Curcumin: from ancient medicine to current clinical trials

H Hatcher, R Planalp, J Cho, F M Torti, S V Torti, H Hatcher, R Planalp, J Cho, F M Torti, S V Torti

Abstract

Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. The pleiotropic activities of curcumin derive from its complex chemistry as well as its ability to influence multiple signaling pathways, including survival pathways such as those regulated by NF-kappaB, Akt, and growth factors; cytoprotective pathways dependent on Nrf2; and metastatic and angiogenic pathways. Curcumin is a free radical scavenger and hydrogen donor, and exhibits both pro- and antioxidant activity. It also binds metals, particularly iron and copper, and can function as an iron chelator. Curcumin is remarkably non-toxic and exhibits limited bioavailability. Curcumin exhibits great promise as a therapeutic agent, and is currently in human clinical trials for a variety of conditions, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis and Alzheimer's disease.

Figures

Figure 1
Figure 1
Curcuma longa (from Koehler’s Medicinal-Plants).
Figure 2
Figure 2
Stages in tumor progression inhibited by curcumin.
Figure 3
Figure 3
Curcumin I, II, III (curcumin, demethoxycurcumin, bis-demethyoxy curcumin), and keto-enol tautomers of curcumin.
Figure 4
Figure 4
Nomenclature of regions of Curcumin l. (A) β-diketone or keto-enol (see Fig. 3); (B) phenolic; (C) alkene linker.

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