Probable tiger-to-tiger transmission of avian influenza H5N1

Roongroje Thanawongnuwech, Alongkorn Amonsin, Rachod Tantilertcharoen, Sudarat Damrongwatanapokin, Apiradee Theamboonlers, Sunchai Payungporn, Kamonchart Nanthapornphiphat, Somchuan Ratanamungklanon, Eakchai Tunak, Thaweesak Songserm, Veravit Vivatthanavanich, Thawat Lekdumrongsak, Sawang Kesdangsakonwut, Schwann Tunhikorn, Yong Poovorawan, Roongroje Thanawongnuwech, Alongkorn Amonsin, Rachod Tantilertcharoen, Sudarat Damrongwatanapokin, Apiradee Theamboonlers, Sunchai Payungporn, Kamonchart Nanthapornphiphat, Somchuan Ratanamungklanon, Eakchai Tunak, Thaweesak Songserm, Veravit Vivatthanavanich, Thawat Lekdumrongsak, Sawang Kesdangsakonwut, Schwann Tunhikorn, Yong Poovorawan

Abstract

During the second outbreak of avian influenza H5N1 in Thailand, probable horizontal transmission among tigers was demonstrated in the tiger zoo. Sequencing and phylogenetic analysis of those viruses showed no differences from the first isolate obtained in January 2004. This finding has implications for influenza virus epidemiology and pathogenicity in mammals.

Figures

Figure 1
Figure 1
Histopathologic and immunohistochemical evidence of H5N1 virus in tiger: A) Mild multifocal nonsuppurative encephalitis; B) Influenza A virus antigen in nuclei and cytoplasm visible as brown staining.
Figure 2
Figure 2
Numbers of sick, dead, or euthanized tigers during the outbreak. The animals were fed cooked chicken carcasses or pork after October 16, 2004. Isolates from the sick tigers, pre- and posttreated with oseltamivir, were A/Tiger/Thailand/CU-T3/04 (October 18) and A/Tiger/Thailand/CU-T7/04 (October 24).

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Source: PubMed

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