Combined respiratory training in an individual with C9orf72 amyotrophic lateral sclerosis

Raele Robison, Lauren C Tabor-Gray, James P Wymer, Emily K Plowman, Raele Robison, Lauren C Tabor-Gray, James P Wymer, Emily K Plowman

Abstract

This case study examined the impact of a respiratory strength training program targeting inspiratory and expiratory musculature in an individual with C9orf72 amyotrophic lateral sclerosis (ALS). The individual tolerated 24 months of respiratory training completed at home, 50 repetitions per day, and 5 days per week. Significant increases in maximum inspiratory pressure (from 71 to 134 centimeters of water), maximum expiratory pressure (from 108 to 197 centimeters of water) and peak cough flow (from 331 to 655 Liters per minute) were noted and forced vital capacity remained unchanged. A moderate intensity respiratory strength training program applied early in the disease progression improved function in this C9orf72 ALS individual.

Figures

Figure 1
Figure 1
(A) Maximum expiratory pressure (MEP cmH2O) and (B) Maximum inspiratory pressure (MIP cmH2O) measurements for the combined respiratory training participant over the 24‐month training period. At baseline, A.C.'s MEP was 108 cmH2O representing a 6 cmH2O reduction as compared to established normative data based on his age and gender. His baseline MIP (71 cmH2O) was reduced by 47 cmH2O. After 24 months of training, his MEP and MIP improved by 89% and 82%, respectively, and are presently above expected values for his age and gender.

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Source: PubMed

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