Physical activity and functional limitations in older adults: a systematic review related to Canada's Physical Activity Guidelines

Donald H Paterson, Darren Er Warburton, Donald H Paterson, Darren Er Warburton

Abstract

Background: The purpose was to conduct systematic reviews of the relationship between physical activity of healthy community-dwelling older (>65 years) adults and outcomes of functional limitations, disability, or loss of independence.

Methods: Prospective cohort studies with an outcome related to functional independence or to cognitive function were searched, as well as exercise training interventions that reported a functional outcome. Electronic database search strategies were used to identify citations which were screened (title and abstract) for inclusion. Included articles were reviewed to complete standardized data extraction tables, and assess study quality. An established system of assessing the level and grade of evidence for recommendations was employed.

Results: Sixty-six studies met inclusion criteria for the relationship between physical activity and functional independence, and 34 were included with a cognitive function outcome. Greater physical activity of an aerobic nature (categorized by a variety of methods) was associated with higher functional status (expressed by a host of outcome measures) in older age. For functional independence, moderate (and high) levels of physical activity appeared effective in conferring a reduced risk (odds ratio ~0.5) of functional limitations or disability. Limitation in higher level performance outcomes was reduced (odds ratio ~0.5) with vigorous (or high) activity with an apparent dose-response of moderate through to high activity. Exercise training interventions (including aerobic and resistance) of older adults showed improvement in physiological and functional measures, and suggestion of longer-term reduction in incidence of mobility disability. A relatively high level of physical activity was related to better cognitive function and reduced risk of developing dementia; however, there were mixed results of the effects of exercise interventions on cognitive function indices.

Conclusions: There is a consistency of findings across studies and a range of outcome measures related to functional independence; regular aerobic activity and short-term exercise programmes confer a reduced risk of functional limitations and disability in older age. Although a precise characterization of a minimal or effective physical activity dose to maintain functional independence is difficult, it appears moderate to higher levels of activity are effective and there may be a threshold of at least moderate activity for significant outcomes.

Figures

Figure 1
Figure 1
Results of the literature search for functional limitations.
Figure 2
Figure 2
Prospective cohort studies of the odds ratio of functional limitations or disability in ADLs and IADLs or quality of life disability indexes in relation to physical activity level. The odds ratio (OR) for each level (1,2,3) of physical activity are compared with the lowest physical activity group assigned as the referent (physical activity group = 0, OR = 1). The odds ratios are those reported for analyses statistically adjusted for confounder variables. The OR is an approximation as the actual data may have been separated into men versus women, or other groupings and thus in assembling the data these values have been combined. The level of physical activity was determined from analysis of types of activities that were reported for each activity level in each study; for example, in a number of studies there were only two activity groups but to be in the higher group there had to be report of vigorous activities or walking of 1 hour per day. Thus the physical activity groups were determined to require: 3 - vigorous activities and/or high volume of systematic activity (walking for exercise); 2 - moderate level of activity from participation in normal walking or gardening with a volume of 3-5 days/week and 30 min per day; 1 - participation mainly in light activities of daily living with only occasional walking or gardening; and some physical activity groups were scored as 2.5 as they included vigorous activity (not included in group 2) or exercise walking but at a lower volume than group 3. Dashed lines indicate study data where only two activity groups were categorized, whereas solid lines join the data points for studies in which more than two activity groups were formed.
Figure 3
Figure 3
Prospective cohort studies of odds ratio of lower functional performance or functional limitations in "higher" level functions (such as walking a distance or climbing stairs) in relation to physical activity level. The odds ratio (OR) for each level (1,2,3) of physical activity are compared with the lowest physical activity group assigned as the referent (physical activity group = 0, OR = 1). The odds ratios are those reported for analyses statistically adjusted for confounder variables. The OR is an approximation as the actual data may have been separated into men versus women, or other groupings and thus in assembling the data these values have been combined. The level of physical activity was determined from analysis of types of activities that were reported for each activity level in each study; for example, in a number of studies there were only two activity groups but to be in the higher group there had to be report of vigorous activities or walking of 1 hour per day. Thus the physical activity groups were determined to require: 3 - vigorous activities and/or high volume of systematic activity (walking for exercise); 2 - moderate level of activity from participation in normal walking or gardening with a volume of 3-5 days/week and 30 min per day; 1 - participation mainly in light activities of daily living with only occasional walking or gardening; and some physical activity groups were scored as 2.5 as they included vigorous activity (not included in group 2) or exercise walking but at a lower volume than group 3. Dashed lines indicate study data where only two activity groups were categorized, whereas solid lines join the data points for studies in which more than two activity groups were formed.
Figure 4
Figure 4
Results of the literature search for cognitive function.

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