Efficacy and safety of radiofrequency ablation for treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials

Hua Zhang, Bo Wang, Jie He, Zhongju Du, Hua Zhang, Bo Wang, Jie He, Zhongju Du

Abstract

Objective: To evaluate the efficacy and safety of radiofrequency ablation for the treatment of knee osteoarthritis.

Methods: A literature review was conducted using the PubMed, Cochrane Review, Embase, and Google Scholar databases. Two reviewers independently assessed the eligibility of all retrieved studies. The research was reported based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure the reliability and verity of the results. The statistical analysis was performed using STATA version 13.0.

Results: Nine randomized controlled trials were collected for the data extraction and meta-analysis. Significant differences in the pain score at 4, 12, and 24 weeks were found between patients treated with radiofrequency ablation and those treated with placebo. Furthermore, the use of radiofrequency ablation was associated with an improved outcome of the Western Ontario and McMaster Universities Arthritis Index at 4, 12, and 24 weeks. No serious adverse events were observed in any patients who underwent radiofrequency ablation.

Conclusion: Radiofrequency ablation is efficacious and safe for reducing pain and improving knee function in patients with knee osteoarthritis, without increasing the risk of adverse effects.

Keywords: Knee osteoarthritis; adverse event; knee function; meta-analysis; pain; radiofrequency ablation.

Conflict of interest statement

Declaration of conflicting interest: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Flow diagram of study selection. RCT, randomized controlled trial.
Figure 2.
Figure 2.
Risk-of-bias summary.
Figure 3.
Figure 3.
Risk-of-bias graph.
Figure 4.
Figure 4.
Meta-analysis of pain score. WMD, weighted mean difference; CI, confidence interval.
Figure 5.
Figure 5.
Meta-analysis of Western Ontario and McMaster Universities Arthritis Index. WMD, weighted mean difference; CI, confidence interval.
Figure 6.
Figure 6.
Meta-analysis of Lequesne index. WMD, weighted mean difference; CI, confidence interval.
Figure 7.
Figure 7.
Meta-analysis of adverse effects. RD, risk difference; CI, confidence interval.
Figure 8.
Figure 8.
Publication bias. SE, standard error; MD, mean difference.

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Source: PubMed

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