Analysis of the Single Ventricle Reconstruction Trial Using Restricted Mean Survival Time and Shunt Type Received
Stephen J Dolgner, Yuen L Tjoeng, Titus Chan, Stephen J Dolgner, Yuen L Tjoeng, Titus Chan
No abstract availableKeywords: cardiology; congenital heart surgery; single ventricle; survival analysis; nonproportional hazards.
Figures
This figure shows superior 6‐year outcomes for infants with single ventricle heart disease who received right ventricle‐to‐pulmonary artery shunt for initial pulmonary blood flow in comparison with those who received modified Blalock‐Thomas‐Taussig shunt. A, Survival estimates for patients who received right ventricle‐to‐pulmonary artery shunt and modified Blalock‐Thomas‐Taussig shunt for initial pulmonary blood flow. B, Difference in restricted mean survival time between groups by time since initial surgery. Estimates below the horizontal black line favor better survival in the right ventricle‐to‐pulmonary artery shunt group. P value represents the restricted mean survival time difference between groups at 6 years of follow‐up. MBTTS indicates modified Blalock‐Thomas‐Taussig shunt; RMST, restricted mean survival time; and RVPAS, right ventricle‐to‐pulmonary artery shunt.
References
- Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt PC, Ghanayem NS, et al. Comparison of shunt types in the Norwood procedure for single‐ventricle lesions. N Engl J Med. 2010;362:1980–1992. doi: 10.1056/NEJMoa0912461
- Newburger JW, Sleeper LA, Gaynor JW, Hollenbeck‐Pringle D, Frommelt PC, Li JS, Mahle WT, Williams IA, Atz AM, Burns KM, et al. Transplant‐free survival and interventions at 6 years in the SVR trial. Circulation. 2018;137:2246–2253. doi: 10.1161/CIRCULATIONAHA.117.029375
- Gregson J, Sharples L, Stone GW, Burman CF, Ohrn F, Pocock S. Nonproportional hazards for time‐to‐event outcomes in clinical trials: JACC review topic of the week. J Am Coll Cardiol. 2019;74:2102–2112. doi: 10.1016/j.jacc.2019.08.1034
- Dolgner SJ, Nguyen VP, Krieger EV, Stempien‐Otero A, Dardas TF. Long‐term adult congenital heart disease survival after heart transplantation: a restricted mean survival time analysis. J Heart Lung Transplant. 2021;40:698–706. doi: 10.1016/j.healun.2021.02.019
- Wilder TJ, McCrindle BW, Phillips AB, Blackstone EH, Rajeswaran J, Williams WG, DeCampli WM, Jacobs JP, Jacobs ML, Karamlou T, et al. Survival and right ventricular performance for matched children after stage‐1 Norwood: Modified Blalock‐Taussig shunt versus right‐ventricle‐to‐pulmonary‐artery conduit. J Thorac Cardiovasc Surg. 2015;150:1440–50, 1452 e1–8; discussion 1450–1452. doi: 10.1016/j.jtcvs.2015.06.069
Source: PubMed