The International Testicular Cancer Linkage Consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred
Phuong L Mai, Michael Friedlander, Kathy Tucker, Kelly-Anne Phillips, David Hogg, Michael A S Jewett, Radka Lohynska, Gedske Daugaard, Stéphane Richard, Catherine Bonaïti-Pellié, Axel Heidenreich, Peter Albers, Istvan Bodrogi, Lajos Geczi, Edith Olah, Peter A Daly, Parry Guilford, Sophie D Fosså, Ketil Heimdal, Ludmila Liubchenko, Sergei A Tjulandin, Hans Stoll, Walter Weber, Douglas F Easton, Darshna Dudakia, Robert Huddart, Michael R Stratton, Lawrence Einhorn, Larissa Korde, Katherine L Nathanson, D Timothy Bishop, Elizabeth A Rapley, Mark H Greene, Phuong L Mai, Michael Friedlander, Kathy Tucker, Kelly-Anne Phillips, David Hogg, Michael A S Jewett, Radka Lohynska, Gedske Daugaard, Stéphane Richard, Catherine Bonaïti-Pellié, Axel Heidenreich, Peter Albers, Istvan Bodrogi, Lajos Geczi, Edith Olah, Peter A Daly, Parry Guilford, Sophie D Fosså, Ketil Heimdal, Ludmila Liubchenko, Sergei A Tjulandin, Hans Stoll, Walter Weber, Douglas F Easton, Darshna Dudakia, Robert Huddart, Michael R Stratton, Lawrence Einhorn, Larissa Korde, Katherine L Nathanson, D Timothy Bishop, Elizabeth A Rapley, Mark H Greene
Abstract
Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population.
Materials and methods: Families with >or=2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families.
Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism, TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families.
Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial cases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation.
Published by Elsevier Inc.
Source: PubMed