Modulation of physical activity to optimize pain sensation following an intra-articular corticosteroid injection in patients with knee osteoarthritis

Yoann Dessery, Étienne L Belzile, Sylvie Turmel, Jean Doré, Binta Diallo, Philippe Corbeil, Yoann Dessery, Étienne L Belzile, Sylvie Turmel, Jean Doré, Binta Diallo, Philippe Corbeil

Abstract

Background: Intra-articular corticosteroid injection is often used to relieve pain caused by knee osteoarthritis. This study aims to assess the impact after an intra-articular corticosteroid injection treatment on objective and subjective measurement of physical function in knee osteoarthritis patients.

Methods: Fourteen patients with unilateral knee osteoarthritis participated in this open-label uncontrolled trial. The intra-articular corticosteroid injection was given at the end of the second week. Physical activity was objectively measured by an accelerometer worn by the participants for eight weeks. Symptoms, quality of life and spatiotemporal parameters of gait were assessed every two weeks.

Results: From the injection until six weeks later, pain and stiffness were reduced by approximately 60%. Patients' daily physical activity time was significantly improved after injection: participation in light and moderate physical activities increased during four and two weeks, respectively.

Conclusions: The beneficial effects after the intra-articular corticosteroid injection are visible in the duration and intensity of the knee osteoarthritis patients' daily physical activity. However, these effects declined gradually two weeks after injection. Modulating the intensity and duration of physical activity would allow patients to optimize pain sensation over a longer period following an intra-articular corticosteroid injection. Trial Registration. This trial was registered with ClinicalTrials: NCT02049879.

Figures

Figure 1
Figure 1
Flow diagram of the study (according to CONSORT statement). Diagram illustrates recruitment of patients suffering from KOA, reasons for exclusion, and the treatment received, including 6-week follow-up.
Figure 2
Figure 2
Answers to the questionnaires divided into different domains and collected before injection and every two weeks after injection for six weeks. ***P < 0.001.
Figure 3
Figure 3
Mean daily distance covered and activity time during the two-week periods from two weeks before the injection to six weeks after the injection. *P < 0.05.
Figure 4
Figure 4
Mean daily intensity level (intensity 1 = 1 MET, intensity 2 = 2 METs, and so on) of physical activity during the two-week periods from two weeks before the injection to six weeks after the injection. *P < 0.05; **P < 0.01.

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Source: PubMed

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