Radiological prognostic factors of chronic subdural hematoma recurrence: a systematic review and meta-analysis

Ishita P Miah, Yeliz Tank, Frits R Rosendaal, Wilco C Peul, Ruben Dammers, Hester F Lingsma, Heleen M den Hertog, Korné Jellema, Niels A van der Gaag, Dutch Chronic Subdural Hematoma Research Group, Ishita P Miah, Yeliz Tank, Frits R Rosendaal, Wilco C Peul, Ruben Dammers, Hester F Lingsma, Heleen M den Hertog, Korné Jellema, Niels A van der Gaag, Dutch Chronic Subdural Hematoma Research Group

Abstract

Purpose: Chronic subdural hematoma (CSDH) is associated with high recurrence rates. Radiographic prognostic factors may identify patients who are prone for recurrence and who might benefit further optimization of therapy. In this meta-analysis, we systematically evaluated pre-operative radiological prognostic factors of recurrence after surgery.

Methods: Electronic databases were searched until September 2020 for relevant publications. Studies reporting on CSDH recurrence in symptomatic CSDH patients with only surgical treatment were included. Random or fixed effects meta-analysis was used depending on statistical heterogeneity.

Results: Twenty-two studies were identified with a total of 5566 patients (mean age 69 years) with recurrence occurring in 801 patients (14.4%). Hyperdense components (hyperdense homogeneous and mixed density) were the strongest prognostic factor of recurrence (pooled RR 2.83, 95% CI 1.69-4.73). Laminar and separated architecture types also revealed higher recurrence rates (RR 1.37, 95% CI 1.04-1.80 and RR 1.76 95% CI 1.38-2.16, respectively). Hematoma thickness and midline shift above predefined cut-off values (10 mm and 20 mm) were associated with an increased recurrence rate (RR 1.79, 95% CI 1.45-2.21 and RR 1.38, 95% CI 1.11-1.73, respectively). Bilateral CSDH was also associated with an increased recurrence risk (RR 1.34, 95% CI 0.98-1.84).

Limitations: Limitations were no adjustments for confounders and variable data heterogeneity. Clinical factors could also be predictive of recurrence but are beyond the scope of this study.

Conclusions: Hyperdense hematoma components were the strongest prognostic factor of recurrence after surgery. Awareness of these findings allows for individual risk assessment and might prompt clinicians to tailor treatment measures.

Keywords: CSDH; CT; Chronic subdural hematoma; Predictors; Recurrence.

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Hematoma architecture types: a homogeneous; b laminar; c separated; d trabecular type
Fig. 2
Fig. 2
Flow-chart of included studies
Fig. 3
Fig. 3
Forest plot on CSDH recurrence: a uni- versus bilateral hematoma; b hematoma thickness < or > 20 mm; c midline shift < or > 10 mm
Fig. 4
Fig. 4
Forest plot on CSDH recurrence: a homogeneous versus mixed density hematoma; b iso- and hypodensity versus hyper- and mixed density hematoma
Fig. 5
Fig. 5
Forest plot on CSDH recurrence: a laminar hematoma architecture; b separated hematoma architecture

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