Dietary intake of nutrients and its correlation with fatigue in multiple sclerosis patients

Sama Bitarafan, Mohammad-Hossein Harirchian, Shahriar Nafissi, Mohammad-Ali Sahraian, Mansoureh Togha, Fereydoun Siassi, Ahmad Saedisomeolia, Elham Alipour, Nakisa Mohammadpour, Maryam Chamary, Niyaz Mohammadzadeh Honarvar, Ali-Akbar Saboor-Yaraghi, Sama Bitarafan, Mohammad-Hossein Harirchian, Shahriar Nafissi, Mohammad-Ali Sahraian, Mansoureh Togha, Fereydoun Siassi, Ahmad Saedisomeolia, Elham Alipour, Nakisa Mohammadpour, Maryam Chamary, Niyaz Mohammadzadeh Honarvar, Ali-Akbar Saboor-Yaraghi

Abstract

Background: The role of nutrition in the progression of multiple sclerosis (MS) and related complications such as fatigue has been reported by several studies. The aim of this study is the assessment of nutritional status and its relationship with fatigue in multiple sclerosis patients.

Methods: This is a cross-sectional study, in which 101 relapsing-remitting MS patients were enrolled. The fatigue status was determined using the validated Persian version of of the Modified Fatigue Impact Scale (MFIS). Dietary intake was assessed using a 3-day food record questionnaire and compared to dietary reference intake (DRI) values. Association between variables was determined using Pearson Correlation Coefficient.

Results: In the preset study, 25 men and 76 women (total = 101) were enrolled. Analysis of dietary intake showed that daily intake of vitamin D, folate, calcium, and magnesium were significantly lower than DRI in all of patients. In men, zinc intake was significantly lower than DRI; while, in women, iron was significantly below the DRI level. After adjusting for energy, MFIS and its physical subscale were highly correlated with intake of folate and magnesium.

Conclusion: Our findings support that lower magnesium and folate diets are correlated with higher fatigue scores in MS patients.

Keywords: Dietary Intake; Folate; Magnesium; Modified Fatigue Impact Scale; Multiple Sclerosis.

References

    1. Jankosky C, Deussing E, Gibson RL, Haverkos HW. Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. Virus Res. 2012;163(2):424–30.
    1. Riccio P. The molecular basis of nutritional intervention in multiple sclerosis: a narrative review. Complement Ther Med. 2011;19(4):228–37.
    1. Habek M, Hojsak I, Brinar VV. Nutrition in multiple sclerosis. Clin Neurol Neurosurg. 2010;112(7):616–20.
    1. Schwarz S, Leweling H. Multiple sclerosis and nutrition. Mult Scler. 2005;11(1):24–32.
    1. Branas P, Jordan R, Fry-Smith A, Burls A, Hyde C. Treatments for fatigue in multiple sclerosis: a rapid and systematic review. Health Technol Assess. 2000;4(27):1–61.
    1. Ziemssen T. Multiple sclerosis beyond EDSS: depression and fatigue. J Neurol Sci. 2009;277(Suppl 1):S37–S41.
    1. Kasatkin DS, Spirin NN. Possible mechanisms of the formation of chronic fatigue syndrome in the clinical picture of multiple sclerosis. Neurosci Behav Physiol. 2007;37(3):215–9.
    1. Paulig M. Multiple sclerosis: fatigue. Nervenheilkunde. 2006;25(12):1029–33.
    1. Bakshi R. Fatigue associated with multiple sclerosis: diagnosis, impact and management. Mult Scler. 2003;9(3):219–27.
    1. Payne A. Nutrition and diet in the clinical management of multiple sclerosis. J Hum Nutr Diet. 2001;14(5):349–57.
    1. Cox IM, Campbell MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet. 1991;337(8744):757–60.
    1. Werbach MR. Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev. 2000;5(2):93–108.
    1. Kos D, Kerckhofs E, Nagels G, D'Hooghe BD, Duquet W, Duportail M, et al. Assessing fatigue in multiple sclerosis: Dutch modified fatigue impact scale. Acta Neurol Belg. 2003;103(4):185–91.
    1. Flachenecker P, Kumpfel T, Kallmann B, Gottschalk M, Grauer O, Rieckmann P, et al. Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters. Mult Scler. 2002;8(6):523–6.
    1. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(1):53–8.
    1. Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69(2):292–302.
    1. Harirchian MH, Nasergivechi S, Maddah M, Meysamie A, Amini H, Shandiz EE, et al. Evaluation of the Persian version of modified fatigue impact scale in Iranian patients with multiple sclerosis. Iran J Neurol. 2013;12(1):32–4.
    1. Ghajarzadeh M, Jalilian R, Eskandari G, Ali SM, Reza AA. Validity and reliability of Persian version of Modified Fatigue Impact Scale (MFIS) questionnaire in Iranian patients with multiple sclerosis. Disabil Rehabil. 2013;35(18):1509–12.
    1. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) Neurology. 1983;33(11):1444–52.
    1. Ramsaransing GS, Mellema SA, De Keyser J. Dietary patterns in clinical subtypes of multiple sclerosis: an exploratory study. Nutr J. 2009;8:36.
    1. Timmerman GM, Stuifbergin AK. Eating patterns in women with multiple sclerosis. J Neurosci Nurs. 1999;31(3):152–8.
    1. Saka M, Saka M, Koseler E, Metin S, Bilen S, Aslanyavrusu M, et al. Nutritional status and anthropometric measurements of patients with multiple sclerosis. Saudi Med J. 2012;33(2):160–6.
    1. Hewson DC, Phillips MA, Simpson KE, Drury P, Crawford MA. Food intake in multiple sclerosis. Hum Nutr Appl Nutr. 1984;38(5):355–67.
    1. Sahraian MA, Khorramnia S, Ebrahim MM, Moinfar Z, Lotfi J, Pakdaman H. Multiple sclerosis in Iran: a demographic study of 8,000 patients and changes over time. Eur Neurol. 2010;64(6):331–6.
    1. Bodnar LM, Wisner KL. Nutrition and depression: implications for improving mental health among childbearing-aged women. Biol Psychiatry. 2005;58(9):679–85.
    1. Pennington CR. Disease and malnutrition in British hospitals. Proc Nutr Soc. 1997;56(1B):393–407.
    1. National Multiple Sclerosis Society (U.S.) Halper J, Holland NJ. Consortium of Multiple Sclerosis Centers. Improving Care for Persons with Multiple Sclerosis: Nursing in the New Millenium; New York, NY: National Multiple Sclerosis Society (U.S.); 1997.
    1. Fisk JD, Pontefract A, Ritvo PG, Archibald CJ, Murray TJ. The impact of fatigue on patients with multiple sclerosis. Can J Neurol Sci. 1994;21(1):9–14.
    1. Yasui M, Ota K. Experimental and clinical studies on dysregulation of magnesium metabolism and the aetiopathogenesis of multiple sclerosis. Magnes Res. 1992;5(4):295–302.
    1. Yasui M, Yase Y, Ando K, Adachi K, Mukoyama M, Ohsugi K. Magnesium concentration in brains from multiple sclerosis patients. Acta Neurol Scand. 1990;81(3):197–200.
    1. Kurantsin-Mills J, Cassidy MM, Stafford RE, Weglicki WB. Marked alterations in circulating inflammatory cells during cardiomyopathy development in a magnesium-deficient rat model. Br J Nutr. 1997;78(5):845–55.
    1. Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 2003;26(3):137–46.
    1. Saedisomeolia A, Djalali M, Moghadam AM, Ramezankhani O, Najmi L. Folate and vitamin B12 status in schizophrenic patients. J Res Med Sci. 2011;16(Suppl 1):S437–S441.
    1. Godfrey PS, Toone BK, Carney MW, Flynn TG, Bottiglieri T, Laundy M, et al. Enhancement of recovery from psychiatric illness by methylfolate. Lancet. 1990;336(8712):392–5.
    1. Jacobson W, Saich T, Borysiewicz LK, Behan WM, Behan PO, Wreghitt TG. Serum folate and chronic fatigue syndrome. Neurology. 1993;43(12):2645–7.

Source: PubMed

Szponzorok és közreműködők

Egészségi állapot

Kábítószer-beavatkozások

3
Iratkozz fel