Feasibility of a Randomized Clinical Trial of Cardiac Resynchronization Therapy With or Without an Implantable Defibrillator in Older Patients

Andrew D Althouse, Sandeep Kumar Jain, Alaa Shalaby, Madhurmeet Singh, Raul Weiss, Larissa Myaskovsky, Sana M Al-Khatib, Samir Saba, Andrew D Althouse, Sandeep Kumar Jain, Alaa Shalaby, Madhurmeet Singh, Raul Weiss, Larissa Myaskovsky, Sana M Al-Khatib, Samir Saba

No abstract available

Keywords: aged; cardiac resynchronization therapy; defibrillators; heart failure; humans.

Figures

Figure 1.

Overall design of the study with its observational prospective registry (n=60 patients) and its RCT (n=42 patients) components is shown in panel A. Panel B details the enrollment timeline for the observational registry and the RCT. Kaplan Meier curves are shown comparing the overall survival of patients enrolled in the observational registry versus the RCT (panel C) and for those in the randomized trial who received a CRT-P versus a CRT-D (panel D). UPMC = University of Pittsburgh Medical Center; OSUMC = Ohio State University Medical Center; VA PITT = Veterans Affairs hospital of Pittsburgh; LVEF = left ventricular ejection fraction; NYHA = New York Heart Association; CRT-P = cardiac resynchronization therapy pacemaker; CRT-D = cardiac resynchronization therapy defibrillator; OBS = observational registry; RCT = randomized controlled trial; HR = hazard ratio; CI = confidence interval.