. Rev. 2014; CD006832.
    1. Abu‐Khaber HA, Abouelela AMZ, Abdelkarim EM. Effect of electrical muscle weakness and facilitating weaning from mechanical ventilation. Alex. J. Med. 2013; 49: 309–15.
    1. Karatzanos E, Gerovasili V, Zervakis D et al Electrical muscle stimulation: an effective form of exercise and early mobilization to preserve muscle strength in critically ill patients. Crit. Care Res. Pract. 2012; 2012: 432752.
    1. Zanotti E, Felicetti G, Maini M et al Peripheral muscle strength training in bed‐bound patients with COPD receiving mechanical ventilation: effect of electrical stimulation. Chest 2003; 124: 292–6.
    1. Burke D, Gorman E, Stokes D et al An evaluation of neuromuscular electrical stimulation in critical care using the ICF framework: a systematic review and meta‐analysis. Clin. Respir. J. 2014; 10: 407–20.
    1. Brummel NE, Girard TD, Ely EW et al Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT‐ICU) trial. Intensive Care Med. 2014; 40: 370–9.
    1. Burtin C, Clerckx B, Robbeets C et al Early exercise in critically ill patients enhances short‐term functional recovery. Crit. Care Med. 2009; 37: 2499–505.
    1. Dantas CM, Silva PF, Siqueira FH et al Influence of early mobilization on respiratory and peripheral muscle strength in critically ill patients. Rev. Bras. Ter Intensiva 2012; 24: 173–8.
    1. Denehy L, Skinner EH, Edbrooke L et al Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow‐up. Crit. Care 2013; 17: R156.
    1. Jones C, Eddleston J, McCairn A et al Improving rehabilitation after critical illness through outpatient physiotherapy classes and essential amino acid supplement: a randomized controlled trial. J. Crit. Care 2015; 30: 901–7.
    1. Kayambu G, Boots R, Paratz J. Early physical rehabilitation in intensive care patients with sepsis syndromes: a pilot randomised controlled trial. Intensive Care Med. 2015; 41: 865–74.
    1. Pattanshetty RB, Gaude GS. Effect of multimodality chest physiotherapy in prevention of ventilator‐associated pneumonia: a randomized clinical trial. Indian J. Crit. Care Med. 2010; 14: 70–6.
    1. Kayambu G, Boots R, Paratz J. Physical therapy for the critically ill in the ICU: a systematic review and meta‐analysis. Crit. Care Med. 2013; 41: 1543–54.
    1. Nadel S, Goldstein B, Williams MD et al Researching severe sepsis and organ dysfunction in children: a global perspective (RESOLVE) study group. Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet 2007; 369: 836–43.
    1. Inwald DP, Tasker RC, Peters MJ et al Emergency management of children with severe sepsis in the United Kingdom: the results of the Paediatric Intensive Care Society sepsis audit. Arch. Dis. Child. 2009; 94: 348–53.
    1. Shime N, Kawasaki T, Saito O et al Incidence and risk factors for mortality in paediatric severe sepsis: results from the national paediatric intensive care registry in Japan. Intensive Care Med. 2012; 38: 1191–7.
    1. The Japanese Society of Intensive Care Medicine, Committee of Pediatric Intensive Care . Consensus statement for the management of pediatric severe sepsis. J. Jpn. Soc. Intensive Care Med. 2014; 21: 67–88.
    1. Brierley J, Carcillo JA, Choong K et al Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit. Care Med. 2009; 37: 666–88.
    1. Vincent JL, Moreno R, Takala J et al The SOFA (Sepsis‐related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis‐Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996; 22: 707–10.
    1. Goldstein B, Giroir B, Randolph A et al International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr. Crit. Care Med. 2005; 6: 2–8. erratum in Pediatr Crit Care Med 2005;6:500.
    1. Fleming S, Thompson M, Stevens R et al Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age, a systematic review of observational studies. Lancet 2011; 377: 1011–8.
    1. Thompson M, Harnden A, Perera R et al Deriving temperature and age appropriate heart rate centiles for children with acute infections. Arch. Dis. Child. 2009; 94: 361–5.
    1. Bonafide CP, Brady PW, Keren R et al Development of heart and respiratory rate percentile curves for hospitalized children. Pediatrics 2013; 131: e1150–7.
    1. O'Leary F, Hayen A, Lockie F et al Defining normal ranges and centiles for heart and respiratory rates in infants and children: a cross‐sectional study of patients attending an Australian tertiary hospital paediatric emergency department. Arch. Dis. Child. 2015; 100: 733–7.
    1. Gebara BM. Values for systolic blood pressure. Pediatr. Crit. Care Med. 2005; 6: 500.
    1. Nakagawa S, Shime N. Respiratory rate criteria for pediatric systematic inflammatory response syndrome. Pediatr. Crit. Care Med. 2014; 15: 182.
    1. Japanese Resuscitation Council . JRC Resuscitation Guidelines 2015. Tokyo: Igaku‐Shoin Ltd, 2016.
    1. Warren DW, Jarvis A, LeBlanc L et al Revisions to the Canadian Triage and Acuity Scale paediatric guidelines (PaedCTAS). CJEM 2008; 10: 224–43.
    1. Weiss SL, Fitzgerald JC, Pappachan J et al Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am. J. Respir. Crit. Care Med. 2015; 191: 1147–57.
    1. Leteurtre S, Duhamel A, Salleron J et al PELOD‐2: an update of the pediatric logistic organ dysfunction score. Crit. Care Med. 2013; 41: 1761–73.
    1. Uemura O, Honda M, Matsuyama T et al Age, gender, and body length effects on reference serum creatinine levels determined by an enzymatic method in Japanese children:a multicenter study. Clin. Exp. Nephrol. 2011; 15: 694–9.
    1. Kasai M, Shime N, Saitou A et al Investigating blood culture collection in a Japanese pediatric clinical setting. J. J. A. Inf. D. 2013; 87: 620–3.
    1. Morello JA, Matushek SM, Dunne WM et al Performance of a BACTEC nonradiometric medium for pediatric blood cultures. J. Clin. Microbiol. 1991; 29: 359–62.
    1. Long SS, Pickering LK, Prober CG. Principles and Practice of Pediatric Infectious Disease (third edition). Philadelphia: Saunders, 2009; 1342.
    1. Ventura AM, Shieh HH, Bousso A et al Double‐blind prospective randomized controlled trial of dopamine versus epinephrine as first‐line vasoactive drugs in pediatric septic shock. Crit. Care Med. 2015; 43: 2292–302.
    1. Choong K, Bohn D, Fraser DD et al Vasopressin in pediatric vasodilatory shock: a multicenter randomized controlled trial. Am. J. Respir. Crit. Care Med. 2009; 180: 632–9.
    1. Raimer PL, Han YY, Weber MS et al A normal capillary refill time of ≤2 seconds is associated with superior vena cava oxygen saturations of ≥70%. J. Pediatr. 2011; 158: 968–72.
    1. Fleming S, Gill P, Jones C et al The diagnostic value of capillary refill time for detecting serious illness in children: a systematic review and meta‐analysis. PLoS ONE 2015; 10: e0138155.
    1. Fleming S, Gill P, Jones C et al Validity and reliability of measurement of capillary refill time in children: a systematic review. Arch. Dis. Child. 2015; 100: 239–49.
    1. Tibby SM, Hatherill M, Murdoch IA. Capillary refill and core‐peripheral temperature gap as indicators of haemodynamic status in paediatric intensive care patients. Arch. Dis. Child. 1999; 80: 163–66.
    1. de Oliveira CF, de Oliveira DS, Gottschald AF et al ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation. Intensive Care Med. 2008; 34: 1065–75.
    1. Lacroix J, Hébert PC, Hutchison JS et al Transfusion strategies for patients in pediatric intensive care units. N. Engl. J. Med. 2007; 356: 1609–19.
    1. Zimmerman JJ, Williams MD. Adjunctive corticosteroid therapy in pediatric severe sepsis: observations from the RESOLVE study. Pediatr. Crit. Care Med. 2011; 12: 2–8.
    1. Infectious Disease Surveillance Center, National Institute of Infectious Diseases . Trends in invasive meningococcal disease, week 13, 2013 to week 52, 2014, Japan. IASR 2015; 2015(36): 179–81.
    1. Valoor HT, Singhi S, Jayashree M. Low‐dose hydrocortisone in pediatric septic shock: an exploratory study in a third world setting. Pediatr. Crit. Care Med. 2009; 10: 121–125.
    1. Joannes‐Boyau O, Honoré PM, Perez P et al High‐volume versus standard‐volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial. Intensive Care Med. 2013; 39: 1535–46.
    1. Long E, Shann F, Pearson G et al A randomised controlled trial of plasma filtration in severe paediatric sepsis. Crit. Care Resusc. 2013; 15: 198–204.
    1. INIS Collaborative Group , Brocklehurst P, Farrell B et al Treatment of neonatal sepsis with intravenous immune globulin. N. Engl. J. Med. 2011; 365: 1201–11.
    1. Vlasselaers D, Milants I, Desmet L et al Intensive insulin therapy for patients in paediatric intensive care: aprospective, randomised controlled study. Lancet 2009; 373: 547–56.
    1. Jeschke MG, Kulp GA, Kraft R et al Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial. Am. J. Respir. Crit. Care Med. 2010; 182: 351–9.
    1. Agus MS, Steil GM, Wypij D et al Tight glycemic control versus standard care after pediatric cardiac surgery. N. Engl. J. Med. 2012; 367: 1208–19.
    1. Macrae D, Grieve R, Allen E et al A randomized trial of hyperglycemic control in pediatric intensive care. N. Engl. J. Med. 2014; 370: 107–18.
    1. Srinivasan V, Agus MSD. Tight glucose control in critically ill children‐a systematic review and meta‐analysis. Pediatr. Diabetes 2014; 15: 75–83.
    1. Han YY, Carcillo JA, Dragotta MA et al Early reversal of pediatric‐neonatal septic shock by community physicians is associated with improved outcome. Pediatrics 2003; 112: 793–9.
    1. Carcillo JA, Kuch BA, Han YY et al Mortality and functional morbidity after use of PALS/APLS by community physicians. Pediatrics 2009; 124: 500–8.
    1. Paul R, Neuman MI, Monuteaux MC et al Adherence to PALS Sepsis Guidelines and hospital length of stay. Pediatrics 2012; 130: e273–80.
    1. Banerjee S, Singhi SC, Singh S et al The intraosseous route is a suitable alternative to intravenous route for fluid resuscitation in severely dehydrated children. Indian Pediatr. 1994; 31: 1511–20.

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