Levels of serum 25-hydroxy-vitamin d in benign and malignant breast masses
Sadaf Alipour, Maryam Hadji, Ladan Hosseini, Ramesh Omranipour, Azin Saberi, Akram Seifollahi, Leila Bayani, Nooshin Shirzad, Sadaf Alipour, Maryam Hadji, Ladan Hosseini, Ramesh Omranipour, Azin Saberi, Akram Seifollahi, Leila Bayani, Nooshin Shirzad
Abstract
Background: The true association between breast cancer and vitamin D is currently under investigation. We compared serum 25-hydroxy-vitamin D levels in women with benign and malignant breast masses and controls.
Materials and methods: Levels of vitamin D were measured by electrochemiluminescense. Serum levels >35 ng/ml, 25-35 ng/ml, 12.5-25 ng/ml and <12.5 ng/ml were considered as normal, mild, moderate and severe vitamin D deficiency, respectively.
Results: Overall, 364 women were included in the control, 172 in the benign and 136 in the malignant groups. The median serum vitamin D level was significantly lower in breast cancers than controls. Levels were also lower in malignant than benign cases and in benign cases than controls although statistically non-significant.
Conclusions: Multinomial logistic regression analysis showed that severe vitamin D deficiency causes a three-fold increase in the risk of breast cancer while this was not the case for moderate and mild deficiency.
Source: PubMed