The prognostic utility of the SYNTAX score on 1-year outcomes after revascularization with zotarolimus- and everolimus-eluting stents: a substudy of the RESOLUTE All Comers Trial
Scot Garg, Patrick W Serruys, Sigmund Silber, Joanna Wykrzykowska, Robert Jan van Geuns, Gert Richardt, Pawel E Buszman, Henning Kelbæk, Adrianus Johannes van Boven, Sjoerd H Hofma, Axel Linke, Volker Klauss, William Wijns, Carlos Macaya, Philippe Garot, Carlo DiMario, Ganesh Manoharan, Ran Kornowski, Thomas Ischinger, Antonio Bartorelli, Eric Van Remortel, Jacintha Ronden, Stephan Windecker, Scot Garg, Patrick W Serruys, Sigmund Silber, Joanna Wykrzykowska, Robert Jan van Geuns, Gert Richardt, Pawel E Buszman, Henning Kelbæk, Adrianus Johannes van Boven, Sjoerd H Hofma, Axel Linke, Volker Klauss, William Wijns, Carlos Macaya, Philippe Garot, Carlo DiMario, Ganesh Manoharan, Ran Kornowski, Thomas Ischinger, Antonio Bartorelli, Eric Van Remortel, Jacintha Ronden, Stephan Windecker
Abstract
Objectives: This study assessed the ability of the SYNTAX score (SXscore) to stratify risk in patients treated with percutaneous coronary intervention (PCI) using zotarolimus-eluting or everolimus-eluting stents.
Background: The SXscore can identify patients treated with PCI who are at highest risk of adverse events.
Methods: The SXscore was calculated prospectively in 2,033 of the 2,292 patients enrolled in the RESOLUTE All Comers study (RESOLUTE III All Comers Trial: A Randomized Comparison of a Zotarolimus-Eluting Stent With an Everolimus-Eluting Stent for Percutaneous Coronary Intervention). Clinical outcomes in terms of a patient-oriented composite endpoint (POCE) of all-cause death, myocardial infarction (MI), and repeat revascularization; the individual components of POCE; target lesion failure (TLF) (a composite of cardiac death, target-vessel MI, and clinically driven target lesion revascularization); and stent thrombosis were subsequently stratified according to SXscore tertiles: SXscore(LOW) ≤ 9 (n = 698), 9 <SXscore(MID) ≤ 17 (n = 676); SXscore(HIGH) >17 (n = 659).
Results: At 12-month follow-up, rates of POCE, MI, repeat revascularization, TLF, and the composite of death/MI were all significantly higher in patients in the highest SXscore tercile. Rates of stent thrombosis were all highest in the SXscore(HIGH) tertile (p > 0.05). After multivariate adjustment, the SXscore was identified as an independent predictor of POCE, MI, repeat revascularization, and TLF (p < 0.05 for all). At 12-month follow-up, the SXscore, ACEF score, and Clinical SXscore had C-statistics of 0.57, 0.78, and 0.67, respectively, for mortality and of 0.62, 0.56, 0.63, respectively, for POCE. No significant between-stent differences were observed for TLF or POCE in any of the SXscore tertiles.
Conclusions: The SYNTAX score is able to stratify risk amongst an all-comers population treated with PCI with second-generation drug-eluting stents (DES); however, improvements can be made with the inclusion of clinical variables. (RESOLUTE III All Comers Trial: A Randomized Comparison of a Zotarolimus-Eluting Stent With an Everolimus-Eluting Stent for Percutaneous Coronary Intervention; NCT00617084).
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Source: PubMed