Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort
Tracey L Weissgerber, Paula L McGee, Leslie Myatt, John C Hauth, Michael W Varner, Ronald J Wapner, John M Thorp Jr, Brian M Mercer, Alan M Peaceman, Susan M Ramin, Philip Samuels, Anthony C Sciscione, Margaret Harper, George Saade, Yoram Sorokin, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, J Roberts, S Caritis, T Kamon, M Cotroneo, D Fischer, P Reed, S Quinn, V Morby, F Porter, R Silver, J Miller, K Hill, D J Rouse, A Northen, P Files, J Grant, M Wallace, K Bailey, S Bousleiman, R Alcon, K Saravia, F Loffredo, A Bayless, C Perez, M Lake, M Talucci, K Boggess, K Dorman, J Mitchell, K Clark, S Timlin, J Bailit, C Milluzzi, W Dalton, C Brezine, D Bazzo, K Leveno, J Sheffield, L Moseley, M Santillan, K Buentipo, J Price, L S Hermann, C Melton, Y Gloria-McCutchen, B Espino, M Dinsmoor, T Matson-Manning, G Mallett, S Blackwell, K Cannon, S Lege-Humbert, Z Spears, M Carpenter, J Tillinghast, M Seebeck, J Iams, F Johnson, S Fyffe, C Latimer, S Frantz, J Wylie, M Talucci, M Hoffman, J Benson, Z Reid, C Tocci, P Meis, M Swain, J Tolosa, W Smith, L Davis, E Lairson, S Butcher, S Maxwell, D Fisher, J Moss, B Stratton, G Hankins, J Brandon, C Nelson-Becker, G Olson, L Pacheco, G Norman, S Blackwell, P Lockhart, D Driscoll, M Dombrowski, E Thom, R Clifton, T Boekhoudt, L Leuchtenburg, V Pemberton, J Cutler, W Barouch, C Spong, S Tolivaisa, G D Anderson, Tracey L Weissgerber, Paula L McGee, Leslie Myatt, John C Hauth, Michael W Varner, Ronald J Wapner, John M Thorp Jr, Brian M Mercer, Alan M Peaceman, Susan M Ramin, Philip Samuels, Anthony C Sciscione, Margaret Harper, George Saade, Yoram Sorokin, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, J Roberts, S Caritis, T Kamon, M Cotroneo, D Fischer, P Reed, S Quinn, V Morby, F Porter, R Silver, J Miller, K Hill, D J Rouse, A Northen, P Files, J Grant, M Wallace, K Bailey, S Bousleiman, R Alcon, K Saravia, F Loffredo, A Bayless, C Perez, M Lake, M Talucci, K Boggess, K Dorman, J Mitchell, K Clark, S Timlin, J Bailit, C Milluzzi, W Dalton, C Brezine, D Bazzo, K Leveno, J Sheffield, L Moseley, M Santillan, K Buentipo, J Price, L S Hermann, C Melton, Y Gloria-McCutchen, B Espino, M Dinsmoor, T Matson-Manning, G Mallett, S Blackwell, K Cannon, S Lege-Humbert, Z Spears, M Carpenter, J Tillinghast, M Seebeck, J Iams, F Johnson, S Fyffe, C Latimer, S Frantz, J Wylie, M Talucci, M Hoffman, J Benson, Z Reid, C Tocci, P Meis, M Swain, J Tolosa, W Smith, L Davis, E Lairson, S Butcher, S Maxwell, D Fisher, J Moss, B Stratton, G Hankins, J Brandon, C Nelson-Becker, G Olson, L Pacheco, G Norman, S Blackwell, P Lockhart, D Driscoll, M Dombrowski, E Thom, R Clifton, T Boekhoudt, L Leuchtenburg, V Pemberton, J Cutler, W Barouch, C Spong, S Tolivaisa, G D Anderson
Abstract
Objective: The anti-oxidant and proangiogenic protein haptoglobin (Hp) is believed to be important for implantation and pregnancy, although its specific role is not known. The three phenotypes (1-1, 2-1 and 2-2) differ in structure and function. Hp 2-2 is associated with increased vascular stiffness in other populations. We examined whether Hp phenotype is associated with abnormal uterine artery Doppler (UAD) in pregnancy.
Methods: We conducted a secondary analysis of a preeclampsia prediction cohort nested within a larger placebo-controlled randomized clinical trial of antioxidants for prevention of preeclampsia. We determined Hp phenotype in 2184 women who completed UAD assessments at 17 weeks gestation. Women with notching were re-evaluated for persistent notching at 24 weeks' gestation. Logistic regression was used to assess differences in UAD indices between phenotype groups.
Results: Hp phenotype did not significantly influence the odds of having any notch (p = 0.32), bilateral notches (p = 0.72), or a resistance index (p = 0.28) or pulsatility index (p = 0.67) above the 90th percentile at 17 weeks' gestation. Hp phenotype also did not influence the odds of persistent notching at 24 weeks (p = 0.25).
Conclusions: Hp phenotype is not associated with abnormal UAD at 17 weeks' gestation or with persistent notching at 24 weeks.
Keywords: Ethnicity; haptoglobin; pregnancy; race; vascular resistance; women.
Conflict of interest statement
Declaration of Interests
The authors report no conflicts of interest.
Source: PubMed