A Single Bout of Upper-Body Exercise Has No Effect on Postprandial Metabolism in Persons with Chronic Paraplegia

Matthew T Farrow, Jennifer L Maher, Tom E Nightingale, Dylan Thompson, James L J Bilzon, Matthew T Farrow, Jennifer L Maher, Tom E Nightingale, Dylan Thompson, James L J Bilzon

Abstract

Purpose: The acute effects of a single bout of upper-body exercise on postprandial metabolism in persons with spinal cord injury are currently not well understood. The primary aim of this study was to evaluate the effects of a single bout of upper-body high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) in comparison with a no-exercise control (REST) condition on postprandial metabolic responses in persons with chronic paraplegia.

Methods: Ten participants (eight males, two females; age, 49 ± 10 yr; time since injury, 22 ± 13 yr) with chronic paraplegia took part in a randomized crossover study, consisting of three trials: HIIE (8 × 60 s at 70% peak power output [PPEAK]), MICE (25 min at 45% PPEAK), and REST, at least 3 d apart. Exercise was performed in the fasted state, and participants consumed a mixed-macronutrient liquid meal 1-h postexercise. Venous blood and expired gas samples were collected at regular intervals for 6-h postmeal consumption.

Results: There were no significant differences in postprandial incremental area under the curve for triglycerides (P = 0.59) or glucose (P = 0.56) between conditions. Insulin incremental area under the curve tended to be lower after MICE (135 ± 85 nmol·L-1 per 360 min) compared with REST (162 ± 93 nmol·L-1 per 360 min), but this did not reach statistical significance (P = 0.06, d = 0.30). Participants reported a greater fondness (P = 0.04) and preference for HIIE over MICE.

Conclusions: After an overnight fast, a single bout of upper-body exercise before eating has no effect on postprandial metabolism in persons with chronic paraplegia, irrespective of exercise intensity. This suggests that alternative exercise strategies may be required to stimulate postprandial substrate oxidation for this population.

Trial registration: ClinicalTrials.gov NCT04011137.

Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine.

Figures

FIGURE 1
FIGURE 1
Schematic of experimental trial days (laboratory visits 2–4).
FIGURE 2
FIGURE 2
Heart rate (expressed as a % of HRPEAK) at 0%, 25%, 50%, 75%, and 100% of exercise completion during MICE and HIIE. *Significant difference (P ≤ 0.05) between conditions.
FIGURE 3
FIGURE 3
Serum concentrations of insulin (A) across each condition and iAUC (individual responses also denoted) for serum insulin (B) across the 6-h postprandial period after consumption of the MMTT. The hashed box represents consumption of the meal.
FIGURE 4
FIGURE 4
Serum concentrations of glucose (A) across each condition and iAUC (individual responses are also denoted) for serum glucose (B) across the 6-h postprandial period after consumption of the MMTT. The hashed box represents consumption of the meal.
FIGURE 5
FIGURE 5
Serum concentrations of triglycerides (A) across each condition and iAUC (individual responses are also denoted) for serum triglycerides (B) across the 6-h postprandial period after consumption of the MMTT. The hashed box represents consumption of the meal.

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Source: PubMed

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