Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis

Bei Pan, Long Ge, Yang-Qin Xun, Ya-Jing Chen, Cai-Yun Gao, Xue Han, Li-Qian Zuo, Hou-Qian Shan, Ke-Hu Yang, Guo-Wu Ding, Jin-Hui Tian, Bei Pan, Long Ge, Yang-Qin Xun, Ya-Jing Chen, Cai-Yun Gao, Xue Han, Li-Qian Zuo, Hou-Qian Shan, Ke-Hu Yang, Guo-Wu Ding, Jin-Hui Tian

Abstract

Introduction: Current international guidelines recommend aerobic, resistance, and combined exercises for the management of type 2 diabetes mellitus (T2DM). In our study, we conducted a network meta-analysis to assess the comparative impact of different exercise training modalities on glycemic control, cardiovascular risk factors, and weight loss in patients with T2DM.

Methods: We searched five electronic databases to identify randomized controlled trials (RCTs) that compared the differences between different exercise training modalities for patients with T2DM. The risk of bias in the included RCTs was evaluated according to the Cochrane tool. Network meta-analysis was performed to calculate mean difference the ratio of the mean and absolute risk differences. Data were analyzed using R-3.4.0.

Results: A total of 37 studies with 2208 patients with T2DM were included in our study. Both supervised aerobic and supervised resistance exercises showed a significant reduction in HbA1c compared to no exercise (0.30% lower, 0.30% lower, respectively), however, there was a less reduction when compared to combined exercise (0.17% higher, 0.23% higher). Supervised aerobic also presented more significant improvement than no exercise in fasting plasma glucose (9.38 mg/dl lower), total cholesterol (20.24 mg/dl lower), triacylglycerol (19.34 mg/dl lower), and low-density lipoprotein cholesterol (11.88 mg/dl lower). Supervised resistance showed more benefit than no exercise in improving systolic blood pressure (3.90 mmHg lower]) and total cholesterol (22.08 mg/dl lower]. In addition, supervised aerobic exercise was more powerful in improving HbA1c and weight loss than unsupervised aerobic (HbA1c: 0.60% lower; weight loss: 5.02 kg lower) and unsupervised resistance (HbA1c: 0.53% lower) exercises.

Conclusion: Compared with either supervised aerobic or supervised resistance exercise alone, combined exercise showed more pronounced improvement in HbA1c levels; however, there was a less marked improvement in some cardiovascular risk factors. In terms of weight loss, there were no significant differences among the combined, supervised aerobic, and supervised resistance exercises.

Trial registration: Our study protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO); registration number: CRD42017067518 .

Keywords: Cardiovascular risk factors; Exercise training; Frequentist network meta-analysis; Glycemic control; Type 2 diabetes mellitus; Weight loss.

Conflict of interest statement

Ethics approval and consent to participate

Ethics approval and participants consent are not required because this study is a meta-analysis based on the published studies.

Consent for publication

Not applicable.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

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Fig. 1
Flow Diagram
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Fig. 2
network plot

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