Effects of energy drinks on blood pressure, heart rate, and electrocardiographic parameters: An experimental study on healthy young adults

Shokoufeh Hajsadeghi, Fatemeh Mohammadpour, Mohammad Javad Manteghi, Kiarash Kordshakeri, Masoud Tokazebani, Elham Rahmani, Morteza Hassanzadeh, Shokoufeh Hajsadeghi, Fatemeh Mohammadpour, Mohammad Javad Manteghi, Kiarash Kordshakeri, Masoud Tokazebani, Elham Rahmani, Morteza Hassanzadeh

Abstract

Objective: To evaluate the effects of the consumption of energy drinks on cardiovascular parameters in a group of healthy young individuals.

Methods: In a quasi-experimental study, 44 healthy adult participants aged between 15 and 30 years were evaluated. The blood pressure (BP) as well as electrocardiographic indices, including heart rate (HR), PR interval, QRS duration, corrected QT (QTc) interval, and ST-T changes were recorded before consumption of a caffeine-containing energy drink and at the specific time points over a 4-h test duration.

Results: We found statistically significant HR decline (p=0.004) and more frequent ST-T changes (p=0.004) after the participants consumed the energy drink. However, readings for systolic BP (p=0.44), diastolic BP (p=0.26), PR interval (p=0.449), QRS duration (p=0.235), and QTc interval (p=0.953) showed no significant change post-consumption.

Conclusion: In conclusion, we demonstrated that the consumption of energy drinks could contribute to HR decline and ST-T change in healthy young adults.

Conflict of interest statement

Conflict of interest: None declared. All of the expenses of the present study were covered by agrant from Iran University of Medical Sciences.

Figures

Figure 1
Figure 1
Systolic blood pressure (mean) of the participants during the test. Analysis by repeated measures ANOVA
Figure 2
Figure 2
Diastolic blood pressure (mean) of the participants during the test. Analysis by repeated measures ANOVA
Figure 3
Figure 3
Heart rate (mean) of the participants during the test. Analysis by repeated measures ANOVA

References

    1. Reissig CJ, Strain EC, Griffiths RR. Caffeinated energy drinks.A growing problem. Drug Alcohol Depend. 2009;99:1–10.
    1. Abian-Vicen J, Puente C, Salinero JJ, González-Millán C, Areces F, Muñoz G, et al. A caffeinated energy drink improves jump performance in adolescent basketball players. Amino Acids. 2014;46:1333–41.
    1. Lara B, Gonzalez-Millán C, Salinero JJ, Abian-Vicen J, Areces F, Barbero-Alvarez JC, et al. Caffeine-containing energy drink improves physical performance in female soccer players. Amino Acids. 2014;46:1385–92.
    1. Clauson KA, Shields KM, McQueen CE, Persad N. Safety issues associated with commercially available energy drinks. J Am Pharm Assoc (Wash) 2008;48:e55–e63.
    1. Garriott JC, Simmons LM, Poklis A, Mackell MA. Five cases of fatal overdose from caffeine-containing “look-alike” drugs. J Anal Toxicol. 1985;9:141–3.
    1. Kerrigan S, Lindsey T. Fatal caffeine overdose. two case reports. Forensic Sci Int. 2005;153:67–9.
    1. Grasser EK, Yepuri G, Dulloo AG, Montani JP. Cardio- and cerebrovascular responses to the energy drink Red Bull in young adults:a randomized cross-over study. Eur J Nutr. 2011;53:1561–71.
    1. Steinke L, Lanfear DE, Dhanapal V, Klaus JS. Effect of “energy drink” consumption on hemodynamic and electrocardiographic parameters in healthy young adults. Ann Pharmacother. 2009;43:596–602.
    1. Worthley MI, Prabhu A, De Sciscio P, Schultz C, Sanders P, Willoughby SR. Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med. 2010;123:184–7.
    1. Nienhueser J, Brown GA, Shaw BS, Shaw I. Effects of energy drinks on metabolism at rest and during submaximal treadmill exercise in college age males. Int J ExercSci. 2011;4:65–76.
    1. Jonjev ZS, Bala G. High-energy drinks may provoke aortic dissection. Coll Antropol. 2013;2:227–9.
    1. Hsue PY, Salinas CL, Bolger AF, Benowitz NL, Waters DD. Acute aortic dissection related to crack cocaine. Circulation. 2002;105:1592–5.
    1. Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A, Feeley M. Effects of caffeine on human health. Food Addit Contam. 2003;20:1–30.
    1. Alford C, Cox H, Wescott R. The effects of red bull energy drink on human performance and mood. Amino Acids. 2001;21:139–50.
    1. Ragsdale FR, Gronli TD, Batool N, Haight N, Mehaffey A, McMahon EC, et al. Effect of Red Bull energy drink on cardiovascular and renal function. Amino Acids. 2010;38:1193–200.
    1. Sung BH, Lovallo WR, Pincomb GA, Wilson MF. Effects of caffeine on blood pressure response during exercise in normotensive healthy young men. Am J Cardiol. 1990;65:909–13.
    1. Lemery R, Pecarskie A, Bernick J, Williams K, Wells GA. A prospective placebo controlled randomized study of caffeine in patients with supraventricular tachycardia undergoing electrophysiologic testing. J Cardiovasc Electrophysiol. 2015;26:1–6.
    1. Franks AM, Schmidt JM, McCain KR, Fraer M. Comparison of the effects of energy drink versus caffeine supplementation on indices of 24-hour ambulatory blood pressure. Ann Pharmacother. 2012;46:192–9.
    1. Geiß KR, Jester I, Falke W, Hamm M, Waag KL. The effect of a taurine-containing drink on performance in 10 endurance-athletes. Amino Acids. 1994;7:45–56.
    1. Bichler A, Swenson A, Harris MA. A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids. 2006;31:471–6.
    1. McClaran SR, Wetter TJ. Low doses of caffeine reduce heart rate during submaximal cycle ergometry. J Intern Soc Sports Nutrition. 2007;4:11.
    1. Mosqueda-Garcia R, Tseng CJ, Biaggioni I, Robertson RM, Robertson D. Effects of caffeine on baroreflex activity in humans. Clin Pharmacol Ther. 1990;48:568–74.
    1. Whitsett TL, Manion CV, Christensen HD. Cardiovascular effects of coffee and caffeine. Am J Cardiol. 1984;53:918–22.
    1. Pincomb GA, Lovallo WR, Passey RB, Whitsett TL, Silverstein SM, Wilson MF. Effects of caffeine on vascular resistance, cardiac output, and myocardial contractility in young men. Am J Cardiol. 1985;56:119–22.
    1. Engels HJ, Wirth JC, Celik S, Dorsey JL. Influence of caffeine on metabolic and cardiovascular functions during sustained light intensity cycling and at rest. Int J Sport Nutr. 1999;9:361–70.
    1. Sullivan JJ, Knowlton RG, Brown DD. Caffeine affects heart rate and blood pressure response to prolonged walking. J Cardiopulm Rehabil. 1992;12:418–22.
    1. Gould L, Verkatararaman K, Goswami M, Gomprecht RF. The cardiac effects of coffee. Angiology. 1973;24:455–63.
    1. Robertson D, Frolich JC, Carr RK, Watson JT, Hollifield JW, Shand DG. Effects of caffeine on plasma rennin activity, catecholamines and blood pressure. N Engl J Med. 1978;298:181–6.
    1. Sutherland DJ, McPherson DD, Renton KW, Spencer CA, Montague TJ. The effect of caffeine on cardiac rate, rhythm, and ventricular repolarization. Analysis of 18 normal subjects and 18 patients with primary ventricular dysrhythmia. Chest. 1985;87:319–24.
    1. Newcombe PF, Renton KW, Rautaharju PM, Spencer CA, Montague TJ. High-dose caffeine and cardiac rate and rhythm in normal subjects. Chest. 1988;94:90–4.
    1. Chelsky LB, Cutler JE, Griffith K, Kron J, McClelland JH, McAnulty JH. Caffeine and ventricular arrhythmias. An electrophysiological approach. JAMA. 1990;264:2236–40.
    1. Myers MG. Caffeine and cardiac arrhythmias. Ann Intern Med. 1991;114:147–50.
    1. Smith M. Intensive care management of patients with subarachnoid haemorrhage. Curr Opin Anesthesiol. 2007;20:400–7.
    1. Tung P, Kopelnik A, Banki N, Ong K, Ko N, Lawton MT, et al. Predictors of neurocardio genic injury after subarachnoid hemorrhage. Stroke. 2004;35:548–53.
    1. Macmillan CSA, Grant IS, Andrews PJD. Pulmonary and cardiac sequelae of subarachnoid haemorrhage:time for active management. Intensive Care Med. 2002;28:1012–23.

Source: PubMed

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