Effect of exercise on glucose variability in healthy subjects: randomized crossover trial

Franciele Ramos Figueira, Daniel Umpierre, Patrícia Martins Bock, Gustavo Waclawovsky, Ana Paula Guerra, Anderson Donelli, Michael Andrades, Karina Rabello Casali, Beatriz D Schaan, Franciele Ramos Figueira, Daniel Umpierre, Patrícia Martins Bock, Gustavo Waclawovsky, Ana Paula Guerra, Anderson Donelli, Michael Andrades, Karina Rabello Casali, Beatriz D Schaan

Abstract

The aim of this study was to evaluate the acute effect of aerobic (AER) and eccentric (ECC) exercise on glucose variability, correlating it with circulating markers of inflammation and oxidative stress in healthy subjects. Sixteen healthy subjects (32 ± 12 years old) wore a continuous glucose monitoring system for three days. Participants randomly performed single AER and ECC exercise sessions. Glucose variability was evaluated by glucose variance (VAR), glucose coefficient of variation (CV%) and glucose standard deviation (SD). Blood samples were collected to evaluate inflammatory and oxidative stress markers. When compared with the pre-exercise period of 0-6 h, all the indices of glucose variability presented comparable reductions 12-18 h after both exercises (∆AER: VAR= 151.5, ∆CV% = 0.55 and ∆SD = 3.1 and ECC: ∆VAR = 221.2 , ∆CV% = 3.7 and ∆SD = 6.5). Increased interleukin-6 (IL-6) levels after AER (68.5%) and ECC (30.8%) (P<0.001) were observed, with no differences between sessions (P = 0.459). Uric acid levels were increased after exercise sessions (3% in AER and 4% in ECC, P = 0.001). In conclusion, both AER and ECC exercise sessions reduced glucose variability in healthy individuals. Inflammatory cytokines, such as IL-6, and stress oxidative markers might play a role in underlying mechanisms modulating the glucose variability responses to exercise (clinicalTrials.gov NCT02262208).

Keywords: Acute exercise aerobic; Acute exercise eccentric; Glucose variability; Inflammation; Oxidative stress.

Conflict of interest statement

All other authors have no conflict of interest to declare.

Figures

FIG. 1
FIG. 1
Flow diagram. Note: International Physical Activity Questionnaire (IPAQ); Continuous glucose monitoring system (CGMS); aerobic (AER) eccentric (ECC) exercise; ferric reducing ability of plasma (FRAP); interleukin-6 (IL-6).
FIG. 2
FIG. 2
Absolute glucose levels (CGMS), detailed in the first 3 h and 5 h after aerobic (AER) and eccentric (ECC) exercise. Note: data are reported as mean ± SEM. Generalized estimating equations (GEE); Bonferroni correction.
FIG. 3
FIG. 3
Glucose variability evaluated before and after aerobic (AER) or eccentric (ECC) exercise (n=15) Note: glucose variance (panel A), glucose coefficient of variation (panel B), glucose standard deviation (panel C). Generalized estimating equations (GEE); Bonferroni correction. *P

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Source: PubMed

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