A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by Turkish Neonatal Society

Mehmet Yekta Oncel, Ilke Mungan Akın, Mehmet Kenan Kanburoglu, Cuneyt Tayman, Senay Coskun, Fatma Narter, Ilkay Er, Tinatin Gelenava Oncan, Asli Memisoglu, Merih Cetinkaya, Demet Oguz, Omer Erdeve, Esin Koc, Neo-Covid Study Group, Turan Derme, Dilek Şahin, Bülent Güzel, Arzu Bilge Tekin, Yasemin Akın, Ahmet Kale, Hüseyin Aktürk, Mehmet Özsürmeli, Nazife Reyyan Gök, Rabia Merve Palalıoğlu, Abdurrahman Hamdi İnan, Hülya Özdemir, Esra Esim Büyükbayrak, İbrahim Polat, Gülser Bingöl Dikdere, Leyla Bilgin, Tuğba Saraç Sivrikoz, İbrahim Caner, Hilal Uslu Yuvacı, Nursu Kara, Ali Galip Zebitay, Emel Okulu, Erkan Kalafat, Nurdan Uras, Bülent Tekin, Nükhet Aladağ Çiftdemir, Muhammet Bulut, Ali Bülbül, Nilüfer Okur, Ferda Özlü, Kadir Şerafettin Tekgündüz, Adil Umut Zübarioğlu, Hüseyin Altunhan, Baran Cengiz Arcagök, Canan Aygün, Nihat Demir, İsmail Kürşat Gökçe, Nazlı Dilay Gültekin, Handan Hakyemez Toptan, Ferit Kulalı, Sinan Tüfekçi, Funda Tüzün, Akan Yaman, Hüseyin Üstün, Mehmet Yekta Oncel, Ilke Mungan Akın, Mehmet Kenan Kanburoglu, Cuneyt Tayman, Senay Coskun, Fatma Narter, Ilkay Er, Tinatin Gelenava Oncan, Asli Memisoglu, Merih Cetinkaya, Demet Oguz, Omer Erdeve, Esin Koc, Neo-Covid Study Group, Turan Derme, Dilek Şahin, Bülent Güzel, Arzu Bilge Tekin, Yasemin Akın, Ahmet Kale, Hüseyin Aktürk, Mehmet Özsürmeli, Nazife Reyyan Gök, Rabia Merve Palalıoğlu, Abdurrahman Hamdi İnan, Hülya Özdemir, Esra Esim Büyükbayrak, İbrahim Polat, Gülser Bingöl Dikdere, Leyla Bilgin, Tuğba Saraç Sivrikoz, İbrahim Caner, Hilal Uslu Yuvacı, Nursu Kara, Ali Galip Zebitay, Emel Okulu, Erkan Kalafat, Nurdan Uras, Bülent Tekin, Nükhet Aladağ Çiftdemir, Muhammet Bulut, Ali Bülbül, Nilüfer Okur, Ferda Özlü, Kadir Şerafettin Tekgündüz, Adil Umut Zübarioğlu, Hüseyin Altunhan, Baran Cengiz Arcagök, Canan Aygün, Nihat Demir, İsmail Kürşat Gökçe, Nazlı Dilay Gültekin, Handan Hakyemez Toptan, Ferit Kulalı, Sinan Tüfekçi, Funda Tüzün, Akan Yaman, Hüseyin Üstün

Abstract

Limited data are available on pregnant women with COVID-19 and their neonates. We aimed to evaluate the epidemiological and clinical characteristics of newborns born to women infected with COVID-19. A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey. Pregnant women (n = 125) who had a positive RT-PCR test and their newborns were enrolled. Cesarean section, prematurity, and low-birthweight infant rates were 71.2%, 26.4%, and 12.8%, respectively. Eight of 125 mothers (6.4%) were admitted to an intensive care unit for mechanical ventilation, among whom six died (4.8%). Majority of the newborns (86.4%) were followed in isolation rooms in the NICU. Four of 120 newborns (3.3%) had a positive RT-PCR test result. Although samples taken on the first day were negative, one neonate became positive on the second day and the other two on the fifth day. Sample from deep tracheal aspirate was positive on the first day in an intubated case.Conclusion: COVID-19 in pregnant women has important impacts on perinatal and neonatal outcomes. Maternal mortality, higher rates of preterm birth and cesarean section, suspected risk of vertical transmission, and low rate of breastfeeding show that family support should be a part of the care in the NICU.Trial registration: ClinicalTrials.gov identifier: NCT04401540 What is Known: • The common property of previous reports was the conclusions on maternal outcomes, rather than neonatal outcomes. • Published data showed similar outcomes between COVID-19 pregnant women and others. What is New: • Higher maternal mortality, higher rates of preterm birth and cesarean section, suspected risk of vertical transmission especially in a case with deep tracheal aspiration during the intubation, and the possible role of maternal disease severity on the outcomes are remarkable findings of this study. • In contrast to recommendation for breastfeeding, parents' preference to formula and expressed breast milk due to anxiety and lack of information shows that family support should be a part of the care in the NICU.

Keywords: COVID-19; Newborn; Pregnancy; SARS-CoV-2.

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Imaging findings of four newborns with SARS-CoV-2

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Source: PubMed

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