A 3-week multimodal intervention involving high-intensity interval training in female cancer survivors: a randomized controlled trial

Joachim Schmitt, Nathalie Lindner, Monika Reuss-Borst, Hans-Christer Holmberg, Billy Sperlich, Joachim Schmitt, Nathalie Lindner, Monika Reuss-Borst, Hans-Christer Holmberg, Billy Sperlich

Abstract

To compare the effects of a 3-week multimodal rehabilitation involving supervised high-intensity interval training (HIIT) on female breast cancer survivors with respect to key variables of aerobic fitness, body composition, energy expenditure, cancer-related fatigue, and quality of life to those of a standard multimodal rehabilitation program. A randomized controlled trial design was administered. Twenty-eight women, who had been treated for cancer were randomly assigned to either a group performing exercise of low-to-moderate intensity (LMIE; n = 14) or a group performing high-intensity interval training (HIIT; n = 14) as part of a 3-week multimodal rehabilitation program. No adverse events related to the exercise were reported. Work economy improved following both HIIT and LMIE, with improved peak oxygen uptake following LMIE. HIIT reduced mean total body fat mass with no change in body mass, muscle or fat-free mass (best P < 0.06). LMIE increased muscle and total fat-free body mass. Total energy expenditure (P = 0.45) did not change between the groups, whereas both improved quality of life to a similar high extent and lessened cancer-related fatigue. This randomized controlled study demonstrates that HIIT can be performed by female cancer survivors without adverse health effects. Here, HIIT and LMIE both improved work economy, quality of life and cancer-related fatigue, body composition or energy expenditure. Since the outcomes were similar, but HIIT takes less time, this may be a time-efficient strategy for improving certain aspects of the health of female cancer survivors.

Keywords: Cancer survivors; cardiorespiratory fitness; energy expenditure; exercise; rehabilitation; sense wear.

© 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

References

    1. Aaronson, N. K. , Ahmedzai S., Bergman B., Bullinger M., Cull A., Duez N. J., et al. 1993. The European Organization for Research and Treatment of Cancer QLQ‐C30: a quality‐of‐life instrument for use in international clinical trials in oncology. J. Natl Cancer Inst. 85:365–376.
    1. Adachi, H. , Koike A., Obayashi T., Umezawa S., Aonuma K., Inada M., et al. 1996. Does appropriate endurance exercise training improve cardiac function in patients with prior myocardial infarction? Eur. Heart J. 17:1511–1521.
    1. Adamsen, L. , Quist M., Andersen C., Moller T., Herrstedt J., Kronborg D., et al. 2009. Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial. BMJ 339:b3410.
    1. Barnes, K. R. , and Kilding A. E.. 2015. Strategies to improve running economy. Sports Med. 45:37–56.
    1. Bassett, D. R. Jr , and Howley E. T.. 2000. Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med. Sci. Sports Exerc. 32:70–84.
    1. Battaglini, C. L. , Mills R. C., Phillips B. L., Lee J. T., Story C. E., Nascimento M. G., et al. 2014. Twenty‐five years of research on the effects of exercise training in breast cancer survivors: a systematic review of the literature. World J. Clin. Oncol. 5:177–190.
    1. Bouchard, C. , Lesage R., Lortie G., Simoneau J. A., Hamel P., Boulay M. R., et al. 1986. Aerobic performance in brothers, dizygotic and monozygotic twins. Med. Sci. Sports Exerc. 18:639–646.
    1. Bruce, R. A. , Kusumi F., and Hosmer D.. 1973. Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am. Heart J. 85:546–562.
    1. Buffart, L. M. , de Backer I. C., Schep G., Vreugdenhil A., Brug J., and Chinapaw M. J.. 2013. Fatigue mediates the relationship between physical fitness and quality of life in cancer survivors. J. Sci. Med. Sport 16:99–104.
    1. Cohen, D. 1988. Statistical power analysis for the behavioral sciences. Lawrence Erlbaum Associates, Hillsdale, NJ.
    1. Courneya, K. S. , and Friedenreich C. M.. 2001. Framework PEACE: an organizational model for examining physical exercise across the cancer experience. Ann. Behav. Med. 23:263–272.
    1. Devin, J. L. , Sax A. T., Hughes G. I., Jenkins D. G., Aitken J. F., Chambers S. K., et al. 2015. The influence of high‐intensity compared with moderate‐intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial. J. Cancer Surviv.[Epub ahead of print].
    1. Drenowatz, C. , Eisenmann J. C., Pivarnik J. M., Pfeiffer K. A., and Carlson J. J.. 2013. Differences in energy expenditure between high‐ and low‐volume training. Eur. J. Sport Sci. 13:422–430.
    1. Edvardsen, E. , Skjonsberg O. H., Holme I., Nordsletten L., Borchsenius F., and Anderssen S. A.. 2015. High‐intensity training following lung cancer surgery: a randomised controlled trial. Thorax 70:244–250.
    1. Elliott, A. D. , Rajopadhyaya K., Bentley D. J., Beltrame J. F., and Aromataris E. C.. 2014. Interval training versus continuous exercise in patients with coronary artery disease: a meta‐analysis. Heart Lung Circ. 24:149–157.
    1. Farooqi, N. , Slinde F., Haglin L., and Sandstrom T.. 2013. Validation of SenseWear Armband and ActiHeart monitors for assessments of daily energy expenditure in free‐living women with chronic obstructive pulmonary disease. Physiol. Rep. 1:e00150.
    1. Ferlay, J. , Steliarova‐Foucher E., Lortet‐Tieulent J., Rosso S., Coebergh J. W., Comber H., et al. 2013. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur. J. Cancer 49:1374–1403.
    1. Fong, D. Y. , Ho J. W., Hui B. P., Lee A. M., Macfarlane D. J., Leung S. S., et al. 2012. Physical activity for cancer survivors: meta‐analysis of randomised controlled trials. BMJ 344:e70.
    1. Gielen, S. , Laughlin M. H., O'Conner C., and Duncker D. J.. 2015. Exercise training in patients with heart disease: review of beneficial effects and clinical recommendations. Prog. Cardiovasc. Dis. 57:347–355.
    1. Hardcastle, S. J. , Ray H., Beale L., and Hagger M. S.. 2014. Why sprint interval training is inappropriate for a largely sedentary population. Front Psychol. 5:1505.
    1. Hazell, T. J. , Hamilton C. D., Olver T. D., and Lemon P. W.. 2014. Running sprint interval training induces fat loss in women. Appl. Physiol. Nutr. Metab. 39:944–950.
    1. Heinrich, K. M. , Becker C., Carlisle T., Gilmore K., Hauser J., Frye J., et al. 2015. High‐intensity functional training improves functional movement and body composition among cancer survivors: a pilot study. Eur. J. Cancer Care (Engl) 24:812–817.
    1. Hwang, C. L. , Yu C. J., Shih J. Y., Yang P. C., and Wu Y. T.. 2012. Effects of exercise training on exercise capacity in patients with non‐small cell lung cancer receiving targeted therapy. Support. Care Cancer 20:3169–3177.
    1. Jensen, B. E. , Fletcher B. J., Rupp J. C., Fletcher G. F., Lee J. Y., and Oberman A.. 1996. Training level comparison study. Effect of high and low intensity exercise on ventilatory threshold in men with coronary artery disease. J. Cardiopulm. Rehabil. 16:227–232.
    1. Kampshoff, C. S. , Chinapaw M. J., Brug J., Twisk J. W., Schep G., Nijziel M. R., et al. 2015. Randomized controlled trial of the effects of high intensity and low‐to‐moderate intensity exercise on physical fitness and fatigue in cancer survivors: results of the Resistance and Endurance exercise After ChemoTherapy (REACT) study. BMC Med. 13:275.
    1. Kangas, M. , Bovbjerg D. H., and Montgomery G. H.. 2008. Cancer‐related fatigue: a systematic and meta‐analytic review of non‐pharmacological therapies for cancer patients. Psychol. Bull. 134:700–741.
    1. Kessler, H. S. , Sisson S. B., and Short K. R.. 2012. The potential for high‐intensity interval training to reduce cardiometabolic disease risk. Sports Med. 42:489–509.
    1. Lin, J. M. , Brimmer D. J., Maloney E. M., Nyarko E., Belue R., and Reeves W. C.. 2009. Further validation of the Multidimensional Fatigue Inventory in a US adult population sample. Popul. Health Metr. 7:18.
    1. Little, J. P. , and Francois M. E.. 2014. High‐intensity interval training for improving postprandial hyperglycemia. Res. Q. Exerc. Sport 85:451–456.
    1. Martin, E. , Battaglini C., Hands B., and Naumann F. L.. 2015. Higher‐intensity exercise helps cancer survivors remain motivated. J. Cancer Surviv. [Epub ahead of print].
    1. Midtgaard, J. , Christensen J. F., Tolver A., Jones L. W., Uth J., Rasmussen B., et al. 2013. Efficacy of multimodal exercise‐based rehabilitation on physical activity, cardiorespiratory fitness, and patient‐reported outcomes in cancer survivors: a randomized, controlled trial. Ann. Oncol. 24:2267–2273.
    1. Schmitz, K. H. , Courneya K. S., Matthews C., Demark‐Wahnefried W., Galvao D. A., Pinto B. M., et al. ; American College of Sports Medicine . 2010. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med. Sci. Sports Exerc. 42:1409–1426.
    1. Schwarz, R. , and Hinz A.. 2001. Reference data for the quality of life questionnaire EORTC QLQ‐C30 in the general German population. Eur. J. Cancer 37:1345–1351.
    1. Sedjo, R. L. , Byers T., Ganz P. A., Colditz G. A., Demark‐Wahnefried W., Wolin K. Y., et al. 2014. Weight gain prior to entry into a weight‐loss intervention study among overweight and obese breast cancer survivors. J. Cancer Surviv. 8:410–418.
    1. Smets, E. M. , Garssen B., Bonke B., and de Haes J. C.. 1995. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J. Psychosom. Res. 39:315–325.
    1. Speck, R. M. , Courneya K. S., Masse L. C., Duval S., and Schmitz K. H.. 2010. An update of controlled physical activity trials in cancer survivors: a systematic review and meta‐analysis. J. Cancer Surviv. 4:87–100.
    1. del Vecchio, F. B. , Gentil P., Coswig V. S., and Fukuda D. H.. 2015. Commentary: why sprint interval training is inappropriate for a largely sedentary population. Front Psychol. 6:1359.
    1. van Waart, H. , Stuiver M. M., van Harten W. H., Geleijn E., Kieffer J. M., Buffart L. M., et al. 2015. Effect of low‐intensity physical activity and moderate‐ to high‐intensity physical exercise during adjuvant chemotherapy on physical fitness, fatigue, and chemotherapy completion rates: results of the PACES randomized clinical trial. J. Clin. Oncol. 33:1918–1927.

Source: PubMed

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