Newborn vitamin A supplementation does not affect nasopharyngeal carriage of Streptococcus pneumoniae in Bangladeshi infants at age 3 months
Christian L Coles, Alain Labrique, Samir K Saha, Hasmot Ali, Hassan Al-Emran, Mahbubur Rashid, Parul Christian, Keith P West Jr, Rolf Klemm, Christian L Coles, Alain Labrique, Samir K Saha, Hasmot Ali, Hassan Al-Emran, Mahbubur Rashid, Parul Christian, Keith P West Jr, Rolf Klemm
Abstract
Nasopharyngeal (NP) carriage of S. pneumoniae (Spn) is a risk factor for pneumococcal disease and its transmission. We assessed the impact of vitamin A (VA) supplementation shortly after birth in reducing Spn colonization in early infancy in rural Bangladesh. We recruited 500 infants participating in a cluster-randomized trial that reported a 15% reduction in mortality following receipt of an oral dose of VA (52.25 μmol) compared to placebo. NP specimens were collected at the age of 3 mo to study the effect of VA on the prevalence of culture-confirmed Spn. Analyses were conducted by intention to treat. Spn carriage prevalence did not differ between VA and placebo recipients [OR = 0.83 (95% CI: 0.55-1.27); P = 0.390]. Spn carriage at the age of 3 mo was not lowered by VA given at birth. Results are similar to those from an Indian study in which impact on Spn carriage was assessed at the age of 4 mo [OR = 0.73 (95% CI: 0.48-1.10); P = 0.128]. The point estimate of the pooled effect size for the 2 studies is OR = 0.78 [(95% CI: 0.58-1.04); P = 0.095], which may imply a modest impact on carriage. If so, then the evidence thus far would suggest that Spn carriage reduction is unlikely to be a primary ancillary benefit of newborn VA supplementation.
Trial registration: ClinicalTrials.gov NCT00128557.
Conflict of interest statement
Author disclosures: C. Coles, A. Labrique, S. Saha, H. Ali, M. Rashid, P. Christian, K. West, and R. Klemm, no conflicts of interest.
Source: PubMed