Subzero balance - simple modified ultrafiltration (SBUF-SMUF) technique for pediatric cardiopulmonary bypass

Joel Bierer, Mark Henderson, Roger Stanzel, Suvro Sett, David Horne, Joel Bierer, Mark Henderson, Roger Stanzel, Suvro Sett, David Horne

Abstract

The use of cardiopulmonary bypass (CPB) can be associated with significant hemodilution, coagulopathy and a systemic inflammatory response for infants and children undergoing cardiac surgery. Intra-operative ultrafiltration has been used for decades to ameliorate these harmful effects. The novel combination of a continuous and non-continuous form of ultrafiltration, Subzero Balance Simple Modified Ultrafiltration (SBUF-SMUF) here described, seeks to enhance recovery from pediatric cardiac surgery and CPB.

Keywords: SBUF-SMUF; cardiac surgery; cardiopulmonary bypass; pediatric; simple modified; subzero balance; ultrafiltration.

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
CPB Circuit for SBUF-SMUF: (a) SBUF. Blood flow is shunted in a veno-venous fashion by an anti-clockwise rotation of the S85 roller pump. Braun Infusomat®Space pumps accurately remove a specified ultrafiltrate effluent volume and also reinfuse a specified volume of physiologic solution to the venous reservoir. The clamp can be removed to bypass the Braun syringe pump regulation and allow for high-volume ultrafiltration as needed, (b) SMUF. After termination of CPB, the polarity of the S85 roller pump is reversed to clockwise and stop-link disengaged. Blood flow is shunted in a veno-arterial fashion through the ultrafiltration circuit. Braun Infusomat®Space pumps are deactivated during SMUF, as shown by the dotted lines. The S150 arterial pump can be activated to transfuse the patient if required.

References

    1. Bronicki RA, Hall M. Cardiopulmonary bypass-induced inflammatory response: Pathophysiology and treatment. Pediatr Crit Care Med 2016; 17(8): S272–S278.
    1. Bierer J, Stanzel R, Henderson M, et al.. Ultrafiltration in pediatric cardiac surgery review. World J Pediatr Congenit Hear Surg 2019; 10(6): 778–788.
    1. Naik SK, Knight A, Elliott MJ. A successful modification of ultrafiltration for cardiopulmonary bypass in children. Perfusion 1991; 6(1): 41–50.
    1. Myers GJ, Leadon RB, Mitchell LB, et al.. Simple modified ultrafiltration. Perfusion 2000; 15(5): 447–452.
    1. Journois D, Israel-Biet D, Pouard P, et al.. High-volume, zero-balanced hemofiltration to reduce delayed inflammatory response to cardiopulmonary bypass in children. Anesthesiology 1996; 85: 965–976.
    1. Zhang T, Jiang SL, Gao CQ, et al.. Effect of subzero-balanced ultrafiltration on lung gas exchange capacity after cardiopulmonary bypass in adult patients with heart valve disease. Heart Surg Forum 2011; 14(1): 22–27.
    1. Osthaus WA, Görler H, Sievers J, et al.. Bicarbonate-buffered ultrafiltration during pediatric cardiac surgery prevents electrolyte and acid-base balance disturbances. Perfusion 2009; 24(1): 19–25.
    1. Grist G, Whittaker C, Merrigan K, et al.. The correlation of fluid balance changes during cardiopulmonary bypass to mortality in pediatric and congenital heart surgery patients. J Extra Corpor Technol 2011; 43(4): 215–226.

Source: PubMed

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